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Interaction between polyene antifungal drug and saturated phospholipid monolayer regulated by calcium ions at the air-water interface.

Authors:
Juan Wang Hao Zhu

Colloids Surf B Biointerfaces 2021 Jul 22;207:111998. Epub 2021 Jul 22.

Shaanxi Engineering Research Center of Controllable Neutron Source, School of Science, Xijing University, Xi'an, 710123, China.

Amphotericin B (AmB) is a polyene antifungal drug, which could directly form pores on the sterol-free phospholipid monolayers. The interaction between AmB and phospholipid can be affected by calcium ions, but the mechanism is still unclear. DPPC is a saturated phospholipid with -PC group, which is often used to simulate the outer cell membrane leaflet. Read More

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Insufficient Iron in Floral Buds Impairs Pollen Development by Disrupting Tapetum Function.

Plant J 2021 Jul 26. Epub 2021 Jul 26.

Agricultural Biotechnology Research Center, Academia Sinica, Taipei, 11529, Taiwan.

Reduction of crop yield due to iron (Fe) deficiency has always been a concern in agriculture. How insufficient Fe in floral buds affects pollen development remains unexplored. Here, plants transferred to Fe-deficient medium at the reproductive stage had reduced floral Fe content and viable pollen and showed a defective pollen outer wall, all restored by supplying floral buds with Fe. Read More

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Metabolic profiling, in vitro propagation, and genetic assessment of the endangered rare plant Anarrhinum pubescens.

J Genet Eng Biotechnol 2021 Jul 26;19(1):108. Epub 2021 Jul 26.

Department of Chemistry, Claflin University, Orangeburg, SC, 29115, USA.

Background: Anarrhinum pubescens Fresen. (Plantaginaceae) is a rare plant, endemic to the Saint Catherine area, of South Sinai, Egypt. Earlier studies have reported the isolation of cytotoxic and anti-cholinesterase iridoid glucosides from the aerial parts of the plant. Read More

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First Report of Fusarium graminearum Causing Flower Blight On Hemp (Cannabis sativa) in Kentucky.

Plant Dis 2021 Jul 26. Epub 2021 Jul 26.

University of Kentucky, Plant Pathology, 201 Plant Science Building, Lexington, Kentucky, United States, 40546;

In October of 2020, a grower in Boyle County, KY, reported mold and blight symptoms on flowers of field-grown hemp. Plants were approaching harvest, and the mold was affecting 100% of the cultivar 'White CBG' being grown for cannabinoid (CBD) extraction. Mycelium colonized the flower heads and any seeds within bracts. Read More

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First report of black spot on Ophiopogon japonicus caused by Alternaria alternata in Zhejiang Province, China.

Plant Dis 2021 Jul 26. Epub 2021 Jul 26.

China Jiliang University, 92270, Hangzhou, Zhejiang, China;

Ophiopogon japonicus (Linn. f.) Ker-Gawl, a traditional Chinese medicinal plant, is widely cultured in China. Read More

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Activation by TyrR in K-12 by Interaction between TyrR and the α-subunit of RNA polymerase.

J Bacteriol 2021 Jul 26:JB0025221. Epub 2021 Jul 26.

Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, 792 Elizabeth Street, Victoria 3000, Australia.

A novel selection was developed for RpoA α-CTD mutants altered in activation by the TyrR regulatory protein of K-12. This allowed the identification of an aspartate to asparagine substitution in residue 250 (DN250) as an Act mutation. Amino acid residues known to be close to D250 were altered by mutagenesis, and substitutions DR250, RE310 and RD310 were all shown to be defective in activation. Read More

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Improvement in communication during patient handoff between areas from a children's hospital.

Arch Argent Pediatr 2021 Aug;119(4):259-265

Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: Patient handoff is an interactive process including data communication and responsible transfer in order to safely maintain the continuity of care. Failure in this process may result in inadequate care and favor the occurrence of errors.

Objective: To implement a standardized instrument for patient handoff from the intensive care unit (ICU) to the intermediate-medium care unit (IMCU), and compare communication between health care providers before and after the intervention. Read More

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[Association of number and quality of embryos transferred with early pregnancy loss in infertile women at an advanced age undergoing frozen-thawed embryo transfer].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1050-1055

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the association of the number and quality of embryos transferred in frozen-thawed embryo transfer (FET) cycle with the occurrence of early pregnancy loss in infertile women at an advanced age.

Methods: We collected the data of a total of 2622 infertile women aged 36 years or older receiving FET between January, 2015 and December, 2018. The occurrence of early pregnancy loss was analyzed in these women, and the relation of age, the number and quality of embryos transferred with early pregnancy loss was explored in the overall cohort and in different age (36-37, 38-39, 40, 41, 42, 43, 44 and 45-48 years) groups. Read More

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Prescribing antipsychotic medication for adults with intellectual disability: shared responsibilities between mental health services and primary care.

BJPsych Bull 2021 Jul 26:1-5. Epub 2021 Jul 26.

Imperial College London, UK.

Aims And Method: We conducted a secondary analysis of data from a Prescribing Observatory for Mental Health audit to assess the quality of requests from intellectual disability services to primary care for repeat prescriptions of antipsychotic medication.

Results: Forty-six National Health Service Trusts submitted treatment data on 977 adults with intellectual disability, receiving antipsychotic medication for more than a year, for whom prescribing responsibility had been transferred to primary care. Therapeutic effects had been monitored in the past 6 months in 80% of cases with a documented communication indicating which service was responsible for this and 72% of those with no such communication. Read More

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Human Milk Antibodies Against SARS-CoV-2: A Longitudinal Follow-Up Study.

J Hum Lact 2021 Jul 26:8903344211030171. Epub 2021 Jul 26.

Amsterdam UMC, Vrije Universiteit, University of Amsterdam, Emma Children's Hospital, Amsterdam Reproduction & Development Research Institute, Department of Pediatrics, Amsterdam, the Netherlands.

Background: Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Coronavirus Disease 2019 (COVID-19). These antibodies may serve as protection against COVID-19 in infants. However, the evolution of these human milk antibodies over time is unclear. Read More

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Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus.

J Am Heart Assoc 2021 Jul 26:e019437. Epub 2021 Jul 26.

Department of Pediatrics Yale University School of Medicine New Haven CT.

Background Proteinuria and glomerular segmental fibrosis are inevitable complications of diabetic nephropathy though their mechanisms are poorly understood. Understanding the clinical characteristics and pathogenesis of proteinuria and glomerular segmental fibrosis in diabetic nephropathy is, therefore, urgently needed for patient management of this severe disease. Methods and Results Diabetes mellitus was induced in podocyte-specific glucocorticoid receptor knockout (GR) mice and control littermates by administration of streptozotocin. Read More

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Incorporation of Antimicrobial Bio-Based Carriers onto Poly(vinyl alcohol--ethylene) Surface for Enhanced Antimicrobial Activity.

ACS Appl Mater Interfaces 2021 Jul 26. Epub 2021 Jul 26.

Department of Food Science and Technology, University of California-Davis, Davis, California 95616, United States.

A biobased rechargeable antimicrobial modification approach was developed using a covalent immobilization of food grade yeast cell wall particles on a model plastic film. We demonstrate the applications of this modification approach on poly(vinyl alcohol--ethylene) surface to inactivate inoculated bacteria with or without the presence of organic content, reducing the cross-contamination between food contact surface and model fresh produce, and inhibiting the growth of biofilms on the film surface. These biobased cell wall particle modified plastic films can enhance the binding of chlorine to the plastic surface in the form of -halamine, extend the stability of chlorine against high organic content and ambient storage, and improve the rechargeability of the plastic films. Read More

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Isolation and Differentiation of Adipose-Derived Stem Cells into Odontoblast-Like Cells: A Preliminary .

Cell J 2021 Aug 17;23(3):288-293. Epub 2021 Jul 17.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

Objective: The aim of present study was to isolate and differentiate human adipose-derived stem cells (ASCs) into odontoblast-like cells.

Materials And Methods: In this experimental study, human adipose tissues were taken from the buccal fat pad of three individuals (mean age: 24.6 ± 2. Read More

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Embodied energy in China: drivers and inequality at a regional level.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

School of Management and Economics, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.

China is a large economy with unbalanced economic growth throughout different regions, posing a great challenge to allocating energy saving and carbon emissions reduction responsibilities. This paper applies the multi-regional input-output tables of China in 2007 and 2012 to evaluate the status of embodied energy consumption. The embodied energy transfer of eight regions in China is analyzed based on a demand-side perspective. Read More

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An optimisation study of a solar tower receiver: the influence of geometry and material, heat flux, and heat transfer fluid on thermal and mechanical performance.

Heliyon 2021 Jul 8;7(7):e07489. Epub 2021 Jul 8.

Royal Commission for Jubail, Education Sector in Jubail (JTI & JIC), Jubail Industrial City, 31961, Saudi Arabia.

The solar receiver is considered the cornerstone of the solar tower power system. In particular, it receives high-temperature heat flux rays, and extracts the maximum heat energy to be transferred to the heat transfer fluid, while minimising any thermal and mechanical stresses. Reducing the solar receiver size helps to reduce the loss of spillage; consequently, the thermal stress increases. Read More

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Individual Subject Approaches to Mapping Sensory-Biased and Multiple-Demand Regions in Human Frontal Cortex.

Curr Opin Behav Sci 2021 Aug 11;40:169-177. Epub 2021 Jun 11.

Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA.

Sensory modality, widely accepted as a key factor in the functional organization of posterior cortical areas, also shapes the organization of human frontal lobes. 'Deep imaging,' or the practice of collecting a sizable amount of data on individual subjects, offers significant advantages in revealing fine-scale aspects of functional organization of the human brain. Here, we review deep imaging approaches to mapping multiple sensory-biased and multiple-demand regions within human lateral frontal cortex. Read More

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Neuromuscular electrical stimulation for a dysphagic stroke patient with cardiac pacemaker using magnet mode change: A case report.

World J Clin Cases 2021 Jul;9(19):5313-5318

Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul 04763, South Korea.

Background: Electromagnetic interference (EMI), means disturbance to the operation of implanted electrical devices caused by external sources. If cardiac pacemaker is implanted into the body, the risk of EMI should be considered when performing neuromuscular electrical stimulation (NMES). So far, no case has been reported that clinical magnets are used to safely manage the EMI risk of patients with cardiac pacemaker in NMES. Read More

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Management of Airways through Rapid Tracheostomy in a Severely Burnt Patient Attended to via Helicopter.

Case Rep Emerg Med 2021 1;2021:5590275. Epub 2021 Jul 1.

Anesthesiology and Intensive Care Department "Pugliese Ciaccio" Hospital, 88100 Catanzaro (CZ), Italy.

In Catanzaro, Italy, an adult male with severe burns all over his body and in a state of coma was promptly rescued by the medical team at the air ambulance service (HEMS), who provided airway safety through laryngeal mask placement (LMA). The patient was subsequently transferred to the nearest Hub center, where an emergency tracheostomy was performed to ensure better airway management during the flight to the nearest available major burn center. This is the first documented case at regional level of a patient undergoing rapid tracheostomy through an imminent transfer with air ambulance. Read More

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Phase I/II Clinical Trial of Autologous Activated Platelet-Rich Plasma (aaPRP) in the Treatment of Severe Coronavirus Disease 2019 (COVID-19) Patients.

Int J Inflam 2021 7;2021:5531873. Epub 2021 Jul 7.

HayandraLab, Yayasan Hayandra Peduli, Jakarta, Indonesia.

Background: The outbreak of Coronavirus Disease 2019 (COVID-19) has been increasing rapidly. This disease causes an increase in proinflammatory cytokine production that leads to cytokine storm or cytokine release syndrome (CRS). Autologous activated platelet-rich plasma (aaPRP) contains various types of growth factors and anti-inflammatory cytokines that may have the potential to suppress CRS. Read More

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Risk factors of pregnancy failure in elderly infertility patients undergoing human assisted reproductive technology.

Am J Transl Res 2021 15;13(6):7306-7311. Epub 2021 Jun 15.

Reproductive Medicine, Maternal and Child Health Hospital of Hubei Province Wuhan, Hubei Province, China.

Objective: To investigate the risk factors of pregnancy failure in elderly infertile patients undergoing human assisted reproductive technology (ART).

Methods: A total of 565 infertile patients undergoing ART were selected and divided into failed pregnancy group (127 cases) and continued pregnancy group (438 cases). Their clinical data were collected, and the influencing factors of pregnancy failure were assessed and compared by univariate and multivariate analysis. Read More

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Ventral hernia repair under neuraxial anesthesia.

Eur Surg 2021 Jul 20:1-5. Epub 2021 Jul 20.

Department of Biomedical Sciences for Health, IRCCS Policlinico San Donato, Division of General and Foregut Surgery, University of Milan, Piazza Malan 1, 20097 San Donato Milanese (Milano), Italy.

Background: Acute strangulated ventral hernia is associated with operative morbidity and mortality. General anesthesia may increase the operative risk, especially in morbidly obese and COVID-19-positive individuals.

Methods: A 67-year-old woman with body mass index (BMI) 51 kg/m, hospitalized for SARS-CoV-2-related interstitial pneumonia and renal failure, presented with acute abdominal pain, nausea, vomiting, and abdominal tenderness secondary to giant ventral hernia strangulation. Read More

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Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.

Front Immunol 2021 8;12:701415. Epub 2021 Jul 8.

Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, United States.

Background: Lacrimal gland secretory dysfunction in Sjögren syndrome (SS) causes ocular surface desiccation that is associated with increased cytokine expression and number of antigen-presenting cells (APCs) in the conjunctiva. This study evaluated the hypothesis that desiccating stress (DS) alters the percentage and gene expression of myeloid cell populations in the conjunctiva.

Methods: DS was induced by pharmacologic suppression of tear secretion and exposure to drafty low humidity environment. Read More

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Variations in length of stay of inpatients with COVID-19: A nationwide test of the new model of care under vision 2030 in Saudi Arabia.

Saudi J Biol Sci 2021 Jul 20. Epub 2021 Jul 20.

Jazan Health Affairs, Jazan City, Jazan, Saudi Arabia.

Objective: The coronavirus disease 2019 (COVID-19) has impacted the Kingdom of Saudi Arabia (KSA) as it has other nations. However, length of stay (LOS), as a healthcare quality indicator, has not been examined across the healthcare regions in the KSA. Therefore, this study aimed to examine factors associated with LOS to better understand the Saudi Health System's performance in response to the COVID-19 pandemic in the newly suggested five Saudi regional business units (BUs). Read More

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Role of pharmacist during COVID-19 pandemic: A retrospective study focused on critically ill COVID-19 patients.

Saudi Pharm J 2021 Jul 16. Epub 2021 Jul 16.

Department of Clinical Pharmacy, College of Pharmacy - King Saud University, Riyadh, Saudi Arabia.

Background And Aim: During the Coronavirus 2019 (COVID-19) crisis, there has been a huge demand for medications and unprecedented utilization of intensive care unit (ICU) services that subsequently and profoundly impacted the quality of medical care provided to COVID-19 patients. This study aimed to shed light on the role of pharmacists on the health care provided to critically ill COVID-19 patients.

Methods: A retrospective study, was conducted in Diriyah hospital in Riyadh, Saudi Arabia on all COVID-19 patients admitted to the ICU between June 27th and August 15th, 2020 until patients were transferred to the medical ward, discharged, or deceased. Read More

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[Techniques for island design of pectoralis major muscle flap and risk control].

Authors:
Xiaohong Chen

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):641-644

The pectoralis major muscle flap has been clinically used for more than 40 years. When harvesting the traditional pectoralis major muscle flaps, it is necessary to cut the upper half of the pectoralis major muscle, and use the thoracoacromial vessels and its surrounding pectoralis major muscle as the pedicle, resulting in the loss of the function of the pectoralis major muscle. Hypertrophic pedicle also squeezes the responsible vessels and prevents the flap from being transferred to recipient area, often leading to the partial necrosis of the flap end. Read More

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The plastic Trojan horse: Biofilms increase microplastic uptake in marine filter feeders impacting microbial transfer and organism health.

Sci Total Environ 2021 Jul 21;797:149217. Epub 2021 Jul 21.

Institute of Marine Sciences, School of Biological Sciences, University of Portsmouth, Portsmouth PO4 9LY, UK. Electronic address:

Microplastic pollution has become a major source of concern, with a large body of literature surrounding the impacts of microplastic ingestion by biota. However, many of these studies utilise virgin microbeads, which are not reflective of environmental microplastics that are rapidly colonised with microbial communities (plastisphere) in marine ecosystems. It is a concern therefore that current evidence of the impacts of microplastics on biota are unrepresentative of the environmental microplastic pollution. Read More

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Perianesthesia Care of the Oncologic Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy: A Retrospective Study.

J Perianesth Nurs 2021 Jul 21. Epub 2021 Jul 21.

Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA.

Purpose: This study was to understand the perianesthesia care for patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS  + HIPEC).

Method: This is a retrospective study.

Design: The perioperative electronic medical records of 189 CRS  + HIPEC surgical cases at a hospital of Western Pennsylvania from 2012 to 2018 were analyzed to study the characteristics of perianesthesia care for CRS  + HIPEC surgery. Read More

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Fatal pedestrian crashes at intersections: Trend mining using association rules.

Accid Anal Prev 2021 Jul 21:106306. Epub 2021 Jul 21.

School of Engineering, Deakin University, Geelong, Victoria 3220, Australia. Electronic address:

In 2018, about 6,677 pedestrians were killed on the US roadways. Around one-fourth of these crashes happened at intersections or near intersection locations. This high death toll requires careful investigation. Read More

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Evaporation in Brazilian dryland reservoirs: Spatial variability and impact of riparian vegetation.

Sci Total Environ 2021 Jul 18;797:149059. Epub 2021 Jul 18.

Department of Agricultural Engineering, Federal University of Ceará (UFC), Fortaleza, Brazil.

Evaporation is a major factor controlling the hydrological dynamics of surface water reservoirs in dry environments, therefore quantification with minimal uncertainties is desired. The aim of this paper is to assess the spatial variability and impact of riparian vegetation on reservoir evaporation by remote sensing. Eight reservoirs located in subhumid and semi-arid climates in the Brazilian Drylands were studied. Read More

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Neuroplasticity induced by the retention period of a complex motor skill learning in rats.

Behav Brain Res 2021 Jul 21:113480. Epub 2021 Jul 21.

Master's and Doctoral Programs in Physical Therapy, University of the City of São Paulo, São Paulo, SP, Brazil. Electronic address:

Learning complex motor skills is an essential process in our daily lives. Moreover, it is an important aspect for the development of therapeutic strategies that refer to rehabilitation processes since motor skills previously acquired can be transferred to similar tasks (motor skill transfer) or recovered without further practice after longer delays (motor skill retention). Different acrobatic exercise (AE) training protocols induce plastic changes in areas involved in motor control and improvement in motor performance. Read More

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