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Impact of Plasmatic Progesterone on the Day of Frozen Embryo Transfer in Hormone-induced Cycles.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):608-615. Epub 2021 Sep 21.

Instituto Valenciano de Infertilidad, Lisboa, Portugal.

Objective:  To establish a relationship between serum progesterone values on the day of frozen blastocyst transfer in hormone-replaced cycles with the probability of pregnancy, miscarriage or delivery.

Methods:  This was an ambispective observational study including all frozen-thawed embryo transfer cycles performed at our department following in vitro fecundation from May 2018 to June 2019. The outcomes evaluated were β human chorionic gonadotropin (β-hCG)-positive pregnancy and delivery. Read More

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Depth of thermal dispersion of monopolar radiofrequency heating in the vaginal wall.

Biomed Phys Eng Express 2021 Sep 21. Epub 2021 Sep 21.

Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20993, UNITED STATES.

The use of energy-based devices to treat genitourinary syndrome of menopause, termed vaginal thermotherapy (VTT), has gained significant interest in recent years. Among the primary safety concerns of this relatively new procedure is the possibility of unintentionally heating tissues adjacent to the vaginal wall, i.e. Read More

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September 2021

Rapid and delayed effects of single-walled carbon nanotubes in glioma cells.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Department of Physics and Mathematics, University of Eastern Finland, Yliopistokatu 7, Joensuu, North Karelia , 80101, FINLAND.

Single-walled carbon nanotubes (SWCNTs) demonstrate a strong potential as an optically activated theranostic nano-agent. However, using SWCNTs in theranostics still requires revealing mechanisms of the SWCNT-mediated effects on cellular functions. Even though rapid and delayed cellular responses can differ significantly and may lead to undesirable consequences, understanding of these mechanisms is still incomplete. Read More

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September 2021

Ag-decorated GaN for high-efficiency photoreduction of carbon dioxide into tunable syngas under visible light.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Tianjin University of Technology, Xiqing District, Bin Shui West Road 391, Tianjin, 300191, CHINA.

Visible light-driven photoreduction of CO2 and H2O to tunable syngas is an appealing strategy for both artificial carbon neutral and Fischer-Tropsch processes. However, the development of photo-catalysts with high activity and selectivity remains challenging. For this case, we here design a hybrid catalyst, synthesized by in-situ deposition of Ag crystals on GaN nanobelts, that delivers a tunable H2/CO ratio between 0. Read More

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September 2021

Electrochemcial methods for neural interface electrodes.

J Neural Eng 2021 Sep 21. Epub 2021 Sep 21.

University of Freiburg, Georges-Köhler-Allee 103, Freiburg im Breisgau, Baden-Württemberg, 79110, GERMANY.

Objective: Neural interfaces often rely on charge transfer processes between electrodes and the tissue or electrolyte. Electrochemical processes are at the core of electrode function and, therefore, the key to neural interface stability, electrode performance characterization, and utilization of electrodes as chemical sensors. Electrochemical techniques offer a variety of options to investigate the charge transfer and electrocatalytic properties of electrodes. Read More

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September 2021

Magnetic enhancement of oxygen evolution reaction performance of NiCo-spinel oxides.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Hunan University, Lushan Road (S), Yuelu District, Changsha, Hunan Province, Changsha, 410082, CHINA.

Low-cost and high-efficiency transition metal oxide catalysts are desired for high-efficiency water splitting technology. An applying magnetic field (MF) enhancement method is presented to improve the oxygen evolution reaction (OER) performance of NiCo-spinel magnetic catalysts, the enhancement of OER performance depends on the applied magnetic field strength and magnetic properties of catalysts. The maximum enhanced current density percentage of about 90. Read More

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September 2021

Decontamination of emerging pharmaceutical pollutants using carbon-dots as robust materials.

J Hazard Mater 2021 Sep 12;423(Pt B):127145. Epub 2021 Sep 12.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. Electronic address:

Environmental pollution is a critical issue that requires proper measures to maintain environmental health in a sustainable and effective manner. The growing persistence of several active pharmaceutical residues, such as antibiotics like tetracycline, and anti-inflammatory drugs like diclofenac in water matrices is considered an issue of global concern. Numerous sewage/drain waste lines from the domestic and pharmaceutical sector contain an array of toxic compounds, so-called "emerging pollutants" and possess adverse effects on entire living ecosystem and damage its biodiversity. Read More

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September 2021

Mathematical correlations in two-phase modeling of fluidized bed adsorbers.

J Hazard Mater 2021 Sep 15;423(Pt B):127218. Epub 2021 Sep 15.

Ford Motor Company, Research and Advanced Engineering, Dearborn, MI 48121, USA.

Choosing proper formulas for estimating different variables is imperative when modeling a fluidized bed using two-phase theory. In this study, a two-phase model was used to model the adsorption of volatile organic compounds (VOC) in a multistage fluidized bed adsorber. Two different approaches were used to describe gas flow and mixing in the emulsion phase, perfectly mixed (EGPM: Emulsion Gas - Perfectly Mixed) and plug flow (EGPF: Emulsion Gas - Plug flow). Read More

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September 2021

Protective effects of lycopene on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B-exposed broilers.

Poult Sci 2021 Aug 19;100(11):101441. Epub 2021 Aug 19.

College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province, 225009, P. R. China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu Province, 225009, P. R. China. Electronic address:

This study was conducted to investigate the effects of lycopene (LYC) on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B (AFB)-exposed broilers. A total of 192 healthy 1-day-old male broilers were randomly divided into 3 groups with 8 replicates of 8 birds each. Birds in the 3 groups were fed basal diet (control), basal diet with 100 µg/kg AFB, and basal diet with 100 µg/kg AFB and 200 mg/kg LYC, respectively. Read More

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Mechanism study of improving anaerobic co-digestion performance of waste activated sludge and food waste by FeO.

J Environ Manage 2021 Sep 18;300:113745. Epub 2021 Sep 18.

Key Laboratory of the Three Gorges Reservoir Region's Eco-environments, Ministry of Education, College of Environment and Ecology, Chongqing University, 174 Shapingba Road, Chongqing, 400045, PR China.

A large amount of waste activated sludge (WAS) and food waste (FW) are produced every year in China. Anaerobic co-digestion is considered to be an effective way to solve this problem. This study applied FW/WAS mixture as co-substrate to create different digestive environment, aiming to understand the mechanism of FeO particles in promoting AD performance. Read More

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September 2021

Optimization of acrylic-styrene latex-based biofilms as a platform for biological indoor air treatment.

Chemosphere 2021 Sep 7;287(Pt 3):132182. Epub 2021 Sep 7.

Institute of Sustainable Processes, University of Valladolid, Dr. Mergelina s/n., Valladolid, 47011, Spain; Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n., Valladolid 47011, Spain. Electronic address:

Biotechnologies have emerged as a promising solution for indoor air purification with the potential to overcome the inherent limitations of indoor air treatment. These limitations include the low concentrations and variability of pollutants and mass-transfer problems caused by pollutant hydrophobicity. A new latex-based biocoating was herein optimized for the abatement of the volatile organic compounds (VOCs) toluene, trichloroethylene, n-hexane, and α-pinene using acclimated activated sludge dominated by members of the phylum Patescibacteria. Read More

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September 2021

Maternal-Neonatal Transfer of SARS CoV-2 IgG Antibodies among Parturient Women Treated with BNT162b2 mRNA Vaccine during Pregnancy.

Am J Obstet Gynecol MFM 2021 Sep 18:100492. Epub 2021 Sep 18.

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: The exclusion of pregnant women from COVID-19 mRNA vaccine trials raised hesitancy regarding the benefit of vaccination of pregnant women, hence little is known about the vaccine's efficacy in this population.

Objective: To determine the maternal-neonatal transplacental transfer of SARS CoV-2 antibodies among vaccinated parturient women. A control group of COVID 19 recovered patients was included in order to compare IgG levels between vaccinated and recovered patients. Read More

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September 2021

Short non-coded peptides interacting with cofactors facilitated the integration of early chemical networks.

Biosystems 2021 Sep 18:104547. Epub 2021 Sep 18.

Instituto Multidisciplinario de Biología Vegetal (IMBIV), CONICET, Universidad Nacional de Córdoba (UNC). Facultad de Ciencias Exactas, Físicas y Naturales. Av. Vélez Sarsfield 299, CC 495, 5000, Córdoba, Argentina. Electronic address:

Independently developed iron-sulphur/thioester- and phosphate-driven chemical reactions would have set up two distinct reaction networks prior to coupling in a proto-metabolic system supporting a minimal organisation closure. Each chemical system assisted initially by simple catalysts and then by more complex cofactors would have provided the precursors of the small metabolites and monomer units along with their respective polymers through dehydrating template-independent assemblies. For example, acylation reactions mediated by activated thioester groups produced peptides, fatty acids and polyhydroxyalkanoates, while phosphorylation reactions by phosphorylating agents allowed the synthesis of polysaccharides, polyribonucleotides and polyphosphates. Read More

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September 2021

Wireless Sensor Networks for Pharmaceutical Lyophilization: Quantification of Local Gas Pressure and Temperature in Primary Drying.

Eur J Pharm Biopharm 2021 Sep 18. Epub 2021 Sep 18.

School of Aeronautical and Astronautical Engineering, Purdue University, West Lafayette, IN 47906; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47906.

Wireless sensor networks have become prolific in a wide range of industrial processes and offer several key advantages over their wired counterparts in terms of positioning flexibility, modularity, interconnectivity, and data routing. We demonstrate their utility in pharmaceutical lyophilization by developing a series of wireless devices to measure spatial variations in gas pressure and temperature during primary drying. The influence of shelf temperature, chamber pressure, excipient concentration, and dryer configuration are explored for various representative cycles using a laboratory-scale pharmaceutical lyophilizer. Read More

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September 2021

Dynamic mRNA polyplexes benefit from bioreducible cleavage sites for in vitro and in vivo transfer.

J Control Release 2021 Sep 18. Epub 2021 Sep 18.

Pharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) Munich, Butenandtstrasse 5-13, D-81377 Munich, Germany. Electronic address:

Currently, messenger RNA (mRNA)-based lipid nanoparticle formulations revolutionize the clinical field. Cationic polymer-based complexes (polyplexes) represent an alternative compound class for mRNA delivery. After establishing branched polyethylenimine with a succinylation degree of 10% (succPEI) as highly effective positive mRNA transfection standard, a diverse library of PEI-like peptides termed sequence-defined oligoaminoamides (OAAs) was screened for mRNA delivery. Read More

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September 2021

Spread of SARS-CoV-2 in hospital areas.

Environ Res 2021 Sep 18:112074. Epub 2021 Sep 18.

Infectious Diseases Unit, Son Espases University Hospital, Palma, Mallorca, Spain; Balearic Islands Health Research Institute (IdISBa), Son Espases University Hospital, Palma, Mallorca, Spain. Electronic address:

We performed a systematic sampling and analysis of airborne SARS-CoV-2 RNA in different hospital areas to assess viral spread. Systematic air filtration was performed in rooms with COVID-19 infected and uninfected patients, in corridors adjacent to these rooms and intensive care units, and in open spaces. RNA was extracted from the filters and real-time reverse transcription polymerase chain reaction was performed using the LightMix Modular SARS-CoV-2 E-gene. Read More

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September 2021

Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.

Eur J Pharmacol 2021 Sep 18:174511. Epub 2021 Sep 18.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Egypt.

Cognitive impairments such as dementia are considered the biggest challenges for public health. Benzodiazepines are often prescribed for treatment of anxiety disorder but they are associated with elevated risk of dementia. The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice. Read More

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September 2021

A hydride transfer complex reprograms NAD metabolism and bypasses senescence.

Mol Cell 2021 Sep;81(18):3848-3865.e19

CRCHUM, 900 Saint-Denis St, Montréal, QC H2X 0A9, Canada; Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada. Electronic address:

Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex that reprograms NAD metabolism by transferring reducing equivalents from NADH to NADP. Read More

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September 2021

Metal-Free Catalysis: A Redox-Active Donor-Acceptor Conjugated Microporous Polymer for Selective Visible-Light-Driven CO Reduction to CH.

J Am Chem Soc 2021 Sep 21. Epub 2021 Sep 21.

Molecular Materials Laboratory, School of Advanced Materials (SAMat), Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.

Achieving more than a two-electron photochemical CO reduction process using a metal-free system is quite exciting and challenging, as it needs proper channeling of electrons. In the present study, we report the rational design and synthesis of a redox-active conjugated microporous polymer (CMP), TPA-PQ, by assimilating an electron donor, tris(4-ethynylphenyl)amine (TPA), with an acceptor, phenanthraquinone (PQ). The TPA-PQ shows intramolecular charge-transfer (ICT)-assisted catalytic activity for visible-light-driven photoreduction of CO to CH (yield = 32. Read More

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September 2021

Switching the Mechanism of NADH Photooxidation by Supramolecular Interactions.

Chemistry 2021 Sep 21. Epub 2021 Sep 21.

University of Ulm, Institute of Inorganic Chemistry I Materials and Catalysis, Albert-Einstein-Allee 11, 89081, Ulm, GERMANY.

A series of three Ru(II) polypyridine complexes was investigated for the selective photocatalytic oxidation of NAD(P)H to NAD(P) + in water. A combination of (time-resolved) spectroscopic studies and photocatalysis experiments revealed that ligand design can be used to control the mechanism of the photooxidation: For prototypical Ru(II) complexes a 1 O 2 pathway was found. Rudppz ([(tbbpy) 2 Ru(dppz)]Cl 2 , tbbpy = 4,4´-di- tert -butyl-2,2´-bipyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine), instead, initiated the cofactor oxidation by electron transfer from NAD(P)H enabled by supramolecular binding between substrate and catalyst. Read More

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September 2021

Effect of Hypoxia on Photosystem II of Tropical Seagrass Enhalus acoroides in the Dark.

Photochem Photobiol 2021 Sep 21. Epub 2021 Sep 21.

CAS and Shandong Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, China.

Hypoxia induced by eutrophication has become an important factor threatening the survival of coastal life such as Enhalus acoroides. The purpose of the current study was to explore the effect of hypoxia on photosystem II (PSII) of E. acoroides in the dark. Read More

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September 2021

Unsupervised cross-lingual model transfer for named entity recognition with contextualized word representations.

PLoS One 2021 21;16(9):e0257230. Epub 2021 Sep 21.

College of Mechanical and Vehicle Engineering, Taiyuan University of Technology, Taiyuan, China.

Named entity recognition (NER) is one fundamental task in the natural language processing (NLP) community. Supervised neural network models based on contextualized word representations can achieve highly-competitive performance, which requires a large-scale manually-annotated corpus for training. While for the resource-scarce languages, the construction of such as corpus is always expensive and time-consuming. Read More

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September 2021

D-BIN: A Generalized Disentangling Batch Instance Normalization for Domain Adaptation.

IEEE Trans Cybern 2021 Sep 21;PP. Epub 2021 Sep 21.

Pattern recognition is significantly challenging in real-world scenarios by the variability of visual statistics. Therefore, most existing algorithms relying on the independent identically distributed assumption of training and test data suffer from the poor generalization capability of inference on unseen testing datasets. Although numerous studies, including domain discriminator or domain-invariant feature learning, are proposed to alleviate this problem, the data-driven property and lack of interpretation of their principle throw researchers and developers off. Read More

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September 2021

Globally Localized Multisource Domain Adaptation for Cross-Domain Fault Diagnosis With Category Shift.

IEEE Trans Neural Netw Learn Syst 2021 Sep 21;PP. Epub 2021 Sep 21.

Deep learning has demonstrated splendid performance in mechanical fault diagnosis on condition that source and target data are identically distributed. In engineering practice, however, the domain shift between source and target domains significantly limits the further application of intelligent algorithms. Despite various transfer techniques proposed, either they focus on single-source domain adaptation (SDA) or they utilize multisource domain globally or locally, which both cannot address the cross-domain diagnosis effectively, especially with category shift. Read More

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September 2021

Performance Enhancement of a Novel Surface Plasmon Resonance Biosensor using Thallium Bromide.

IEEE Trans Nanobioscience 2021 Sep 21;PP. Epub 2021 Sep 21.

In this paper, we present the performance enhancement of the SPR biosensor using a novel dielectric material of thallium bromide (TIBr). The proposed structure comprised of six layers, including BK7 prism, silver (Ag), aluminum arsenide (AlAs), TIBr, black phosphorus (BP), and a sensing layer. In this investigation, we have considered four structures using the above-defined layers for the performance comparison and heightened the impact of TIBr in the proposed SPR sensor. Read More

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September 2021

Changing the Care Environment for Acute Intoxication: Providing Intoxicated Adults With an Alternative to the Emergency Department and Jail.

J Stud Alcohol Drugs 2021 Sep;82(5):678-684

School of Nursing, Department of Social & Behavioral Sciences, University of California-San Francisco, San Francisco, California.

Objective: This study examines models of sobering centers throughout the United States and identifies best practices and barriers to providing care to acutely intoxicated adults.

Method: A survey was developed and distributed from June to October 2019 to leadership of sobering centers in the United States that provided short-term (<24 hour) care to adults admitted for being intoxicated in public.

Results: The author screened 53 programs: 37 met inclusion criteria and 26 (70%) responded. Read More

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September 2021

Phylogenomic and comparative genomic analyses of species of the family : Proposals for the genera gen. nov. and gen. nov., merger of the genus with the genus , and transfer of some misclassified species of the genus into other genera.

Int J Syst Evol Microbiol 2021 Sep;71(9)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

The evolutionary relationships among species of the family were examined based on 255 available genomes representing >85 % of the species from this family. In a phylogenetic tree based on concatenated sequences of 118 core proteins, most species of the genus grouped within one large cluster which also included members of the genera and . Within this large cluster 18-30 clades/subclades of species of the genus consisting of between 1 and 36 species, were observed. Read More

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September 2021

Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis.

Bioengineered 2021 Dec;12(1):7188-7204

Department of Stomatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.

Oral squamous cell carcinoma (OSCC) poses a threat to public health worldwide. LncRNA APCDD1L-AS1 has been reported to participate in tumorigenesis and development of acquired chemoresistance. However, the role of APCDD1L-AS1 in 5-fluorouracil (5-FU) resistance regulation within OSCC is still obscure. Read More

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December 2021

Comparative analysis of clinical outcome and quality of life between amputations and combined bone and flap reconstructions at the lower leg.

Disabil Rehabil 2021 Sep 21:1-5. Epub 2021 Sep 21.

Department of General and Trauma surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany.

Purpose: At the lower leg, soft tissue defects with exposed bones, tendons, or hardware require flap coverage. In this retrospective study, we analyzed combined bone and soft tissue reconstructions compared to amputations of the lower leg in a civilian setting.

Materials And Methods: Patients who underwent combined bone and flap reconstruction (LR) or amputation (LA) of the lower leg were eligible for the study. Read More

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September 2021

Quantitative Account of the Bonding Properties of a Rubredoxin Model Complex [Fe(SCH)], = -2, -1, +2, +3.

J Chem Theory Comput 2021 Sep 21. Epub 2021 Sep 21.

Advanced Computing, Mathematics and Data Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P.O. Box 999, MS K1-83, Richland, Washington 99352, United States.

Iron-sulfur clusters play important roles in biology as parts of electron-transfer chains and catalytic cofactors. Here, we report a detailed computational analysis of a structural model of the simplest natural iron-sulfur cluster of rubredoxin and its cationic counterparts. Specifically, we investigated adiabatic reduction energies, dissociation energies, and bonding properties of the low-lying electronic states of the complexes [Fe(SCH)] using multireference (CASSCF, MRCISD), and coupled cluster [CCSD(T)] methodologies. Read More

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September 2021