Cancer Lett 2021 Oct 9. Epub 2021 Oct 9.
School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong, China; State Key Laboratory of Liver Research (The University of Hong Kong), The University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address:
Aberrated PLK4 expression has been reported in different malignancies and causes centrosome amplification, aneuploidy, and genomic instability. However, the mechanism by which PLK4 is regulated in carcinogenesis remains not fully characterised. Here, we showed that PLK4 was overexpressed in human HCC and overexpression of PLK4 predicted poorer patient prognosis. Read More