753,136 results match your criteria transcription factor

Cell identity specification in plants: lessons from flower development.

J Exp Bot 2021 Apr 17. Epub 2021 Apr 17.

Plant Cell and Molecular Biology, Institute of Biology, Humboldt-Universitaet zu Berlin, Germany.

Multicellular organisms display a fascinating complexity of cellular identities and patterns of diversification. The concept of ''cell type'' aims to describe and categorize this complexity. In this review, we discuss the traditional concept of cell types and highlight the impact of single-cell technologies and spatial omics on the understanding of cellular differentiation in plants. Read More

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G protein gamma 7 suppresses progression of lung adenocarcinoma by inhibiting E2F transcription factor 1.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Department of radiation oncology, QiLu hospital of ShanDong university, Jinan, Shandong 250012, PR China. Electronic address:

G protein gamma 7 (GNG7) has been found to be aberrantly expressed in some kinds of malignant tumors. In this study, we mainly discuss the antitumor role of it in lung adenocarcinoma (LUAD) cells. Protein levels of GNG7 in LUAD tissues were measured by western blot and immunohistochemical analysis. Read More

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Overexpression of rice OsWNK9 promotes arsenite tolerance in transgenic Arabidopsis plants.

J Biotechnol 2021 Apr 14. Epub 2021 Apr 14.

Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, 400084, India. Electronic address:

Protein kinases are involved in the transfer of phosphate group to serine, threonine, and tyrosine residues of a target protein. 'With No Lysine kinase' (WNK) is a member of the serine/threonine protein kinase family, which has conserved catalytic lysine (K) residue in subdomain I instead of being in subdomain II.The WNKs family members in plants are stress inducible and have been validated for their role in abiotic stress tolerance. Read More

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IRAK2 has a critical role in promoting feed-forward amplification of epidermal inflammatory responses.

J Invest Dermatol 2021 Apr 14. Epub 2021 Apr 14.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan, 48109, USA. Electronic address:

Many inflammatory skin diseases are characterized by altered epidermal differentiation. Whether this altered differentiation promotes inflammatory responses has been unknown. Here we show that IRAK2, a member of the signaling complex downstream of IL-1/IL-36, correlates positively with disease severity in both AD and psoriasis. Read More

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A transcriptional regulatory module controls lipid accumulation in soybean.

New Phytol 2021 Apr 17. Epub 2021 Apr 17.

State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, INASEED, Chinese Academy of Sciences, Beijing, 100101, China.

Soybean (Glycine max) is one of the most important oilseed crops. However, limited information is known about the regulatory mechanism of oil accumulation in soybean. In this study, a member of tandem CCCH zinc finger (TZF) proteins, GmZF392, from our previous RNA-seq analysis for seed-preferred transcription factors, was found to function as a positive regulator of lipid production. Read More

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Apoplastic lipid barriers regulated by conserved homeobox transcription factors extend seed longevity in multiple plant species.

New Phytol 2021 Apr 17. Epub 2021 Apr 17.

Instituto de Biología Molecular y Celular de Plantas, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Camino de Vera, 46022, Valencia, Spain.

Cutin and suberin are lipid polyesters deposited in specific apoplastic compartments. Their fundamental roles in plant biology include controlling the movement of gases, water and solutes, and conferring pathogen resistance. Both cutin and suberin have been shown to be present in the Arabidopsis seed coat where they regulate seed dormancy and longevity. Read More

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MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases.

Neurosci Bull 2021 Apr 17. Epub 2021 Apr 17.

Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.

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A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression.

J Cancer Res Clin Oncol 2021 Apr 17. Epub 2021 Apr 17.

School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Background: The Hippo pathway is widely considered to inhibit cell growth and play an important role in regulating the size of organs. However, recent studies have shown that abnormal regulation of the Hippo pathway can also affect tumor invasion and metastasis. Therefore, finding out how the Hippo pathway promotes tumor development by regulating the expression of target genes provides new ideas for future research on targeted drugs that inhibit tumor progression. Read More

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Improving the design of an oxidative stress sensing biosensor in yeast.

FEMS Yeast Res 2021 Apr 17. Epub 2021 Apr 17.

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.

Transcription factor (TF)-based biosensors have proven useful for increasing biomanufacturing yields, large-scale functional screening, and in environmental monitoring. Most yeast TF-based biosensors are built from natural promoters, resulting in large DNA parts retaining considerable homology to the host genome, which can complicate biological engineering efforts. There is a need to explore smaller, synthetic biosensors to expand the options for regulating gene expression in yeast. Read More

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GATA2 participates in the recanalization of lymphatic vessels after surgical lymph node extirpation.

Genes Cells 2021 Apr 17. Epub 2021 Apr 17.

Division of Physiology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, 983-8536, Japan.

Lymphatic recanalization failure after lymphadenectomy constitutes a major risk of lymphedema in cancer surgery. It has been reported that GATA2, a zinc finger transcription factor, is expressed in lymphatic endothelial cells and is involved in the development of fetal lymphatic vessels. GATA3, another member of the GATA family of transcription factors, is required for the differentiation of lymphoid tissue-inducer (LTi) cells and is essential for lymph node formation. Read More

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The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach.

Biofactors 2021 Apr 17. Epub 2021 Apr 17.

Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India.

Bleomycin (BLM) injury is associated with the severity of acute lung injury (ALI) leading to fibrosis, a high-morbidity, and high-mortality respiratory disease of unknown etiology. BLM-induced ALI is marked by the activation of a potent fibrogenic cytokine transcription growth factor beta-1 (TGFβ-1), which is considered a critical cytokine in the progression of alveolar injury. Previously, our work demonstrated that a diet-derived compound curcumin (diferuloylmethane), represents its antioxidative and antifibrotic application in TGF-β1-mediated BLM-induced alveolar basal epithelial cells. Read More

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Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a.

Geroscience 2021 Apr 17. Epub 2021 Apr 17.

Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Road, Sudbury, Ontario, P3E 2C6, Canada.

Aging is associated with changes in regulation, particularly among diverse regulators in the brain. We assayed prominent regulatory elements in mouse brain to explore their relationship to one another, stress, and aging. Notably, unphosphorylated (activated) forkhead transcription factor 3a (uFOXO3a) expressed exponential decline congruent with increasing age-related mortality. Read More

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Circular RNA_0000190 and its target microRNA-767-5p are dysregulated, and they are related to risk stratification as well as prognosis in multiple myeloma patients.

Ir J Med Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Hematology, The First People's Hospital of Jingmen, No. 67 Xiangshan Avenue, Jingmen, 448000, People's Republic of, China.

Background: This study aimed to explore the correlation between circular RNA_0000190 (circ_0000190) and microRNA-767-5p (miR-767-5p), and their correlations with biochemical indices, risk stratification, treatment response, and survival in multiple myeloma (MM) patients.

Methods: Bone marrow (BM) plasma cells of 86 MM patients (during standard diagnostic procedures) and 30 healthy donors (HDs) (examination of the eligibility for BM transplantation) were obtained, among which circ_0000190 and miR-767-5p expressions were detected using reverse transcription quantitative polymerase chain reaction. In MM patients, Durie-Salmon stage and International Staging System (ISS) stage were assessed. Read More

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Identification of crucial long non-coding RNAs and mRNAs along with related regulatory networks through microarray analysis in esophageal carcinoma.

Funct Integr Genomics 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiation Oncology, Anyang Cancer Hospital, The 4th Affiliated Hospital of Henan University of Science and Technology, Anyang, 455000, Henan Province, China.

Esophageal carcinoma (EC) is a tremendous threat to human health and life worldwide. Long non-coding RNAs (lncRNAs) have been identified as crucial players in carcinomas including EC. An in-depth understanding on regulatory networks of lncRNAs contributes to the better management of EC. Read More

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Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage.

Cell Biol Toxicol 2021 Apr 16. Epub 2021 Apr 16.

Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China.

Increasing evidences have shown that pregnant women might miscarry after exposure with environmental BaP (benzo(a)pyrene). Additionally, BPDE (benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide), the ultimate metabolite of BaP, could induce dysfunctions of human trophoblast cells. However, it is rarely correlated between miscarriage and trophoblast dysfunctions. Read More

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Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways.

J Mol Med (Berl) 2021 Apr 16. Epub 2021 Apr 16.

Institute of Experimental and Clinical Pharmacology, Faculty of Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold Heller Strasse 3, 24105, Kiel, Germany.

The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO). Intracerebroventricular infusion of pioglitazone over 5 days before and 24 or 48 h after MCAO alleviated neurological impairments, inhibited apoptosis 24 h, and activated the PI3K/Akt pathway along with increased phosphorylation of Akt (ser473) and GSK-3β (ser9) in the peri-infarct cortical areas 48 h after MCAO. In primary cortical neurons, pioglitazone suppressed the glutamate-induced release of lactate dehydrogenase by a PPARγ-dependent mechanism. Read More

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Short-, medium-, and long-chain fatty acid profiles and signaling is responsive to dietary phytase and lactic acid treatment of cereals along the gastrointestinal tract of growing pigs.

J Anim Sci 2021 Apr 17. Epub 2021 Apr 17.

Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Dietary and microbially derived fatty acids (FA) play important roles in gut mucosal inflammatory signaling, barrier function and oxidative stress response. Nevertheless, little information is available about gastrointestinal FA profiles and receptor distribution in pigs, especially for long-chain FA (LCFA). Therefore, the present pilot study aimed to 1) investigate the gastrointestinal FA profiles; 2) link the luminal FA profiles to the mucosal expression of genes related to FA sensing and signaling; and 3) assess potential dietary effects on gut and systemic lipid metabolism in pigs. Read More

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Cannabidiol converts NFκB into a tumor suppressor in glioblastoma with defined antioxidative properties.

Neuro Oncol 2021 Apr 17. Epub 2021 Apr 17.

Neurosurgical Research, Department of Neurosurgery, University Hospital, LMU Munich, Germany.

Background: The transcription factor NFκB drives neoplastic progression of many cancers including primary brain tumors (glioblastoma; GBM). Precise therapeutic modulation of NFκB activity can suppress central oncogenic signalling pathways in GBM, but clinically applicable compounds to achieve this goal have remained elusive.

Methods: In a pharmacogenomics study with a panel of transgenic glioma cells we observed that NFκB can be converted into a tumor suppressor by the non-psychotropic cannabinoid Cannabidiol (CBD). Read More

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Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.

Oncogene 2021 Apr 16. Epub 2021 Apr 16.

Children's Health Research Institute, London, ON, Canada.

The unfolded protein response (UPR) is activated in pancreatic pathologies and suggested as a target for therapeutic intervention. In this study, we examined activating transcription factor 3 (ATF3), a mediator of the UPR that promotes acinar-to-ductal metaplasia (ADM) in response to pancreatic injury. Since ADM is an initial step in the progression to pancreatic ductal adenocarcinoma (PDAC), we hypothesized that ATF3 is required for initiation and progression of PDAC. Read More

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MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.

Oncogene 2021 Apr 16. Epub 2021 Apr 16.

Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, China.

Colorectal cancer (CRC) is one of the leading cancers worldwide, accounting for high morbidity and mortality. The mechanisms governing tumor growth and metastasis in CRC require detailed investigation. The results of the present study indicated that the transcription factor (TF) myocyte enhancer factor 2A (MEF2A) plays a dual role in promoting proliferation and metastasis of CRC by inducing the epithelial-mesenchymal transition (EMT) and activation of WNT/β-catenin signaling. Read More

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Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.

Nat Commun 2021 Apr 16;12(1):2304. Epub 2021 Apr 16.

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Mitochondria play a pivotal role in the generation of signals coupling metabolism with neurotransmitter release, but a role for mitochondrial-produced ROS in regulating neurosecretion has not been described. Here we show that endogenously produced hydrogen peroxide originating from axonal mitochondria (mtHO) functions as a signaling cue to selectively regulate the secretion of a FMRFamide-related neuropeptide (FLP-1) from a pair of interneurons (AIY) in C. elegans. Read More

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Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer.

Trends Mol Med 2021 Apr 13. Epub 2021 Apr 13.

UMR 9018, CNRS, Université Paris Saclay, Institut Gustave Roussy, Villejuif F-94805, France; Koltzov Institute of Developmental Biology, Moscow 117334, Russia. Electronic address:

DUX4, a gene encoding a transcription factor involved in early embryogenesis, is located within the D4Z4 subtelomeric repeat on chromosome 4q35. In most healthy somatic tissues, DUX4 is heavily repressed by multiple genetic and epigenetic mechanisms, and its aberrant expression is linked to facioscapulohumeral muscular dystrophy (FSHD) where it has been extensively studied. Recently, DUX4 expression has been implicated in oncogenesis, although this is much less explored. Read More

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Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis.

BMC Biol 2021 Apr 16;19(1):79. Epub 2021 Apr 16.

Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230021, Anhui, China.

Background: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that involves a variety of cell types. However, how the epigenetic dysregulations of peripheral immune cells contribute to the pathogenesis of RA still remains largely unclear.

Results: Here, we analysed the genome-wide active DNA regulatory elements of four major immune cells, namely monocytes, B cells, CD4 T cells and CD8 T cells, in peripheral blood of RA patients, osteoarthritis (OA) patients and healthy donors using Assay of Transposase Accessible Chromatin with sequencing (ATAC-seq). Read More

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A SNP of HD-ZIP I transcription factor leads to distortion of trichome morphology in cucumber (Cucumis sativus L.).

BMC Plant Biol 2021 Apr 16;21(1):182. Epub 2021 Apr 16.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Background: Trichomes are excellent model systems for the analysis of cell differentiation and play essential roles in plant protection. From cucumber inbred line 'WD1', we identified an EMS-induced trichome abnormally developing mutant, nps, which exhibited smaller, denser and no pyramid-shaped head trichomes.

Results: Using F and BC populations constructed from a cross between nps and '9930', the genetic analysis showed that the nps trait is controlled by a single recessive nuclear gene. Read More

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Gibberellins: regulating genes and germination.

New Phytol 1998 Nov;140(3):363-383

Biology Department, The Pennsylvania State University, 208 Mueller Laboratory, University Park, Pennsylvania 16802, USA.

The range of processes regulated by gibberellins (GAs) covers all aspects of the life history of the plant from seed germination to vegetative growth and flowering. In seeds there has been an intensive search, using the techniques of both biochemistry and cell biology, for the regulatory molecules linking GA perception to gene regulation and the events of germination. Although a GA receptor has yet to be identified, the site of perception has been localized to the plasma membrane. Read More

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November 1998

Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism.

Horm Metab Res 2021 Apr 16. Epub 2021 Apr 16.

Genetic and Endocrinology Unit, Pediatric Department, Menoufia University, Shebin ElKoum, Menofia, Egypt.

The contribution of PAX8 genetic variants to congenital hypothyroidism (CH) is not well understood. We aimed to study the genetic variability of exons 3 and 5 of PAX8 gene among a cohort of children with congenital hypothyroidism in correspondence to their clinical aspect. Blood samples were collected from 117 children (63 girls and 54 boys) with CH and enrolled as cases (Group I). Read More

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Interleukin-35 regulates peripheral T cell activity in patients with Kawasaki disease.

Int Immunopharmacol 2021 Apr 13;96:107642. Epub 2021 Apr 13.

Department of General Internal Medicine, The Children's Hospital Affiliated to Xi'an Jiaotong University (Xi'an Children's Hospital), Xi'an, Shaanxi Province 710003, China. Electronic address:

Interleukin-35 (IL-35) regulates immune cell function in inflammation, infection, cancer, and autoimmune diseases. However, the modulatory activity of IL-35 exerted on T cells is not fully understood in Kawasaki disease. For this purpose, the present study included 28 patients with Kawasaki disease and 16 healthy controls. Read More

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Decoding molecular markers and transcriptional circuitry of naive and primed states of human pluripotency.

Stem Cell Res 2021 Apr 8;53:102334. Epub 2021 Apr 8.

Centre of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Prayagraj 211002, India. Electronic address:

Pluripotent stem cells (PSCs) have been observed to occur in two distinct states - naive and primed. Both naive and primed state PSCs can give rise to tissues of all the three germ layers in vitro but differ in their potential to generate germline chimera in vivo. Understanding the molecular mechanisms that govern these two states of pluripotency in human can open a plethora of opportunities for studying early embryonic development and in biomedical applications. Read More

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Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2.

Bioorg Med Chem 2021 Mar 24;38:116115. Epub 2021 Mar 24.

School of Chemistry, University of New South Wales (UNSW), Sydney, Australia. Electronic address:

Prolyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors. PHD inhibitors show promise for the treatment of diseases including anaemia, cardiovascular disease and stroke. In this work, a pharmacophore-based virtual high throughput screen was used to identify novel potential inhibitors of human PHD2. Read More

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Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.

Biochem Biophys Res Commun 2021 Apr 13;557:26-32. Epub 2021 Apr 13.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China; International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment and Standards, China. Electronic address:

Development of novel targeted therapies remains the priority in hepatocellular carcinoma (HCC) treatments. Early reports have demonstrated that androgen receptor (AR) plays a suppressive role in HCC progression. However, the underlying mechanisms by which AR attenuates HCC development are still elusive, especially under hypoxic conditions. Read More

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