814,068 results match your criteria transcription factor

TNFR2 is a regulatory target of pol-miR-194a and promotes the antibacterial immunity of Japanese flounder Paralichthys olivaceus.

Dev Comp Immunol 2022 Jun 22:104477. Epub 2022 Jun 22.

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, CAS Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

MicroRNAs (miRNAs) are regulatory RNAs that modulate target gene expression after transcription. Pol-miR-194a had been reported to be a miRNA of Japanese flounder (Paralichthys olivaceus) involved in Edwardsiella tarda infection. Here, we identified tumor necrosis factor receptor 2 (TNFR2) as a target gene of pol-miR-194a. Read More

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Microbiota-Independent Spontaneous Dermatitis Associated With Increased Sebaceous Lipid Production in Tmem79-Deficient Mice.

J Invest Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Electronic address:

TMEM79 is a predisposing gene for atopic dermatitis (AD). Tmem79-deficient mice develop spontaneous dermatitis in a biphasic pattern. The 1-phase dermatitis is unique, as it occurs independent of microbiota status, whereas the 2-phase dermatitis is microbiota-dependent. Read More

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Induction and modulation of the unfolded protein response during porcine deltacoronavirus infection.

Vet Microbiol 2022 Jun 14;271:109494. Epub 2022 Jun 14.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. Electronic address:

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that has the potential for cross-species infection. Many viruses have been reported to induce endoplasmic reticulum stress (ERS) and activate the unfolded protein response (UPR). To date, little is known about whether and, if so, how the UPR is activated by PDCoV infection. Read More

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Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells.

Phytomedicine 2022 Jun 19;104:154287. Epub 2022 Jun 19.

Formula-Pattern Research Center, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, Jiangxi 330004, China. Electronic address:

Background: Restoring immune homeostasis by targeting the Th17/Treg response is a potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) is a phytochemical naturally occurring in Astragalus membranaceus that has good anti-inflammatory, anti-oxidant and anti-stress properties. However, the effects of AS-IV on the homeostasis of Th17/Treg cells in colitis mice remains unknown. Read More

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ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms.

Curr Hematol Malig Rep 2022 Jun 25. Epub 2022 Jun 25.

Diagnostic Laboratories, Versiti, 638 N 18th St, Milwaukee, WI, 53233, USA.

Purpose Of Review: This review describes ANKRD26-related thrombocytopenia (RT) from a molecular, clinical, and laboratory perspective, with a focus on the clinical decision-making that takes place in the diagnosis and management of families with ANKRD26-RT.

Recent Findings: ANKRD26-related thrombocytopenia (ANKRD26-RT) is a non-syndromic autosomal dominant thrombocytopenia with predisposition to hematologic neoplasm. The clinical presentation is variable with moderate thrombocytopenia with normal platelet size and absent to mild bleeding being the hallmark which makes it difficult to distinguish from other inherited thrombocytopenias. Read More

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Loss of function of the bHLH transcription factor Nrd1 in tomato enhances resistance to Pseudomonas syringae.

Plant Physiol 2022 Jun 25. Epub 2022 Jun 25.

Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA.

Basic helix-loop-helix (bHLH) transcription factors constitute a superfamily in eukaryotes, but their roles in plant immunity remain largely uncharacterized. We found that the transcript abundance in tomato (Solanum lycopersicum) leaves of one bHLH transcription factor-encoding gene, Nrd1 (negative regulator of resistance to DC3000 1), increased significantly after treatment with the immunity-inducing flgII-28 peptide. Plants carrying a loss-of-function mutation in Nrd1 (Δnrd1) showed enhanced resistance to Pseudomonas syringae pv. Read More

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The genomes of chicory, endive, great burdock and yacon provide insights into Asteraceae paleo-polyploidization history and plant inulin production.

Mol Ecol Resour 2022 Jun 25. Epub 2022 Jun 25.

Guangdong Laboratory for Lingnan Modern Agriculture (Shenzhen Branch), Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, 518120, China.

Inulin is an important reserve polysaccharide in Asteraceae plants, and is also widely used as sweetener, dietary fiber, and prebiotics. Nevertheless, lack of genomic resources for inulin-producing plants hinders extensive studies on inulin metabolism and regulation. Here, we present chromosome-level reference genomes for four inulin-producing plants: chicory (Cichorium intybus), endive (Cichorium endivia), great burdock (Arctium lappa) and yacon (Smallanthus sonchifolius), with assembled genome size 1. Read More

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GmNAC181 promotes symbiotic nodulation and salt tolerance of nodulation by directly regulating GmNINa expression in soybean.

New Phytol 2022 Jun 25. Epub 2022 Jun 25.

National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China.

Soybean (Glycine max) is one of the most important crops worldwide. Under low nitrogen condition, soybean can form a symbiotic relationship with rhizobia to acquire sufficient nitrogen for their growth and production. Nodulation signaling controls soybean symbiosis with rhizobia. Read More

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The Functional Diversity of Tissue-Resident Natural Killer Cells Against Infection.

Immunology 2022 Jun 25. Epub 2022 Jun 25.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.

For decades, studies of natural killer (NK) cells have focused on those found in peripheral blood (PBNK cells) as the prototype for NK cell biology. Only recently have researchers begun to explore the diversity of tissue-resident NK (tr-NK) cells. While tr-NK cells were initially identified from mice parabiosis and intravascular staining experiments, they can also be identified by tissue retention markers such as CD69, CD103, and others. Read More

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An example of parenchymal renal sparing in the context of complex malformations due to a novel mutation in the PBX1 gene.

Birth Defects Res 2022 Jun 25. Epub 2022 Jun 25.

UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Introduction: PBX1 encodes the pre-B cell leukemia factor 1, a Three Amino acid Loop Extension (TALE) transcription factor crucial to regulate basic developmental processes. PBX1 loss-of-function variants have been initially described in association with renal malformations in both isolated and syndromic forms.

Case Report: Herein, we report a male infant presenting multiple organ malformations (cleidosternal dysostosis, micrognathia, left lung hypoplasia, wide interatrial defect, pulmonary hypertension, total anomalous pulmonary venous return, intestinal malrotation) and carrying the heterozygous de novo c. Read More

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TaSRO1 plays a dual role in suppressing TaSIP1 to fine tune mitochondrial retrograde signaling and enhance salinity stress tolerance.

New Phytol 2022 Jun 24. Epub 2022 Jun 24.

The Key Laboratory of Plant Development and Environment Adaptation Biology, Ministry of Education, School of Life Science, Shandong University, Qingdao, 266237, P. R. China.

Initially discovered in yeast, mitochondrial retrograde signaling has long been recognized as an essential in the perception of stress by eukaryotes. However, how to maintain the optimal amplitude and duration of its activation under natural stress conditions remains elusive in plants. Here, we show that TaSRO1, a major contributor to the agronomic performance of bread wheat plants exposed to salinity stress, interacted with a transmembrane domain-containing NAC transcription factor TaSIP1, which could translocate from the endoplasmic reticulum (ER) into the nucleus and activate a number of mitochondrial dysfunction stimulon (MDS) genes. Read More

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Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance.

Genome Biol 2022 Jun 24;23(1):136. Epub 2022 Jun 24.

Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.

Background: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endotoxin tolerance, profiling the coding and non-coding transcriptome, chromatin accessibility and epigenetic modifications.

Results: We describe the spectrum of enhancers under acute and tolerance conditions and the regulatory networks between these enhancers and biological processes including gene expression, splicing regulation, transcription factor binding and enhancer RNA signatures. Read More

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An in vitro redox adaptation model for metastatic prostate cancer: Establishing, characterizing, and Cabazitaxel response evaluating.

Clin Exp Pharmacol Physiol 2022 Jun 24. Epub 2022 Jun 24.

Bursa Uludag University, Faculty of Medicine, Medical Biology Department, Bursa, Turkey.

Little is known about the redox-adapted cancer cells for understanding their pharmacologically targetable features and chemotherapeutic responses. Thus, we presented the first in vitro redox adaptation model for metastatic prostate cancer (mPC), LNCaP-HPR, with enhanced oxidative stress resistance accompanying poor Cabazitaxel response. After establishing, the cells were characterized by comparing the viability, death, oxidative stress, total GSH levels, and the mRNA and protein levels of the redox-sensitive transcription factors responsible for the adaptation, Nrf-2, NF-κB, and HIF-1α. Read More

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DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival.

Breast Cancer Res 2022 Jun 24;24(1):43. Epub 2022 Jun 24.

Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Background: Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the specific types of NACT. DNA methylation is an epigenetic mechanism known to play an important role in regulating gene expression and may serve as a biomarker for treatment response and survival. Read More

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Clinical significance of cyclin-dependent kinase inhibitor 2C expression in cancers: from small cell lung carcinoma to pan-cancers.

BMC Pulm Med 2022 Jun 24;22(1):246. Epub 2022 Jun 24.

Ward of Pulmonary and Critical Care Medicine, Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

Background: Cyclin-dependent kinase inhibitor 2C (CDKN2C) was identified to participate in the occurrence and development of multiple cancers; however, its roles in small cell lung carcinoma (SCLC) remain unclear.

Methods: Differential expression analysis of CDKN2C between SCLC and non-SCLC were performed based on 937 samples from multiple centers. The prognosis effects of CDKN2C in patients with SCLC were detected using both Kaplan-Meier curves and log-rank tests. Read More

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A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma.

Biol Proced Online 2022 Jun 24;24(1). Epub 2022 Jun 24.

Department of Dermatology, Xiangya Hospital, Central South University, 87# Xiangya Road, Changsha, 41008, Hunan, China.

Background: The prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients remains poor due to the lack of therapeutic options. However, few studies have investigated the factors contributing to the prognosis of WT Bf-CM patients.

Methods: In this paper, we proposed and validated a novel 7-RNA based signature to predict the prognosis of WT Bf-CM by analyzing the information from TCGA database. Read More

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Identification and expression analysis of GARP superfamily genes in response to nitrogen and phosphorus stress in Spirodela polyrhiza.

BMC Plant Biol 2022 Jun 25;22(1):308. Epub 2022 Jun 25.

The State Key Laboratory of Freshwater Ecology and Biotechnology, The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.

Background: GARP transcription factors perform critical roles in plant development and response to environmental stimulus, especially in the phosphorus (P) and nitrogen (N) sensing and uptake. Spirodela polyrhiza (giant duckweed) is widely used for phytoremediation and biomass production due to its rapid growth and efficient N and P removal capacities. However, there has not yet been a comprehensive analysis of the GRAP gene family in S. Read More

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Adaptation insights from comparative transcriptome analysis of two Opisthopappus species in the Taihang mountains.

BMC Genomics 2022 Jun 24;23(1):466. Epub 2022 Jun 24.

College of Life Science, Shanxi Normal University, Taiyuan, 030031, China.

Opisthopappus is a major wild source of Asteraceae with resistance to cold and drought. Two species of this genus (Opisthopappus taihangensis and O. longilobus) have been employed as model systems to address the evolutionary history of perennial herb biomes in the Taihang Mountains of China. Read More

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Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.

Calcif Tissue Int 2022 Jun 24. Epub 2022 Jun 24.

Institute of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, 246 Xuefu Road, Nangang, Harbin, 150001, Heilongjiang, People's Republic of China.

Our previous gene profiling analysis showed that the transcription cofactor vestigial-like 3 (VGLL3) gene expression was upregulated by mechanical tension in the mouse cranial suture, coinciding with accelerated osteoblast differentiation. Therefore, we hypothesized that VGLL3 plays a significant role in osteogenic differentiation. To clarify the function of VGLL3 in osteoblasts, we examined its expression characteristics in mouse bone tissue and the osteoblastic cell line MC3T3-E1. Read More

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FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes.

NPJ Regen Med 2022 Jun 24;7(1):33. Epub 2022 Jun 24.

Key Laboratory of Regenerative Medicine of Ministry of Education, Department of Developmental & Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.

Upon injury, the liver is capable of substantial regeneration from the original tissue until an appropriate functional size. The underlying mechanisms controlling the liver regeneration processes are not well elucidated. Previous studies have proposed that the transcription factor FoxO3 is involved in various liver diseases, but its exact role in the regulation of liver regeneration remains largely unclear. Read More

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A comparative genomic analysis of lichen-forming fungi reveals new insights into fungal lifestyles.

Sci Rep 2022 Jun 24;12(1):10724. Epub 2022 Jun 24.

Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul, 08826, Korea.

Lichen-forming fungi are mutualistic symbionts of green algae or cyanobacteria. We report the comparative analysis of six genomes of lichen-forming fungi in classes Eurotiomycetes and Lecanoromycetes to identify genomic information related to their symbiotic lifestyle. The lichen-forming fungi exhibited genome reduction via the loss of dispensable genes encoding plant-cell-wall-degrading enzymes, sugar transporters, and transcription factors. Read More

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LXR agonist modifies neuronal lipid homeostasis and decreases PGD2 in the dorsal root ganglia in western diet-fed mice.

Sci Rep 2022 Jun 24;12(1):10754. Epub 2022 Jun 24.

Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, 60153, USA.

The prevalence of peripheral neuropathy is high in diabetic and overweight populations. Chronic neuropathic pain, a symptom of peripheral neuropathy, is a major disabling symptom that leads to a poor quality of life. Glucose management for diabetic and prediabetic individuals often fail to reduce or improve pain symptoms, therefore, exploring other mechanisms is necessary to identify effective treatments. Read More

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Clinical risk, sociodemographic factors, and SARS-CoV-2 infection over time in Ontario, Canada.

Sci Rep 2022 Jun 24;12(1):10534. Epub 2022 Jun 24.

ICES, Toronto, Canada.

We aimed to determine whether early public health interventions in 2020 mitigated the association of sociodemographic and clinical risk factors with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a population-based cohort study of all adults in Ontario, Canada who underwent testing for SARS-CoV-2 through December 31, 2020. The outcome was laboratory-confirmed SARS-CoV-2 infection, determined by reverse transcription polymerase chain reaction testing. Read More

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In-frame editing of transcription factor gene RDD1 to suppress miR166 recognition influences nutrient uptake, photosynthesis, and grain quality in rice.

Masao Iwamoto

Sci Rep 2022 Jun 24;12(1):10795. Epub 2022 Jun 24.

Division of Crop Genome Editing, Institute of Agrobiological Sciences, NARO, Tsukuba Ibaraki, 305-8604, Japan.

The transcription factor-encoding gene RDD1 increases the uptake of nutrient ions, photosynthetic activity under ambient and high CO conditions, and grain productivity, and microRNA166 (miR166) regulates its transcript levels. This study found that CRISPR/Cas9 genome editing of rice plants to inhibit miR166-RDD1 transcript pairing (R1-Cas plants) increased RDD1 transcript levels, NH and PO uptake, and photosynthetic activity under high CO conditions in rice. However, the panicle weight of the R1-Cas plants decreased compared with the wild-type (WT) plants. Read More

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Epigenetic Reprogramming Leads to Downregulation of CD4 and Functional Changes in African Green Monkey Memory CD4 T Cells.

J Immunol 2022 Jun 24. Epub 2022 Jun 24.

Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;

African green monkeys (AGMs), are a natural host for a lentivirus related to HIV, SIV. SIV-infected AGMs rarely progress to AIDS despite robust viral replication. Though multiple mechanisms are involved, a primary component is the animals' ability to downregulate CD4 expression on mature CD4 Th cells, rendering these cells resistant to infection by SIV. Read More

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Multifaceted regulation of enhancers in cancer.

Biochim Biophys Acta Gene Regul Mech 2022 Jun 22;1865(6):194839. Epub 2022 Jun 22.

Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China. Electronic address:

Enhancer is one kind of cis-elements regulating gene transcription, whose activity is tightly controlled by epigenetic enzymes and histone modifications. Active enhancers are classified into typical enhancers, super-enhancers and over-active enhancers, according to the enrichment and location of histone modifications. Epigenetic factors control the level of histone modifications on enhancers to determine their activity, such as histone methyltransferases and acetylases. Read More

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Mechanisms used by cancer cells to tolerate drug-induced replication stress.

Cancer Lett 2022 Jun 21:215804. Epub 2022 Jun 21.

Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

Activation of oncogenes in cancer cells forces cell proliferation, leading to DNA replication stress (RS). As a consequence, cancer cells heavily rely on the intra S-phase checkpoint for survival. This fundamental principle formed the basis for the development of inhibitors against key players of the intra S-phase checkpoint, ATR and CHK1. Read More

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Atrogin-1 knockdown inhibits the autophagy-lysosome system in mammalian and avian myotubes.

Comp Biochem Physiol A Mol Integr Physiol 2022 Jun 21:111262. Epub 2022 Jun 21.

Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.

Atrogin-1 plays an important role in ubiquitin-proteasome proteolysis in vertebrate skeletal muscles. Recently, atrogin-1 has been shown to be involved in the autophagy-lysosome system, another proteolytic system, in the murine and fish hearts and skeletal muscles. With the aim to elucidate the effect of atrogin-1 on the autophagy-lysosome system in mammalian and avian skeletal muscles, this study has examined the effects of atrogin-1 knockdown on autophagy-lysosome-related proteins in C2C12 and chicken embryonic myotubes. Read More

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Nrf2 pathway in vegetable oil-induced inflammation of large yellow croaker (Larimichthys crocea).

Fish Shellfish Immunol 2022 Jun 21. Epub 2022 Jun 21.

Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs) & Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, 266237, Qingdao, Shandong, PR China. Electronic address:

This study was conducted to investigate the effects and regulation of dietary vegetable oil (VO, enriched with α-linolenic acid [ALA] and linoleic acid [LNA]) on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB) pathways in large yellow croaker. In vivo study showed that the VO diet significantly decreased the activity of antioxidant enzymes and antioxidant enzyme-related mRNA expression in the liver tissue, in comparison with the fish oil (FO) diet (P < 0.05). Read More

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Transcription factor-based direct conversion of human fibroblasts to functional astrocytes.

Stem Cell Reports 2022 Jun 7. Epub 2022 Jun 7.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Neurology, Stem Cells, Aging and Neurodegeneration, Lund, Sweden; Lund Stem Cell Center, Lund, Sweden. Electronic address:

Astrocytes are emerging key players in neurological disorders. However, their role in disease etiology is poorly understood owing to inaccessibility of primary human astrocytes. Pluripotent stem cell-derived cells fail to mimic age and due to their clonal origin do not mimic genetic heterogeneity of patients. Read More

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