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Factor structure of borderline personality disorder and response to Systems Training for Emotional Predictability and Problem Solving.

Personal Ment Health 2022 Jan 26. Epub 2022 Jan 26.

Department of Psychiatry, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, USA.

Differential response to the Systems Training for Emotional Predictability and Problem Solving (STEPPS) program was compared in subgroups identified through latent class analysis (LCA). STEPPS is an evidence-based group treatment program for patients with borderline personality disorder (BPD). A reanalysis of data was conducted using data from a 20-week randomized controlled trial and 1-year follow-up. Read More

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January 2022

Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery.

J Obstet Gynaecol Res 2022 Jan 26. Epub 2022 Jan 26.

Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Aim: A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Read More

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January 2022

[Flow-Experience in Old Age: An Investigation of Influencing Factors and Therapy Benefits for Geriatric Patients].

Psychother Psychosom Med Psychol 2022 Jan 26. Epub 2022 Jan 26.

Klinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Klinikum Nürnberg, Deutschland.

Flow experience, a feeling of being absorbed in an activity without reflection and with maximum depth, has positive effects on psychological and physical well-being, performance, and life satisfaction. Little research has been done on flow experience in old age, and there are no studies on geriatric patients. In the present study, elderly patients (mean age:81. Read More

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January 2022

Developing Dashboards to Address Children's Health Disparities in Ohio.

Appl Clin Inform 2022 Jan 26;13(1):100-112. Epub 2022 Jan 26.

CATALYST, Center for the Advancement of Team Science, Analytics, and Systems Thinking in Health Services and Implementation Science Research, College of Medicine, The Ohio State University, Columbus, Ohio, United States.

Objectives:  Social determinants of health (SDoH) can be measured at the geographic level to convey information about neighborhood deprivation. The Ohio Children's Opportunity Index (OCOI) is a composite area-level opportunity index comprised of eight health domains. Our research team has documented the design, development, and use cases of a dashboard solution to visualize OCOI. Read More

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January 2022

Lessons Learned from OpenNotes Learning Mode and Subsequent Implementation across a Pediatric Health System.

Appl Clin Inform 2022 Jan 26;13(1):113-122. Epub 2022 Jan 26.

Information Services and Technology, Children's Healthcare of Atlanta, Atlanta, Georgia, United States.

Background:  The 21st Century Cures Act has accelerated adoption of OpenNotes, providing new opportunities for patient and family engagement in their care. However, these regulations present new challenges, particularly for pediatric health systems aiming to improve information sharing while minimizing risks associated with adolescent confidentiality and safety.

Objective:  Describe lessons learned preparing for OpenNotes across a pediatric health system during a 4-month trial period (referred to as "Learning Mode") in which clinical notes were not shared by default but decision support was present describing the upcoming change and physicians could request feedback on complex cases from a multidisciplinary team. Read More

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January 2022

What has the pandemic revealed about the shortcomings of modern epidemiology? What can we fix or do better?

Am J Epidemiol 2022 Jan 27. Epub 2022 Jan 27.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

In this commentary, we discuss themes that emerged from the symposium about what modern epidemiology as a science may learn from the coronavirus disease 19 (COVID-19) pandemic. We reflect on the successes and limitations of this discipline from multiple perspectives, including junior and senior epidemiologists and scientists on the front lines of generating evidence for the COVID-19 pandemic response from Wuhan, China to Ontario, Canada. These themes include: the role of the traditional scientific process in a public health emergency; epidemiologic methods and data that are critical for an effective pandemic response; the interventions that epidemiologists recommended and interventions that we may explore in the future; inequitable impacts of the COVID-19 pandemic contrasted with homogeneity in epidemiologists' workforce; effective and honest communication of uncertainty; trust and collaboration; and the extent to which these themes are currently reflected in our training programs and discipline. Read More

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January 2022

Diastereoselective synthesis of glycopyrans 1,2-annulated with dioxazinanes from 1,2-anhydrosugars and -substituted nitrones.

Org Biomol Chem 2022 Jan 26. Epub 2022 Jan 26.

Natural Product and Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Jammu-180001, India.

1,2-Annulated pyranose sugars fused with six membered rings have emerged as an important class of carbohydrates with wide biological and synthetic utility. We now describe zinc chloride catalyzed one pot diastereoselective synthesis of sugar fused dioxazinanes from 1,2-anhydro sugars and -substituted aromatic nitrones. Various aromatic nitrones with different substituents undergo the reaction smoothly. Read More

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January 2022

Building an Advising Model for Physician Assistant Education.

J Physician Assist Educ 2022 Jan 25. Epub 2022 Jan 25.

Shani Fleming, MPH, PA-C, is an associate professor for the Physician Assistant Leadership and Learning Academy and Chief Equity, Diversity, and Inclusion Officer, Graduate School, University of Maryland Baltimore in Baltimore, Maryland. Karen L. Gordes, PhD, DSc, PT, is the chief learning officerzz and an associate professor for the Physician Assistant Leadership and Learning Academy, Graduate School, University of Maryland Baltimore in Baltimore, Maryland. Violet Kulo, EdD, MS, is an associate professor in Health Professions Education for the Physician Assistant Leadership and Learning Academy and Program Director of Masters in Health Professions Education, Graduate School, University of Maryland Baltimore in Baltimore, Maryland. James F. Cawley, MPH, PA-C, is a scholar in residence and visiting professor at the Physician Assistant Leadership and Learning Academy, Graduate School, University of Maryland Baltimore in Baltimore, Maryland.

Abstract: Physician assistant education is balancing an explosion of new programs, an increase in novice faculty, and expectations from accreditation standards to track student progress longitudinally. The traditional "one-size fits all" model of advising will not meet the demands of this changing educational environment. This article introduces a longitudinal advising model that integrates various strategies from existing models such as proactive, appreciative advising, and the GROW (Goal, Reality, Options, Will) coaching model with a focus on the goal of achieving the new Physician Assistant Education Association (PAEA) Competencies for the New Graduate. Read More

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January 2022

Obesity Among Industrial Workers in Brazil: A Cross-sectional Study on Prevalence and Associated Factors.

J Occup Environ Med 2022 Jan 25. Epub 2022 Jan 25.

Post-graduate Program in Collective Health, University of Vale do Rio dos Sinos, UNISINOS, São Leopoldo, RS, Brazil (Xavier, Garcez, da Silva, Olinto); Life Sciences Area, University of West Santa Catarina, UNOESC, Joaçaba, SC, Brazil (Xavier); Post-graduate Program in Nutrition Sciences, Federal University of Health Science of Porto Alegre, UFCSPA, Porto Alegre, RS, Brazil (Garcez); Social Service of Industry of Rio Grande do Sul (SESI-RS), Porto Alegre, RS, Brazil (Cibeira, Germano); Post-graduate Program in Food, Nutrition and Health, Federal University of Rio Grande do Sul State, UFRGS, Porto Alegre, RS, Brazil (Olinto).

Objective: Estimate the prevalence of obesity and its associated factors among industrial workers.

Methods: This is a cross-sectional study of secondary data from workers aged 18 to 59 years in the State of Rio Grande do Sul, Brazil.

Results: A total of 20,820 workers (12,372 male and 8,448 female) were investigated. Read More

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January 2022

Aortic diastolic pressure decay explains sex-related differences in the subendocardial viability ratio: the Wakuya study.

J Hypertens 2022 Jan 25. Epub 2022 Jan 25.

Miyagi University of Education Medical Center, Sendai Wakuya National Health Insurance Hospital Wakuya Medical and Welfare Center, Miyagi, Japan.

Objective: Coronary heart disease is the leading cause of mortality in women. Despite a higher risk of heart failure after the first myocardial infarction in women compared with men, the sex-specific mechanisms are unknown. We hypothesized that myocardial ischemia is attributable to sex-related diastolic alterations in the central hemodynamics. Read More

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January 2022

Sertraline-Associated Burning Mouth Syndrome: A Rare Adverse Effect of a Frequently Prescribed Antidepressant.

J Clin Psychopharmacol 2022 Jan 25. Epub 2022 Jan 25.

Department of Psychiatry, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka

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January 2022

ANNSURG-D-21-01390R1: Surgical Performance Anxiety and Wellbeing Among Surgeons: A Cross-Sectional Study in the United Kingdom.

Authors:
Roy Phitayakorn

Ann Surg 2022 Jan 25. Epub 2022 Jan 25.

General and Endocrine Surgery Director of Medical Student Education and Surgery Education Research, The Massachusetts General Hospital, Boston, MA.

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January 2022

Context, COVID-19 and comorbidities: exploring emergent directions in syndemics and HIV research.

Curr Opin HIV AIDS 2022 Jan 25. Epub 2022 Jan 25.

Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada Centre for Gender and Sexual Health Equity, Vancouver, British Columbia, Canada United Nations University Institute for Water, Environment & Health, Hamilton, Canada Ontario Institute for Studies in Education, University of Toronto, Toronto, Ontario, Canada Department of Psychiatry and Behavioral Sciences, The George Washington University, Washington, District of Columbia, USA Center for Global Health and Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA Edmund A. Walsh School of Foreign Service, Georgetown University, Washington, District of Columbia, USA.

Purpose Of Review: The purpose of this review is to identify themes across articles that aimed to explore HIV-related syndemics in 2020 and 2021 and to discuss their implications for research on syndemics.

Recent Findings: We identified 189 articles on syndemics between 2020 and 2021. Key themes across studies included COVID-19; mental health and psychosocial challenges; substance use; socio-structural factors; protective factors; and methodological approaches. Read More

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January 2022

Cardiometabolic and Vascular Disease Factors and Mild Cognitive Impairment and Dementia.

Gerontology 2022 Jan 26:1-9. Epub 2022 Jan 26.

Gerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Introduction: There is empirical evidence that cardiovascular risk factors and vascular pathology contribute to cognitive impairment and dementia.

Methods: We profiled cardiometabolic and vascular disease (CMVD) and CMVD burden in community-living older adults in the Singapore Longitudinal Ageing Study cohort and examined the association of CMVD risk markers with the prevalence and incidence of mild cognitive impairment (MCI) and dementia from a median 3.8 years of follow-up. Read More

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January 2022

Seroprevalence of SARS-CoV-2 Neutralizing Antibodies among Blood Donors in Ho Chi Minh City, Vietnam, August-November 2020.

Am J Trop Med Hyg 2022 Jan 26. Epub 2022 Jan 26.

Training Center, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Relatively little is known about the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies and COVID-19-related behaviors in the general population in Vietnam, where the first case of COVID-19 was detected on January 22, 2020. We surveyed a group of 885 blood donors at community blood donation sessions in Ho Chi Minh City from August 27 to November 7, 2020. Blood was collected to test for SARS-CoV-2 IgG antibodies using the plaque reduction neutralization test. Read More

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January 2022

A comparative study on the physicochemical properties, reactivity and long-term performance of sulfidized nanoscale zerovalent iron synthesized with different kinds of sulfur precursors and procedures in simulated groundwater.

Water Res 2022 Jan 19;212:118097. Epub 2022 Jan 19.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

There are plentiful ways to synthesize sulfidized nanoscale zerovalent iron (S-nZVI), and this study investigated the influence of sulfur reagents (NaS, NaSO, NaSO) and sulfidation sequence (co-sulfidation and post-sulfidation method) on the physicochemical properties, reactivity, and long-term performance of S-nZVI in simulated groundwater. The results suggested that the co-sulfidized nZVI (S-nZVI) has higher reactivity (∼2-fold) than S-nZVI due to the stronger electron transfer capacity, deriving from the higher content of Fe and reductive sulfur species. However, during aging, the reactivity of S-nZVI would be lost more rapidly than S-nZVI, due to the faster corrosion of Fe and more oxidation of reductive sulfur species. Read More

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January 2022

Effects of parental care and overprotection on adolescents' diurnal cortisol profiles.

Horm Behav 2022 Jan 23;140:105121. Epub 2022 Jan 23.

Department of Psychology, Faculty of Social Sciences, University of Macau, China; Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, China. Electronic address:

Parental bonding is a strong determinant of children's health. One of the proposed pathways through which parenting impacts children's health is by altering the functioning of stress response systems. The current study aims to investigate the associations between two types of parental bonding (care and overprotection) and functioning of hypothalamic-pituitary-adrenal (HPA) axis (i. Read More

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January 2022

UPLC-QQQ-MS/MS-based widely targeted metabolomic analysis reveals the effect of solid-state fermentation with Eurotium cristatum on the dynamic changes in the metabolite profile of dark tea.

Food Chem 2022 Jan 4;378:131999. Epub 2022 Jan 4.

Key Laboratory of Ministry of Education for Tea Science, College of Horticulture, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China. Electronic address:

Eurotium cristatum is the predominant fungus and key contributor to the characteristics of post-fermented Fu brick tea (FBT) during manufacturing. In this study, the influence of solid-state fermentation (SSF) with E. cristatum on the chemical profile dynamic changes of dark tea was investigated. Read More

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January 2022

Efficient and simple simultaneous adsorption removal of multiple aflatoxins from various liquid foods.

Food Chem 2022 Jan 19;380:132176. Epub 2022 Jan 19.

Suzhou Municipal Center for Disease Prevention and Control, Suzhou, China. Electronic address:

In this study, a polydopamine modified nanofibers membrane (PDA-PS NFsM) was prepared and evaluated as the adsorbent for simultaneous removal of a variety of aflatoxins in various liquid foods, including edible oil, soy sauce and milk, rice vinegar and liquor. The removal efficiency for every single aflatoxin from all samples involved above was more than 76.5% within 1 h at 25 °C, except the liquors with higher ethanol content, for which the efficiency was lower. Read More

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January 2022

Recommending HPV vaccination at age 9: A national survey of primary care professionals.

Acad Pediatr 2022 Jan 23. Epub 2022 Jan 23.

Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA 27599-7400; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, 27559-7295. Electronic address:

Objective: Several U.S. health organizations, including the American Academy of Pediatrics, now encourage primary care professionals to recommend HPV vaccination before the traditionally targeted ages of 11-12 years as a strategy to increase vaccination timeliness. Read More

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January 2022

Effect of micro-aerobic conditions based on semipermeable membrane-covered on greenhouse gas emissions and bacterial community during dairy manure storage at industrial scale.

Environ Pollut 2022 Jan 23:118879. Epub 2022 Jan 23.

Engineering Laboratory for AgroBiomass Recycling & Valorizing, College of Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

This study evaluated the greenhouse gas emissions of solid dairy manure storage with the micro-aerobic group (MA; oxygen concentration <5%) and control group (CK; oxygen concentration <1%), and explained the difference in greenhouse gas emissions by exploring bacterial community succession. The results showed that the MA remained the micro-aerobic conditions, which the maximum and average oxygen concentrations were 4.1% and 1. Read More

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January 2022

Toxicological effects of atenolol and venlafaxine on zebrafish tissues: Bioaccumulation, DNA hypomethylation, and molecular mechanism.

Environ Pollut 2022 Jan 23:118898. Epub 2022 Jan 23.

School of Environment and Energy, South China University of Technology, Guangzhou, 510006, PR China; The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, China; The Key Laboratory of Environmental Protection and Eco-Remediation of Guangdong Regular Higher Education Institutions, China. Electronic address:

The beta-blocker atenolol (ATE), and the selective serotonin and norepinephrine reuptake inhibitor, venlafaxine (VEN) are frequently detected in municipal wastewater effluents, but little is known about their ecotoxic effect on aquatic animals. Herein, ATE and VEN were selected to explore their accumulation and global DNA methylation (GDM) in zebrafish tissues after a 30-day exposure. Molecular dynamics (MD) stimulation was used to investigate the toxic mechanism of ATE and VEN exposure. Read More

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January 2022

Influences of landform and urban form factors on urban heat island: Comparative case study between Chengdu and Chongqing.

Sci Total Environ 2022 Jan 23:153395. Epub 2022 Jan 23.

School of Architecture and Urban Planning, Chongqing University, Chongqing 400045, PR China. Electronic address:

Although the degraded urban thermal environment has been widely concerned, whether monocentric or polycentric urban development can alleviate urban heat island (UHI) is still debatable, particularly considering different types of cities in plain and mountainous settings. To fill the gap, this study chose the cases of Chengdu on alluvial flatlands and Chongqing on mountainous landforms in China for comparison. Adapting to natural landforms, Chengdu has a dominated monocentric urban form, whereas Chongqing has a naturally polycentric urban form. Read More

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January 2022

Impact of COVID-19 on Radiology Trainee Safety, Education, and Wellness: Challenges Experienced and Proposed Solutions for the Future.

J Am Coll Radiol 2022 Jan 11. Epub 2022 Jan 11.

Program Director, Body Imaging Fellowship, Massachusetts General Hospital, Boston, Massachusetts; and Panel Chair, Gynecology and Obstetrics Panel 2, ACR Appropriateness Criteria.

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January 2022

Characterization of novel Tn7-derivatives and Tn7-like transposon found in Proteus mirabilis of food-producing animal origin in China.

J Glob Antimicrob Resist 2022 Jan 23. Epub 2022 Jan 23.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.

Objectives: This study aimed to clarify the characteristics of Tn7-derivatives transposons in MDR Proteus mirabilis strains isolated from anal swabs of chicken and swine in China, from 2015 to 2020.

Methods: The Tn7 tnsA gene was screened in two hundred and seven P. mirabilis isolates by PCR. Read More

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January 2022

In search of coronary thrombosis as the cause of myocardial infarction: unraveling a 20 century mystery.

Am J Med 2022 Jan 23. Epub 2022 Jan 23.

From the Division of Cardiology, Department of Medicine, UCSF Fresno Medical Education Program, Fresno, CA. Electronic address:

For the greater part of the 20 century, the pathophysiology of acute myocardial infarction regarding whether thrombosis was either present or primary was debated until 1973 when pathologists and clinicians met and by consensus, finally decided that the data supported that transmural infarction (what we now refer to as ST elevation MI) was caused by thrombus in the vessel supplying the infarcted territory. As the data for this consensus came from pathological analysis, it took another 7 years until angiographic and interventional data in humans with acute presentations of transmural infarction convincingly indicated that thrombus was indeed responsible. Subsequently, in patients presenting with either syndromes of unstable angina or non-transmural (later called non-ST elevation) myocardial infarction, it was established through angiographic and other interventional approaches that thrombus formation was also causative in a substantial proportion of these patients. Read More

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January 2022

IL-17RA-signaling in Lgr5 intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.

Immunity 2022 Jan 20. Epub 2022 Jan 20.

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA. Electronic address:

The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Here, we used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut. Read More

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January 2022

Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2.

Cell Rep 2022 Jan;38(4):110253

Department of Pharmacology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China; Institute of Hematology, Zhejiang University and Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, Zhejiang 310003, China. Electronic address:

Acute myeloid leukemia (AML) is a genetically heterogeneous and frequently fatal malignancy. The ten-eleven translocation (TET)-mediated DNA demethylation is known to be critically associated with AML pathogenesis. Through chemical compound screening, we find that the opioid receptor agonist, loperamide hydrochloride (OPA1), significantly suppresses AML cell viability. Read More

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January 2022

Proteomic screen reveals diverse protein transport between connected neurons in the visual system.

Cell Rep 2022 Jan;38(4):110287

Neuroscience Department and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

Intercellular transfer of toxic proteins between neurons is thought to contribute to neurodegenerative disease, but whether direct interneuronal protein transfer occurs in the healthy brain is not clear. To assess the prevalence and identity of transferred proteins and the cellular specificity of transfer, we biotinylated retinal ganglion cell proteins in vivo and examined biotinylated proteins transported through the rodent visual circuit using microscopy, biochemistry, and mass spectrometry. Electron microscopy demonstrated preferential transfer of biotinylated proteins from retinogeniculate inputs to excitatory lateral geniculate nucleus (LGN) neurons compared with GABAergic neurons. Read More

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January 2022

Immediate or Postponed Intervention for Infected Necrotizing Pancreatitis.

N Engl J Med 2022 Jan;386(4)

Postgraduate Institute of Medical Education and Research, Chandigarh, India

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January 2022