Pain 2021 Jan 5. Epub 2021 Jan 5.
Medical Research Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Rd. 2, Guangzhou 510080, China Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd. 2, Guangzhou 510080, China Zhongshan School of Medicine of Sun Yat-sen University, 74 Zhongshan Rd. 2, Guangzhou 510080, China College of Food Science and Technology, Hainan University, 58 Renmin Avenue, Haikou 570228, China State Key Laboratory of Marine Resources Utilization of South China Sea, 58 Renmin Avenue, Haikou 570228, China.
Abstract: Adults are more likely to suffer from chronic pain than minors, and its underlying mechanism remains unclear. SIRT1 as important aging-related protein with function of lifespan extension, whether SIRT1 plays a role in the different pain vulnerability of adult and juvenile remains unclear. Here, we found that the expression level of SIRT1 in dorsal root ganglia (DRG) was related to the pain vulnerability. Read More