67,331 results match your criteria traditional technologies

Endoscopic retrograde appendicitis therapy: a novel approach for peri-appendiceal abscess.

Endoscopy 2021 May 12. Epub 2021 May 12.

Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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Development and Clinical Uses of a Mobile Application for Smart Wound Nursing Management.

Adv Skin Wound Care 2021 Jun;34(6):1-6

At Central South University, Changsha, Hunan, China; Qijian Zhang, MS, RN; Weiwei Dai, MS, RN; and Hanzhang Tian, MS, RN, are Enterostomal Therapists at the Wound Center, Xiangya Hospital; Qiongfang Tang, BS, RN, is a Wound Therapist at the Wound Center, Xiangya Hospital; Weihong Huang, MD, is Professor, Mobile Health Ministry of Education - China Mobile Joint Laboratory, Xiangya Hospital; and Shihui Wang, MD, is User Interface Designer, School of Architecture and Art. Acknowledgments: This work was supported in part by the National Key R&D Program of China under Grant 2017YFC0909900 (Integrated Service System of Precision Medicine based on Telemedicine and Mobile Health Network) and the Key R&D Program of Hunan Province China under grant 2017SK2013 (Research and Application of Integrated Medical and Social Care Service Model Supported by Big Data and Mobile Health Technologies). The authors have disclosed no other financial relationships related to this article. Submitted March 10, 2020; accepted in revised form June 19, 2020.

Objective: Establishing a smart platform for wound nursing management is imperative to accelerating the development of this specialty. A mobile application (app) was created based on the clinical needs of wound care to improve working efficiency and wound management, as well as enable information sharing and categorical retrieval of patient records.

Methods: Supported by the National Mobile Laboratory of China, the authors' wound care center collaborated with information technology engineers and user interface designers to establish a multidisciplinary team of experts in wound nursing information management and develop a digital app. Read More

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The influence on oxidative stress markers, inflammatory factors and intestinal injury-related molecules in Wahui pigeon induced by lipopolysaccharide.

PLoS One 2021 12;16(5):e0251462. Epub 2021 May 12.

College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.

Introduction: The intestinal structure is the foundation for various activities and functions in poultry. An important question concerns the changes in the intestinal status under endotoxin stimulation. This study aimed to investigate the mechanism of intestinal injury induced by lipopolysaccharide (LPS) in Wahui pigeons. Read More

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Recent perspectives of nanotechnology in burn wounds management: a review.

Ruan Na Tian Wei

J Wound Care 2021 May;30(5):350-370

Department of Biomedical Engineering.

Objective: The burden of the management of problematic skin wounds characterised by a compromised skin barrier is growing rapidly. Almost six million patients are affected in the US alone, with an estimated market of $25 billion annually. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. Read More

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Unraveling the Ion Adsorption Kinetics in Microporous Carbon Electrodes: A Multiscale Quantum-Continuum Simulation and Experimental Approach.

ACS Appl Mater Interfaces 2021 May 12. Epub 2021 May 12.

Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550, United States.

Understanding sorption in porous carbon electrodes is crucial to many environmental and energy technologies, such as capacitive deionization (CDI), supercapacitor energy storage, and activated carbon filters. In each of these examples, a practical model that can describe ion electrosorption kinetics is highly desirable for accelerating material design. Here, we proposed a multiscale model to study the ion electrosorption kinetics in porous carbon electrodes by combining quantum mechanical simulations with continuum approaches. Read More

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Heterotrophic nitrification and related functional gene expression characteristics of Alcaligenes faecalis SDU20 with the potential use in swine wastewater treatment.

Bioprocess Biosyst Eng 2021 May 12. Epub 2021 May 12.

State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, 266237, People's Republic of China.

A new heterotrophic nitrifying bacterium was isolated from the compost of swine manure and rice husk and identified as Alcaligenes faecalis SDU20. Strain SDU20 had heterotrophic nitrification potential and could remove 99.7% of the initial NH-N. Read More

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Factors associated with HIV testing among traditional healers and their clients in rural Uganda: Results from a cross-sectional study.

Int J STD AIDS 2021 May 12:9564624211015028. Epub 2021 May 12.

Department of Emergency Medicine, 12295Weill Cornell Medicine, New York, NY, USA.

Uptake of HIV testing is suboptimal in Uganda, particularly in rural communities. Reaching UNAIDS 95-95-95 goals requires strategies to increase HIV testing among hard-to-reach populations. This cross-sectional study sought to characterize engagement with HIV testing among traditional healers and their clients in rural Uganda. Read More

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Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells.

Bioconjug Chem 2021 May 12. Epub 2021 May 12.

Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), V.le Regina Elena 291, 00161 Rome, Italy.

Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases through selective gene silencing. However, successful clinical application of nucleic acid-based therapy requires novel delivery options. Herein, to achieve efficient delivery of negatively charged siRNA duplexes, the internal cavity of "humanized" chimeric Archaeal ferritin (HumAfFt) was specifically decorated with novel cationic piperazine-based compounds (PAs). Read More

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New Insights into the Quantitative Relationship between Surface Chemistry of Fullerene (C60) and Solubility Parameters and Compatibility with Polymers.

J Phys Chem B 2021 May 12. Epub 2021 May 12.

College of Science, Nanjing Forestry University, Nanjing 210037, China.

The quantitative relationship between the surface chemistry of carbon materials and the compatibility with polymers is a fundamental and vital physical chemistry problem in the field of polymer nanocomposites. Traditional experimental methods are difficult to solve this problem, so no theory has been formed to guide the functionalization of carbon materials. In this work, the quantitative relationship between functional groups and Hildebrand (δ) and transformed Hansen (δ and δ) solubility parameters of fullerene (C60) was determined by molecular dynamics simulation. Read More

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The Path to Eldership: Results from a Contemporary Indigenous Australian Community.

Gerontologist 2021 May 12. Epub 2021 May 12.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background And Objectives: Traditionally, Elders have held a unique social position within Indigenous Australian communities. This study aimed to identify the characteristics of Indigenous Elders that distinguish them from other people in their community.

Research Design And Methods: Using a community-based participatory research approach, the study was conducted in a regional Indigenous community in Southeast Queensland. Read More

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A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine.

Chem Commun (Camb) 2021 May;57(38):4726-4729

Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China. and University of Chinese Academy of Sciences, Beijing 100049, P. R. China and Institute of Molecular Medicine, Renji Hospital, School of Medicine and School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.

A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. Read More

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Optimization of the drying process of autumn fruits rich in antioxidants: a study focusing on rosehip ( L.) and sea buckthorn ( (L.) A. Nelson) and their bioactive properties.

Food Funct 2021 May;12(9):3939-3953

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.

Nowadays, it is very important to identify the traditional uses of different plants and to create the context in which new cultural or economic value is given to local resources. In this study, two wild fruits traditionally harvested in autumn in Romania were selected to investigate the effects of drying conditions on the chemical compositions and bioactivities exerted by the extracts and to select the best conditions in terms of air temperature and time of drying. The extracts obtained were assessed in terms of antioxidant capacity and enzyme inhibitory activity, and their main bioactive compounds were identified and quantified. Read More

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An overview of recent advances and applications of FT-IR spectroscopy for quality, authenticity, and adulteration detection in edible oils.

Crit Rev Food Sci Nutr 2021 May 12:1-19. Epub 2021 May 12.

Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Authenticity and adulteration detection are primary concerns of various stakeholders, such as researchers, consumers, manufacturers, traders, and regulatory agencies. Traditional approaches for authenticity and adulteration detection in edible oils are time-consuming, complicated, laborious, and expensive; they require technical skills when interpreting the data. Over the last several years, much effort has been spent in academia and industry on developing vibrational spectroscopic techniques for quality, authenticity, and adulteration detection in edible oils. Read More

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The relationship between prescription of ultrafiltration and intradialytic hypotension in Chinese hemodialysis patients.

Ann Palliat Med 2021 May 12. Epub 2021 May 12.

Department of Traditional Chinese Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: Intradialytic hypotension (IDH) remains the most frequent severe side effect of hemodialysis (HD) and increases patient morbidity and mortality. Excessive ultrafiltration (UF) is considered the leading cause of IDH. This study developed a suitable prescription of UF to reduce the incidences of IDH episodes. Read More

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Rotundic acid reduces LPS-induced acute lung injury in vitro and in vivo through regulating TLR4 dimer.

Phytother Res 2021 May 11. Epub 2021 May 11.

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Acute lung injury (ALI) is a serious clinical disease. Rotundic acid (RA), a natural ingredient isolated from Ilex rotunda Thunb, exhibits multiple pharmacological activities. However, RA's therapeutic effect and mechanism on ALI remain to be elucidated. Read More

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Simultaneous quantitative analysis of ten bioactive flavonoids in Citri Reticulatae Pericarpium Viride (Qing Pi) by ultrahigh-performance liquid chromatography and high-resolution mass spectrometry combined with chemometric methods.

Phytochem Anal 2021 May 11. Epub 2021 May 11.

College of Pharmacy, Jinan University, Guangzhou, China.

Introduction: Citri Reticulatae Pericarpium Viride (Qing Pi in Chinese) is a clinically effective Chinese herb, which contains biologically valuable flavonoids. Qing Pi is divided into two commodity specifications, Si Hua Qing Pi (SHQP) and Ge Qing Pi (GQP), based on the harvesting time. The flavonoid contents in Qing Pi from different origins and commodity specifications may vary significantly, which will affect their therapeutic functions. Read More

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New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch.

Nat Prod Bioprospect 2021 May 11. Epub 2021 May 11.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Read More

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Science, misinformation and digital technology during the Covid-19 pandemic.

Hist Philos Life Sci 2021 May 11;43(2):68. Epub 2021 May 11.

Departamento de Filosofía I, Universidad de Granada, Granada, Spain.

Three interdependent factors are behind the current Covid-19 pandemic distorted narrative: (1) science´s culture of "publish or perish", (2) misinformation spread by traditional media and social digital media and (3) distrust of technology for tracing contacts and its privacy-related issues. In this short paper, I wish to tackle how these three factors have added up to give rise to a negative public understanding of science in times of a health crisis, such as the current Covid-19 pandemic and finally, how to confront all these problems. Read More

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Nexus between green logistic operations and triple bottom line: evidence from infrastructure-led Chinese outward foreign direct investment in Belt and Road host countries.

Environ Sci Pollut Res Int 2021 May 11. Epub 2021 May 11.

School of Economics and Management, Tsinghua University, Beijing, People's Republic of China.

The Belt and Road initiative (BRI) mainly relies on the traditional and underdeveloped logistical trade routes including the terrestrial and oceanic Silk Road. The poor logistic infrastructure across the BRI region not only restricts trade potential and economic progress but also creates several social and environmental challenges. Therefore, this study investigates the relationship between green logistic operations, economic, environmental, and social indicators of countries along with the BRI. Read More

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Combining Serum DNA Methylation Biomarkers and Protein Tumor Markers Improved Clinical Sensitivity for Early Detection of Colorectal Cancer.

Int J Genomics 2021 21;2021:6613987. Epub 2021 Apr 21.

Department of Clinical Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, Jiangsu 210014, China.

Background: Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide and in China. Early CRC screening is the best approach to reduce its incidence and mortality rates. The ColoDefense test, a multiplex qPCR assay simultaneously detecting both methylated and genes, has demonstrated improved clinical performance on either methylation biomarker alone for CRC screening with both blood and stool samples. Read More

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Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design.

Acta Pharm Sin B 2021 May 7. Epub 2021 May 7.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.

Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of ARDS, underscoring the urgency for exploiting effective therapy. However, proper medications for ARDS are still lacking due to poor pharmacokinetics, non-specific side effects, inability to surmount pulmonary barrier, and inadequate management of heterogeneity. Read More

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DNA-Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo-Controlled Osteoarthritis Gene Therapy.

Adv Sci (Weinh) 2021 05 1;8(9):2004793. Epub 2021 Mar 1.

Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. China.

Gene therapy is identified as a powerful strategy to overcome the limitations of traditional therapeutics to achieve satisfactory effects. However, various challenges related to the dosage form, delivery method, and, especially, application value, hampered the clinical transition of gene therapy. Here, aiming to regulate the cartilage inflammation and degeneration related abnormal IL-1 mRNA expression in osteoarthritis (OA), the interference oligonucleotides is integrated with the Au nanorods to fabricate the spherical nucleic acids (SNAs), to promote the stability and cell internalization efficiency. Read More

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Highly variable chloroplast genome from two endangered Papaveraceae lithophytes and .

Ecol Evol 2021 May 19;11(9):4158-4171. Epub 2021 Mar 19.

Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of China Beijing China.

The increasingly wide application of chloroplast (cp) genome super-barcode in taxonomy and the recent breakthrough in cp genetic engineering make the development of new cp gene resources urgent and significant. is recognized as the most genotypes complicated and taxonomically challenging plant taxa in Papaveraceae. However, there currently are few reports about cp genomes of the genus . Read More

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The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway.

J Cancer 2021 7;12(11):3325-3334. Epub 2021 Apr 7.

Department of Thoracic Surgery, The Third Affifiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), Kunming 650118, China.

To investigate the effects of Maytenus compound on the proliferation of hepatocellular carcinoma (HCC) cells and and to explore the underlying mechanism. The half maximal inhibitory concentration (IC50) values of Maytenus compound in HepG2 and BEL-7402 cells were determined by the MTS assay. HepG2 and BEL-7402 cells were treated with different concentrations of Maytenus compound. Read More

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Potential Mechanism of on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics.

Drug Des Devel Ther 2021 4;15:1915-1930. Epub 2021 May 4.

Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Background: , a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer's disease.

Aim Of The Study: To elucidate the mechanism by which modulates lipid metabolism and explore the medicinal effects of at a holistic level.

Materials And Methods: The potential active ingredients of and targets involved in regulating lipid metabolism were identified using a network pharmacology approach. Read More

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Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice.

Drug Des Devel Ther 2021 4;15:1903-1914. Epub 2021 May 4.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China.

Aim: Silymarin contains various flavonoids and exhibits antioxidative, anti-inflammatory, and anticancer effects, in addition to other pharmacological properties. This study explored the alleviating effect of silymarin on multiple-organ damage induced by D-galactose/lipopolysaccharide in Kunming mice.

Methods: Kunming mice were injected intraperitoneally with D-galactose (30 mg/kg·BW)/LPS (3 μg/kg·BW) and then treated using silymarin with different doses (75 mg/kg·bw and 150 mg/kg·bw) via intragastric administration. Read More

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Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology.

Drug Des Devel Ther 2021 4;15:1883-1902. Epub 2021 May 4.

Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.

Background: Rhubarb, as a traditional Chinese medicine, is the preferred drug for the treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism in vivo is still unclear.

Methods: In this study, the chemical components in rhubarb were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology. Read More

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A Modified Removable Space Maintainer for Compromised Dentition of Children: A Case Series.

Int J Clin Pediatr Dent 2020 Nov-Dec;13(6):722-724

Department of Pedodontics and Preventive Dentistry, Institute of Dental Studies and Technologies, Modinagar, Uttar Pradesh, India.

Despite the attempt in prevention, premature loss of primary teeth remains to be a frequent problem in pediatric dentistry, resulting in disturbance of arch integrity and unfavorably affecting the alignment of permanent successors. Space maintainers (SMs) are distinctive appliances used for maintaining space created due to premature loss of primary teeth. But at times the dentition of children is so compromised that it prevents the use of a conventional SM. Read More

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Colonial Virus": COVID-19, creative arts and public health communication in Ghana.

Ghana Med J 2020 Dec;54(4 Suppl):86-96

Department of Painting & Sculpture, Faculty of Art, College of Art and Built Environment, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Since March 2020, Ghana's creative arts communities have tracked the complex facets of the COVID-19 pandemic through various art forms. This paper reports a study that analysed selected 'COVID art forms' through arts and health and critical health psychology frameworks. Art forms produced between March and July 2020, and available in the public sphere - traditional media, social media and public spaces - were collated. Read More

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December 2020

Recently updated global diabetic retinopathy screening guidelines: commonalities, differences, and future possibilities.

Eye (Lond) 2021 May 11. Epub 2021 May 11.

Department of Research, Ophthalmic epidemiology & Low Vision, King Khalid Eye Hospital, Riyadh, Kingdom of Saudi Arabia.

Diabetic retinopathy (DR) is a global health burden. Screening for sight-threatening DR (STDR) is the first cost-effective step to decrease this burden. We analyzed the similarities and variations between the recent country-specific and the International Council of Ophthalmology (ICO) DR guideline to identify gaps and suggest possible solutions for future universal screening. Read More

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