11,907 results match your criteria tract organs

Chronic oral exposure to pesticides and their consequences on metabolic regulation: role of the microbiota.

Eur J Nutr 2021 Apr 10. Epub 2021 Apr 10.

PeriTox UMR_I 01 Laboratory, University Center for Health Research, CURS-UPJV, Picardy Jules Verne University, 80054, Amiens cedex 1, France.

Pesticides have long been used in agriculture and household treatments. Pesticide residues can be found in biological samples for both the agriculture workers through direct exposure but also to the general population by indirect exposure. There is also evidence of pesticide contamination in utero and trans-generational impacts. Read More

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A review of anti-tumour effects of ginsenoside in gastrointestinal cancer.

J Pharm Pharmacol 2021 Apr 9. Epub 2021 Apr 9.

School of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Objectives: Gastrointestinal cancer, one of the major causes of cancer-related deaths in the world, refers to malignant conditions of the gastrointestinal (GI) tract and other organs. Although conventional therapy has been successful to some extent in cancer treatment, drug resistance and cancer recurrence still limit the therapeutic efficacy. There is increasing evidence indicating that ginsenoside, as a kind of high nutritional value and widely used traditional Chinese medicine, could contribute to the promotion of treatment in GI cancer, which deserves further investigation. Read More

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Immune-related adverse events with immune checkpoint inhibitors: Special reference to the effects on the lungs.

Medicine (Baltimore) 2021 Apr;100(14):e25275

Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.

Abstract: Immune checkpoint inhibitors (ICIs) have emerged as evolutionary treatments for malignant diseases. Although ICIs can cause immune-related adverse events (irAEs) in various organs, precise timing after ICI initiation has been scarcely reported. Elucidating the effects of irAEs, such as time to onset, involvement of major organs, influence on progression-free survival (PFS), and overall survival (OS), are critical issues for physicians. Read More

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Adhesion Receptor Adgrg2/Gpr64 Is In The Gi-Tract Selectively Expressed In Mature Intestinal Tuft Cells.

Mol Metab 2021 Apr 5:101231. Epub 2021 Apr 5.

NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark. Electronic address:

Objective: GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known mainly to be expressed in parathyroid gland and epididymis. The aim of this investigation was to delineate the cellular expression of GPR64 throughout the body with focus on the GI tract.

Methods: Transgenic Gpr64 reporter mice were histologically examined throughout the body and reporter protein expression in intestinal tuft cells was confirmed by specific cell ablation. Read More

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Oral Codelivery of WR-1065 Using Curcumin-Linked ROS-Sensitive Nanoparticles for Synergistic Radioprotection.

ACS Biomater Sci Eng 2021 Apr 7. Epub 2021 Apr 7.

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

Protecting the body from radiation damage is a huge medical challenge. Amifostine and curcumin are both effective radioprotectants, but their use has been greatly restricted due to various reasons including low bioavailability. Nanoscale drug delivery systems of poly(ethylene glycol)-poly(ε-caprolactone) copolymers can improve the bioavailability of drugs due to excellent biocompatibility, biodegradability, and long circulation characteristics. Read More

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A comparison of CFPD, compartment, and uniform distribution models for radiation dosimetry of radionuclides in the lung.

J Radiol Prot 2021 Apr 6. Epub 2021 Apr 6.

Department of Biomedical Engineering, University of Massachusetts Lowell, Lowell, 01854, UNITED STATES.

Radioactive aerosols that arise from natural sources and nuclear accidents can be a long-term hazard to human health. Despite the heterogeneous particle deposition in the respiratory tract, uniform aerosol doses have long been assumed in respiratory radiation dosimetry predictions such as in the compartment and uniform distribution models. It is unclear how these deposition patterns affect internal radiation doses, which are critical in the health assessment of radioactive hazards. Read More

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[A total replacement of the both ureters and urinary bladder by ileal conduit in a woman with contracted bladder and Ormonds disease].

Urologiia 2021 Mar(1):107-111

Department of urology of North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

A description of the successful surgical treatment of a patient with irreversible changes in both ureters and bladder resulting from a severe form of Ormond's disease and interstitial cystitis, resulting in contracted bladder, is presented. For the first time in clinical practice, a one-stage cystectomy, a bilateral ureterectomy with complete replacement of both ureters and the bladder with two isoperistaltic small bowel segment was performed. The postoperative course was uneventful. Read More

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Polypharmacy and Drug Use Pattern among Indonesian Elderly Patients Visiting Emergency Unit.

Acta Med Indones 2021 Jan;53(1):60-76

Division of Geriatrics, Department of Internal Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: polypharmacy is a major concern for elderly patients, as it links to high morbidity related to drug interaction and adverse drug effects. Not much is known about profile of polypharmacy among elderly subjects visiting emergency department (ED) for acute conditions.

Methods: a cross sectional study conducted between July to December 2018 in ED of Cipto Mangunkusumo Hospital Jakarta Indonesia. Read More

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January 2021

Spatial architecture of biliary tree in mammals: Fractal and Euclidean geometric features.

J Anat 2021 Apr 4. Epub 2021 Apr 4.

Department of Clinical Anatomy, Faculty of Medicine, Ivane Javakhishvili Tbilisi State University (TSU, Tbilisi, GA, USA.

The study of the fractal architecture of various organs and structures expanded the possibilities for determining the ranges of their functioning and structural arrangement, which, as a result, was reflected in the development of new approaches to diagnostics and therapeutic impacts. The architecture of the excretory duct systems, similar to the hemo- and lymph- circulatory beds and the bronchial tree, is considered fractal. At the same time, information about hitherto unknown structures of the biliary tree continues to appear in the literature. Read More

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The non-syndromic clinical spectrums of mtDNA 3243A>G mutation.

Xiya Shen Ailian Du

Neurosciences (Riyadh) 2021 Apr;26(2):128-133

From the Department of Neurology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The m.3243A >G mutation in the tRNA Leu (UUR) gene (MT-TL1) of the mitochondrial DNA is the most widely seen pathogenic mtDNA mutation which has major phenotypic variations. The clinical phenotype involves various organs such as the brain and nerves, skeletal muscles, heart, endocrine system, gastrointestinal tract, and skin. Read More

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Development and operation of a digital platform for sharing pathology image data.

BMC Med Inform Decis Mak 2021 Apr 3;21(1):114. Epub 2021 Apr 3.

Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Background: Artificial intelligence (AI) research is highly dependent on the nature of the data available. With the steady increase of AI applications in the medical field, the demand for quality medical data is increasing significantly. We here describe the development of a platform for providing and sharing digital pathology data to AI researchers, and highlight challenges to overcome in operating a sustainable platform in conjunction with pathologists. Read More

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Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation.

Molecules 2021 Mar 26;26(7). Epub 2021 Mar 26.

Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Korea.

Phytoncide is known to have antimicrobial and anti-inflammatory properties. This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Read More

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The 40-Year Mystery of Insect Odorant-Binding Proteins.

Biomolecules 2021 Mar 30;11(4). Epub 2021 Mar 30.

Dijon, CNRS, INRAE, Université de Bourgogne Franche-Comté, Centre des Sciences du Goût et de l'Alimentation, 21000 Dijon, France.

The survival of insects depends on their ability to detect molecules present in their environment. Odorant-binding proteins (OBPs) form a family of proteins involved in chemoreception. While OBPs were initially found in olfactory appendages, recently these proteins were discovered in other chemosensory and non-chemosensory organs. Read More

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Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.

J Clin Med 2021 Mar 31;10(7). Epub 2021 Mar 31.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, Denmark.

The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Read More

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Role of Clinical-Demographic Data in Survival Rates of Advanced Laryngeal Cancer.

Medicina (Kaunas) 2021 Mar 15;57(3). Epub 2021 Mar 15.

Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy.

: Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is well known, yet only a few studies have been conducted on their role as risk factors of prognosis. The aim of the study was to assess the impact of clinical-demographic data on overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) in patients with advanced-stage laryngeal cancer (Stage III-IV) who underwent total laryngectomy. Read More

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Characterization of the Pelodiscus sinensis polymeric immunoglobulin receptor (P. sinensis pIgR) and its response to LPS and Aeromonas sobria.

Dev Comp Immunol 2021 Mar 30:104072. Epub 2021 Mar 30.

College of Animal Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, Zhejiang Province, China. Electronic address:

The polymeric immunoglobulin receptor (pIgR) is one of the most vital components of mucosal immunity that plays a pivotal role in mediating transcytosis of polymeric immunoglobulin (pIg) on epithelial surfaces for protection against invading pathogens. Herein, we cloned the full-length cDNA of Pelodiscus sinensis pIgR, designated as P. sinensis pIgR, made of an open reading frame (ORF) of 1848 bp, molecular weight of 68. Read More

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Endothelial Dysfunction in the Brain: Setting the Stage for Stroke and Other Cerebrovascular Complications of COVID-19.

Stroke 2021 Apr 2:STROKEAHA120032711. Epub 2021 Apr 2.

Australian Centre for Blood Diseases, Central Clinical School, Monash University and Alfred Health, Melbourne, VIC, Australia.

The Coronavirus disease 2019 (COVID)-19 pandemic has already affected millions worldwide, with a current mortality rate of 2.2%. While it is well-established that severe acute respiratory syndrome-coronavirus-2 causes upper and lower respiratory tract infections, a number of neurological sequelae have now been reported in a large proportion of cases. Read More

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Twenty-year Experience with Genitourinary Lymphoma at a Community Hospital.

Clin Med Res 2021 Mar 31. Epub 2021 Mar 31.

Department of Urology, Gundersen Health System, La Crosse, Wisconsin, USA

Non-Hodgkin lymphoma is the seventh most common cancer in the United States. It may involve any extranodal organ, although involvement of the genitourinary (GU) tract accounts for <5% of all primary extranodal lymphomas. Published GU lymphoma literature is currently limited to small case series and case reports. Read More

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Sperm DNA integrity status is associated with DNA methylation signatures of imprinted genes and non-imprinted genes.

J Assist Reprod Genet 2021 Mar 30. Epub 2021 Mar 30.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

Purpose: To evaluate the association between the DNA methylation of specific genes and sperm DNA integrity status in human sperm samples.

Methods: A total of 166 semen samples were evaluated (86 controls and 80 cases with impaired sperm DNA integrity). We detected the methylation status of 257 CpG sites among two imprinted genes (H19 and SNRPN) and four non-imprinted genes related to male infertility (MTHFR, GSTM1, DAZL, and CREM) by using a targeted next-generation sequencing method. Read More

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High prevalence of extrapulmonary tuberculosis in dairy farms: Evidence for possible gastrointestinal transmission.

PLoS One 2021 30;16(3):e0249341. Epub 2021 Mar 30.

National Animal Tuberculosis Reference Laboratory, Division of Zoonoses Surveillance, China Animal Health and Epidemiology Center, Qingdao, Shandong, China.

Bovine tuberculosis (bTB) caused by Mycobacterium bovis (M. bovis) represents one of major zoonotic diseases among cattle, it also affects the health of human, other domestic animals and wild life populations. Inhalation of infected aerosol droplets is considered as the most frequent route of the infection. Read More

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Development and Characterization of Saturated Fatty Acid-Engineered, Silica-Coated Lipid Vesicular System for Effective Oral Delivery of Alfa-Choriogonadotropin.

AAPS PharmSciTech 2021 Mar 29;22(3):118. Epub 2021 Mar 29.

Department of Pharmacology, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad, Gujarat, India.

The present study was designed to develop an efficient, safe, and patient-friendly dosage form, for oral delivery of alfa-choriogonadotropin, used in the treatment of female reproductive infertility. Silica-coated, saturated fatty acid (dipalmitoylphosphatidylcholine (DPPC))-engineered, nanolipidic vesicular (NLVs) system was developed for systemic delivery of therapeutic peptide, alfa-choriogonadotropin, through oral route. DPPC-based NLVs were formulated using the technique of thin-film hydration and were coated with silica to form a homogeneous surface silica shell. Read More

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Comparative study on lesions of reproductive disorders of cows and female dromedary camels slaughtered at Addis Ababa, Adama and Akaki abattoirs with bacterial isolation and characterization.

BMC Vet Res 2021 Mar 29;17(1):134. Epub 2021 Mar 29.

College of Veterinary Medicine, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Reproduction is a basic prerequisite to efficient livestock production. Reproductive performance depends on the normal structure and function of genital organs. A cross-sectional study was conducted from November 2016 to May 2017 to identify and compare the frequency of reproductive tract pathological lesions and to isolate bacteria associated to uterine lesions in female dromedary camels and cows slaughtered at Akaki camel slaughterhouse and Addis Ababa and Adama municipal abattoirs. Read More

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Novel rhein integrate transphytosomes as non-invasive local therapy for osteoarthritis to ameliorate cartilage deterioration in MIA-arthritic rats.

Colloids Surf B Biointerfaces 2021 Mar 19;202:111713. Epub 2021 Mar 19.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address:

Rhein (RH), a natural chondroprotective agent, suffers from poor systemic availability (20-25%) after oral administration concomitant to side effects on the gastrointestinal tract and liver. We present a new approach for non-invasive local targeted delivery of rhein to ameliorate cartilage deterioration employing cartilage-homing phospholipids nanocarriers. This is the first work to elaborate RH loaded transphytosome (RH-T-PHY) as novel nanovesicular systems for transdermal drug delivery based on an advantageous hybrid between phytosomes and transfersomes or bilosomes. Read More

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Hydronephrosis Caused by Metastatic Breast Cancer.

Case Rep Oncol 2021 Jan-Apr;14(1):378-385. Epub 2021 Mar 9.

Department of Specialized Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

Breast cancer metastasizes mainly to organs such as bone, lung, and liver, whereas metastases to the peritoneum and urinary tract are rare. Metastasis to the peritoneum or urinary tract may result in renal dysfunction, infection, and painful hydronephrosis. In our hospital, 1,409 breast cancer surgeries were performed between January 2004 and December 2015, and 7 cases of hydronephrosis associated with recurrence were observed. Read More

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The occurrence of elephant endotheliotropic herpesvirus infection in wild and captive Asian elephants in Thailand: Investigation based on viral DNA and host antibody.

Vet World 2021 Feb 27;14(2):545-550. Epub 2021 Feb 27.

Laboratory of Veterinary Biomedicine, Faculty of Veterinary Science, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand.

Background And Aim: Elephant endotheliotropic herpesvirus (EEHV) is a serious disease, threatening the life of young elephants. Many elephants have been infected with no clinical signs and may serve as carriers spreading this disease. It is important to monitor the disease through clinical signs and molecular diagnosis. Read More

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February 2021

SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2.

J Biochem 2021 Mar 27. Epub 2021 Mar 27.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that has given rise to the devastating global pandemic. In most cases, SARS-CoV-2 infection results in the development of viral pneumonia and acute respiratory distress syndrome, known as "coronavirus disease 2019" or COVID-19. Intriguingly, besides the respiratory tract, COVID-19 affects other organs and systems of the human body. Read More

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Novel bi-allelic variants in DNAH2 cause severe asthenoteratozoospermia with multiple morphological abnormalities of the flagella.

Reprod Biomed Online 2021 Jan 22. Epub 2021 Jan 22.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei 230032, China. Electronic address:

Research Question: Multiple morphological abnormalities of the flagella (MMAF) is characterized by excessive immotile spermatozoa with severe flagellar abnormalities in the ejaculate. Previous studies have reported a heterogeneous genetic profile associated with MMAF. What other genetic variants might explain the cause of MMAF?

Design: Whole-exome sequencing was conducted in a cohort of 90 Chinese patients with MMAF. Read More

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January 2021

Evaluation of hemodynamics after mitral valve replacement with the St Jude Medical Epic bioprosthesis: a Japanese single-center experience.

J Artif Organs 2021 Mar 26. Epub 2021 Mar 26.

Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

To assess the early hemodynamics after mitral valve replacement (MVR) using the St Jude Medical (SJM) Epic bioprosthesis. MVR was performed using the SJM Epic bioprosthesis in 35 patients from June 2018 to April 2020; three patients were excluded because the postoperative transthoracic echocardiography (TTE) data were unavailable. Data from postoperative TTE at 1 week and 3 months after the procedure were reviewed. Read More

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First report of urinary tract infection caused by Comamonas kerstersii in a goat.

BMC Vet Res 2021 Mar 25;17(1):133. Epub 2021 Mar 25.

Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Via G. Salvemini, 1, 06126, Perugia, Italy.

Background: Comamonas kerstersii is rarely associated with infections in humans and has never been reported in animals until now.

Case Presentation: Herein, we describe a case of urinary tract infection caused by C. kerstersii in a young goat. Read More

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Ocular and auditory abnormalities in vitiligo patients: A case- control study.

Clin Exp Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Departments of Dermatology and Venereology, Faculty of Medicine, Alexandria University, Egypt.

Background: Vitiligo is characterized by the destruction of functional melanocytes in the skin. This destruction could target melanocytes anywhere in the body, which could affect function of organs where they reside. Melanocytes in the skin, uveal tract and ear are similar in their physiology and morphology and share a common embryologic origin. Read More

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