AAPS PharmSciTech 2021 Mar 29;22(3):118. Epub 2021 Mar 29.
Department of Pharmacology, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad, Gujarat, India.
The present study was designed to develop an efficient, safe, and patient-friendly dosage form, for oral delivery of alfa-choriogonadotropin, used in the treatment of female reproductive infertility. Silica-coated, saturated fatty acid (dipalmitoylphosphatidylcholine (DPPC))-engineered, nanolipidic vesicular (NLVs) system was developed for systemic delivery of therapeutic peptide, alfa-choriogonadotropin, through oral route. DPPC-based NLVs were formulated using the technique of thin-film hydration and were coated with silica to form a homogeneous surface silica shell. Read More