J Psychiatry Neurosci 2021 Apr 12;46(2):E303-E312. Epub 2021 Apr 12.
From the EA 4712 Comportement et noyaux gris centraux, Université de Rennes 1, France (Robert, Batail, Drapier); the Psychiatry Department, Centre Hospitalier Guillaume Régnier, 108 Boulevard Général Leclerc, 35000, Rennes, France (Robert, Domain, Batail, Drapier); the Radiology Department, CHU Rennes, 2 Rue Henri le Guilloux, 35000 Rennes, France (Bannier, Ferre); the University of Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, Empenn-ERL U 1228, 35000 Rennes, France (Bannier, Corouge, Ferre, Barillot); the Institut de Neurosciences de la Timone, Campus Santé Timone, 27, Bd Jean Moulin 13005 Marseille, France (Comte); the University of Lille & CHU Lille, Inserm, U1171, Degenerative and Vascular Cognitive Disorders, 59000, Lille, France (Dondaine); and the Psychiatry Department, CHU Saint-Etienne, Team PsyR2-Centre de Recherche en Neuroscience de Lyon, (CRNL) CNRS UMR 5292-Inserm U1028, University of Lyon and Saint Etienne, France (Fakra).
Background: Major depressive disorder (MDD) is characterized by impaired cortical-subcortical functional connectivity. Apathy adds to functional impairment, but its cerebral basis in MDD remains unknown. Our objective was to describe impairments in functional connectivity during emotional processing in MDD (with varying levels of congruency and attention), and to determine their correlation with apathy. Read More