148,488 results match your criteria toxic effects

Rapid, ultrasensitive and non-enzyme electrochemiluminescence detection of hydrogen peroxide in food based on the ssDNA/g-CN nanosheets hybrid.

Food Chem 2021 Apr 8;357:129753. Epub 2021 Apr 8.

School of the Environment, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Hydrogen peroxide (HO) is usually used as a fungicide in food, it is carcinogenic, accelerates aging or inducing toxic effects such as cardiovascular disease. Herein, to meet the demand for effective and fast detection of HO in food, a novel non-enzymatic electrochemiluminescence (ECL) sensor based on single-stranded DNA (ssDNA)/g-CN nanosheets (NS) was established. The ssDNA/g-CN NS hybrid was prepared by simple mixing g-CN NS and ssDNA solution together. Read More

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Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends.

Pharmacol Res 2021 Apr 17:105618. Epub 2021 Apr 17.

Inflammation Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, J&K, India-180001; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:

The use of biologically active compounds derived from plants i.e. phytochemicals, have been known for ages for their pharmacological activities in the treatment of autoimmune disorders like rheumatoid arthritis (RA). Read More

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Release and cytotoxicity screening of the printer emissions of a CdTe Quantum Dots-based fluorescent ink.

Toxicol Lett 2021 Apr 17. Epub 2021 Apr 17.

LEITAT Technological Center, Carrer de la Innovació 2, 08225, Terrassa, Barcelona, Spain. Electronic address:

The fluorescent properties of cadmium telluride (CdTe) containing quantum dots (QDs) have led to novel products and applications in the ink and pigment industry. The toxic effects of the emissions associated to the use of printing ink containing CdTe QDs might differ from those of conventional formulations which do not integrate nanoparticles, as CdTe QDs might be emitted. Within this work, the airborne emissions of a water-soluble fluorescent ink containing polyethylene glycol (PEG)-coated CdTe QDs of 3-5 nm diameter have been characterized and studied under controlled conditions during household inkjet printing in a scenario simulating the use phase. Read More

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Doxorubicin loaded magnetism nanoparticles based on cyclodextrin dendritic-graphene oxide inhibited MCF-7 cell proliferation.

Biomol Concepts 2021 Apr 20;12(1):8-15. Epub 2021 Apr 20.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz, University of Medical Sciences, Tabriz, Iran.

Doxorubicin (DOX) is an effective chemotherapeutic agent used for the treatment of various types of cancer. However, its poor solubility, undesirable side effects, and short half-life have remained a challenge. We used a formulation based on graphene oxide as an anticancer drug delivery system for DOX in MCF-7 breast cancer cells, to address these issues. Read More

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The Correlation Between UGT1A1 Gene Phenotypes and the Clinical Prognosis of Advanced Colorectal Cancer After FOLFIRI Therapy.

Cancer Biother Radiopharm 2021 Apr 20. Epub 2021 Apr 20.

Department of Abdominal Oncology, The Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guiyang, People's Republic of China.

This study aimed to investigate the correlations between the different phenotypes of the uridine diphosphate glucuronyl transferase (UGT) 1A1 gene and the treatment of advanced colorectal cancer with the FOLFIRI regimen. A total of 240 advanced colorectal cancer patients with stage IV colon cancer or recurrence after radical surgery between January 2014 and December 2018 were included in a retrospective study. All participants were treated with the FOLFIRI regimen until the disease progressed or an intolerable level of toxicity occurred. Read More

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c.1905 + 1G>A Promotes Fluoropyrimidine-Induced Anemia, a Prognostic Factor in Disease-Free Survival, in Colorectal Cancer.

Genet Test Mol Biomarkers 2021 Apr;25(4):276-283

Department of Medical Oncology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.

In 10-30% of colorectal cancer (CRC) patients, toxic reactions occur after fluoropyrimidine-based chemotherapy. A dihydropyridine dehydrogenase ( gene variant, c.1905 + 1G>A, leads to intolerance to fluoropyrimidines. Read More

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Characterization of DinJ-YafQ toxin-antitoxin module in Tetragenococcus halophilus: activity, interplay, and evolution.

Appl Microbiol Biotechnol 2021 Apr 20. Epub 2021 Apr 20.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, People's Republic of China.

Tetragenococcus halophilus is a moderately halophilic lactic acid bacterium widely used in high-salt food fermentation because of its coping ability under various stress conditions. Bacterial toxin-antitoxin (TA) modules are widely distributed and play important roles in stress response, but those specific for genus Tetragenococcus have never been explored. Here, a bona fide TA module named DinJ-YafQ was characterized in T. Read More

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Efficacy and Safety of Weekly Paclitaxel With or Without Oral Alisertib in Patients With Metastatic Breast Cancer: A Randomized Clinical Trial.

JAMA Netw Open 2021 Apr 1;4(4):e214103. Epub 2021 Apr 1.

US Oncology, Houston, Texas.

Importance: Elevated expression of AURKA adversely affects prognosis in estrogen receptor (ER)-positive and ERBB2 (formerly HER2)-negative and triple-negative breast cancer and is associated with resistance to taxanes.

Objective: To compare paclitaxel alone vs paclitaxel plus alisertib in patients with ER-positive and ERBB2-negative or triple-negative metastatic breast cancer (MBC).

Design, Setting, And Participants: In this randomized clinical trial conducted with the US Oncology Network, participants were randomized to intravenous (IV) paclitaxel 90 mg/m2 on days 1, 8, and 15 on a 28-day cycle or IV paclitaxel 60 mg/m2 on days 1, 8, and 15 plus oral alisertib 40 mg twice daily on days 1 to 3, 8 to 10, and 15 to 17 on a 28-day cycle. Read More

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Severe Toxic Effects on Pelagic Copepods from Maritime Exhaust Gas Scrubber Effluents.

Environ Sci Technol 2021 Apr 20. Epub 2021 Apr 20.

IVL Swedish Environmental Research Institute, Kristineberg Marine Research Station, Kristineberg 566, 451 78 Fiskebäckskil, Sweden.

To reduce sulfur emission from global shipping, exhaust gas cleaning systems are increasingly being installed on board commercial ships. These so-called scrubbers extract SO by spraying water into the exhaust gas. An effluent is created which is either released directly to the sea (open-loop system) or treated to remove harmful substances before release (closed-loop system). Read More

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Aquatic biodiversity enhances multiple nutritional benefits to humans.

Proc Natl Acad Sci U S A 2021 Apr 5;118(15). Epub 2021 Apr 5.

Department of Zoology, Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Humanity depends on biodiversity for health, well-being, and a stable environment. As biodiversity change accelerates, we are still discovering the full range of consequences for human health and well-being. Here, we test the hypothesis-derived from biodiversity-ecosystem functioning theory-that species richness and ecological functional diversity allow seafood diets to fulfill multiple nutritional requirements, a condition necessary for human health. Read More

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Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice.

J Food Biochem 2021 Apr 20:e13737. Epub 2021 Apr 20.

College of Food Science and Technology, Hunan Agricultural University, Changsha, China.

Areca nut and Fuzhuan brick tea, a type of natural plant products, have obvious effects of fat reduction and weight loss; however, there is no report on their synergistic effect. This study investigated the effects of Fuzhuan brick tea supplemented with different concentrations of areca nut (5% (LAF), 10% (MAF), and 20% (HAF)) on serum and gut microbiota in Kunming (KM) mice. The results showed that Fuzhuan brick tea supplemented with areca nuts (AFTs) could reduce weight, prevent the accumulation of fat, inhibit the increase in the levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, blood glucose, free fatty acid, insulin, and total bile acid, alleviate the decrease in high-density lipoprotein cholesterol level, and regulate the composition of gut microbiota by high-fat diet intervention. Read More

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Role of model organisms and nanocompounds in human health risk assessment.

Environ Monit Assess 2021 Apr 20;193(5):285. Epub 2021 Apr 20.

Department of Earth, Environment and Life Sciences, University of Genova, Genova, 16132, Italy.

Safeguarding the environment is one of the most serious modern challenges, as increasing amounts of chemical compounds are produced and released into the environment, causing a serious threat to the future health of the Earth as well as organisms and humans on a global scale. Ecotoxicology is an integrative science involving different physical, chemical, biological, and social aspects concerned with the study of toxic effects caused by natural or synthetic pollutants on any constituents of ecosystems, including animals (including humans), plants, or microorganisms, in an integral context. In recent decades, this science has undergone considerable development by addressing environmental risk assessments through the biomonitoring of indicator species using biomarkers, model organisms, and nanocompounds in toxicological assays. Read More

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Toxicity of biogenic zinc oxide nanoparticles to soil organic matter cycling and their interaction with rice-straw derived biochar.

Sci Rep 2021 Apr 19;11(1):8429. Epub 2021 Apr 19.

Department of Environmental Sciences and Engineering, Government College University Faisalabad, Allama Iqbal Road, Faisalabad, 38000, Pakistan.

Given the rapidly increasing use of metal oxide nanoparticles in agriculture as well as their inadvertent addition through sewage sludge application to soils, it is imperative to assess their possible toxic effects on soil functions that are vital for healthy crop production. In this regard, we designed a lab study to investigate the potential toxicity of one of the most produced nanoparticles, i.e. Read More

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Factors affecting the pharmacokinetics of pyrazinamide and its metabolites in patients co-infected with HIV - implications for individualized dosing.

Antimicrob Agents Chemother 2021 Apr 19. Epub 2021 Apr 19.

Unit for Pharmacokinetics and Drug Metabolism, Dept. Pharmacology, Sahlgrenska Academy at University of Gothenburg, Sweden.

Pyrazinamide is a first-line drug used in the treatment of tuberculosis. High exposure of pyrazinamide and its metabolites may result in hepatotoxicity whereas low exposure of pyrazinamide has been correlated to treatment failure by first-line antitubercular therapy. The aim of this study was to describe the pharmacokinetics and metabolism of pyrazinamide in patients co-infected with tuberculosis and HIV. Read More

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Marine harmful algal blooms (HABs) in the United States: History, current status and future trends.

Harmful Algae 2021 Feb 3;102:101975. Epub 2021 Mar 3.

Environmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, NOAA, Seattle, WA, 98112, United States.

Harmful algal blooms (HABs) are diverse phenomena involving multiple. species and classes of algae that occupy a broad range of habitats from lakes to oceans and produce a multiplicity of toxins or bioactive compounds that impact many different resources. Here, a review of the status of this complex array of marine HAB problems in the U. Read More

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February 2021

Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells.

J Nanosci Nanotechnol 2021 Oct;21(10):5083-5098

Retired from EPA, Durham NC 27709, USA.

With the advancement of nanotechnology, nanoparticles are widely used in many different industrial processes and consumer products. Copper nanoparticles (Cu NPs) are among the most toxic nanomaterials. We investigated Cu NPs toxicity in Human Hepatocellular carcinoma (HepG2) cells by examining signaling pathways, and microRNA/mRNA interactions. Read More

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October 2021

Stable isotope analysis reveals differential effects of soil nitrogen and nitrogen dioxide on the water use efficiency in hybrid poplar leaves.

New Phytol 2001 Feb;149(2):233-246

Swiss Federal Institute for Forest, Snow and Landscape Research, WSL, CH-8903 Birmensdorf, Switzerland.

•  The effects of nitrogen dioxide (NO ) exposure are reported on the physiology, morphology and carbon partitioning of hybrid poplar clone cuttings (Populus ×euramericana) grown under high and low soil nitrogen supply. •  Plants were exposed to filtered air or NO -enriched air (80-135 nl l ) over 12 wk growth in phytotrons. Stable isotope analysis, combined with CO and H O gas exchange measurements, biomass analysis and morphological development, was used to assess the integrated long-term effects of NO . Read More

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February 2001

The deposition of atmospheric ammonia and its effects on plants.

New Phytol 1993 Oct;125(2):283-305

Department of Botany, University of Queensland, Brisbane, Qld 4072, Australia.

Across Europe, total nitrogen deposition is increasing and, of this total, atmospheric ammonia can contribute up to 50-80%. Average deposition of ammonia in the UK is likely to be around 15-20 kg ha yr , while in The Netherlands, which has some of the highest rates of deposition, this value is likely to be between 40 and 50 kg ha yr . It is argued that because of the processes of assimilation and nitrification this ammonia is an acidifying pollutant. Read More

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October 1993

Causal mechanisms by which sulphate, nitrate and acidity influence frost hardiness in red spruce: review and hypothesis.

Lucy J Sheppard

New Phytol 1994 May;127(1):69-82

Institute of Terrestrial Ecology, Bush Estate, Penicuik, Midlothian EH26 OQB.

This paper summarizes results from four experiments in which red spruce seedlings (Picea rubens Sarg.) were exposed to simulated acid mist containing SO , NH , NO and H ions. Seedlings were grown in compost, with or without fertilizer, in charcoal filtered air in open-top chambers near Edinburgh, Scotland. Read More

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Secondary metabolites in plant defence mechanisms.

New Phytol 1994 Aug;127(4):617-633

Biochemistry & Physiology Department, AFRC Institute of Arable Crops Research, Rothamsted Experimental Station, Harpenden, Herts AL5 2JQ, UK.

Many secondary metabolites found in plants have a role in defence against herbivores, pests and pathogens. In this review, a few examples are described and discussed, and some of the problems in determining the precise role(s) of such metabolites highlighted. The role of secondary metabolites in defence may involve deterrence/anti-feedant activity, toxicity or acting as precursors to physical defence systems. Read More

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Effect of some triazole fungicides on intracellular pH and on cell membrane permeability in leaves of Elodea densa (Planch.) Casp.

G Romani N Beffagna

New Phytol 1991 Mar;117(3):431-437

Università degli Studi di Milano, Dipartimento di Biologia - Centro di studio del C.N.R. sulla biologia cellulare e molecolare delle piante, via G. Celoria 26, 20133 Milano, Italy.

Recent data obtained in this laboratory have shown that a number of triazole fungicides induce in leaves of barley and Elodea densa an early release of solutes and an inhibition of H extrusion. This paper deals with the early effects of two triazoles, penconazole and flusilazol, on intracellular pH and plasmamembrane permeability in Elodea densa leaves. Different effects were found at low (0. Read More

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Calcium amelioration of aluminium toxicity effects on root hair development in soybean [Glycine max (L.) Merr.].

New Phytol 1993 Mar;123(3):531-538

Department of Agriculture, the University of Queensland, Brisbane, Queensland, Australia 4072.

Low activities of the monomeric aluminium (Al) species, Al , Al(OH) and Al(OH) in solution reduce root growth and root hair development in soybean [Glycine max (L.) Merr.]. Read More

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The effects of nickel, calcium and magnesium on the acid phosphatase activity of two Alyssum species.

New Phytol 1989 Apr;111(4):631-616

Plant Physiology Laboratory, Department of Plant Biology, University of Florence, Via Micheli 1, 50121 Florence, Italy.

Root Surface acid phosphatase activity was assessed in seedlings of two species of Alyssum, one endemic to Tuscan serpentines (Alyssum bertolonii Desv.) and the other of wide occurrence (Alyssum saxatile L.), cultivated in solutions to which various concentrations of Ni , Ca and Mg were added. Read More

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Effects of dry-deposited sulphur dioxide on fungal decomposition of angiosperm tree leaf litter I. Changes in communities of fungal saprotrophs.

New Phytol 1992 Sep;122(1):97-110

Institute of Terrestrial Ecology, Merlewood Research Station, Grange-over-Sands, Cumbria, LA11 6JU, UK.

Comparisons of the saprotrophic fungi isolated from ash (Fraxinus excelsior L.), birch (Betula spp.), hazel (Corylus avellana L. Read More

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September 1992

The cell cycle in plant development.

Dennis Francis

New Phytol 1992 Sep;122(1):1-20

School of Pure and Applied Biology, University of Wales College of Cardiff, P.O. Box 915, Cardiff CF1 3TL, UK.

The aim of this review is to discuss the molecular controls of the cell cycle in relation to higher plant development. An analysis is made of the current models of the cell cycle based on the biochemistry and genetics of the budding yeast, Saccharomyces cerevisiae and the fission yeast, Schizosaccharomyces pombe. What emerges are universal mechanisms observed in a wide range of taxonomic groups involving a group of protein kinases which regulate the transition from both post-synthetic interphase (G2) to mitosis and from pre-synthetic interphase (G1) to DNA synthetic-(S) phase. Read More

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September 1992

Excessive ammonia inhalation causes liver damage and dysfunction by altering gene networks associated with oxidative stress and immune function.

Ecotoxicol Environ Saf 2021 Apr 16;217:112203. Epub 2021 Apr 16.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, People's Republic of China; Key Laboratory of Swine Facilities Engineering, Ministry of Agriculture and Rural Affairs, Harbin, People's Republic of China. Electronic address:

Ammonia (NH) is a major gaseous pollutant in livestock production and has adverse effects on production, health and welfare of animals. The liver is one of the target organs of NH, and excessive NH inhalation can induce liver damage. However, the toxicity assessment of NH on pig liver and its mechanism have not been reported yet. Read More

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In vitro toxic synergistic effects of exogenous pollutants-trimethylamine and its metabolites on human respiratory tract cells.

Sci Total Environ 2021 Apr 6;783:146915. Epub 2021 Apr 6.

Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development (Department of Education, China), School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.

The wide presence of volatile organic amines in atmosphere has been clarified to relate to adverse effects on human respiratory health. However, toxic effects of them on human respiratory tract and their metabiotic mechanism of in vivo transformation have not been elucidated yet. Herein, cell viability and production of reactive oxygen species (ROSs) were first investigated during acute exposure of trimethylamine (TMA) to bronchial epithelial cells (16HBE), along with identification of toxic metabolites and metabolic mechanisms of TMA from headspace atmosphere and cell culture. Read More

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Regional target loads of atmospheric nitrogen and sulfur deposition for the protection of stream and watershed soil resources of the Adirondack Mountains, USA.

Environ Pollut 2021 Apr 10;281:117110. Epub 2021 Apr 10.

U.S. Geological Survey New York Water Science Center, 425 Jordan Road, Troy, NY, 12180, USA.

Acidic deposition contributes to a range of environmental impacts across forested landscapes, including acidification of soil and drainage water, toxic aluminum mobilization, depletion of available soil nutrient cations, and impacts to forest and aquatic species health and biodiversity. In response to decreasing levels of acidic deposition, soils and drainage waters in some regions of North America have become gradually less acidic. Thresholds of atmospheric deposition at which adverse ecological effects are manifested are called critical loads (CLs) and/or target loads (TLs). Read More

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Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases.

Pharmacol Res 2021 Apr 16:105615. Epub 2021 Apr 16.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR 999078, China. Electronic address:

Naturally occurring coumestans are known as a collection of plant-derived polycyclic aromatic secondary metabolites which are characterized by the presence of an oxygen heterocyclic four-ring system comprising a coumarin moiety and a benzofuran moiety sharing a C=C bond. Recently, there is an increasing attention in excavating the medicinal potential of coumestans, particularly coumestrol, wedelolactone, psoralidin and glycyrol, in a variety of diseases. This review is a comprehensive inventory of the chemical structures of coumestans isolated from various plant sources during the period of 1956-2020, together with their reported biological activities. Read More

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Cytotoxic and antimicrobial potential of benzimidazole derivatives.

Arch Pharm (Weinheim) 2021 Apr 19:e2100076. Epub 2021 Apr 19.

Department of Biology, Faculty of Arts and Sciences, İnönü University, Malatya, Turkey.

New benzimidazole derivatives were synthesized and their structures were characterized by spectroscopic and microanalysis techniques. The cytotoxic properties of ten benzimidazole derivatives, five of which were synthesized in our previous studies, were determined against the lung cancer cell line, A549, and the healthy lung epithelial cell line, BEAS-2B. Among the ten compounds tested, based on the 72-h incubation results, compound 12 was the most cytotoxic against the A549 cell line, whereas against the BEAS-2B cell line, it was as cytotoxic as cisplatin. Read More

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