16,305 results match your criteria totally studies

Association between Serum Vitamin D Concentration Status and Matrix Metalloproteinase-9 in Patients Undergoing Elective Percutaneous Coronary Intervention.

Iran J Pharm Res 2020 ;19(4):135-142

Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Cardiovascular diseases (CVD) have become increasingly life-threatening during recent decades. Several studies have shown that matrix metalloproteinase-9 (MMP-9) plays an important role in the process of atherosclerosis and heart remodeling. On the other hand, Vitamin D deficiency has been recognized as a risk factor for CVD. Read More

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January 2020

Genome-wide association and transcriptome analysis of root color-related genes in Gossypium arboreum L.

Planta 2021 Apr 11;253(5):95. Epub 2021 Apr 11.

School of Agriculture Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China.

Main Conclusion: The significant number loci and candidate genes of root color in Gossypium arboreum are identified and provide a theoretical basis of root color for cotton. A stimulating phenomenon was observed on the 4th day of sowing in the root color of some G. arboreum accessions that turned red. Read More

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Left-side vs. right-side hepatectomy for hilar cholangiocarcinoma: a meta-analysis.

World J Surg Oncol 2021 Apr 10;19(1):107. Epub 2021 Apr 10.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang Province, China.

Goals: We aim to draw a conclusion which type of hepatectomy could be the priority for hilar cholangiocarcinoma patients.

Background: Surgery is established as only potentially curative treatment for hilar cholangiocarcinoma. However, whether hepatectomy should be preferred to the left-side hepatectomy, which includes left hemihepatectomy, extended left hemihepatectomy, and left trisectionectomy, or right-side hepatectomy, which represents right hemihepatectomy, extended right hemihepatectomy, and right trisectionectomy, is debated. Read More

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The impact of prenatal stressful life events on adverse birth outcomes: A systematic review and meta-analysis.

J Affect Disord 2021 Mar 31;287:406-416. Epub 2021 Mar 31.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Centre for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Background: Stressful life events as important stressors have gradually been recognized as the potential etiology that may lead to adverse birth outcomes such as preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). However, researches on this topic have shown relatively inconsistent results. This systematic review and meta-analysis was performed to synthesize available data on the association between prenatal stressful life events and increased risks of PTB, LBW, and SGA. Read More

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Three-dimensional heterogeneity analysis of climate aid's carbon reduction effect.

J Environ Manage 2021 Apr 7;289:112524. Epub 2021 Apr 7.

School of Economics, Wuhan University of Technology, Wuhan, Hubei, 430070, PR China.

Exploring the effectiveness of climate aid is crucial to distribute funds scientifically and maximize its impact. A body of related literature has estimated the impact of international climate aid on carbon emissions. However, these studies did not adequately consider the multi-dimensional heterogeneity of climate aid's carbon reduction effect. Read More

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Is sonic hedgehog expression in saliva related to taste sensitivity in adults?

Physiol Behav 2021 Apr 3;236:113412. Epub 2021 Apr 3.

Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey. Electronic address:

Recent studies have demonstrated the critical role of the sonic hedgehog in the sensory perception of taste. Salivary sonic hedgehog stimulates taste bud stem cells, also acts as a taste bud growth factor, and contributes to the receptors' development and longevity in the taste buds. This study's objective was to investigate the possible relationship between taste sensitivity and sonic hedgehog expression in saliva in normal-weight and pre-obese/obese participants (totally 46 male (47. Read More

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Native and foreign healthcare workers' knowledge of appropriate use of antibiotics: a prospective pre-post study in Danish nursing homes.

Prim Health Care Res Dev 2021 Apr 5;22:e12. Epub 2021 Apr 5.

Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark and consultant at Task Force Reducing Hospital Infections, Capital Region of Denmark, Copenhagen, Denmark.

Aim: The aim was to determine the association between healthcare workers' (HCWs) country of birth and their knowledge of appropriate use of antibiotics, and whether the association changed after an educational intervention.

Background: Older residents in nursing homes have been recognized to receive excessively antibiotic treatments. HCWs often represent an important link between the older resident and the general practitioner prescribing the antibiotics, thus their knowledge of appropriate use of antibiotics is important. Read More

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Venous thromboembolism in COVID-19: A systematic review and meta-analysis.

Vasc Med 2021 Apr 4:1358863X21995566. Epub 2021 Apr 4.

Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.

Severe coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism events (VTE). This study performed a systematic review in PubMed/EMBASE of studies reporting the prevalence of VTE in patients with COVID-19 who were totally screened/assessed for deep vein thrombosis (DVT) and/or for pulmonary embolism (PE). Among 47 candidate studies ( = 6459; 33 in Europe), 17 studies ( = 3973; weighted age 63. Read More

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Adverse effects of conjugated linoleic acids supplementation on circulating lipoprotein (a) levels in overweight and obese individuals: results of a systematic review and meta-analysis of randomized controlled trials.

Am J Cardiovasc Dis 2021 15;11(1):124-135. Epub 2021 Feb 15.

Nutrition Research Center, Shiraz University of Medical Sciences Shiraz, Iran.

Conjugated Linoleic Acids (CLA) may have beneficial effects on the prevention of atherosclerosis, but their net effects on circulating levels of lipoprotein (a) [Lp (a)] are unclear. The present study aimed to systematically review and analyze the Randomized Clinical Trials (RCTs) assessing the effects of CLA on circulating Lp (a) concentrations. A literature search of SCOPUS, PubMed-Medline, ISI, Web of Science, and Cochrane library databases was conducted for the relevant RCTs investigating the effects of CLA supplementation on circulating Lp (a) levels, which had been published up to 20 August 2020. Read More

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February 2021

Application of Mixture Cure with the Doubly Censoring Model in Estimation of Initiation Age and Prevalence of Water-Pipe Smoking in Iran: a New Approach in Population-Based Studies.

Tanaffos 2020 Jul;19(3):243-249

Department of Epidemiology and Biostatistics, School of Public health, Tehran University of Medical Sciences, Tehran, Iran.

Background: The initiation age and prevalence of smoking water-pipe are two important parameters for establishing preventive policies. Thus, the present study was conducted to introduce a new approach for estimating and evaluating the effect of demographic variables on the initiation age and prevalence of smoking water-pipe.

Materials And Methods: The STEPwise approach for non-communicable disease risk factors surveillance (STEPS) 2011 data were used and daily smokers and non-smokers with the age range of 16 to 70 years were included in the study. Read More

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Anatomical factors associated with progression of hallux valgus.

Foot Ankle Surg 2021 Mar 26. Epub 2021 Mar 26.

Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan.

Background: The purpose of this study was to clarify the incidence rate and the risk factors for the progression of the hallux valgus deformity.

Methods: Patients who had weight-bearing radiographs of the foot taken twice or more, with a ≥2-year interval, were retrospectively analyzed. Progression of the deformity was defined as an increase in the hallux valgus angle of ≥5° during the follow-up. Read More

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Post-authorization pharmacovigilance for hemophilia in Europe and the USA: Independence and transparency are keys.

Blood Rev 2021 Mar 20:100828. Epub 2021 Mar 20.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan, Italy.

The regulatory process is currently designed to ensure drug safety during the pre-marketing process. Due to limitations of the pivotal studies owing to their short duration and small number of highly selected cases, some adverse drug reactions (ADRs) are not detected, particularly the rarest and those which appear a long time after exposure. Thus it is essential to foster pharmacovigilance run totally independently from marketing authorization holders in order to attain transparent surveillance. Read More

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Abbreviated MRI Protocol for the Assessment of Ablated Area in HCC Patients.

Int J Environ Res Public Health 2021 Mar 30;18(7). Epub 2021 Mar 30.

Hepatobiliary Surgical Oncology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.

Background: Liver Imaging Reporting and Data Systems (LI-RADS) Treatment Response Algorithm (TRA) was created to provide a standardized assessment of hepatocellular carcinoma (HCC) following loco regional therapy. The aim of this study was to compare sensitivity of standard MRI protocol versus abbreviated protocol (only T1-Weigthed fat suppressed (FS) sequences pre- and post-contrast phase) in the detection of ablated area according to LI-RADS Treatment Response (LR-TR) categories.

Methods: From January 2015 to June 2020, we selected 64 patients with HCC, who underwent Radiofrequency ablation (RFA) or Microwave ablation (MWA) treatment. Read More

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Pharmaceuticals Market, Consumption Trends and Disease Incidence Are Not Driving the Pharmaceutical Research on Water and Wastewater.

Int J Environ Res Public Health 2021 Mar 4;18(5). Epub 2021 Mar 4.

Tecnologico de Monterrey, School of Engineering and Science, Av. Eugenio Garza Sada Sur No. 2501, Col. Tecnológico, Monterrey 64849, Mexico.

Pharmaceuticals enhance our quality of life; consequently, their consumption is growing as a result of the need to treat ageing-related and chronic diseases and changes in the clinical practice. The market revenues also show an historic growth worldwide motivated by the increase on the drug demand. However, this positivism on the market is fogged because the discharge of pharmaceuticals and their metabolites into the environment, including water, also increases due to their inappropriate management, treatment and disposal; now, worldwide, this fact is recognized as an environmental concern and human health risk. Read More

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Black Soldier Fly () Larvae and Prepupae Defatted Meals in Diets for Zebrafish ().

Animals (Basel) 2021 Mar 6;11(3). Epub 2021 Mar 6.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres n. 31, 98166 Messina, Italy.

The black soldier fly (BSF) is receiving increasing attention as a sustainable fishmeal alternative protein source for aquaculture. To date, no studies have explored the effects of fishmeal replacement with BSF V instar larvae or prepupae meals due to their peculiar nutritional properties on fish performances. This study investigated the effects of 100% replacement of fishmeal (control diet) with defatted BSF meals (V instar larvae and prepupae meals, treatments) on growth performance and welfare of zebrafish (), from larvae to adults, in a 60-day feeding trial. Read More

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Patients' Perspectives about Lifestyle Behaviors and Health in the Context of Family Medicine: A Cross-Sectional Study in Portugal.

Int J Environ Res Public Health 2021 Mar 14;18(6). Epub 2021 Mar 14.

Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal.

Lifestyle interventions are recognized as essential in the prevention and treatment of non-communicable diseases. Previous studies have shown that Portuguese patients tend to give more importance to diagnostic and laboratory tests than to lifestyle measures, and seem unaware that behavioral risks are the main modifiable risk factors. The study aimed to analyze patients' perspectives about lifestyle behaviors and health in the context of family medicine in Portugal. Read More

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The complete chloroplast genome of (Chenopodiaceae), a desert halophyte shrub in China.

Mitochondrial DNA B Resour 2021 Mar 24;6(3):1152-1153. Epub 2021 Mar 24.

College of Agriculture and Animal Husbandry, Qinghai University, Xining, PR China.

, one of the dominant plant species of desert vegetation, adapts well to the arid, saline, and alkaline environment in the Qinghai-Tibetan Plateau. Here, we reported the complete chloroplast sequence and characters of based on the Illumina NovaSeq Platform. The chloroplast genome is 151,622 bp in length, containing a pair of inverted repeated (IR) regions of 23,701 bp, a large single copy (LSC) region of 84,658 bp, and a small single copy (SSC) region of 19,562 bp. Read More

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An Analysis of the Psychosocial Challenges Faced by the University Students During COVID-19 Pandemic, and the Students' Knowledge, Attitudes, and Practices Toward the Disease.

Noro Psikiyatr Ars 2021 Mar 15;58(1):3-10. Epub 2021 Feb 15.

Marmara University School of Medicine, Department of Psychiatry, Istanbul, Turkey.

Introduction: The aims of the present study were 1) to identify the major psychosocial challenges faced by students of a university in Istanbul, during the initial period of the COVID-19 outbreak, 2) to assess how these interacted with their level of knowledge, attitudes, and practices toward COVID-19 and the related health measures in place.

Methods: As part of an international research, a total of 2583 university students from Istanbul participated in an online survey, which included questions in several domains including their studies and daily life before and after the outbreak, their concerns and worries about the pandemic, their level of knowledge on COVID-19, their views on the policies implemented by the government and their institution, their attitude and practices toward the protective measures.

Results: Majority of the students reported to suffer from financial adversities due to the outbreak. Read More

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Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis.

Endocr Relat Cancer 2021 Mar 1. Epub 2021 Mar 1.

K Toulis, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Differentiated thyroid cancer (DTC) represents the most common form of thyroid neoplasms and is becoming increasingly prevalent. Evidence suggests a possible relationship between DTC diagnosis and subsequent atrial fibrillation (AF). If confirmed, this may present an alarming health risk (AF) in an otherwise condition with a relatively good prognosis (DTC). Read More

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Risk Factors for Totally Implantable Central Venous Access Port-related Infection in Patients With Malignancy.

Anticancer Res 2021 Mar;41(3):1547-1553

Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: We sought to identify the risk factors of totally implantable central venous access port (TICVAP)-related infections in patients with malignant disease.

Patients And Methods: Overall, 324 consecutive patients who received a TICVAP at our institution were retrospectively analysed. We further analysed cases of TICVAP-related complications. Read More

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Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.

Adv Exp Med Biol 2021 ;1303:319-331

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.

Asthma is a chronic disease characterized by airway hyperresponsiveness, which can be caused by exposure to an allergen, spasmogen, or be induced by exercise. Despite its prevalence, the exact mechanisms by which the airway becomes hyperresponsive in asthma are not fully understood. There is evidence that myosin light-chain kinase is overexpressed, with a concomitant downregulation of myosin light-chain phosphatase in the airway smooth muscle, leading to sustained contraction. Read More

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Short- and long-term outcomes of 486 consecutive laparoscopic splenectomy in a single institution.

Medicine (Baltimore) 2021 Apr;100(13):e25308

Department of General Surgery.

Abstract: Since its introduction in 1991, laparoscopic splenectomy (LS) has become the gold standard in elective spleen surgery in many centres. However, there still lack the report of long-term outcomes of LS with the large-scale cases. The aim of the present study was to analyze the short- and long-term outcomes of LS in a single institution over 16 years, and to compare the perioperative outcomes of totally laparoscopic splenectomy (TLS) and hand-assisted laparoscopic splenectomy (HALS) for splenomegaly. Read More

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Protopanaxadiol alleviates neuropathic pain by spinal microglial dynorphin A expression following glucocorticoid receptor activation.

Br J Pharmacol 2021 Mar 30. Epub 2021 Mar 30.

King's Lab, Shanghai Jiao Tong University School of Pharmacy, 800 Dongchuan Road, Shanghai, 200240, China.

Background And Purpose: New remedies are required for the treatment of neuropathic pain due to insufficient efficacy of available therapies. This study provides a novel approach to develop painkillers for chronic pain treatment.

Experimental Approach: The rat formalin pain test and spinal nerve ligation model of neuropathic pain were used to evaluate antinociception of Protopanaxadiol (PPD). Read More

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Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.

Neurobiol Aging 2021 Mar 1. Epub 2021 Mar 1.

Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

The solute carrier (SLC) transporters have been suggested to play important roles in neurodegenerative disorders. Recently, seven SLC transporters were identified to be associated with Parkinson's disease (PD) by genome-wide association studies. However, few replications were conducted, and whether rare variants in these genes were associated with PD was not explored yet. Read More

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Ethnomedicinal Plants of Hasankeyf (Batman-Turkey).

Front Pharmacol 2020 11;11:624710. Epub 2021 Mar 11.

Faculty of Pharmacy, Department of Pharmaceutical Botany, Istanbul University, Istanbul, Turkey.

Hasankeyf is an ancient city, dating back to more than 10,000 years, in the Southeast Anatolia Region of Turkey. The area is separated by the Tigris River on both sides and located in the Batman province. However, as a result of a dam project, in February 2020, this ancient city and some of its surrounding villages were totally flooded. Read More

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Influence of tin (Sn) doping on CoO for enhanced photocatalytic dye degradation.

Chemosphere 2021 Mar 19;277:130325. Epub 2021 Mar 19.

Faculty of Engineering and Science, Western Norway University of Applied Sciences, Bergen, 5063, Norway.

Wastewater remediation is one of the special issues that have been discussed in recent years and one of the main pollutants was dyes which totally changes the water behavior. To eradicate the organic compounds from the wastewater and reuse it, there are numerous steps have been taken into consideration. Dye degradation via photocatalysis is one of the promising technique with good efficiency. Read More

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