11,166 results match your criteria total thyroidectomy


Transoral endoscopic thyroidectomy using a self-retaining retractor as an alternative to carbon dioxide gas insufflation: A comparative analysis of 131 cases.

Oral Oncol 2021 Jul 31;121:105463. Epub 2021 Jul 31.

Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Republic of Korea. Electronic address:

Although transoral endoscopic thyroid surgery affords several advantages, the use of carbon dioxide (CO2) gas to create and maintain the working space may cause complications such as subcutaneous emphysema and a CO2 embolism. We have used a self-retaining retractor as an alternative to CO2 gas insufflation for some time; we here report its feasibility and safety. We reviewed the medical records of 131 patients who underwent transoral endoscopic thyroid lobectomy; we compared the "CO2 group" and the "retractor" group. Read More

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Meta-analysis on continuous nerve monitoring in thyroidectomies.

Head Neck 2021 Aug 3. Epub 2021 Aug 3.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

In the last decade, the introduction of continuous intraoperative recurrent laryngeal nerve (RLN) monitoring (C-IONM) has enabled the operator to verify the functional integrity of the vagus nerve-recurrent laryngeal nerve (VN-RLN) axis in real-time. We aim to present the current evidence on C-IONM utility for thyroid surgery by conducting the first meta-analysis on this technique. A systematic review of literature was conducted by two independent reviewers via Ovid in the Medline, EMBASE, and Cochrane reviews databases. Read More

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Primary synovial sarcoma of thyroid gland: A case report and review of literature.

Int J Surg Case Rep 2021 Jul 26;85:106245. Epub 2021 Jul 26.

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Read More

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Diffuse intrathyroidal dissemination of papillary thyroid carcinoma with no stromal fibrosis at presentation: A pattern of aggressive differentiated thyroid carcinoma.

Pathol Res Pract 2021 Jun 23;224:153510. Epub 2021 Jun 23.

Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Electronic address:

Background: Multifocal Papillary thyroid carcinoma (PTC) is a very common condition. In certain cases, it is possible to find tens to hundreds of foci with a diffuse intrathyroidal spread in the whole thyroid with no stromal fibrosis. Herein, PTC with such features was nominated as diffuse disseminate variant (DDV) PTC. Read More

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Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report.

World J Surg Oncol 2021 Jul 29;19(1):225. Epub 2021 Jul 29.

Department of Endocrinology and Metabolism, Kocaeli University Faculty of Medicine, İzmit, Kocaeli, Turkey.

Background: Extramedullary leukemia, also known as myeloid sarcoma, is a rare form of acute myeloid leukemia and often accompanies bone marrow involvement. Myeloid infiltration of the thyroid gland is extremely rare. Here, a unique case in which thyroid cancer tissue was infiltrated with myeloid cells is presented. Read More

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Highly sensitive electrochemical immunosensor using a protein-polyvinylidene fluoride nanocomposite for human thyroglobulin.

Bioelectrochemistry 2021 Jul 16;142:107888. Epub 2021 Jul 16.

LABEL, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas 69067-005, Brazil. Electronic address:

The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods. This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs). The functionalized polymer matrices were characterized by UV-Vis, FTIR, XPS, SEM, dynamic light scattering, and free surface energy. Read More

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Indication for radioactive iodine in patients with papillary thyroid carcinoma without apparent disease after total thyroidectomy but with elevated antithyroglobulin antibodies.

Clin Endocrinol (Oxf) 2021 Jul 29. Epub 2021 Jul 29.

Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil.

Objective: To evaluate a criterion for the selective indication of radioactive iodine (RAI) based on the short-term behaviour of antithyroglobulin antibodies (TgAb) in patients with papillary thyroid carcinoma (PTC) who have negative thyroglobulin (Tg) and neck ultrasonography (US) without abnormalities after total thyroidectomy but elevated TgAb.

Design: This was a prospective study that evaluated 216 patients with low- or intermediate-risk PTC who had nonstimulated Tg ≤ 0.2 ng/ml and no US abnormalities but elevated TgAb 3 months after thyroidectomy. Read More

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Risk Factors for Contralateral Occult Carcinoma in Patients With Unilateral Papillary Thyroid Carcinoma: A Retrospective Study and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 12;12:675643. Epub 2021 Jul 12.

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Background: Bilateral lesions are common in papillary thyroid carcinoma (PTC). For patients with unilateral PTC, occult carcinoma that is not detected preoperatively, but pathologically after surgery, might remain in the contralateral lobe. In this situation, inadequate surgical extent could cause relapse and even lead to re-operation. Read More

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Graves' disease and recurrence in ectopic thyroid tissue after total thyroidectomy.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.

We report a case of a 46-year-old woman who presented with a midline neck mass 2 years after total thyroidectomy for Graves' disease. Despite levothyroxine treatment withdrawal, she remained biochemically with subclinical hyperthyroidism. Her thyroid stimulating hormone receptor antibodies were consistently elevated. Read More

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Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes.

JAMA Netw Open 2021 Jul 1;4(7):e2118526. Epub 2021 Jul 1.

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Importance: Hashimoto thyroiditis (HT) has been suggested to be associated with papillary thyroid cancer (PTC) development. However, its association with PTC progression remains unclear.

Objective: To examine the association between HT and PTC presentation and outcomes. Read More

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Primary Extra-Osseous Ewing Sarcoma of the Thyroid: A Case Report and Review of the Literature.

Head Neck Pathol 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.

Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a history of breast carcinoma in whom a unique hypermetabolic left thyroid nodule was identified during a follow-up PET-CT scan. Read More

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The Effect of Transoral Endoscopic Thyroidectomy Vestibular Approach on Regional Cerebral Oxygen Saturation: A Prospective Observational Study.

Surg Laparosc Endosc Percutan Tech 2021 Jul 23. Epub 2021 Jul 23.

Departments of Anesthesiology and Reanimation General Surgery, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Turkey.

Background: Decreased regional cerebral oxygen saturation (rSO2) is associated with neurological events. We aimed to investigate the effects of carbon dioxide (CO2) insufflation applied to the neck during transoral endoscopic thyroidectomy vestibular approach (TOETVA) surgery on the rSO2.

Materials And Methods: Patients scheduled for TOETVA and open thyroidectomy (OT) were enrolled between October 2019 and November 2020. Read More

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Metastatic Malignant Struma Ovarii and Graves' Disease: A Rare Occurrence.

AACE Clin Case Rep 2021 Jul-Aug;7(4):243-246. Epub 2021 Jan 6.

Tan Tock Seng Hospital, Department of Endocrinology, Novena, Singapore.

Objective: Malignant struma ovarii (SO) is a rare condition. Although there have been a few reported cases of malignant SO with coexisting Graves' disease (GD), the exact incidence of metastasis in these cases is not known. We report a rare case of metastatic malignant SO coexisting with GD. Read More

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January 2021

A Prediction Model for Contralateral Central Neck Lymph Node Metastases in Unilateral Papillary Thyroid Cancer.

Int J Endocrinol 2021 30;2021:6621067. Epub 2021 Jun 30.

Department of General Surgery, Xiangya Hospital Central South University, Changsha 410008, Hunan, China.

The health problems caused by the frequent relapse of papillary thyroid carcinoma (PTC) remain a worldwide concern since the morbidity rate of PTC ranks the highest among thyroid cancers. Residues from contralateral central lymph node metastases (con-CLNM) are the key reason for persistence or recurrence of unilateral papillary thyroid carcinoma (uni-PTC); however, the ability to assess the status of con-CLNM in uni-PTC patients is limited. To clarify the risk factors of con-CLNM, a total of 250 patients with uni-PTC who underwent total thyroidectomy and bilateral central lymph node dissection were recruited in this study. Read More

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Effect of TSH Suppression Therapy on Bone Mineral Density in Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis.

J Clin Endocrinol Metab 2021 Jul 24. Epub 2021 Jul 24.

Department of Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

Context: As subclinical hyperthyroidism increases the risk of osteoporosis and fractures, concerns are growing about the long-term skeletal safety of thyrotropin (TSH) suppression therapy after total thyroidectomy in patients with differentiated thyroid cancer (DTC).

Objective: We aimed to determine the effect of TSH suppression therapy on bone mineral density (BMD) in DTC patients.

Methods: We searched PubMed, Embase, the Cochrane library, and other sources. Read More

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Thyroid surgery outcomes at a Children's Hospital: The value of a multidisciplinary team approach.

J Pediatr Surg 2021 Jul 7. Epub 2021 Jul 7.

Division of Pediatric Surgery, Department of Surgery, Baylor College of Medicine, Texas Children's Hospital, 6701 Fannin Street, Suite 1210, Houston, TX 77030, United States. Electronic address:

Background: Our purpose is to describe the structure, function and outcomes of our multidisciplinary pediatric thyroid program and to evaluate our experience in comparison to other high-volume centers.

Methods: We reviewed all thyroid operations performed 10/2012 through 09/2019, and examined number of cases per year, patient demographics, procedures, final diagnoses and results. Primary outcomes were hypoparathyroidism and recurrent laryngeal nerve (RLN) injury at 12 months. Read More

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Can Cytologic and Sonographic Features Help Prevent Overtreatment of Bethesda V Thyroid Nodules?

J Surg Res 2021 Jul 20;268:112-118. Epub 2021 Jul 20.

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Although nearly half of thyroid nodules with Bethesda V cytology (suspicious for malignancy) may be benign or harbor low-grade neoplasms that can be sufficiently treated with lobectomy, many patients with Bethesda V cytology continue to be treated with total thyroidectomy. The objectives of this study were to establish whether cytomorphologic and ultrasonographic features can determine appropriate surgery for thyroid nodules with Bethesda V cytology and how often patients are overtreated with total instead of partial thyroidectomy.

Methods: Utilizing a 10-y prospective database starting January 1, 2004, cytomorphologic and ultrasonographic features of thyroid nodules with Bethesda V cytology were reviewed. Read More

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Primary thyroid teratoma in adults: A case report and systematic review of the literature.

Mol Clin Oncol 2021 Aug 23;15(2):169. Epub 2021 Jun 23.

Third Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Extragonadal germ cell tumors are uncommon in adults and only 2-5% of teratomas develop in extragonadal sites. Primary thyroid teratomas represent <0.1% of all primary thyroid gland neoplasms. Read More

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[Establishment of model to predict lateral neck recurrence of central lymph node metastasis in papillary thyroid carcinoma].

Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):775-780

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To explore the risk factors for lateral neck recurrence of central lymph node metastasis (CLMN) in papillary thyroid cancer (PTC), and to construct a model to predict the recurrence. The records of 245 consecutive PTC patients with CLMN underwent surgical treatment from 1996 to 2009 in our department were retrospectively reviewed. The threshold value of CLNM number is determined by ROC curve. Read More

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The sensorimotor changes of the lower lip and chin after transoral endoscopic thyroidectomy vestibular approach.

Updates Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Otolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, No. 20 Yuhuangding East Road, Yantai, 264000, China.

The transoral endoscopic thyroidectomy vestibular approach (TOETVA) can lead to abnormal sensorimotor changes in the lower lip and chin because of its incision design. This study aimed to explore the surgical outcomes of these changes after TOETVA. A total of 122 patients who underwent TOETVA were reviewed. Read More

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Nomogram for the Prediction of Biochemical Incomplete Response in Papillary Thyroid Cancer Patients.

Cancer Manag Res 2021 13;13:5641-5650. Epub 2021 Jul 13.

Division of Breast & Thyroid Surgical Oncology, Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

Purpose: To develop a nomogram for predicting biochemical incomplete response (BIR) in the dynamic risk stratification (DRS) of papillary thyroid carcinoma (PTC) patients without structural recurrence, and to investigate its validity.

Patients And Methods: Overall, 1705 (1005 and 700 in the training and validation cohorts, respectively) PTC patients treated with total thyroidectomy without structural recurrence were included. multivariate logistic regression analyses were performed to determine the significant predictors of BIR in the training cohort. Read More

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Comparison of the transoral endoscopic thyroidectomy vestibular approach and open thyroidectomy: A propensity score-matched analysis of surgical outcomes and safety in the treatment of papillary thyroid carcinoma.

Surgery 2021 Jul 17. Epub 2021 Jul 17.

Department of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, China.

Background: The transoral endoscopic thyroidectomy vestibular approach has been demonstrated to have similar surgical outcomes as open thyroidectomy for selected papillary thyroid carcinomas. This study aimed to evaluate and compare the surgical outcomes and safety of the transoral endoscopic thyroidectomy vestibular approach with those of open thyroidectomy in the treatment of papillary thyroid carcinoma with a diameter between >1 cm and ≤3.5cm. Read More

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False-Positive 123I-Uptake Mimics Metastatic Lung Disease in a Patient With Interstitial Lung Disease Secondary to Scleroderma.

Clin Nucl Med 2021 Jul 20. Epub 2021 Jul 20.

From the Lewis Katz School of Medicine at Temple University Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Temple Health System, Lewis Katz School of Medicine, Philadelphia, PA.

Abstract: A 59-year-old woman with a history of papillary thyroid cancer status post total thyroidectomy and 131I ablation therapy presented with lower back pain and leg weakness. MRI of the lumbar spine revealed homogenously enhancing lesions at L1-L2 and L3-L4. Subsequent whole-body 123I-Na scan demonstrated significant 123I retention in the mid to distal esophagus, as well as diffuse uptake in basal segments of the lungs bilaterally. Read More

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Thyroid collision tumor containing oncocytic carcinoma, classical and hobnail variants of papillary carcinoma and areas of poorly differentiated carcinoma.

Arch Endocrinol Metab 2021 Jul 16. Epub 2021 Jul 16.

Serviço de Onco-Endocrinologia, Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Collision tumors are rare and may comprise components with different behavior, treatments, and prognosis. We report an unprecedented case of aggressive thyroid collision tumor containing widely invasive oncocytic carcinoma (OC), classical and hobnail (HPTC) variants of papillary carcinoma, and poorly differentiated carcinoma (PDTC). The patient underwent total thyroidectomy, radioactive iodine therapy, and within months progressed with local recurrence, and pulmonary metastases requiring neck dissection, external radiotherapy and systemic treatment with sorafenib. Read More

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Thyroglobulin/thyrotropin ratio for predicting long-term response in differentiated thyroid carcinoma: a retrospective study.

Arch Endocrinol Metab 2021 Jul 16. Epub 2021 Jul 16.

Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp), Botucatu, SP, Brasil,

Objective: Thyrotropin-stimulated thyroglobulin (STg) after total thyroidectomy is a prognosis marker for differentiated thyroid carcinoma (DTC). As Tg level is influenced by thyrotropin (TSH), perhaps the STg/TSH ratio is also a prognosis marker for these tumours. We aimed to compare STg/TSH ratio and first STg level in differentiated thyroid carcinoma patients for their ability to predict the long-term response to initial treatment. Read More

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Total thyroidectomy can still remain the method of choice in some Bethesda III cases.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jul 20. Epub 2021 Jul 20.

Institute of Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (BTT). The aim of our study was to evaluate ultrasonographic and cytological features, mutation profile and surgery treatment in rare thyroid tumours.

Methods: An analysis of 8 BTT out of 487 patients, who underwent thyroid surgery between June 2016 and June 2020. Read More

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Thyroid surgery during the COVID-19 pandemic: results from a systematic review.

J Endocrinol Invest 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Endocrinology and Diabetology, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Lugano, Switzerland.

Purpose: During the COVID-19 pandemic, elective thyroid surgery is experiencing delays. The problem is that the COVID-19 pandemic is ongoing. The research purposes were to systematically collect the literature data on the characteristics of those thyroid operations performed and to assess the safety/risks associated with thyroid surgery during the COVID-19 pandemic. Read More

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Poorly differentiated thyroid carcinoma coexisting with Graves' disease involving T3 thyrotoxicosis due to increased D1 and D2 activities.

Thyroid 2021 Jul 18. Epub 2021 Jul 18.

Kansai Medical University, Department of Internal Medicine II, 2-3-1 Shinmachi, Hirakata, Osaka, Japan, 573-1191;

Background Poorly differentiated thyroid carcinoma is rare and typically euthyroid. We report a novel rarer case of poorly differentiated thyroid carcinoma involving T3 thyrotoxicosis. Patients' Findings A 77-year-old man visited Kuma Hospital due to a neck tumor. Read More

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Malignancy rates and initial management of Thy3 thyroid nodules in a district general hospital: The 'Reading' experience.

Endocrinol Diabetes Metab 2021 Jul 24;4(3):e00243. Epub 2021 Feb 24.

Department of ENT Royal Berkshire NHS Foundation Trust Hospital Reading Berkshire UK.

Background: Ultrasound-guided fine-needle aspiration cytology is the gold standard for investigating thyroid nodules. Stratifying the Thy3 thyroid nodule risk of malignancy is essential for clinical decision-making. According to the Royal College of Pathologists Guidance (2016), the rate of malignancy for Thy3a is 5-15% and for Thy3f 15-30%. Read More

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Sutureless Thyroidectomy With Intraoperative Neuromonitoring and Energy-Based Device Without Sternotomy for Symptomatic Substernal Goiter Harboring Thyroiditis of Gland Parenchyma.

Cureus 2021 Jul 8;13(7):e16258. Epub 2021 Jul 8.

General Surgery, Giresun University Faculty of Medicine, Giresun, TUR.

Since substernal goiter first being described by Haller in 1749, a consensus on the definition of this entity has not been ensured, yet. Despite substernal goiter or retrosternal goiter is delineated as an enlarged thyroid gland with a component extending into the mediastinum, at least 10 definitions have described being able to depict the most accurate definition for substernal goiter. Of note, no consensus still has been declared on the therapeutic management of asymptomatic substernal goiter. Read More

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