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Examining concurrent validity between COMLEX-USA Level 2-Cognitive Evaluation and COMLEX-USA Level 2-Performance Evaluation.

J Osteopath Med 2021 May 13. Epub 2021 May 13.

Midwestern University, Glendale, AZ, USA.

Context: The Comprehensive Osteopathic Medical Licensing Examination of the United States of America (COMLEX-USA) is a three level examination used as a pathway to licensure for students in osteopathic medical education programs. COMLEX-USA Level 2 includes a written assessment of Fundamental Clinical Sciences for Osteopathic Medical Practice (Level 2-Cognitive Evaluation [L2-CE]) delivered in a computer based format and separate performance evaluation (Level 2-Performance Evaluation [L2-PE]) administered through live encounters with standardized patients. L2-PE was designed to augment L2-CE. Read More

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PD-L1 and CD47 co-expression predicts survival and enlightens future dual-targeting immunotherapy in non-small cell lung cancer.

Thorac Cancer 2021 May 12. Epub 2021 May 12.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Backgroud: Recent studies have indicated that programmed cell death-ligand 1 (PD-L1) and cluster of differentiation 47 (CD47) play an essential role in tumor immune evasion and may serve as potential targets for combined immunotherapy. The aim of our study was to evaluate the PD-L1/CD47 expression status in lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD), and explore its survival impact and relevance with the immune microenvironment.

Methods: The specimens from 190 LUSC and 240 LUAD patients who underwent intent-to-treat surgeries were retrospectively collected for immunohistochemistry assays of PD-L1, CD47, cluster of differentiation 8 (CD8), and cluster of differentiation 68 (CD68). Read More

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5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression.

Pharmacopsychiatry 2021 May 12. Epub 2021 May 12.

Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Introduction: Despite the ethnic differences in ( allele relates to better antidepressant response in Korean and Japanese people, while allele with better response in Caucasians), it is unclear whether and its high expression locus are interactively associated with antidepressant treatment outcome. We investigated the individual and interaction effects of these polymorphisms on antidepressant treatment outcomes in the Korean population.

Methods: A total of 464 Korean subjects with major depressive disorder completed 6 weeks of antidepressant monotherapy. Read More

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Homeopathic Treatment in Patients with Polycystic Ovarian Syndrome: A Case Series.

Homeopathy 2021 May 12. Epub 2021 May 12.

Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Kolkata, West Bengal. Under CCRH, Ministry of AYUSH, Govt. of India, Kolkata, West Bengal, India.

Background And Objectives:  Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder in women of reproductive age. It is characterized by various clinical presentations such as ovulatory dysfunction, polycystic ovaries, and hyperandrogenism. Considering the side effects associated with conventional treatment and the patients who fail to respond to these measures, there is a demand for a complementary therapy that would alleviate symptoms of PCOS without side effects. Read More

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[Function-based tests to determine the return-to-activity state in patients with non-specific low back pain].

Sportverletz Sportschaden 2021 May 12. Epub 2021 May 12.

Hochschule Furtwangen, Germany.

Background:  Most people with back pain suffer from non-specific low back pain, for which no specific reasons can be found. Two out of three have recurrent pain episodes. To reduce the likelihood of recurrence and long-lasting pain, functional tests are increasingly used to determine the current functional status. Read More

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Reliability of the Patient and Observer Scar Assessment Scale in Evaluating Linear Scars after Thyroidectomy.

Adv Skin Wound Care 2021 Jun;34(6):1-6

In the Department of Plastic and Reconstructive Surgery, Korea University Hospital, Seoul, Republic of Korea, Jae-Ho Chung, MD, PhD, is Clinical Assistant Professor; Sang-Ho Kwon, MD, is a resident; Ki-Jae Kim, MD, MS, is a resident; Jae-Min Lee, MD, MS, is a resident; Jeong-Min Yoon, MD, MS, is Public Health Physician; Jeong-Hyun Cheon, MD, MS, is Clinical Instructor; Eul-Sik Yoon, MD, PhD, is Professor; Seung-Ha Park, MD, PhD, MBA, is Professor. The authors have disclosed no financial relationships related to this article. Submitted October 19, 2020; accepted in revised form December 4, 2020.

Objective: To compare the reliability of the Patient and Observer Scar Assessment Scale (POSAS) with the Vancouver Scar Scale (VSS) in evaluating thyroidectomy scars.

Methods: At 6 months after the operation, 112 patients who underwent thyroid surgery via collar neck incision were evaluated by two blinded plastic surgeons and two senior residents using the VSS and the observer component of the POSAS. In addition, the observer-reported VAS score and patient-reported Likert score were evaluated. Read More

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Temporary Diverting End-Colostomy in Critically Ill Children with Severe Perianal Wound Infection.

Adv Skin Wound Care 2021 Jun;34(6):322-326

At the Ankara University School of Medicine, Turkey, Emrah Gün, MD, is Fellow, Department of Pediatric Critical Care Medicine; Tanil Kendirli, MD, is Professor, Department of Pediatric Critical Care Medicine; Edin Botan, MD, is Fellow, Department of Pediatric Critical Care Medicine; Halil Özdemir, MD, is Associate Professor, Department of Pediatric Infectious Disease; Ergin Çiftçi, MD, is Professor, Department of Pediatric Infectious Disease; Kübra Konca, MD, is Fellow, Department of Pediatric Infectious Disease; Meltem Koloğlu, MD, is Professor, Department of Pediatric Surgery; Gülnur Göllü, MD, is Associate Professor, Department of Pediatric Surgery; Özlem Selvi Can, MD, is Associate Professor, Department of Pediatric Anesthesia; Ercan Tutar, MD, is Professor, Department of Pediatric Cardiology; Ahmet Rüçhan Akar, MD, is Professor, Department of Cardiovascular Surgery, Heart Center, Cebeci Hospitals; and Erdal İnce, MD, is Professor, Department of Pediatric Infectious Disease. Acknowledgments: The authors wish to thank all the pediatric ICU nursing staff for all their efforts and support for our critically ill pediatric patients. The authors have disclosed no financial relationships related to this article. Submitted June 24, 2020; accepted in revised form September 25, 2020.

Abstract: Broad and deep perianal wounds are challenging in both adult and pediatric ICUs. These wounds, if contaminated with gastrointestinal flora, can cause invasive sepsis and death, and recovery can be prolonged. Controlling the source of infection without diverting stool from the perianal region is complicated. Read More

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A Qualitative Analysis of Ostomy-Related Patient Education Videos on YouTube.

Adv Skin Wound Care 2021 Jun;34(6):314-320

At Medipol University in Istanbul, Turkey, Pelin Basim, MD, is Faculty, Department of General Surgery; and Derya Argun, MD, is Faculty, Department of Internal Medicine. The authors have disclosed no financial relationships related to this article. Submitted October 9, 2020; accepted in revised form December 7, 2020.

Objective: To analyze the content, reliability, and quality of the most viewed YouTube videos targeting patients with ostomies intending to learn about ostomy care (OC).

Methods: Using the keywords "stoma care," "colostomy care," and "ileostomy care," researchers assessed the publicly visible English-language ostomy patient education videos available on YouTube. A total of 84 videos were independently analyzed by two physicians experienced in OC. Read More

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The Quality of Life of Patients with Colorectal Cancer and a Stoma in China: A Quantitative Cross-sectional Study.

Adv Skin Wound Care 2021 Jun;34(6):302-307

In the Ostomy and Wound Care Clinic, Department of Nursing, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University, Changsha, Hunan, China, Huayun Liu, MD, and Xiaomei Zhu, MD, are Enterostomal Therapists. Juping Yu, PhD, is Research Fellow, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, United Kingdom. Pingping He, PhD, is Professor, School of Nursing, University of South China, Hengyang, Hunan. Also in the Department of Nursing, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University, Changsha, Boyong Shen, MD, is Manager, Surgical Ward; Xinhui Tang, BA, is Manager, Ostomy and Wound Care; Xianghua Xu, PhD, is Manager, Nursing Research; Di Wei, MD, is Enterostomal Therapist; Yongyi Chen, PhD, is Manager, Ostomy and Wound Care and Education; and Xuying Li, PhD, is Nurse Manager. Acknowledgments: The authors thank all of the patients who participated in this study and people who helped with data collection. This work was supported by Hunan Provincial Science and Technology Department in China (grant no. 2018SK7005) and Health and Family Planning Commission of Hunan Province in China (grant no. B2019080) and Natural Science of Hunan Provence (Grant No. 2020JJ8090). The authors have disclosed no other financial relationships related to this article. Submitted December 29, 2020; accepted in revised form March 15, 2021.

Objective: To explore quality of life (QOL) in patients with colorectal cancer and a stoma and factors associated with their QOL.

Methods: A quantitative cross-sectional study was carried out in the stoma and wound care clinic of a cancer hospital in China. Participants were recruited from clinic patients. Read More

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Novel Algorithm for the Differential Diagnosis of Hyponatraemia in Anuric Patients Undergoing Maintenance Haemodialysis.

Kidney Blood Press Res 2021 May 12:1-6. Epub 2021 May 12.

Department of Internal Medicine, Second faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia.

Introduction: Hyponatraemia is associated with increased mortality in patients undergoing maintenance haemodialysis. In anuric patients, hyponatraemia development depends on the water-sodium ratio in retained fluid within the interdialysis interval (IDI).

Objective: This study aimed to calculate the retained sodium-retained water ratio in patients on maintenance haemodialysis and make a differential diagnosis of hyponatraemia according to these data. Read More

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Non-Bullous Pemphigoid: A Single-Center Retrospective Study.

Dermatology 2021 May 12:1-7. Epub 2021 May 12.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Introduction: Bullous pemphigoid (BP) is an autoimmune disease that typically presents with blisters, but sometimes early lesions may be eczematous, maculopapular, or urticarial. The aim of the present study was to highlight possible differences between typical bullous and non-bullous pemphigoid (NBP) and compare results with the literature. Material & methods: Patients receiving a diagnosis of BP between January 2000 and December 2019 were analyzed. Read More

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Target therapies plus somatostatin analogues in NETs: a network meta-analysis.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

F de Braud, Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori Milano, Milan, Italy.

Although combination therapy is not recommended in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs), this strategy is widely used in clinical practice. This network meta-analysis of randomized trials evaluates targeted therapies and somatostatin analogues in GEP advanced NETs, either alone or in combination, comparing the efficacy of different single or combined treatment strategies in terms of progression-free survival (PFS). Interventions were grouped as analogues, everolimus, everolimus plus SSAs, sunitinib and placebo. Read More

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Anti-CD20 antibody therapy and risk of infection in patients with demyelinating diseases.

Mult Scler Relat Disord 2021 May 1;52:102988. Epub 2021 May 1.

Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Anti-CD20 antibody therapy may be associated with an increased risk of infections. We therefore investigated risk factors for infection in patients with demyelinating diseases treated with anti-CD20 antibody therapy.

Methods: In this retrospective uncontrolled study, patients ever treated with anti-CD20 antibodies at an academic clinic were identified through the Danish Multiple Sclerosis Registry (DMSR). Read More

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Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study.

Mult Scler Relat Disord 2021 Apr 11;52:102947. Epub 2021 Apr 11.

Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15. Read More

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Texture analysis based on U-Net neural network for intracranial hemorrhage identification predicts early enlargement.

Comput Methods Programs Biomed 2021 May 3;206:106140. Epub 2021 May 3.

Department of Anatomy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China. Electronic address:

Background And Objective: Early hemorrhage enlargement in hypertensive cerebral hemorrhage indicates a poor prognosis. This study aims to predict the early enlargement of cerebral hemorrhage through the intelligent texture analysis of cerebral hemorrhage after segmentation.

Methods: A total of 54 patients with hypertensive intracerebral hemorrhage were selected and divided into enlarged hematoma (enlarged group) and non-enlarged hematoma (negative group). Read More

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The development of a glucose prediction model in critically ill patients.

Comput Methods Programs Biomed 2021 Apr 10;206:106105. Epub 2021 Apr 10.

University of Groningen, University Medical Center Groningen, Department of Intensive Care, Hanzeplein 2, 9713GZ Groningen, The Netherlands.

Purpose: The aim of the current study is to develop a prediction model for glucose levels applicable for all patients admitted to the ICU with an expected ICU stay of at least 24 h. This model will be incorporated in a closed-loop glucose system to continuously and automatically control glucose values.

Methods: Data from a previous single-center randomized controlled study was used. Read More

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Nomograms to Predict Overall and Cancer-Specific Survival in Gastric Signet-Ring Cell Carcinoma.

J Surg Res 2021 May 9;266:13-26. Epub 2021 May 9.

Department of General Surgery, The Third Affiliated Hospital of Wenzhou Medical University. Electronic address:

Background: The objective of our study was to develop and validate nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) of patients with signet-ring cell carcinoma (SRCC) of the stomach.

Methods: Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 1781 patients were randomly allocated to a training set (n = 1335) and a validation set (n = 446). Read More

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Health care utilisation and costs associated with different treatment protocols for newly diagnosed childhood acute lymphoblastic leukaemia: A population-based study in Ontario, Canada.

Eur J Cancer 2021 May 9;151:126-135. Epub 2021 May 9.

Institute for Health Policy, Evaluation and Management, University of Toronto, 155 College St, Toronto, ON, M5T 3MG, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, M4N 3M5, Canada; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Cir, Toronto, ON, M5S 1A8, Canada.

Background: Although different treatment protocols for childhood acute lymphoblastic leukaemia (ALL) all achieve high cure rates, their health care utilisation and costs have not been rigorously compared.

Methods: Disease, treatment, and outcome data were chart abstracted for all children with ALL in Ontario, Canada, diagnosed 2002-2012. Linkage to population-based databases identified health care utilisation. Read More

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Internet-based cognitive assessment tool: Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder.

J Affect Disord 2021 Apr 27;289:125-134. Epub 2021 Apr 27.

Digital Health Section, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Copenhagen Center for Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients' cognition at a much larger scale to a reduced cost. Read More

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Impact of race on outcomes and healthcare utilization following spinal fusion for adolescent idiopathic scoliosis.

Clin Neurol Neurosurg 2021 May 4;206:106634. Epub 2021 May 4.

Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

Objectives: Racial disparities in spine surgery have been shown to impact surgical management and postoperative complications. However, for adolescent patients with idiopathic scoliosis (AIS) treated by posterior spinal fusion (PSF), the influence of race on postoperative outcomes remains unclear. The aim of the study was to investigate the differences in baseline patient demographics, inpatient management, and postoperative complications for adolescents with AIS undergoing elective, posterior spinal surgery (≥ 4 levels). Read More

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Haemodynamic effects of PAH-targeted therapies in pulmonary hypertension due to lung disease: A systematic review and meta-analysis.

Pulm Pharmacol Ther 2021 May 9:102036. Epub 2021 May 9.

Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece. Electronic address:

Background: Pulmonary hypertension (PH) is a negative predictor in patients with lung disease and/or hypoxia (group 3 PH). Current guidelines do not endorse the use of targeted therapies for pulmonary arterial hypertension (PAH) in patients with group 3 PH, due to lack of strong evidence. However, a variety of studies have examined the effect of PAH-targeted therapies in group 3 PH with mixed methods and conflicting results. Read More

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Glass hybrid (glass ionomer) versus composite for non-carious cervical lesions: Survival, restoration quality and costs in randomized controlled trial after 3 years.

J Dent 2021 May 9:103689. Epub 2021 May 9.

Department of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Germany.

Objective: This study compared survival, restoration quality and costs of glass hybrid (GH; EQUIA Forte Fil/EQUIA Forte Coat) and resin composite restorations (RC; OptiBond FL/Filtek Supreme XTE) of sclerotic non-carious cervical lesions.

Methods: This is a cluster-randomized trial (ClinicalTrials.gov: NCT02631161). Read More

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A meta-analysis of transcarotid versus transfemoral transcatheter aortic valve replacement.

Catheter Cardiovasc Interv 2021 May 12. Epub 2021 May 12.

Division of Cardiac Surgery, CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA.

Background: Carotid access has shown promise as an excellent delivery route for transcatheter aortic valve replacement (TAVR). We aimed to compare outcomes of transcarotid (TC) and transfemoral (TF) TAVR by conducting a search and analysis of the best evidence in the literature to shed light on its safety and effectiveness.

Methods: The PubMed/MEDLINE, Embase, and Cochrane library from inception to July 2020 were searched to identify articles reporting comparative data on TC versus TF approaches for TAVR. Read More

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Clinical profile and factors associated with COVID-19 in Yaounde, Cameroon: A prospective cohort study.

PLoS One 2021 12;16(5):e0251504. Epub 2021 May 12.

Public Health Emergency and Operations Centre (PHEOC), Ministry of Public Health, Yaounde, Cameroon.

Background: A year after the COVID-19 pandemic started, there are still few scientific reports on COVID-19 in Africa. This study explores the clinical profiles and factors associated with COVID-19 in Cameroon.

Materials And Methods: In this prospective cohort study, we followed patients admitted for suspicion of COVID-19 at Djoungolo Hospital between 01st April and 31st July 2020. Read More

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Procedural and 1-year outcomes following large vessel coronary artery perforation treated by covered stents implantation: Multicentre CRACK registry.

PLoS One 2021 12;16(5):e0249698. Epub 2021 May 12.

Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland.

Background: Data regarding the clinical outcomes of covered stents (CSs) used to seal coronary artery perforations (CAPs) in the all-comer population are scarce. The aim of the CRACK Registry was to evaluate the procedural, 30-days and 1-year outcomes after CAP treated by CS implantation.

Methods: This multicenter all-comer registry included data of consecutive patients with CAP treated by CS implantation. Read More

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Characteristics of the medical malpractice cases against orthopedists in China between 2016 and 2017.

PLoS One 2021 12;16(5):e0248052. Epub 2021 May 12.

Department of Journal Center, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Background: This study aimed to identify the most frequent reasons for orthopedic medical malpractice, gain insight into the related patient demographics and clinical characteristics, and identify the independent factors associated with it.

Methods: We collected and analyzed the demographic and injury characteristics, hospital levels and treatments, medical errors, and orthopedist's degree of responsibility for the patients who were subject to orthopedic medical malpractice at our institution. Univariate and multivariate analyses were performed to identify the factors associated with the orthopedist's degree of responsibility in the medical malpractice cases. Read More

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Single-use negative pressure wound therapy reduces costs in closed surgical incisions: UK and US economic evaluation.

J Wound Care 2021 May;30(Sup5):S23-S31

Manchester Metropolitan University, UK.

Objective: Single-use negative pressure wound therapy (sNPWT) following closed surgical incisions has a demonstrable effect in reducing surgical site complications (SSC). However, there is little health economic evidence to support its widespread use. We sought to evaluate the cost-effectiveness of sNPWT compared with standard care in reducing SSCs following closed surgical incisions. Read More

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Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial.

J Wound Care 2021 May;30(Sup5):S7-S14

Cardiff University, UK.

Objectives: Perfusion and blood oxygen levels are frequently insufficient in patients with hard-to-heal wounds due to poor circulation, vascular disruption and vasoconstriction, reducing the wound's capacity to heal. This study aimed to investigate the effect of topical oxygen on healing rates in patients with hard-to-heal diabetic foot ulcers (DFUs) (i.e. Read More

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Application of paste-type acellular dermal matrix in hard-to-heal wounds.

J Wound Care 2021 May;30(5):414-418

Department of Plastic and Reconstructive Surgery, College of Medicine, Hanyang University, Seoul, Korea.

Objective: The extracellular matrix (ECM) is one of the most important elements in wound healing. Absence or dysfunction of the ECM may impair wound healing. The application of acellular dermal matrix (ADM) as a substitute for ECM has been suggested. Read More

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Multicomponent compression system use in patients with chronic venous insufficiency: a real-life prospective study.

J Wound Care 2021 May;30(5):400-412

Department of Dermatology, Venereology and Allergology, University Hospital Essen, Essen, Germany.

Objective: Compression therapy is the cornerstone of therapeutic management of patients with chronic venous insufficiency (CVI). This study aimed to evaluate the efficacy and safety of a multicomponent compression system in an unselected population of patients with CVI problems under real-life conditions.

Method: A prospective, multicentre, observational study with a multicomponent two-bandage compression system (UrgoK2, Laboratoires Urgo, France) was conducted in 103 centres in Germany. Read More

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