Sleep Med 2020 10 21;74:73-77. Epub 2020 May 21.
Central Clinical School, University of Sydney, Sydney, NSW, Australia; Sleep and Circadian Research Group CIRUS, Woolcock Institute of Medical Research, Sydney, NSW, Australia; RPA-Charles Perkins Centre Clinic, Sydney, NSW, Australia.
Purpose: Chronic kidney disease (CKD) is common in severe obstructive sleep apnoea (OSA), however prevalence in obesity hypoventilation syndrome (OHS) is not known. This study sought to compare prevalence of CKD in OHS and equally obese OSA patients with comparable apnoea hypopnoea indexes (AHI), and secondarily examine the impact of positive airway pressure (PAP) therapy on CKD parameters.
Methods: Estimated Glomerular Filtration Rate (eGFR) and spot urine protein creatinine ratio (PCR) were obtained in patients with OHS (Partial pressure of carbon dioxide, PaCO2 > 45 mmHg) and OSA (AHI > 20 events per hour, PaCO2 < 45 mmHg) with a body mass index (BMI) > 40 kg/m. Read More