327 results match your criteria total hypopnoea

Sacubitril-valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO-SAS study.

ESC Heart Fail 2021 Jun 8. Epub 2021 Jun 8.

PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France.

Aims: Optimizing medical cardiac treatment for sleep apnoea (SA) in patients with chronic heart failure and reduced ejection fraction (HFrEF) is an expert Grade C recommendation based on six studies encompassing a total of 67 patients only. Whether sacubitril-valsartan (SV), a cornerstone of HFrEF medical treatment, impacts SA is unknown and requires evaluation.

Methods And Results: The ENTRESTO-SAS trial is a six-centre, prospective, open-label real-life cohort study (NCT02916160). Read More

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Dimensional analysis of the upper airway in obstructive sleep apnoea syndrome patients treated with mandibular advancement device: A bi- and three-dimensional evaluation.

J Oral Rehabil 2021 May 11. Epub 2021 May 11.

Department of Stomatology, Medical School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Background: The efficiency of the mandibular advancement device (MAD) in patients with obstructive sleep apnoea syndrome (OSAS) has been demonstrated. Nevertheless, the behaviour of the upper airway once MAD is placed and titrated, and its correlation with the apnoea-hypopnoea index (AHI) is still under discussion.

Objectives: To analyse the morphological changes of the upper airway through a bi- and three-dimensional study and correlate it with the polysomnographic variable, AHI. Read More

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Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1-3.

Thorax 2021 May 7. Epub 2021 May 7.

Respiratory and Sleep Medicine, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland, Australia.

Introduction: Nusinersen is used in spinal muscular atrophy (SMA) to improve peripheral muscle function; however, respiratory effects are largely unknown.

Aim: To assess the effects of nusinersen on respiratory function in paediatric SMA during first year of treatment.

Methods: A prospective observational study in paediatric patients with SMA who began receiving nusinersen in Queensland, Australia, from June 2018 to December 2019. Read More

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Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea.

J Clin Med 2021 Apr 29;10(9). Epub 2021 Apr 29.

Center for Research and Innovation in Precision Medicine of Respiratory Diseases, Department of Pulmonology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania.

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. Read More

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Galectin-3 and neutrophil-to-lymphocyte ratio are indicative of heart remodelling and disease severity in patients with obstructive sleep apnoea.

Sleep Med 2021 Jun 9;82:117-124. Epub 2021 Apr 9.

Unit of Internal Medicine "Guido Baccelli", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, BA, Italy.

Background: Galectin-3, considered as a new inflammatory marker; it is increased in cardiovascular disease. We investigated Galectin-3 in relation to heart damage in patients with OSA and its role in inflammation, based on the Neutrophil-to-Lymphocyte Ratio (NLR).

Methods: Sixty-three consecutive patients (45 males, 18 females, 58. Read More

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New forehead device in positional obstructive sleep apnoea: a randomised clinical trial.

Thorax 2021 Apr 22. Epub 2021 Apr 22.

BioAraba, Osakidetza-Basque Health Service, Vitoria-Gasteiz, Spain

Rationale: Approximately 60% of the patients with obstructive sleep apnoea suffer from a positional effect, and approximately 25% of these patients present events only in the supine position.

Objective: To validate a new positional vibrating device and evaluate its efficacy in reducing the Apnoea-Hypopnoea Index and the total sleep time in the supine position without disturbing sleep.

Methods: A total of 128 patients were recruited for this multicentre, prospective, parallel, randomised controlled trial and were distributed in three arms (general recommendations, inactive and active device). Read More

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Comparing respiratory polygraphy with pulse transit time analysis versus overnight polysomnography in the diagnosis of obstructive sleep apnoea in children.

Sleep Med 2021 May 1;81:457-462. Epub 2021 Mar 1.

FHKAM(Otolaryngology), Department of Otolaryngology, Tuen Mun Hospital, Hong Kong.

Objective: Obstructive sleep apnea syndrome in children is associated with significant morbidity. Polysomnography is the main diagnostic tool but is time consuming and requires skilled manpower to supervise the patient overnight and hence long referral to diagnosis time. However, there are limitations and underestimation of the apnoea hyponea index (AHI) with alternative home sleep apnoea testing (HSAT), such as type 3 respiratory polygraphy (RP). Read More

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Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.

Respirology 2021 Jul 1;26(7):690-699. Epub 2021 Apr 1.

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background And Objective: We evaluated inattention and behavioural outcomes following surgery versus watchful waiting (WW) in school-aged children with mild obstructive sleep apnoea (OSA).

Methods: A prospective randomized controlled study was performed in pre-pubertal children aged 6-11 years with polysomnography (PSG)-confirmed mild OSA. They were assigned randomly to early surgical intervention (ES) or WW. Read More

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Prevalence of Obstructive Sleep Apnoea and Its Association With Atherosclerotic Plaques in a Cohort of Subjects With Mild-Moderate Cardiovascular Risk.

Arch Bronconeumol (Engl Ed) 2021 Feb 13. Epub 2021 Feb 13.

Hospital Universitari Arnau de Vilanova and Santa Maria, Group of Translational Research in Respiratory Medicine, IRB Lleida, Universitat de Lleida, Av. Rovira Roure 80, 25198 Lleida, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Av. Monforte de Lemos, 3-5, Pabellón 11, 28029 Madrid, Spain. Electronic address:

Introduction: Classic cardiovascular risk factors do not explain all the cardiovascular events. Obstructive sleep apnoea (OSA) has been proposed as a potential and prevalent cardiovascular risk factor. Our study aimed to describe the prevalence of OSA in a middle-aged cohort with mild-moderate cardiovascular risk and evaluate its association with atherosclerotic disease. Read More

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February 2021

Sleep-Disordered Breathing in Patients with Motor Neurone Disease: One Size Does Not Fit all.

Neurodegener Dis 2020 18;20(4):131-138. Epub 2021 Mar 18.

Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, South Australia, Australia.

Introduction: Sleep-disordered breathing (SDB) in patients with motor neurone disease (MND) is normally attributed to hypoventilation due to muscle weakness. However, we have observed different patterns of SDB among MND patients referred for non-invasive ventilation, which do not appear to be explained by respiratory muscle weakness alone.

Aim: The aim of this study was to examine the characteristics of SDB in MND. Read More

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Evaluation of a multicomponent grading system for obstructive sleep apnoea: the Baveno classification.

ERJ Open Res 2021 Jan 1;7(1). Epub 2021 Mar 1.

Dept of Chest Diseases, Ege University School of Medicine, Izmir, Turkey.

New findings on pathophysiology, epidemiology, and outcome have raised concerns on the relevance of the apnoea-hypopnoea index (AHI) in the classification of obstructive sleep apnoea (OSA) severity. Recently, a multicomponent grading system decision integrating symptomatology and comorbidities (Baveno classification), was proposed to characterise OSA and to guide therapeutic decisions. We evaluated whether this system reflects the OSA population, whether it translates into differences in outcomes, and whether the addition of AHI improves the scheme. Read More

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January 2021

Typical within and between person variability in non-invasive ventilator derived variables among clinically stable, long-term users.

BMJ Open Respir Res 2021 03;8(1)

Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia

Background: Despite increasing capacity to remotely monitor non-invasive ventilation (NIV), how remote data varies from day to day and person to person is poorly described.

Methods: Single-centre, 2-month, prospective study of clinically stable adults on long-term NIV which aimed to document NIV-device variability. Participants were switched to a ventilator with tele-monitoring capabilities. Read More

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A novel parameter is better than the AHI to assess nocturnal hypoxaemia and excessive daytime sleepiness in obstructive sleep apnoea.

Sci Rep 2021 Feb 25;11(1):4702. Epub 2021 Feb 25.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

To evaluate whether the percentage of total sleep time spent with apnoea and hypopnoea duration time (AHT%) is better than the apnoea-hypopnoea index (AHI) for the assessment of nocturnal hypoxaemia and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnoea (OSA). Patients with suspected OSA were enrolled. Polysomnography, Epworth Sleepiness Scale, self-administered surveys and anthropometric measures were performed. Read More

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February 2021

Atherogenic Index of Plasma in Obstructive Sleep Apnoea.

J Clin Med 2021 Jan 22;10(3). Epub 2021 Jan 22.

Department of Pulmonology, University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.

Background: Dyslipidaemia is well recognised in obstructive sleep apnoea (OSA) and could contribute to the development of cardiovascular disease (CVD). Atherogenic index of plasma (AIP) predicts cardiovascular morbidity and mortality better than the individual lipid levels. The aim of this study was to investigate the AIP in patients with OSA in relation with disease severity. Read More

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January 2021

Multiple, objectively measured sleep dimensions including hypoxic burden and chronic kidney disease: findings from the Multi-Ethnic Study of Atherosclerosis.

Thorax 2021 Jul 4;76(7):704-713. Epub 2020 Dec 4.

Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Background: Poor sleep may contribute to chronic kidney disease (CKD) through several pathways, including hypoxia-induced systemic and intraglomerular pressure, inflammation, oxidative stress and endothelial dysfunction. However, few studies have investigated the association between multiple objectively measured sleep dimensions and CKD.

Methods: We investigated the cross-sectional association between sleep dimensions and CKD among 1895 Multi-Ethnic Study of Atherosclerosis Sleep Ancillary Study participants who completed in-home polysomnography, wrist actigraphy and a sleep questionnaire. Read More

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Establishment of upper respiratory tract model of patients with obstructive sleep apnoea hypopnoea syndrome before and after surgical treatment and its hydrodynamics analysis.

J Pak Med Assoc 2020 Sep;70 [Special Issue](9):64-70

Department of Otorhinolaryngology, Mianyang Central Hospital, Mianyang, China.

Objective: The study aimed to explore the method of constructing the upper respiratory tract model of patients with obstructive sleep apnoea hypopnoea syndrome (OSAHS) and its application in the detection of the changes of flow field characteristics of the upper respiratory tract before and after surgical treatment.

Methods: A 34-year-old male OSAHS patient was taken as the study subject. The improved Han-uvulopalato pharyngoplasty was adopted for treatment. Read More

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September 2020

Myofunctional therapy (oropharyngeal exercises) for obstructive sleep apnoea.

Cochrane Database Syst Rev 2020 11 3;11:CD013449. Epub 2020 Nov 3.

Bilbao, Spain.

Background: Obstructive sleep apnoea (OSA) is a syndrome characterised by episodes of apnoea (complete cessation of breathing) or hypopnoea (insufficient breathing) during sleep. Classical symptoms of the disease - such as snoring, unsatisfactory rest and daytime sleepiness - are experienced mainly by men; women report more unspecific symptoms such as low energy or fatigue, tiredness, initial insomnia and morning headaches. OSA is associated with an increased risk of occupational injuries, metabolic diseases, cardiovascular diseases, mortality, and being involved in traffic accidents. Read More

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November 2020

Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children.

ERJ Open Res 2020 Oct 5;6(4). Epub 2020 Oct 5.

Dept of Laboratory Medicine, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

Introduction: Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate-severe OSA. Read More

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October 2020

European Respiratory Society statement on sleep apnoea, sleepiness and driving risk.

Eur Respir J 2021 Feb 25;57(2). Epub 2021 Feb 25.

School of Medicine, University College Dublin, Dept of Respiratory and Sleep Medicine, St Vincent's University Hospital, Dublin, Ireland

Obstructive sleep apnoea (OSA) is highly prevalent and is a recognised risk factor for motor vehicle accidents (MVA). Effective treatment with continuous positive airway pressure has been associated with a normalisation of this increased accident risk. Thus, many jurisdictions have introduced regulations restricting the ability of OSA patients from driving until effectively treated. Read More

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February 2021

[Sleep apnoea-hypopnoea syndrome in the obese and non-obese: clinical, polysomnographical and clinical characteristics].

An Pediatr (Engl Ed) 2020 Sep 29. Epub 2020 Sep 29.

Unidad Multidisciplinar de Sueño y Ventilación Dr. J. Terán-Santos, Hospital Universitario de Burgos, Burgos, España; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, España.

Introduction: Sleep apnoea-hypopnoea syndrome (SAHS) and childhood obesity are la high prevalence conditions that represent a public health challenge.

Objective: To analyse the association between both and comparing child groups that had or did not have both conditions.

Patients And Methods: A prospective study in children (3-14 years), referred to the "Multidisciplinary Sleep Unit" due to suspected SAHS, between 1 November 2015 and 1 August 2017. Read More

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September 2020

Baclofen destabilises breathing during sleep in healthy humans: A randomised, controlled, double-blind crossover trial.

Br J Clin Pharmacol 2021 Apr 25;87(4):1814-1823. Epub 2020 Oct 25.

Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.

Aims: Periodic breathing is frequent in patients with severe heart failure. Apart from being an indicator of severity, periodic breathing has its own deleterious consequences (sleep-related oxygen desaturations, sleep fragmentation), which justifies attempts to correct it irrespective of the underlying disease. Animal models and human data suggest that baclofen can reconfigure respiratory central pattern generators. Read More

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Prevalence of chronic kidney disease in obesity hypoventilation syndrome and obstructive sleep apnoea with severe obesity.

Sleep Med 2020 10 21;74:73-77. Epub 2020 May 21.

Central Clinical School, University of Sydney, Sydney, NSW, Australia; Sleep and Circadian Research Group CIRUS, Woolcock Institute of Medical Research, Sydney, NSW, Australia; RPA-Charles Perkins Centre Clinic, Sydney, NSW, Australia.

Purpose: Chronic kidney disease (CKD) is common in severe obstructive sleep apnoea (OSA), however prevalence in obesity hypoventilation syndrome (OHS) is not known. This study sought to compare prevalence of CKD in OHS and equally obese OSA patients with comparable apnoea hypopnoea indexes (AHI), and secondarily examine the impact of positive airway pressure (PAP) therapy on CKD parameters.

Methods: Estimated Glomerular Filtration Rate (eGFR) and spot urine protein creatinine ratio (PCR) were obtained in patients with OHS (Partial pressure of carbon dioxide, PaCO2 > 45 mmHg) and OSA (AHI > 20 events per hour, PaCO2 < 45 mmHg) with a body mass index (BMI) > 40 kg/m. Read More

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October 2020

Preliminary comparison of the efficacy of several surgical treatments based on maxillomandibular advancement procedures in adult patients with obstructive sleep apnoea: a systematic review and network meta-analysis.

Eur Arch Otorhinolaryngol 2021 Feb 18;278(2):543-555. Epub 2020 Aug 18.

Department of Otolaryngology-Head and Neck Surgery, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, Anhui, China.

Purpose: To evaluate the efficacy of eight different surgical treatments based on maxillomandibular advancement (MMA), which has emerged in recent years, for adult obstructive sleep apnoea (OSA) patients.

Methods: The literature was searched from January 2010 to May 2020 for studies of adult OSA patients with different types of MMA procedures to perform a network meta-analysis. The outcomes were changes in the apnoea-hypopnoea index (AHI), the lowest pulse oxygen saturation (SpO min) and the Epworth Sleepiness Scale (ESS). Read More

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February 2021

Polysomnography in children with obstructive sleep apnoea and neurocognitive disorders.

Clin Otolaryngol 2020 Nov 16;45(6):885-888. Epub 2020 Sep 16.

Baylor College of Medicine, Houston, TX, USA.

Objective: The neurocognitive associations in paediatric obstructive sleep apnoea (OSA) are well known; however, whether polysomnographic features can predict these associations is unknown. Therefore, the primary objective of this study was to compare common polysomnographic parameters in children with OSA in the presence and absence of neurocognitive dysfunction.

Methods: Polysomnography data for children ages 3-6 years with mild-moderate OSA who as defined by AHI between 5 and 10 were analysed from a single sleep centre at a tertiary paediatric hospital from January 2016 to December 2018. Read More

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November 2020

Cohort profile: FACE, prospective follow-up of chronic heart failure patients with sleep-disordered breathing indicated for adaptive servo ventilation.

BMJ Open 2020 07 19;10(7):e038403. Epub 2020 Jul 19.

Department of Physiology and Functional Exploration - Bichat Hospital, Assistance Publique - Hopitaux de Paris, Paris, Île-de-France, France.

Purpose: FACE is a prospective cohort study designed to assess the effect of adding adaptive servoventilation (ASV) to standard care on morbidity and mortality in patients with chronic heart failure (HF) with preserved (HFpEF), mid-range (HFmrEF) or reduced ejection fraction (HFrEF) who have sleep-disordered breathing (SDB) with an indication for ASV. We describe the study design, ongoing data collection and baseline participant characteristics.

Participants: Consecutive patients with HFpEF, HFmrEF or HFrEF plus SDB with central sleep apnoea (CSA) and indication for ASV were enrolled in the study cohort between November 2009 and December 2018; the ASV group includes those treated with ASV and the control group consists of patients who refused ASV or stopped treatment early. Read More

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Heart failure and sleep-disordered breathing: susceptibility to reduced muscle strength and preclinical congestion (SICA-HF cohort).

ESC Heart Fail 2020 10 23;7(5):2063-2070. Epub 2020 Jun 23.

Department of Cardiology and Pneumology, Germany and German Centre for Cardiovascular Research (DZHK), partner site Göttingen, University of Göttingen Medical Centre, Göttingen, Germany.

Aims: Increased sympathetic activation in patients with heart failure (HF) and sleep-disordered breathing (SDB) provokes cardiac decompensation and protein degradation and could lead to muscle wasting and muscle weakness. The aim of this study was to investigate the differences in body composition, muscle function, and the susceptibility of preclinical congestion among patients with HF and SDB compared with those without SDB.

Methods And Results: We studied 111 outpatients with stable HF who were enrolled into the Studies Investigating Co-morbidities Aggravating Heart Failure. Read More

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October 2020

SAS Care 1: sleep-disordered breathing in acute stroke an transient ischaemic attack - prevalence, evolution and association with functional outcome at 3 months, a prospective observational polysomnography study.

ERJ Open Res 2020 Apr 15;6(2). Epub 2020 Jun 15.

Sleep-Wake-Epilepsy Center, Dept of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Sleep-disordered breathing (SDB) is frequent in patients with acute stroke. Little is known, however about the evolution of SDB after stroke. Most of our knowledge stems from smaller cohort studies applying limited cardiopulmonary sleep recordings or from cross-sectional data collected in different populations. Read More

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Cognitive behavioural therapy for insomnia reduces sleep apnoea severity: a randomised controlled trial.

ERJ Open Res 2020 Apr 17;6(2). Epub 2020 May 17.

The Adelaide Institute for Sleep Health: a Centre of Research Excellence, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Insomnia and obstructive sleep apnoea (OSA) frequently co-occur and may be causally related through sleep fragmentation and/or hyperarousal mechanisms. Previous studies suggest that OSA treatment can improve insomnia severity. However, the effect of insomnia treatment on OSA severity has not been investigated. Read More

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Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting.

Heart 2020 10 18;106(19):1495-1502. Epub 2020 May 18.

Department of Cardiology, National University Heart Centre, Singapore.

Objective: Patients with advanced coronary artery disease are referred for coronary artery bypass grafting (CABG) and it remains unknown if sleep apnoea is a risk marker. We evaluated the association between sleep apnoea and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing non-emergent CABG.

Methods: This was a prospective cohort study conducted between November 2013 and December 2018. Read More

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October 2020