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Knowledge and Attitude towards Cervical Cancer and Human Papillomavirus among Pharmacists in Japan.

Asian Pac J Cancer Prev 2021 Jul 1;22(7):2259-2265. Epub 2021 Jul 1.

Tsuruha Holdings Inc, Sapporo, Hokkaido, Japan.

Objective: The objective of this study was to assess the knowledge and attitude towards cervical cancer and human papillomavirus (HPV) among pharmacists in Japan.

Methods: Questionnaires were disseminated to 788 pharmacists employed by the Tsuruha Holdings Inc. A total of 617 pharmacists responded, generating a response rate of 78. Read More

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Five-year survival and prognostic factors for oropharyngeal squamous cell carcinoma: retrospective cohort of a cancer center.

Oral Maxillofac Surg 2021 Jul 23. Epub 2021 Jul 23.

Department of Dentistry, Postgraduate Program in Dental Sciences, Concentration Area in Oral Pathology and Stomatology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal-RN, CEP, 59056-000, Brazil.

Introduction: Oropharyngeal cancer is characterized by high morbidity and mortality. Prognostic factors for this cancer are therefore useful to predict overall survival and may provide additional therapeutic targets.

Objective: To evaluate the 5-year overall survival and prognostic factors for oropharyngeal squamous cell carcinoma. Read More

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Why not de-intensification for uterine cervical cancer?

Gynecol Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Objective: The majority of uterine cervical cancer is known to be related to human papillomavirus (HPV), and HPV-related tumors are known to be radio-sensitive. In the management of HPV-related oropharyngeal cancer, de-intensification of treatment has been attempted; however, no such attempt is performed in the management of cervical cancer. The aim of this study was to identify a group of patients who can safely be treated by de-escalated treatment intensity. Read More

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Lineage analysis of human papillomavirus type 39 in cervical samples of Iranian women.

Virol J 2021 Jul 22;18(1):152. Epub 2021 Jul 22.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.

Background: The data with regards to the regional variants of distinct HPV types is of great value. Accordance with this, this study aimed to investigate the sequence variations of E6 gene and long control region of HPV 39 among normal, premalignant and malignant cervical samples in order to characterize the frequent HPV 39 variants circulating in Tehran, Iran.

Methods: In total, 70 cervical samples (45 normal, 16 premalignant, and 9 malignant samples) infected with HPV 39 were analyzed by nested-PCR and sequencing. Read More

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Chemoradiotherapy with high-dose cisplatin compared with weekly cisplatin for locally advanced head and neck squamous cell carcinoma.

J Med Imaging Radiat Oncol 2021 Jul 26. Epub 2021 Jul 26.

Department of Radiation Oncology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Introduction: Concurrent chemoradiotherapy (CRT) using high-dose cisplatin (HDC) is standard for patients with locally advanced head and neck squamous cell carcinoma (HNSCC); weekly cisplatin (WC) is an alternative. We aim to compare retrospectively the survival and disease control outcomes between these regimens in our institutional experience.

Methods: Patients with stage III-IV HNSCC treated with definitive or postoperative CRT between 2012 and 2018 were identified. Read More

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Reproductive and Lifestyle Characteristics of Kenyan Women Presenting With Precancerous Cervical Lesions: A Hospital-Based Case-Control Study.

East Afr Health Res J 2019 29;3(2):115-124. Epub 2019 Nov 29.

Department of Microbiology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya.

Background: Cervical cancer is a leading cause of cancer in women, accounting for 68% of cancer-related deaths among women in developing countries. Several reproductive, lifestyle and demographic risk factors are associated with increased risk for cervical cancer. This study examined the association of risk factors with precancerous cervical lesion grade in women attending Nakuru County Referral Hospital. Read More

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November 2019

[The cervical microbiota characteristics in patients with human papillomavirus infection].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):867-874

Department of Microbiology,School of Public Health, Southern Medical University, Guangzhou 510515, China Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

To investigate the characteristics of cervical microbiota in patients with HPV (Human Papillomavirus) infection, and to analyze the associations of cervical microbiota and HPV infection or cervicitis. 300 samples underwent HPV nucleic acid testing was collected in this case-control study from June 2019 to April 2020 in the Zhujiang Hospital of Southern Medical University, there were 150 cases allocated in HPV infection group (HPV+), and 150 cases of negative nucleic acid test were non-infectious Group (HPV-). Next-generation sequencing was used to sequence the V4 region of the bacterial 16S rRNA gene, and QIIME pipeline was used to analysis the microbiota composition of the two groups. Read More

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The projected cost-effectiveness and budget impact of HPV vaccine introduction in Ghana.

Vaccine 2021 Jul 21. Epub 2021 Jul 21.

PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98109, USA.

Background: Cervical cancer is responsible for around one-quarter of all cancer deaths among Ghanaian women. Between 2013 and 2015, Ghana conducted a pilot of HPV vaccination among 10-14-year-old girls in four regions; however, the country has yet to introduce the vaccine nationally. This study projected the cost-effectiveness and budget impact of adding HPV vaccination into Ghana's national immunization program. Read More

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The Potential Impact of High-Risk Human Papillomavirus-Negative Cervical Intraepithelial Neoplasia 2+ on Primary Human Papillomavirus Screening.

Am J Clin Pathol 2021 Jul 24. Epub 2021 Jul 24.

Preventive Gynecology Unit, European Institute of Oncology IRCCS, Milan, Italy.

Objectives: To investigate the prevalence of high-risk human papillomavirus (HPV)-negative cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) and to analyze the distribution of other genotypes in this subset.

Methods: In total, 431 women who underwent excisional surgical treatment for CIN or ICC at the European Institute of Oncology, Milan, Italy, from January 2016 to December 2017 were retrospectively analyzed. The Linear Array HPV genotyping test (Roche Diagnostics) was performed on a postaliquot from high-risk-HPV-negative liquid-based cervical specimens, when available. Read More

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The characteristics and risk factors of human papillomavirus infection: an outpatient population-based study in Changsha, Hunan.

Sci Rep 2021 Jul 23;11(1):15128. Epub 2021 Jul 23.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.

This cross-sectional study investigated the characteristics of cervical HPV infection in Changsha area and explored the influence of Candida vaginitis on this infection. From 11 August 2017 to 11 September 2018, 12,628 outpatient participants ranged from 19 to 84 years old were enrolled and analyzed. HPV DNA was amplified and tested by HPV GenoArray Test Kit. Read More

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Expression of Retroelements in Cervical Cancer and Their Interplay with HPV Infection and Host Gene Expression.

Cancers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

Oncovirology Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20231-050, Brazil.

Retroelements are expressed in diverse types of cancer and are related to tumorigenesis and to cancer progression. We characterized the expression of retroelements in cervical cancer and explored their interplay with HPV infection and their association with expression of neighboring genes. Forty biopsies of invasive cervical carcinoma (squamous cell carcinomas and adenocarcinomas) with genotyped HPV were selected and analyzed for human endogenous retrovirus (HERV) and long interspersed nuclear element 1 (L1) expression through RNA-seq data. Read More

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Surgeon practice patterns in transoral robotic surgery for HPV-related oropharyngeal cancer.

Oral Oncol 2021 Jul 20;121:105460. Epub 2021 Jul 20.

Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States. Electronic address:

Objectives: Analyze how otolaryngologists approach HPV-related oropharyngeal cancer in terms of patient selection for transoral surgery, perceptions of treatment related risks and benefits, and adjuvant treatment decisions.

Materials And Methods: A survey on HPV-related cancer management was distributed to otolaryngologists in the US through RedCap. Differences in responses were analyzed using Pearson's chi-squared and Fisher's exact tests. Read More

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STRIDES - STudying Risk to Improve DisparitiES in Cervical Cancer in Mississippi - Design and baseline results of a Statewide Cohort Study.

Prev Med 2021 Jul 19:106740. Epub 2021 Jul 19.

National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, Rockville, MD, United States of America. Electronic address:

Cervical cancer rates in Mississippi are disproportionately high, particularly among Black individuals; yet, research in this population is lacking. We designed a statewide, racially diverse cohort of individuals undergoing cervical screening in Mississippi. Here, we report the baseline findings from this study. Read More

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HPV 16 and 18 contribute to development of anal dysplasia in HIV infection irrespective of gender and sexual orientation.

HIV Med 2021 Jul 22. Epub 2021 Jul 22.

Infectious Diseases Unit, Azienda Socio Sanitaria Territoriale (ASST) Monza, San Gerardo Hospital, Monza, Italy.

Objectives: The aim of the present study was too investigate prevalence and persistence of human papilloma virus (HPV) and cytological abnormalities (CAs) in the anal swabs of people living with HIV (PLWH): men who have sex with men (MSM), men who have sex with women (MSW) and women (W).

Methods: Between March 2010 and January 2019, an anal swab for cytological and HPV genotyping tests was offered to all PLWH attending our clinic. Logistic regression analysis was conducted to identify predictors of infection. Read More

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Lack of knowledge regarding HPV and its relation to oropharyngeal cancer among medical students.

Cancer Rep (Hoboken) 2021 Jul 22:e1517. Epub 2021 Jul 22.

Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan.

Background: Oropharyngeal cancer (OPC) is an important cause of cancer-related mortality. Early detection of OPC results in a favorable prognosis and higher survival rates. Infection by high-risk types of human papillomavirus (HPV) is a risk factor for OPC with an upward trend globally. Read More

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Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States.

Cancer 2021 Jul 21. Epub 2021 Jul 21.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability.

Methods: Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. Read More

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The role of external genital lesions in HIV seroconversion among men participating in a multinational study.

Sex Transm Dis 2021 Jul 17. Epub 2021 Jul 17.

Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, WI, USA Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, FL, USA Centro de Referência e Treinamento DST/AIDS and Centro Universitário FAM, São Paulo, Brazil Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil Instituto Nacional de Salud Pública, Cuernavaca, México.

Background: Studies in women have shown an increased risk of HIV acquisition with prior HPV infection; however, few studies have been conducted among men. Our objective was to assess whether HPV-related external genital lesions (EGLs) increase risk of HIV seroconversion among men.

Methods: A total of 1379 HIV-negative men aged 18-70 years from the US, Mexico, and Brazil were followed for up to seven years and underwent clinical examination for EGLs and blood draws every six-months. Read More

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Distribution of human papillomavirus in precancerous and cancerous cervical neoplasia in Tunisian women.

Infect Agent Cancer 2021 Jul 16;16(1):52. Epub 2021 Jul 16.

Department of Human and Experimental Pathology, Pasteur Institute of Tunis, University Tunis El Manar, Tunis, Tunisia.

Background: High-risk human papillomavirus (HR-HPV) are responsible for cervical cancer (CC) which represents the second most prevalent gynecological cancer among Tunisian women. Preventive strategies against CC are based on prophylactic vaccines that have not yet been implemented into the national vaccination program of Tunisia. Therefore, the present study aimed to investigate the HPV genotypes distribution in cervical neoplasia in Tunisian women in order to predict the impact of using current HPV vaccines on cancer prevention in Tunisia. Read More

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Distribution of High-risk Human Papillomavirus Genotypes in Cervical Secretions in Punjab.

J Coll Physicians Surg Pak 2021 Jul;30(7):786-791

Institute of Molecular Biology & Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.

Objective: To determine the high risk-human papillomavirus (HR-HPV) prevalence, genotype distribution, and associated risk factors in women with general gynaecological problems.

Study Design: Descriptive, cross-sectional study.

Place And Duration Of Study: Lady Wallingdon Hospital, Lahore from August 2018 to May 2019. Read More

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Human papillomavirus in breast cancer of patients with cervical intraepithelial neoplasia or cervical cancer history. A systematic review and meta-analysis.

J BUON 2021 May-Jun;26(3):707-713

2nd Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.

Purpose: Many cohort studies and meta-analyses support the oncogenic role of the human papilloma virus (HPV) on breast tissue. However, only a few studies examine the association between HPV-positive breast cancer and the prior history of high grade cervical intraepithelial neoplasia (CIN) or cervical cancer. The present systematic review and meta-analysis aimed to determine whether women with a history of high grade CIN or cervical cancer are at a higher risk of developing HPV-positive breast cancer. Read More

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Risk factors of cervical cancer among ethnic minorities in Yunnan Province, China: a case-control study.

Eur J Cancer Prev 2021 Jul 20. Epub 2021 Jul 20.

Medical Administration Department, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Xi Shan county School of Public Health, Kunming Medical University, Cheng Gong New City Department of Gynecology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Xi Shan county, Kunming, Yunnan, China.

Background: Cervical cancer is a common malignant tumor of the female reproductive system in the world, which is a serious threat to women's life and health. According to the latest report, the incidence of cervical cancer is 11.42 per 100 000, and the mortality rate is 3. Read More

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Prevalence and genotype distribution of human papillomavirus among 29 263 women from the Longgang community of Shenzhen.

Trans R Soc Trop Med Hyg 2021 Jul 14. Epub 2021 Jul 14.

Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Human papillomavirus (HPV) vaccination and screening have been demonstrated to be effective methods for controlling cervical cancer. To provide evidence for effective targeted interventions, we investigated the HPV prevalence and genotypic distribution in women of different age groups in the Longgang community of Shenzhen, China.

Methods: A total of 29 263 women were enrolled in the Longgang District Central Hospital from January 2018 to October 2020. Read More

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Nonsmoking and Nondrinking Oral Squamous Cell Carcinoma Patients: A Different Entity.

Front Oncol 2021 28;11:558320. Epub 2021 Jun 28.

Department of Head Neck and Thyroid Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Objective: Our goal was to analyze the demographic and pathologic characteristics as well as prognosis in nonsmoking and nondrinking (NSND) oral squamous cell carcinoma (SCC) patients compared with typical oral SCC patients.

Patients And Methods: A total of 353 patients were retrospectively enrolled and divided into two groups: the NSND group and the current smoking/current drinking (CSCD) group. Demographic, pathologic, and molecular data were compared between the two groups. Read More

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The prevalence and genotype distribution of human papilloma virus in cervical squamous intraepithelial lesion and squamous cell carcinoma in Taizhou, China.

Medicine (Baltimore) 2021 Jul;100(28):e26593

Department of Pathology, Taizhou People's Hospital Affiliated to Dalian Medical University, Taizhou, Jiangsu, China.

Abstract: Human papillomavirus (HPV) infection is a common sexually transmitted disease worldwide and the leading cause of cervical cancer. Current vaccines do not cover all HPV genotypes whereas the distribution of HPV genotypes varies in different geographic regions. The study aimed to investigate the distribution of HPV genotypes in patients with cervical squamous intraepithelial lesion (SIL) and cervical squamous cell carcinoma (SCC) in Taizhou City of Jiangsu Province, China. Read More

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Postoperative Radiation Therapy Refusal in Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.

Laryngoscope 2021 Jul 13. Epub 2021 Jul 13.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, U.S.A.

Objectives/hypothesis: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with good prognosis, unique demographics, and a trend toward treatment deintensification. Patients with this disease may opt out of recommended postoperative radiation therapy (PORT) for a variety of reasons. The aim of this paper was to examine factors that predict patient refusal of recommended PORT in HPV-associated OPSCC, and the association of refusal with overall survival. Read More

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Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States.

Gynecol Oncol 2021 Jul 9. Epub 2021 Jul 9.

UNM Health Sciences Center (HSC), Department of Pathology, Albuquerque, NM, USA; UNM Comprehensive Cancer Center, Center for HPV Prevention, Albuquerque, NM, USA. Electronic address:

Objectives: Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.

Methods: Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology. Read More

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Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women.

Med Sci Monit 2021 Jul 12;27:e929100. Epub 2021 Jul 12.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in pregnant women. MATERIAL AND METHODS A total of 1774 pregnant women were included, and 1774 non-pregnant women were selected as controls. Read More

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The prevalence of human herpesvirus 8 in normal, premalignant, and malignant cervical samples of Iranian women.

Virol J 2021 Jul 10;18(1):144. Epub 2021 Jul 10.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.

Background: Regard to this fact that the main transmission route of HPV and HHV-8 is via sexual activity, it is reasonable to speculate that coinfection of HPV and HHV-8 may have been played an important role in the development of cervical cancer. The aim of this study was to estimate the prevalence of HHV-8 and the frequency of HPV and HHV-8 coinfection in cervical samples of patients with cervical cancer and healthy individuals.

Methods: In total, 364 samples from 61 patients with cervical cancer, 124 women with premalignant lesions, and 179 healthy individuals were investigated by nested-PCR. Read More

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Implementation of quality improvement coaching versus physician communication training for improving human papillomavirus vaccination in primary care: a randomized implementation trial.

Transl Behav Med 2021 Jul 9. Epub 2021 Jul 9.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Many US health departments (HDs) conduct in-person quality improvement (QI) coaching to help primary care clinics improve their HPV vaccine delivery systems and communication. Some HDs additionally conduct remote communication training to help vaccine prescribers recommend HPV vaccination more effectively. Our aim was to compare QI coaching and communication training on key implementation outcomes. Read More

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Cell-Free Human Papillomavirus-DNA for Monitoring Treatment Response of Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.

Laryngoscope 2021 Jul 8. Epub 2021 Jul 8.

Department of Otolaryngology-Head and Neck Surgery, Regina Elena National Cancer Institute IRCCS, Rome, Italy.

Objectives/hypothesis: The aim of this study was to assess the value of cell-free human papillomavirus-DNA (cfHPV-DNA) as a diagnostic test for the post-treatment surveillance of patients with HPV-positive head and neck squamous cell carcinoma (HNSCC) through a systematic review and meta-analysis.

Study Design: Systematic review and meta-analysis.

Methods: A literature search was conducted in three databases (MEDLINE, Embase, and Scopus) in January 2021. Read More

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