50,631 results match your criteria total bilirubin


Impact of acute decompensation on the prognosis of patients with hepatocellular carcinoma.

PLoS One 2022 27;17(1):e0261619. Epub 2022 Jan 27.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background/aims: Organ failure in patients with acute decompensation (AD) is a defining characteristic of acute-on-chronic liver failure (ACLF). However, the clinical features of AD during the long-term clinical course of hepatocellular carcinoma (HCC) are still poorly understood. This study aimed to clarify features and impact of AD/ACLF on the prognosis of patients after treatment for HCC. Read More

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January 2022

Exploring structural dynamics and optical properties of UnaG fluorescent protein upon N57 mutations.

Phys Chem Chem Phys 2022 Jan 27. Epub 2022 Jan 27.

Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France.

UnaG is a new class of fluorescence protein in which an endogenous ligand, namely bilirubin (BLR), plays the role of chromophore. Upon photoexcitation, holoUnaG emits green light. A single mutation at residue 57 induces a decrease in the fluorescence quantum yield. Read More

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January 2022

Development and internal validation of laboratory prognostic score to predict 14-day mortality in terminally ill patients with gastrointestinal malignancy.

Support Care Cancer 2022 Jan 27. Epub 2022 Jan 27.

Department of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, Japan.

Background: Few studies have developed an easy scoring system for the short-term survival of patients with gastrointestinal (GI) malignancy.

Methods: A total of 816 terminally ill patients with GI malignancy were admitted to our palliative care unit. They were randomly divided into the investigation (n = 490) and validation (n = 326) groups. Read More

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January 2022

A Novel Role for Cytochrome P450 Epoxygenase Metabolites in Septic Shock.

Crit Care Explor 2022 Jan 21;4(1):e0622. Epub 2022 Jan 21.

Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.

This is the largest study describing the role of P450 epoxygenase metabolites in septic shock in humans and suggests a novel therapeutic target.

Objectives: Oxylipins are oxidative breakdown products of cell membrane fatty acids. Animal models have demonstrated that oxylipins generated by the P450 epoxygenase pathway may be implicated in septic shock pathology. Read More

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January 2022

Efficacy and safety of alfosbuvir plus daclatasvir in Chinese patients with hepatitis C virus genotypes 1, 2, 3, and 6 infection - an open-label, phase 2 study.

J Viral Hepat 2022 Jan 26. Epub 2022 Jan 26.

The First Hospital of Jilin University, Changchun.

Alfosbuvir is a novel potent HCV NS5B polymerase inhibitor in development for the treatment of chronic HCV infection. Our previous studies indicated that alfosbuvir monotherapy was well-tolerated and druggable in healthy subjects and HCV-infected patients. Here we evaluate the efficacy and safety of alfosbuvir in combination with daclatasvir in Chinese patients with HCV genotype 1, 2, 3, or 6. Read More

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January 2022

Analysis of serum total bilirubin content based on dual-position joint spectrum of "M plus N" theory and the logarithmic method.

Anal Bioanal Chem 2022 Jan 25. Epub 2022 Jan 25.

State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, China.

At present, in the chemical quantitative analysis of complex solutions based on spectroscopy, the accuracy of the content analysis of complex solution is difficult to meet the requirements due to the overlapping spectral lines, low signal-to-noise ratio, and scattering characteristics of various components of complex solution. In this paper, the logarithmic method is used to preprocess the spectral data in the spectral preprocessing stage, and the two-position and multi-mode joint spectral strategy of "M plus N" theory is applied to the quantitative analysis of serum components. The serum samples are illuminated by dual-position ultraviolet LED light source, and the two spectra of the vertical position and the coaxial facing position of the light source and the optical fiber are collected respectively. Read More

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January 2022

Evaluation of staging systems to predict prognosis in hepatocellular carcinoma patients treated with radioembolization.

Heliyon 2022 Jan 13;8(1):e08770. Epub 2022 Jan 13.

Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.

Purpose: To compare the prognostic accuracy of nine staging systems, some of which are well-known and some of which have only been more recently described, for patients with unresectable HCC treated with radioembolization (RE).

Materials And Methods: Individual scores or classes for the following staging systems were recorded or calculated for patients (n = 89) with unresectable HCC who underwent RE at a single tertiary care center from January 2008 to October 2016: Eastern Cooperative Oncology Group, Barcelona Clinic Liver Cancer, Hong Kong Liver Cancer, Okuda, Cancer of the Liver Italian Program (CLIP), Model for End Stage Liver Disease, Child-Pugh (CP) Categorical and Numeric, and Albumin-Bilirubin. For each staging system, a cox proportional hazards regression model was fit to the data and log-rank test statistics, concordance indices, Akaike Information Criteria (AIC) and other diagnostic statistics were calculated. Read More

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January 2022

A combination of portal vein stent insertion and endovascular iodine-125 seed-strip implantation, followed by transcatheter arterial chemoembolization with sorafenib for treatment of hepatocellular carcinoma-associated portal vein tumor thrombus.

J Contemp Brachytherapy 2021 Dec 30;13(6):670-679. Epub 2021 Dec 30.

Interventional Department, The First Hospital of Lanzhou University, Lanzhou City, China.

Purpose: This study aimed to assess efficacy of portal vein stent (PVS) insertion and endovascular iodine-125 (I) seed-strip implantation, followed by transcatheter arterial chemoembolization (TACE) with sorafenib (PVS-I TACE-S) in patients with hepatocellular carcinoma (HCC)-associated type II or type III portal vein tumor thrombus (PVTT).

Material And Methods: A retrospective study was performed on 53 consecutive patients with HCC and type II or type III PVTT, from May 2014 to July 2018. Patients were divided into 2 groups, including group A with 28 patients treated with PVS-I TACE-S, and group B with 25 patients treated with TACE-S. Read More

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December 2021

Treatment outcome and efficacy of therapeutic plasma exchange for transplant-associated thrombotic microangiopathy in a large real-world cohort study.

Bone Marrow Transplant 2022 Jan 25. Epub 2022 Jan 25.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.

The efficacy and outcome of therapeutic plasma exchange (TPE) for transplant-associated thrombotic microangiopathy (TA-TMA) remain controversial. We therefore sought to evaluate the outcome and efficacy of TPE in patients with TA-TMA and to identify TA-TMA patients who would benefit from TPE management. Eighty-two patients with TA-TMA were treated with TPE. Read More

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January 2022

Trastuzumab Emtansine-induced nodular regenerative hyperplasia: is dose reduction enough as a preventable measure?

Dig Dis 2022 Jan 25. Epub 2022 Jan 25.

Introduction: Trastuzumab Emtansine (T-DM1) is a novel antibody-drug conjugate targeting the human epidermal growth factor receptor 2, used in some recurrent metastatic cancers. It was linked to modest increases in serum aminotransferase elevations and bilirubin. More recently, some cases of noncirrhotic portal hypertension have been described in patients on long-term T-DM1. Read More

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January 2022

Availability of Multiple Organ Failure Score Components in Surgical Patients.

Surg Infect (Larchmt) 2022 Jan 24. Epub 2022 Jan 24.

Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.

Scoring systems are often used describe the degree of multi-system organ failure (MOF), however, the data used to calculate these scores are often missing. Studies utilizing these scoring systems often underreport the frequency of missing data. No study has examined the availability of clinical data needed to calculate Sequential Organ Failure Assessment (SOFA), and other organ failure scores. Read More

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January 2022

Interaction of a Jaundice Marker Molecule with Redox Modulatory Nano Hybrid: A Combined Electrochemical and Spectroscopic Study towards the Development of a Theranostics Tool.

ChemMedChem 2022 Jan 24. Epub 2022 Jan 24.

SNBNCBS, CBMS, Block JD, Sector III, Salt Lake City, 700098, Kolkata, INDIA.

This study explores a combined electrochemical and spectroscopic approach to investigate the degradation of bilirubin, a molecular marker of jaundice in humans using a biocompatible nanohybrid (citrate-functionalized Mn 3 O 4 ; C-Mn 3 O 4 NH). The approach is aimed at the development of a facile theranostic tool for treatment, detection and prognosis of jaundice. Linear sweep voltammetry (LSV) studies on bilirubin, C-Mn 3 O 4 NH, a model carrier protein and its complex with bilirubin reveal the efficacy of the nanohybrid for both degradation and detection of bilirubin. Read More

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January 2022

Factors affecting arteriovenous access patency after percutaneous transluminal angioplasty in chronic haemodialysis patients under vascular access monitoring and surveillance: a single-centre observational study.

BMJ Open 2022 Jan 24;12(1):e055763. Epub 2022 Jan 24.

School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan

Objectives: Maintenance of vascular access (VA) patency after percutaneous transluminal angioplasty (PTA) is important and remains a challenge despite VA monitoring and surveillance. The aim of this study was to examine factors affecting the post-PTA arteriovenous access (AVA) patency in patients who have been on close VA monitoring and surveillance for access flow.

Design: Retrospective cohort study. Read More

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January 2022

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Drug Metab Dispos 2022 Jan 24. Epub 2022 Jan 24.

College of Pharmaceutical Sciences, Zhejiang University, China

Estrogen biosynthesis in human placental trophoblasts requires the hOAT4-mediated uptake of fetal derived precursors such as dehydroepiandrosterone-3-sulfate (DHEAS) and 16α-hydroxy-DHEA-S (16α-OH-DHEAS). Scant information is available concerning the contribution of fetal metabolites on the impact of placental estrogen precursor transport and the followed estrogen synthesis. This study substantiated the roles of bilirubin as well as bile acids (taurochenodeoxycholic acid, TCDCA; taurocholic acid, TCA; glycochenodeoxycholic acid, GCDCA; chenodeoxycholic acid, CDCA) on the inhibition of hOAT4-mediated uptake of probe substrate 6-carboxylfluorescein (6-CF) and DHEAS in stably transfected hOAT4-CHO cells, with the IC of 1. Read More

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January 2022

Pyrvinium pamoate ameliorates cyclosporin A- induced hepatotoxicity via the modulation of Wnt/β-catenin signaling and upregulation of PPAR-γ.

Int Immunopharmacol 2022 Jan 21;104:108538. Epub 2022 Jan 21.

Pharmacology and Toxicology department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Background: Cyclosporin A (CsA) is an immunosuppressive agent that can be used to treat autoimmune diseases. Despite its hepatotoxicity, CsA is a backbone in organ transplantation. Pyrvinium pamoate (PP) is an inhibitor of Wnt signaling approved by the U. Read More

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January 2022

Retrospective analysis of direct antiglobulin test positivity at tertiary academic hospital over 10 years.

Transfus Apher Sci 2022 Jan 19:103358. Epub 2022 Jan 19.

Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq., 917798564, Mashhad, Iran. Electronic address:

Background: Hemolytic disease of the fetus and newborn (HDFN) is a clinically significant problem that may potentially affect any pregnancy. Direct antiglobulin test (DAT) is considered to be an important test in identifying newborns who are suspected to have HDN. This study aims in reviewing data regarding a positive DAT result concerning etiology and the development of HDN over a period of 10 years. Read More

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January 2022

Ibrutinib-rituximab followed by R-HCVAD as frontline treatment for young patients (≤65 years) with mantle cell lymphoma (WINDOW-1): a single-arm, phase 2 trial.

Lancet Oncol 2022 Jan 21. Epub 2022 Jan 21.

Department of Hemato-Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Induction with ibrutinib and rituximab provides an opportunity to minimise chemotherapy exposure, because upfront use of these targeted therapies could result in remission without chemotherapy and allow for consolidation with only four cycles of chemotherapy instead of the conventional eight. We aimed to determine the activity and safety of ibrutinib-rituximab induction followed by shortened chemoimmunotherapy (four cycles) with rituximab plus hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (R-HCVAD) alternating with methotrexate-cytarabine in previously untreated patients with mantle cell lymphoma.

Methods: We did a single-centre, single-arm, phase 2 trial in previously untreated patients with mantle cell lymphoma. Read More

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January 2022

Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome.

Vet Res 2022 Jan 24;53(1). Epub 2022 Jan 24.

Basic Veterinary Department, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Dihydromyricetin (DHM), a flavonoid in vine tea, has many pharmacological activities, including anti-inflammatory and antibacterial effects. Lipopolysaccharide is the key inducer of inflammation in avian pathogenic Escherichia coli (E. coli) infection; however, the effect of DHM on E. Read More

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January 2022

Systematic review and meta-analysis of the 2010 ASGE non-invasive predictors of choledocholithiasis and comparison to the 2019 ASGE predictors.

Clin J Gastroenterol 2022 Jan 24. Epub 2022 Jan 24.

David Geffen School of Medicine, University of California, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

In 2019, the American Society for Gastrointestinal Endoscopy (ASGE) guideline on the endoscopic management of choledocholithiasis modified the individual predictors of choledocholithiasis proposed in the widely referenced 2010 guideline to improve predictive performance. Nevertheless, the primary literature, especially for the 2019 iteration, is limited. We performed a systematic review with meta-analysis to examine the diagnostic performance of the 2010, and where possible the 2019, predictors. Read More

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January 2022

Carbamazepine Mitigates Total Parenteral Nutrition Associated Liver Disease in a Novel Ambulatory Piglet Model.

JPEN J Parenter Enteral Nutr 2022 Jan 24. Epub 2022 Jan 24.

Department of Pediatrics, St. Louis University School of Medicine, St. Louis, Missouri.

Background: Total parenteral nutrition (TPN) remains a critical therapeutic option in patients who cannot tolerate enteral feeding. However, while lifesaving, TPN is associated with significant side effects including liver injury, the etiology of which is multifactorial. Carbamazepine (CBZ), an anti-epileptic medication, is known to modulate hepatic fibrosis and hepatocellular injury in a variety of liver diseases. Read More

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January 2022

Characteristics of the Intestinal Microorganisms in Middle-Aged and Elderly Patients: Effects of Smoking.

ACS Omega 2022 Jan 5;7(2):1628-1638. Epub 2022 Jan 5.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.

: Smoking affects the occurrence and development of many diseases. We attempt to study the structure of intestinal flora in the middle-aged and elderly population as well as how smoking affects the intestinal flora. : We collected population information, biochemical indicators, and patient feces from 188 middle-aged and elderly male patients, and their feces were tested for the 16S rRNA gene of intestinal flora. Read More

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January 2022

Potential of PALBI-T score as a prognostic model for hepatocellular carcinoma in alcoholic liver disease.

JGH Open 2022 Jan 5;6(1):36-43. Epub 2022 Jan 5.

Center for Gastroenterology Teine Keijinkai Hospital Sapporo Japan.

Background And Aim: With the control of viral hepatitis, alcoholic hepatocellular carcinoma (HCC) is becoming increasingly important in Japan. In alcoholic cirrhosis, the impact of portal hypertension is significant. Thus, it may be difficult to predict prognosis accurately with the reported prognostic scores. Read More

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January 2022

The Nonlinear Relationship Between Total Bilirubin and Coronary Heart Disease: A Dose-Response Meta-Analysis.

Front Cardiovasc Med 2021 5;8:761520. Epub 2022 Jan 5.

Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Hospital of China Medical University, Shenyang, China.

Evidence suggests that the total bilirubin has a protective effect on coronary heart disease (CHD), but the dose-response relationship remains controversial, and there is no meta-analysis to assess the relationship. As of October 1, 2021, relevant literature was selected from four databases (PubMed, Web of Science, Cochrane Library, and Embase) by using a retrieval strategy. The dose-response curve between the total bilirubin and CHD was fitted by a restricted cubic spline. Read More

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January 2022

Analytical performance validation and clinical application of blood gas analyzer on the detection of neonatal bilirubin.

Transl Pediatr 2021 Dec;10(12):3175-3183

Department of Laboratory, Yanda Hospital, Hebei Province, Langfang, China.

Background: It is not yet clear whether the trace blood gas analyzer can be used for biochemical detection of newborns. This study aimed to evaluate the reliability of the method for the detection of bilirubin in infants.

Methods: Based on the Clinical and Laboratory Standards Institute (CLSI) EP15-A2 document, the analytical performance of the blood gas analyzer method for bilirubin detection in neonates was validated. Read More

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December 2021

Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis.

Cureus 2021 Dec 20;13(12):e20532. Epub 2021 Dec 20.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, USA.

Functional dyspepsia is a common gastrointestinal disorder characterized by postprandial fullness or early satiety and epigastric burning or pain in the absence of organic disease. Acotiamide is a novel prokinetic motility drug being used in functional dyspepsia. Databases like PubMed, PubMed Central, Embase, and Scopus were searched for studies comparing the use of acotiamide and placebo for people with functional dyspepsia. Read More

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December 2021

Prematurity and the Risk of Development of Childhood Obesity: Piecing Together the Pathophysiological Puzzle. A Literature Review.

Authors:
Anupa Gnawali

Cureus 2021 Dec 19;13(12):e20518. Epub 2021 Dec 19.

Family Medicine, University of Cape Town, Cape Town, ZAF.

One of the most devastating public health challenges in the twenty-first century is childhood obesity, and its prevalence is growing at a frightening rate. Premature infants have a greater likelihood of childhood obesity at age six to 16 compared to term infants. This study aims to explore the underlying mechanism of developing childhood obesity in this high-risk group. Read More

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December 2021

Disproportionate Distribution of HBV Genotypes A and D and the Recombinant Genotype D/E in the High and Low HBV Endemic Regions of Uganda: A Wake-Up Call for Regional Specific HBV Management.

Int J Hepatol 2022 11;2022:3688547. Epub 2022 Jan 11.

Department of Microbiology, Makerere University, College of Health Sciences, P. O. Box 7062, Kampala, Uganda.

Background: Hepatitis B virus (HBV) is the leading cause of liver-related diseases. In Uganda, there is a regional disparity in the HBV burden. Our study was aimed at establishing the circulating genotypes in a low and a high endemic region to give plausible explanations for the differences in regional burden and guide the future management of the disease. Read More

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January 2022

Short-term efficacy of precise hepatectomy and traditional hepatectomy for primary liver cancer: a systematic review and meta-analysis.

J Gastrointest Oncol 2021 Dec;12(6):3022-3032

Department of General Surgery, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, China.

Background: As the base of hepatitis B patients has been increasing annually, it has developed into a high incidence source of primary liver cancer worldwide. The fatality rate of liver cancer is still relatively high. Among the many treatment methods, liver resection is the first-line treatment of primary liver cancer. Read More

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December 2021

Prediction of late recurrence after radiofrequency ablation of HBV-related hepatocellular carcinoma with the age-male-albumin-bilirubin-platelets (aMAP) risk score: a multicenter study.

J Gastrointest Oncol 2021 Dec;12(6):2930-2942

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Long-term survivals of patients with HBV-related hepatocellular carcinoma are limited by the high incidence of tumor recurrence after radiofrequency ablation (RFA), identification of the risk factors and understanding the patterns of recurrence can help to improve the comprehensive management of patients after RFA. Therefore, the purpose of the study is to explore the prognostic value of the age-male-albumin-bilirubin-platelets (aMAP) score in patients with early-stage HBV-related hepatocellular carcinoma (HCC) receiving RFA; investigate the risk factors and patterns of late recurrence (LR); and develop a nomogram to predict recurrence-free survival (RFS).

Methods: A retrospective review of HBV-related HCC patients who underwent primary RFA from March 2012 to December 2020 was conducted. Read More

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December 2021

Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how?

World J Gastrointest Oncol 2021 Dec;13(12):2050-2063

Third Medical Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca 400162, Romania.

Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dim prognosis. The role of preoperative and palliative biliary drainage has long been debated. The most common techniques are endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD); however, recently developed endoscopic ultrasound-assisted methods are gaining more atention. Read More

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December 2021