16,604 results match your criteria total bile


Bone healing around titanium implants in a preclinical model of bile duct ligation-induced liver injury.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Objectives: Chronic liver disease increases the risk for periodontal disease and osteoporotic fractures, but its impacts on bone regeneration remain unknown. Herein we studied the impact of liver cirrhosis on peri-implant bone formation.

Material And Methods: A total of 20 male Wistar rats were randomly divided into two groups; one with the common bile duct ligated (BDL) and the respective sham-treated control group (SHAM). Read More

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Rare DNA Mismatch Repair-Related Protein Loss in Patients with Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma and Their Response to Immunotherapy.

Cancer Manag Res 2021 31;13:4283-4290. Epub 2021 May 31.

Department of Abdominal Cancer, West China Medical School, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Purpose: The patients with advanced mismatch repair deficiency (dMMR) cancers can benefit from programmed cell death 1 (PD-1) pathway blockade, regardless of the tumor type. Little is known about the prevalence of dMMR in intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular-cholangiocarcinoma (cHCC-CC). This study aimed to assess the mismatch repair (MMR)-related protein expression in patients with ICC and cHCC-CC. Read More

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The bile salt content of human bile impacts on simulated intestinal proteolysis of β-lactoglobulin.

Food Res Int 2021 Jul 12;145:110413. Epub 2021 May 12.

Gdańsk University of Technology, Faculty of Chemistry, Department of Colloid and Lipid Science, Gabriela Narutowicza 11/12, 80-322 Gdańsk, Poland. Electronic address:

The gastrointestinal hydrolysis of food proteins has been portrayed in scientific literature to predominantly depend on the activity and specificity of proteolytic enzymes. Human bile has not been considered to facilitate proteolysis in the small intestine, but rather to assist in intestinal lipolysis. However, human bile can potentially influence proteins that are largely resistant to gastric digestion, and which are mainly hydrolysed after they have been transferred to the small intestine. Read More

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[Clinical effects of intermittent oro-esophageal tube feeding combined with Xuanqiaoliyan decotion in stroke patients with dysphagia].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):552-556

Department of Neurology, Yidu Central Hospital Affiliated Hospital of Weifang Medical University, Qingzhou 262500, Shandong, China. Corresponding author: Sun Xibo, Email:

Objective: To investigate the clinical effects of intermittent oro-esophageal tube feeding (IOE) combined with Xuanqiaoliyan decotion in stroke patients with dysphagia.

Methods: A prospective study was conducted. Stroke patients with dysphagia admitted to Yidu Central Hospital Affiliated Hospital of Weifang Medical University from January 2018 to December 2019 were enrolled. Read More

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Early laparoscopic cholecystectomy for acute cholecystitis is safe regardless of timing.

Langenbecks Arch Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Surgery, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.

Purpose: The optimal timing for laparoscopic cholecystectomy for acute cholecystitis (AC) has not been resolved. In the revised Tokyo Guidelines from 2018 (TG18), early laparoscopic cholecystectomy (ELC) is recommended regardless of the duration of symptoms. The aim of this study was to evaluate the safety of ELC compared with delayed laparoscopic cholecystectomy (DLC) for AC. Read More

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Serum TBA and GCA Levels Across Pregnancy and the Gestational Age-Specific Reference Intervals for Pregnant Chinese.

Clin Lab 2021 Jun;67(6)

Background: Reference intervals of clinical laboratory indexes are the basis of interpretation of test results. While intrahepatic cholestasis of pregnancy (ICP) could severely threaten maternal and fetal health, reference intervals of the biomarkers serum total bile acids (TBA) and glycocholic acid (GCA) are unsatisfactory. The purpose of this study was to derive gestational age-specific reference intervals for serum TBA and GCA in a Chinese population to promote early diagnosis of ICP. Read More

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Implementation of mandatory ERCP registration in The Netherlands and compliance with European Society of Gastrointestinal Endoscopy performance measures: a multicenter database study.

Endoscopy 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Background:  In 2018, the European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) published quality performance measures for endoscopic retrograde cholangiopancreatography (ERCP). Since January 2016, all endoscopists in the Netherlands have been required to register all ERCP procedures in a nationwide quality registry. This study aimed to evaluate the procedural success rates of ERCP after the implementation of mandatory national registration and to compare these with the ESGE quality performance measures. Read More

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Prophylactic Antibiotics Do Not Prevent Infectious Complications of Endoscopic Ultrasound Fine-Needle Aspiration of Pancreatic Cysts: A Systematic Review and Meta-Analysis.

Pancreas 2021 May-Jun 01;50(5):667-672

From the Department of Medicine, John H Stroger, Jr. Hospital of Cook County.

Abstract: Despite limited evidence, endoscopic societies recommend routine use of antibiotic prophylaxis for endoscopic ultrasound fine-needle aspiration of pancreatic cystic lesions. Recent studies suggest lack of benefit in this setting. Our objective is to conduct a systematic review and meta-analysis to assess the efficacy of antibiotics in prevention of infectious complications after ultrasound fine-needle aspiration of pancreatic cystic lesions. Read More

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A case of intraductal papillary neoplasm of the bile duct accompanied by intraductal papillary mucinous neoplasm of the pancreas and hepatocellular carcinoma.

Clin J Gastroenterol 2021 Jun 9. Epub 2021 Jun 9.

Division of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, Akashi, Hyogo, 673-8558, Japan.

A 73-year-old man with mixed-type intraductal papillary mucinous neoplasm of the pancreas body was followed up for 14 years. Based on imaging findings, the intraductal papillary mucinous neoplasm of the pancreas met the high-risk stigmata, and new hepatic masses were suspected to be intraductal papillary neoplasms of the bile duct. With a diagnosis of intraductal papillary mucinous neoplasm of the pancreas and intraductal papillary neoplasm of the bile duct, the patient had undergone left lateral hepatectomy and distal pancreatectomy. Read More

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Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis.

Clin Interv Aging 2021 1;16:1013-1022. Epub 2021 Jun 1.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Purpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention.

Patients And Methods: We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤60 years old and late-onset sICAS group as age >60 years old. Read More

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Changes in Serum Total Bile Acid Concentrations are Associated with the Risk of Developing Adverse Maternal and Perinatal Outcomes in Pregnant Chinese Women.

Clin Chim Acta 2021 Jun 5. Epub 2021 Jun 5.

Department of Clinical Nutrition, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, China. Electronic address:

Background And Aims: We aimed to investigate the association between total bile acid (TBA) concentrations changes during the second and third trimesters and the risk of developing adverse maternal and perinatal outcomes (AMPO).

Methods: A total of 1569 pregnant Chinese women were enrolled. Serum TBA concentrations were measured during the 16-18 and 29-34 weeks of gestation. Read More

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Pyoderma gangrenosum with primary sclerosing cholangitis-associated colitis successfully treated with concomitant granulocyte and monocyte adsorption apheresis with corticosteroids.

Clin J Gastroenterol 2021 Jun 8. Epub 2021 Jun 8.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

An 18-year-old woman was admitted to our hospital with fever, diarrhea and painful skin ulcers in both pretibial areas starting 19 days earlier. The skin lesions appeared deep necrotic ulcers with violaceous undermined borders. She had been diagnosed as ulcerative colitis and primary sclerosing cholangitis (PSC) 6 and 5 years before, respectively, and had stopped having regular check-up and refused medication for years. Read More

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Efficacy of an artificial neural network algorithm based on thick-slab MRCP images for the automated diagnosis of common bile duct stones.

J Gastroenterol Hepatol 2021 Jun 7. Epub 2021 Jun 7.

Department of Radiology, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Korea.

Backgrounds And Aims: Magnetic resonance cholangiopancreatography (MRCP) can accurately diagnose common bile duct (CBD) stones, but is laborious to interpret. We developed an artificial neural network (ANN) capable of automatically assisting physicians with the diagnosis of CBD stones. This study aimed to evaluate the ANN's diagnostic performance for detecting CBD stones in thick-slab MRCP images and identify clinical factors predictive of accurate diagnosis. Read More

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Evaluation of the role of bile acids and serotonin as markers of pruritus in children with chronic cholestatic liver disease.

Arab J Gastroenterol 2021 Jun 2. Epub 2021 Jun 2.

Cairo University, Department Clinical & Chemical Pathology, Cairo, Egypt. Electronic address:

Background And Study Aims: Pruritus is an annoying symptom with an unclear pathogenesis accompanied by chronic cholestasis. This cross-sectional study was conducted to define the relationship between serum levels of presumed pruritogens (bile acids (BAs) and serotonin) and severity of pruritus in pediatric patients with chronic cholestatic liver disease.

Patients And Methods: A total of 28 children suffering from pruritus due to chronic cholestatic liver disease and 29 age- and sex-matched healthy control subjects were examined. Read More

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Main active components of Jiawei Gegen Qinlian Decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner.

Pharmacol Res 2021 Jun 1:105694. Epub 2021 Jun 1.

College of Animal Sciences and Technology, Guangxi University, Nanning, China. Electronic address:

As an effective drug against acute enteritis diarrhea, Gegen Qinlian decoction(GQD) has a history of 2000 years. However, the potential molecular mechanism through which GQD could protect intestinal barrier from ulcerative colitis(UC) still remains undefined. As an important part of the homeostasis of the colon, gut microbiota is closely related to the dynamic evolution of the surrounding environment and the adjustment of dietary structure. Read More

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Novel Approach via the Round Ligament in Portal Vein Embolization.

World J Surg 2021 Jun 3. Epub 2021 Jun 3.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: The objective of this study was to describe the detailed technique and clinical outcomes of portal vein embolization via the round ligament (RL-PVE) prior to major hepatectomy.

Methods: Between January 2010 and March 2020, a total of 50 portal vein embolization (PVE) procedures were performed in 50 patients. Of them, seven patients who underwent RL-PVE were enrolled in this study. Read More

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Epidemiology and burden of progressive familial intrahepatic cholestasis: a systematic review.

Orphanet J Rare Dis 2021 Jun 3;16(1):255. Epub 2021 Jun 3.

, Roboleo & Co, Leeds, UK.

Background: Progressive familial intrahepatic cholestasis is a rare, heterogeneous group of liver disorders of autosomal recessive inheritance, characterised by an early onset of cholestasis with pruritus and malabsorption, which rapidly progresses, eventually culminating in liver failure. For children and their parents, PFIC is an extremely distressing disease. Significant pruritus can lead to severe cutaneous mutilation and may affect many activities of daily living through loss of sleep, irritability, poor attention, and impaired school performance. Read More

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Do endosonographers agree on the presence of bile duct sludge and the subsequent need for intervention?

Endosc Int Open 2021 Jun 27;9(6):E911-E917. Epub 2021 May 27.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands.

 Endoscopic ultrasonography (EUS) is a tool widely used to diagnose bile duct lithiasis. In approximately one out of five patients with positive findings at EUS, sludge is detected in the bile duct instead of stones. The objective of this study was to establish the agreement among endosonographers regarding: 1. Read More

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Using nontargeted LC-MS metabolomics to identify the Association of Biomarkers in pig feces with feed efficiency.

Porcine Health Manag 2021 Jun 2;7(1):39. Epub 2021 Jun 2.

College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, 510642, China.

Background: Improving feed efficiency is economically and environmentally beneficial in the pig industry. A deeper understanding of feed efficiency is essential on many levels for its highly complex nature. The aim of this project is to explore the relationship between fecal metabolites and feed efficiency-related traits, thereby identifying metabolites that may assist in the screening of the feed efficiency of pigs. Read More

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Assessment of Textbook Outcome in Laparoscopic and Open Liver Surgery.

JAMA Surg 2021 Jun 2:e212064. Epub 2021 Jun 2.

Department of Surgery, Poliambulanza Foundation Hospital, Brescia, Italy.

Importance: Textbook outcome (TO) is a composite measure that captures the most desirable surgical outcomes as a single indicator, yet to date TO has not been defined and assessed in the field of laparoscopic liver resection (LLR) and open liver resection (OLR).

Objective: To obtain international agreement on the definition of TO in liver surgery (TOLS) and to assess the incidence of TO in LLR and OLR in a large international multicenter database using a propensity-score matched analysis.

Design, Setting, And Participants: Patients undergoing LLR or OLR for all liver diseases between January 2011 and October 2019 were analyzed using a large international multicenter liver surgical database. Read More

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Disparate Metabolomic Responses to Fructose Consumption between Different Mouse Strains and the Role of Gut Microbiota.

Metabolites 2021 May 26;11(6). Epub 2021 May 26.

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA.

High fructose consumption has been linked to metabolic syndrome, yet the fructose-induced phenotypes, gene expression, and gut microbiota alterations are distinct between mouse strains. In this study, we aim to investigate how fructose consumption shapes the metabolomic profiles of mice with different genetic background and microbiome. We used fructose-sensitive DBA/2J (DBA) and fructose-resistant C57BL/6J (B6) mice given 8% fructose or regular water for 12 weeks. Read More

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Untargeted Metabolomics Reveals Intestinal Pathogenesis and Self-Repair in Rabbits Fed an Antibiotic-Free Diet.

Animals (Basel) 2021 May 27;11(6). Epub 2021 May 27.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

The prohibition of the use of growth-promoting drug additives in feeds was implemented in China in 2020. However, rabbits can experience symptoms of intestinal disease, such as diarrhea and flatulence, when switching from standard normal diets with antibiotics to antibiotic-free diets. The molecular mechanisms related to the occurrence of these diseases as well as associated physiological and metabolic changes in the intestine are unclear. Read More

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Effective Microorganisms (EM) Improve Internal Organ Morphology, Intestinal Morphometry and Serum Biochemical Activity in Japanese Quails under Challenge.

Molecules 2021 May 8;26(9). Epub 2021 May 8.

Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 13, 10-719 Olsztyn, Poland.

The effect of effective microorganisms (EM) on internal organ morphology, intestinal morphometry, and serum biochemical activity in Japanese quails under challenge was determined. After 30 days of EM addition, one group of quails was orally inoculated with . The second group did not receive EM and was inoculated with . Read More

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Dietary Supplementation with R1 Attenuates Intestinal and Liver Injury in Piglets Challenged by Lipopolysaccharide.

Animals (Basel) 2021 May 16;11(5). Epub 2021 May 16.

Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China.

In this study, a strain of R1 with effective bacteriostatic activity, acid resistance, bile salt resistance, high-temperature resistance was screened. To study the effect of R1 on lipopolysaccharide (LPS)-induced intestinal and liver injury in piglets, twenty-four weaned female piglets were randomly assigned into one of three groups (8 piglets per group). Piglets in the control group and LPS group were fed a basal diet, piglets in the group were fed the basal diet supplemented with R1 (6. Read More

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Superior dialytic removal of bilirubin and bile acids by free fatty acid displacement and its combination with albumin dialysis.

Artif Organs 2021 Jun 1. Epub 2021 Jun 1.

Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.

One of the cardinal features of any liver replacement therapy is the ability to remove accumulated metabolites. The removal of water-soluble substances by dialysis procedures is well established. However, an unsolved problem is the low dialyzability of lipophilic toxins. Read More

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Probiotic-related bacteremia after major hepatectomy for biliary cancer: a report of two cases.

Surg Case Rep 2021 Jun 1;7(1):133. Epub 2021 Jun 1.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai, 980-8574, Japan.

Background: Probiotics have been reported to be beneficial for the prevention of postoperative complications and are often used during the perioperative period. Among the probiotic-related adverse events, bacteremia is rare. Here, we report two cases of probiotic-related bacteremia after major hepatectomy for biliary cancer. Read More

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Percutaneous Transhepatic Papillary Balloon Dilation versus Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stones: A Multicenter Prospective Study.

Radiology 2021 Jun 1:201115. Epub 2021 Jun 1.

From the Department of Interventional Medicine (B.L., Y.L.) and Digestive Department (H.W.), The Second Hospital of Shandong University, 247 Beiyuan Rd, Jinan 250033, PR China; Department of Interventional Oncology, Institute of Shandong University, Jinan, PR China (B.L., Y.L.); Department of Interventional Medicine, Jinxiang People's Hospital, Jining, PR China (J.M.); Department of Hepatobiliary Surgery, Weihai Municipal Hospital, Weihai, PR China (S.L.); Department of Interventional Medicine, Zibo Integrated Traditional Chinese and Western Medicine Hospital, Zibo, PR China (C.L.); Department of General Surgery, Dezhou Municipal Hospital, Dezhou, PR China (H.Q.); Department of Interventional Medicine, Qingdao Hiser Hospital, Qingdao, PR China (D.N.); Department of Interventional Medicine, Weifang Traditional Chinese Medicine Hospital, Weifang, PR China (C.Y.); Department of Interventional Medicine, Linyi Traditional Chinese Medicine Hospital, Linyi, PR China (J.Z.); Department of Radiology, Jiyang People's Hospital, Jinan, PR China (C.W.); Department of Interventional Medicine, Linzi District People's Hospital, Zibo, PR China (Y.J.); Department of Interventional Medicine, Central Hospital of Xinwen Mining Group, Taian, PR China (T.J.); Department of Interventional Medicine, Yiyuan County People's Hospital, Zibo, PR China (J.L.); Department of Interventional Medicine, Huantai County People's Hospital, Zibo, PR China (L.W.); Department of Interventional Medicine, Shanxi Traditional Chinese Medicine Hospital, Taiyuan, PR China (D.S.); Department of General Surgery, Dezhou People's Hospital, Dezhou, PR China (X.H.); Department of Interventional Medicine, Laiwu Traditional Chinese Medicine Hospital, Jinan, PR China (D.L.); Department of Interventional Medicine, Linshu People's Hospital, Linyi, PR China (Z.Z.); Department of Interventional Medicine, Pingyin Traditional Chinese Medicine Hospital, Jinan, PR China, (F.D.); and Digestive Department, Qilu Hospital of Shandong University, Jinan, PR China (T.Y.).

Background Endoscopic retrograde cholangiopancreatography (ERCP) is recommended by major guidelines for the removal of common bile duct (CBD) stones but is technically challenging in patients with low cardiopulmonary reserve and anatomic abnormalities of the upper gastrointestinal (GI) tract. Purpose To compare percutaneous transhepatic papillary balloon dilation (PTPBD) with ERCP for CBD stone removal. Materials and Methods Participants with one to three CBD stones (largest stone ≤30 mm) and without intrahepatic bile duct or gallbladder stones were eligible for this prospective cohort study. Read More

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Effects of Xian-Ling-Gu-Bao capsule on the gut microbiota in ovariectomized rats: Metabolism and modulation.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jun 18;1176:122771. Epub 2021 May 18.

College of Pharmacy and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, PR China. Electronic address:

Xian-Ling-Gu-Bao capsule (XLGB) has been proven to prevent and treat osteoporosis. However, as a long-term oral formula, XLGB's effects on the metabolic capacity, structure and function of gut microbiota have yet to be elucidated in ovariectomized (OVX) rats. Our objectives were to evaluate the capacity of gut microbiota for metabolizing XLGB ingredients and to assess the effect of this prescription on gut microbiota. Read More

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Robotic versus open total pancreatectomy: a retrospective cohort study.

Langenbecks Arch Surg 2021 May 31. Epub 2021 May 31.

Faculty of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Purpose: Robotic total pancreatectomy (RTP), although considered safe and feasible, has rarely been reported. This study aimed to evaluate whether RTP has advantages over open TP (OTP).

Methods: Demographics and perioperative outcomes among patients who underwent RTP (n=14) versus OTP (n=15) between May 2015 and September 2020 were retrospectively analyzed. Read More

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Therapeutic plasma exchange as an effective salvage measure for post-hepatectomy hepatic failure: A case report.

Ann Hepatobiliary Pancreat Surg 2021 May;25(2):270-275

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Major hepatectomy can result in post-hepatectomy hepatic failure (PHHF) and therapeutic plasma exchange (TPE) can be used as a salvage procedure for liver support. We herein present a case of 69-year-old male patient with perihilar cholangiocarcinoma who was successfully managed with salvage TPE. Preoperative portal embolization was performed to reduce the parenchymal resection rate. Read More

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