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Systematic review and meta-analysis of cardiovascular risk in rheumatological disease: Symptomatic and non-symptomatic events in rheumatoid arthritis and systemic lupus erythematosus.

Autoimmun Rev 2021 Aug 26:102925. Epub 2021 Aug 26.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.

Although each autoimmune disease is associated with specific tissue or organ damage, rheumatic diseases share a pro-inflammatory pattern that might increase cardiovascular risk. Retrospective and prospective studies on patients affected by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) highlighted the concept of "accelerated atherosclerosis". Therefore, the purpose of this systematic review and meta-analysis is the assessment of symptomatic or asymptomatic cardiovascular events among patients with rheumatic diseases as RA and SLE. Read More

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Evaluation of pain susceptibility by taking blood pressure in patients with infections: A prospective comparative study.

Medicine (Baltimore) 2021 Aug;100(31):e26511

Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.

Abstract: Pain sensitization leading to polyalgia can be observed during infectious diseases. The blood pressure cuff-evoked pain threshold (BPCEPT) has been used in previous studies as a screening tool for fibromyalgia.We aimed to use the BPCEPT as a screening test for detecting pain sensitization in patients suffering from infectious diseases. Read More

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The first complete mitochondrial genome of edible and medicinal fungus (Gomphidiaceae, Boletales) and insights into its phylogeny.

Mitochondrial DNA B Resour 2021 19;6(8):2355-2357. Epub 2021 Jul 19.

School of Food and Biological Engineering, Chengdu University, Chengdu, P.R. China.

In the present study, we assembled and annotated the complete mitochondrial genome of . The complete mitochondrial genome of was composed of circular DNA molecules, with a size of 37,508 bp. The GC content of the mitogenome was 22. Read More

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Evidence of Horizontal Gene Transfer of 50S Ribosomal Genes , , and in .

Front Microbiol 2021 10;12:683901. Epub 2021 Jun 10.

Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

Horizontal gene transfer (HGT) in the and multidrug efflux pump genes has been shown to play a key role in the genesis of antimicrobial resistance in . In this study, we evaluated if there was evidence of HGT in the genes coding for the ribosomal proteins in the genus. We did this in a collection of 11,659 isolates of , including and commensal species (, , , , , and ). Read More

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Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 11:19322968211023522. Epub 2021 Jun 11.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University and Hospital of Verona, Verona, Italy.

Background: continuous glucose monitoring systems (CGMs) play an important role in the management of T1D, but their accuracy may reduce during rapid glucose excursions. The aim of study was to assess the accuracy of recent rt-CGMs available in Italy, in subjects with T1D during 2 sessions of physical activity: moderate continuous (CON) and interval exercise (IE).

Method: we recruited 22 patients with T1D, on CSII associated or integrated with a CGM, to which a second different sensor was applied. Read More

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Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening.

J Proteomics 2021 07 26;243:104246. Epub 2021 Apr 26.

BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China; BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China; BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, Guangzhou 510006, China. Electronic address:

Colorectal cancer (CRC) is a malignant tumour with high morbidity and mortality worldwide. Efficient screening strategies for CRC and pre-cancerous lesions can promote early medical intervention and treatment, thereby reducing morbidity and mortality. Proteins are generally considered key biomarkers of cancer. Read More

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Prevalence and risk factors associated with prenatal depression among pregnant women in Faisalabad, Pakistan.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2355-2360

Directorate of Medical Sciences, Department of Eastern Medicine, Government College University, Faisalabad, Pakistan.

To determine the prevalence of prenatal depression and explore its association with socio-demographic risk factors, stressful life events and women autonomy/decision-making. The recognition of these problems would play a substantial role in the strategic development of interventions for those Pakistani women who have been suffering from prenatal depression. Analytical cross-sectional study conducted in Allied hospital Faisalabad during a period of 18 months (1st Jan 2019 to 30 June 2020). Read More

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September 2020

Costs of integrating hypertension care into HIV care in rural East African clinics.

AIDS 2021 05;35(6):911-919

Division of HIV, Infectious Diseases & Global Medicine, University of California, San Francisco, California, USA.

Objective: Sub-Saharan Africa faces twin epidemics of HIV and noncommunicable diseases including hypertension. Integrating hypertension care into chronic HIV care is a global priority, but cost estimates are lacking. In the SEARCH Study, we performed population-level HIV/hypertension testing, and offered integrated streamlined chronic care. Read More

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Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors.

Gastroenterology 2021 Jul 19;161(1):128-142.e20. Epub 2021 Mar 19.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Background & Aims: Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early life.

Methods: We prospectively investigated the association of adolescent simple sugar (fructose, glucose, added sugar, total sugar) and sugar-sweetened beverage (SSB) intake with CRC precursor risk in 33,106 participants of the Nurses' Health Study II who provided adolescent dietary information in 1998 and subsequently underwent lower gastrointestinal endoscopy between 1999 and 2015. Read More

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Calcium prescription by Indian orthopaedic surgeons: A survey and a review of literature.

J Clin Orthop Trauma 2021 May 24;16:292-298. Epub 2021 Feb 24.

Department of Orthopaedics, Lokmanya Tilak Municipal Medical College and Hospital, 1st floor College Building, LTMC Hospital, Dr Babasaheb Ambedkar Rd, RB2 Central Railway Quarters, Sion West, Sion, Mumbai, Maharashtra, 400022, India.

Background: Orthopaedic surgeons prefer calcium supplement for various pathologies like fracture, osteoporosis, chronic musculoskeletal pain, yet there is no proper evidence to support the benefits of taking them regularly. The average requirement for calcium is around 500-1000 mg/day for a healthy adult, this amount of calcium is not achieved by diet, especially in developing countries like India. Despite this, the serum calcium level remains unaltered, due to the well-controlled absorption and excretion of calcium by the human body. Read More

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Survival of the Aequalis total shoulder replacement at a minimum 20-year follow-up: a clinical and radiographic study.

J Shoulder Elbow Surg 2021 Oct 3;30(10):2355-2360. Epub 2021 Mar 3.

Shoulder and Elbow Unit, Royal Devon and Exeter Hospital, Exeter, UK.

Aims: Shoulder replacement is increasingly performed for end-stage arthritis. Information on the long-term survival and patient outcomes is very limited. This study aimed to quantify the survival and clinical outcome at a minimum of 20-yr follow-up. Read More

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October 2021

Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis.

J Clin Med 2021 Feb 8;10(4). Epub 2021 Feb 8.

Department of Urology and Oncologic Urology, Wrocław Medical University, 50-556 Wroclaw, Poland.

Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). Despite the significant improvement of primary-tumor downstaging with NAC, up to 50% of patients are eventually found to have advanced residual disease (pT3-T4 and/or histopathologically confirmed nodal metastases (pN+)) at RC. Currently, there is no established standard of care in such cases. Read More

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February 2021

Excess mortality persists in patients with rheumatoid arthritis.

Int J Rheum Dis 2021 Mar 19;24(3):364-372. Epub 2021 Jan 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Objectives: To investigate the causes and risk of death in a large cohort of Korean patients with rheumatoid arthritis (RA).

Methods: Patients in the Hanyang BAE (Bae registry of Autoimmune diseases for Epidemiology) RA cohort who fulfilled the American College of Rheumatology criteria were analyzed. A total of 2355 patients were enrolled from October 2001 to December 2015. Read More

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The quantitative impact of fluid solid interfaces on the catalytic performance of pickering emulsions.

Phys Chem Chem Phys 2021 Jan;23(3):2355-2367

Department of Physics, Soft Matter at Interfaces, Technische Universität Darmstadt, Darmstadt, Germany.

Pickering emulsions (PEs), i.e. particle stabilized emulsions, are used as reaction environments in biphasic catalysis for the hydroformylation of 1-dodecene into tridecanal using the catalyst rhodium (Rh)-sulfoxantphos (SX). Read More

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January 2021

Preliminary Experiences with the Rexon UL-320-FDR: An Automated Thermoluminescent Dosimeter Reader with Removable Contact Heating Planchets and an Infrared Temperature Feedback System.

Health Phys 2021 Apr;120(4):463-471

Department of Nuclear Engineering and Radiological Sciences, College of Engineering, The University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI 48109-2104.

Abstract: The Rexon UL-320 FDR is a novel resistive-heating thermoluminescent dosimeter reader with a unique temperature measurement system and an automated dosimeter processing mechanism. The removable contact heating planchets have black-body adhesives on the back for capturing temperature information with infrared sensors. A heating cycle feedback loop ensures accurate, precise, and reproducible heating sequences. Read More

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Pharmacokinetics of Rosuvastatin: A Systematic Review of Randomised Controlled Trials in Healthy Adults.

Clin Pharmacokinet 2021 02 11;60(2):165-175. Epub 2021 Jan 11.

The George Institute for Global Health, Sydney, NSW, Australia.

Background: Rosuvastatin is a lipid-lowering drug that works by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme responsible for producing cholesterol in humans. The pharmacokinetic data of rosuvastatin are considerably variable across studies.

Objective: To review the pharmacokinetics of rosuvastatin from randomised controlled trials (RCTs) in healthy adults. Read More

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February 2021

Decrease of Coronal Optic Nerve Sheath Diameter is Associated With Postoperative Cognitive Decline in Patients Undergoing Carotid Endarterectomy.

J Cardiothorac Vasc Anesth 2021 Aug 6;35(8):2355-2362. Epub 2020 Nov 6.

Department of Gerontology, Cangzhou Central Hospital, Cangzhou, China.

Objective: Patients undergoing carotid endarterectomy (CEA) have a significant possibility of developing postoperative cognitive decline (POCD). POCD after surgery could be result from cerebral hypotension induced by cross-clamping or postoperative hyperperfusion. Optic nerve sheath diameter (ONSD) exhibits an excellent correlation with invasive intracranial pressure monitoring, Here, the authors explored the risk factors of POCD in patients undergoing CEA, paying close attention to ONSD to test the hypothesis that decrease of coronal ONSD was related to the incidence of POCD. Read More

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Emergency department use among postpartum women with mental health disorders.

Am J Obstet Gynecol MFM 2021 01 20;3(1):100269. Epub 2020 Oct 20.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA.

Background: Mental health disorders are becoming more recognized in pregnancy. Whether mental health disorders are associated with health services utilization after child birth is not completely understood.

Objective: This study aimed to investigate postpartum emergency department use within 30 days of delivery among women with preexisting mental health disorders during pregnancy. Read More

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January 2021

Does ovarian stimulation benefit ovulatory women undergoing therapeutic donor insemination?

Fertil Steril 2021 03 17;115(3):638-645. Epub 2020 Oct 17.

Shady Grove Fertility, Rockville, Maryland.

Objective: To compare clinical and ongoing pregnancy after natural cycle (NC) intrauterine insemination (IUI) versus ovarian stimulation (OS) IUI in ovulatory women undergoing therapeutic donor insemination (TDI).

Design: Retrospective cohort.

Setting: Single infertility center. Read More

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[One-piece mushroom keratoplasty outcomes].

Vestn Oftalmol 2020 ;136(5. Vyp. 2):170-176

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To clinically evaluate the results of one-piece mushroom-shaped keratoplasty.

Material And Methods: A total of 10 patients (10 eyes) were enrolled, all having corneal perforations and deep stromal opacities with involvement of Descemet's membrane. For transplantation, hypothermic preserved donor corneas with mean endothelial cell density of 2896±327 cells per 1 mm were used. Read More

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October 2020

Nurses' Behavior Regarding Pain Treatment in an Emergency Department: A Single-Center Observational Study.

J Pain Res 2020 22;13:2355-2359. Epub 2020 Sep 22.

Anesthesia and Intensive Care Unit, University of Cagliari, Cagliari, Italy.

Purpose: The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting.

Methods: A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data on nurses' approaches to pain, time to analgesia provision, and patient-perceived quality of analgesia. Read More

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September 2020

Gender Differences in Inhaled Pharmacotherapy Utilization in Patients with Obstructive Airway Diseases (OADs): A Population-Based Study.

Int J Chron Obstruct Pulmon Dis 2020 30;15:2355-2366. Epub 2020 Sep 30.

Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada.

Purpose: Gender differences in the incidence, susceptibility and severity of many obstructive airway diseases (OADs) have been well recognized. However, gender differences in the inhaled pharmacotherapy profile are not well characterized.

Methods: We conducted a retrospective cohort study to investigate gender differences in new-users of inhaled corticosteroids (ICS), short-or long-acting beta-agonist (SABA or LABA), ICS/LABA, short-or long-acting muscarinic antagonist (SAMA or LAMA) among patients with asthma, COPD or asthma-COPD overlap (ACO). Read More

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Linseed fibers modulate the production of short-chain fatty acids and improve performance and plasma and skin mucus parameters of silver catfish (Rhamdia quelen).

Fish Physiol Biochem 2020 Dec 2;46(6):2355-2366. Epub 2020 Oct 2.

Department of Animal Science, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul. AV. Roraima n° 1000, Cidade Universitária, Bairro Camobi, Santa Maria, RS, CEP: 97105-900, Brazil.

This study was conducted to evaluate the prebiotic action of distinct linseed fibers on diets for silver catfish (Rhamdia quelen) juvenile. For this, soluble and insoluble fractions of linseed fiber were concentrated separately and combined in four ratios (1:0.5, 1:1, 1:2, 1:4), which were added in diets and evaluated along with a control diet. Read More

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December 2020

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia.

Anal Methods 2020 05;12(18):2355-2362

Department of Pharmacy, The Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan Eastern Road, Shenyang, Liaoning, China.

To better understand the mechanism of hyperlipidemia and discover potential biomarkers, we have used targeted metabolomics to analyze eight amino acid profiles of control and hyperlipidemia rats by a liquid chromatography-mass spectrometry method. With high fat diet, the concentrations of serum of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) were increased by 666.7%, 99. Read More

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Single-Center Noninferiority Randomized Trial on the Efficacy and Safety of Low- and High-Dose Rush Oral Milk Immunotherapy for Severe Milk Allergy.

Int Arch Allergy Immunol 2020 22;181(9):699-705. Epub 2020 Jun 22.

Department of Pediatrics, Osaka Habikino Medical Center, Habikino, Japan.

Introduction: Oral immunotherapy (OIT) has been reported to be effective but associated with a risk of severe symptoms. Thus, an OIT method with decreased risk is required.

Objectives: We aimed to evaluate the efficacy and safety of low- and high-dose OIT regimens in children with severe milk allergy. Read More

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February 2021

Right atrial conduction time for predicting coexistent typical atrial flutter in patients with paroxysmal atrial fibrillation.

J Cardiovasc Electrophysiol 2020 09 29;31(9):2355-2362. Epub 2020 Jun 29.

Department of Cardiology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.

Introduction: Screening of coexistent typical atrial flutter (AFL) in patients with atrial fibrillation (AF) is sometimes challenging. This study investigated whether a prolonged right atrial conduction time (RACT) estimated by tissue Doppler imaging (TDI) predicts patients with concomitant AFL and AF.

Methods And Results: We retrospectively analyzed 398 patients (mean age: 61. Read More

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September 2020

A Single-Center Surgical Experience of Interhemispheric Epidermoids and Proposal of a New Radiological Classification.

World Neurosurg 2020 09 6;141:e606-e614. Epub 2020 Jun 6.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Background: Epidermoids account for <1.5% of all intracranial tumors. Overall, the cerebellopontine angle has been the most commonly reported location. Read More

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September 2020

Radon kinetics in a natural indoor radon chamber.

Sci Total Environ 2020 Sep 6;734:139167. Epub 2020 May 6.

Department of Nuclear Engineering and Radiological Sciences, University of Michigan, 2355 Bonisteel Blvd., Ann Arbor, MI 48104, USA. Electronic address:

An unusual 180 m storage room in the basement of a two-story laboratory building is unventilated, and separated from occupiable rooms by double steel doors. The space completely borders on soil through the concrete floor and two of its concrete walls. The room also contains a separate inner chamber with 1 m thick concrete walls designed to damp vibrations in the room above it. Read More

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September 2020

Antinuclear antibodies positivity is a risk factor of recurrent pregnancy loss: A meta-analysis.

Semin Arthritis Rheum 2020 08 20;50(4):534-543. Epub 2020 May 20.

Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China. Electronic address:

Objective: Immunologic mechanisms have been proposed as part of the pathogenesis mechanisms involved in recurrent pregnancy loss (RPL). Presence of positive antinuclear antibodies (ANA) is regarded as a typical feature of autoimmunity. Many studies had tried to clarify the association of ANA with RPL, but the conclusions were controversial. Read More

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