9,856 results match your criteria total 235


Adolescent-adult nonmetastatic Ewing sarcoma-Experience from a large developing country.

Pediatr Blood Cancer 2021 May 15:e29081. Epub 2021 May 15.

Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.

Background: Outcome and toxicity data in adolescent-adult Ewing sarcoma (AA-ES) patients are sparse and merits exploration.

Methods: Histopathologically confirmed, nonmetastatic AA-ES patients, who received standard institutional combination chemotherapy regimen (Ewing's family of tumors-2001 [EFT-2001]) comprising of ifosfamide plus etoposide and vincristine, doxorubicin plus cyclophosphamide, lasting a total of 12 months between 2013 and 2018, were analyzed for treatment-related toxicities, event-free survival (EFS), and overall survival (OS).

Results: There were 235 patients (primary safety cohort [PSC]) with median age of 23 (15-61) years; 159 (67. Read More

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Cholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Study.

Atherosclerosis 2021 May 6;326:11-16. Epub 2021 May 6.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0317, Oslo, Norway; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Aker, PO Box 4959, Nydalen, 0424, Oslo, Norway. Electronic address:

Background And Aims: There are indications for tracking of circulating total cholesterol concentration (TC) from childhood to later in life. An increased lifelong TC exposure increases the risk of developing atherosclerosis, however little is known about the determinants of TC early in life. We aimed to describe TC in Norwegian offspring aged 6, 12 and 24 months, and to explore if maternal TC, breastfeeding and offspring diet are associated with offspring TC. Read More

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The current status of inpatient cancer rehabilitation provided by designated cancer hospitals in Japan.

Jpn J Clin Oncol 2021 May 15. Epub 2021 May 15.

Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan.

Objective: This survey was conducted to clarify the current status of inpatient cancer rehabilitation provided by designated cancer hospitals in Japan.

Methods: A survey questionnaire was sent to 427 designated cancer hospitals in Japan. Information was sought regarding whether inpatient cancer rehabilitation was provided by the center, and if so, whether respondents regarded such provision as satisfactory. Read More

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A Comparison of Anesthetic Quality Between Interscalene Block and Superior Trunk Block for Arthroscopic Shoulder Surgery: A Randomized Controlled Trial.

Pain Physician 2021 May;24(3):235-242

Department of Anesthesiology and Pain Medicine, Anam Hospital, Korea University College of Medicine, Seoul.

Background: Interscalene block is the most commonly used nerve block for shoulder surgery, and superior trunk block has been investigated as a phrenic-sparing alternative. This randomized controlled trial compared ultrasound-guided interscalene block and superior trunk block as anesthesia for arthroscopic shoulder surgery.

Objectives: Our aims were to determine the superiority of anesthesia quality and compare the risk of hemidiaphragmatic paralysis between these 2 blocks. Read More

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A forensic international market survey of condom lubricants and personal hygiene products using ATR-FTIR coupled to chemometrics.

Sci Justice 2021 May 10;61(3):235-248. Epub 2021 Feb 10.

School of Molecular and Life Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia; Curtin Institute for Functional Molecules and Interfaces, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.

Condom residues may be encountered in forensic investigations as traces in sexual assault or rape cases. Casework studies have shown the value of distinguishing condom residues from other types of personal products used by women. However, up to now, there has been no investigation of their chemical variability within an international context. Read More

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Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada.

Int J Hyg Environ Health 2021 May 10;235:113754. Epub 2021 May 10.

School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada. Electronic address:

Polyfluoroalkyl substances and perfluoroalkyl substances (PFAS) are a family of anthropogenic chemicals that are used in food packaging, waterproof clothing, and firefighting foams for their water and oil resistant properties. Though levels of some PFAS appear to be decreasing in Canada's south, environmental levels have been increasing in the Arctic due to long-range transport. However, the implications of this on human exposures in sub-Arctic and Arctic populations in Canada have yet to be established. Read More

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Achieved low-density lipoprotein cholesterol level and stroke risk: A meta-analysis of 23 randomised trials.

Eur J Prev Cardiol 2021 May 12. Epub 2021 May 12.

Department of Neurology, Sungkyunkwan University School of Medicine, Republic of Korea.

Aims: Lowering the low-density lipoprotein cholesterol level reduces the risk of stroke, but it has not been clear whether the stroke risk would continuously decrease by lowering low-density lipoprotein cholesterol to a very low level. The purpose of this study was to evaluate the association between achieved low-density lipoprotein cholesterol levels and stroke risk.

Methods And Results: A systematic search of MEDLINE, EMBASE and Cochrane Library databases was conducted to identify randomised controlled trials that tested cholesterol-lowering pharmacological therapies and reported both achieved low-density lipoprotein cholesterol levels and stroke outcomes. Read More

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The effects of interventional mitral valve repair using the MitraClip System on the results of pulmonary function testing, pulmonary pressure and diffusing capacity of the lung.

BMC Cardiovasc Disord 2021 May 11;21(1):235. Epub 2021 May 11.

Department of Internal Medicine and Cardiology, Pirna Hospital, Pirna, Germany.

Background: The study analyzes changes in lung function, pulmonary pressure and diffusing capacity of the lung in patients with mitral valve regurgitation (MR) treated by MitraClip implantation.

Methods: A total of 43 patients (19 women and 24 men with an average age of 78.0 ± 6. Read More

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Vestibular Function in Older Adults With Cognitive Impairment: A Systematic Review.

Ear Hear 2021 Apr 22. Epub 2021 Apr 22.

1Department of Translational Neurosciences, University of Antwerp, Antwerp, Belgium 2Department of Otorhinolaryngology-Head and neck surgery, Antwerp University Hospital, Edegem, Belgium 3Department of Education, Health & Social Work, University College Ghent, Ghent, Belgium 4Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), VUB, Brussels, Belgium 5Department of Biomedical Sciences and Institute Born-Bunge, University of Antwerp, Antwerp, Belgium 6Department of Neurology, Antwerp University Hospital, Edegem, Belgium.

Importance: Given the rising prevalence of patients with dementia and those at risk for it, early identification is prioritized. As vestibular dysfunction is associated with Alzheimer's disease (AD) and may contribute to its onset, vestibular assessment may yield an opportunity in early dementia screening.

Objective: This systematic review structures and compares the different raw outcome measures used to assess vestibular function while comparing older adults with preserved cognition to individuals with cognitive impairment, either suffering from mild cognitive impairment (MCI) or AD. Read More

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Long-Read Sequencing to Unravel Complex Structural Variants of Leading to Cone-Rod Dystrophy and Hearing Loss.

Front Cell Dev Biol 2021 21;9:664317. Epub 2021 Apr 21.

Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium.

Inactivating variants as well as a missense variant in the centrosomal gene have been identified in autosomal recessive cone-rod dystrophy with hearing loss (CRDHL), a rare syndromic inherited retinal disease distinct from Usher syndrome. Apart from this, a complex structural variant (SV) implicating has been reported in CRDHL. Here we aimed to expand the genetic architecture of typical CRDHL by the identification of complex SVs of the region and characterization of their underlying mechanisms. Read More

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Clinical manifestations, diagnosis, and treatment outcome of CNS aspergillosis: A systematic review of 235 cases.

Infect Dis Now 2021 May 5. Epub 2021 May 5.

Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.

Aspergillus is a ubiquitous ascomycete that can cause a variety of clinical presentations depending on immune status. Central nervous system aspergillosis is a fatal disease with non-specific clinical features. The aim of this systematic review was to evaluate the epidemiology, clinical features, diagnosis and therapeutic interventions in CNS aspergillosis patients. Read More

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High frequency of potential phosphodiesterase type 5 inhibitor drug interactions in males with HIV infection and erectile dysfunction.

PLoS One 2021 6;16(5):e0250607. Epub 2021 May 6.

San Antonio Military Medical Center, Fort Sam Houston, TX, United States of America.

Objectives: We sought to determine the prevalence of phosphodiesterase type 5 inhibitor (PDE-5) mediated drug-drug interactions (DDIs) in males with HIV infection receiving antiretroviral therapy (ART) and identify factors associated with PDE-5-mediated DDIs.

Methods: Male US Military HIV Natural History Study participants diagnosed with erectile dysfunction (ED) and having a PDE-5 inhibitor and potentially-interacting ART co-dispensed within 30 days were included. DDIs were defined according to criteria found in published guidelines and drug information resources. Read More

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Clinical Outcomes and Prognostic Factors in Patients With Recurrent Patellar Lateral Dislocation Treated With Isolated Medial Patellofemoral Ligament Reconstruction: A Retrospective Single-Center Analysis.

Orthop J Sports Med 2021 Apr 12;9(4):2325967121995803. Epub 2021 Apr 12.

Medical School of Chinese PLA, Beijing, China.

Background: Medial patellofemoral ligament reconstruction (MPFLR) is widely used to treat patellofemoral instability. However, it is still unclear when a concomitant bony procedure is needed.

Purpose: To evaluate the therapeutic efficacy of isolated MPFLR for recurrent patellar lateral dislocation and to identify the prognostic factors for clinical outcomes. Read More

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Bioinformatics analysis of laryngeal squamous cell carcinoma: seeking key candidate genes and pathways.

PeerJ 2021 14;9:e11259. Epub 2021 Apr 14.

Department of Otolaryngology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Background: Laryngeal squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Although much work has been done to optimize its treatment, patients with LSCC still have poor prognosis. Therefore, figuring out differentially expressed genes (DEGs) contained in the progression of LSCC and employing them as potential therapeutic targets or biomarkers for LSCC is extremely meaningful. Read More

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Ten years of experience in counseling gender diverse youth in Flanders, Belgium. A clinical overview.

Int J Impot Res 2021 May 5. Epub 2021 May 5.

Transgender Infopunt, Ghent University Hospital, and Centre for Research on Culture and Gender, Ghent University, Ghent, Belgium.

Research on gender variant children and adolescents has stirred debate on the increased amount of referrals, the sex ratio in referrals, the impact of trans care on their psychological well-being, and the amount of children/adolescents who stop treatment. This retrospective study includes the number of referrals, first contacts at the outpatient clinic and the amount of drop-outs between January 1 2007 to December 31 2016 from the sole Belgian Pediatric Gender clinic. Emotional and behavioral problems, measured by the Child Behavioral Checklist (CBCL) and the Youth Self-Report (YSR), were screened. Read More

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Consultation-liaison psychiatry in Japan: a nationwide retrospective observational study.

BMC Psychiatry 2021 May 5;21(1):235. Epub 2021 May 5.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 1138519, Japan.

Background: Consultation-liaison psychiatry (CLP)-professional psychiatric care provided to coordinate with surgical or medical treatment of inpatients with psychiatric disorders-was included in universal health coverage in Japan in 2012. Despite evidence of benefits of CLP, basic data and geographic distribution information regarding CLP at the national level remain unclear. This study aimed to 1) identify the geographic disparity of CLP in Japan and 2) investigate the association between number of consultations per CLP patient and region. Read More

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Assisted reproductive technology outcomes in women with a chronic viral disease.

AIDS 2021 Jun;35(7):1073-1081

Université de Paris, Faculté de Médecine.

Objective: The aim of this study was to evaluate the cumulative live birth rate in women undergoing in-vitro fertilization/intracytoplasmic-sperm-injection (IVF/ICSI) according to the type of chronic viral infection [HIV, hepatitis-B virus (HBV) and hepatitis-C virus (HCV)].

Design: A cohort study.

Setting: A tertiary-care university hospital. Read More

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Nomogram to predict survival outcome of patients with veno-arterial extracorporeal membrane oxygenation after refractory cardiogenic shock.

Postgrad Med 2021 May 4. Epub 2021 May 4.

The Second School of Clinical Medicine, Southern Medical University, Department of Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China.

Objective: This study aims to develop a nomogram model to predict the survival of refractory cardiogenic shock (RCS) patients that received veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Methods: A total of 235 and 209 RCS patients were supported with VA-ECMO from January 2018 to December 2019 in Guangdong Provincial People's Hospital, and from January 2020 to December 2020 in four third-grade and class-A hospitals were a development cohort (DC) and validation cohort (VC), respectively. Finally, 137 and 98 patients were included in the DC and VC. Read More

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Knowledge and Attitude of Community Nurses on Pressure Injury Prevention: A Cross-sectional Study in an Indonesian City.

Int Wound J 2021 May 4. Epub 2021 May 4.

Department of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

The objectives of this study were to examine the knowledge and attitude of Indonesian community nurses regarding Pressure Injury (PI) prevention. A cross-sectional design was used and included the community nurses permanently working in the Public Health Center (Puskemas) in Bandung, West Java Indonesia. Knowledge was measured using the Pressure Ulcer Knowledge Assessment Tool (PUKAT 2. Read More

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Patient-reported experience of dry eye management: An international multicentre survey.

Cont Lens Anterior Eye 2021 Apr 30:101450. Epub 2021 Apr 30.

Optometry and Vision Science, College of Health and Life Sciences, Aston University, Birmingham, UK. Electronic address:

Purpose: To explore the journey taken by patients in a range of different countries to manage their dry eye symptoms.

Method: Members of the general public who responded positively to the question "Do your eyes ever feel dry?" completed a questionnaire describing their demographics, the impact of their symptomology, the advice they have received and the management options they have tried. The Ocular Surface Disease Index (OSDI) questionnaire was also completed. Read More

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Gynecologic oncology treatment modifications or delays in response to the COVID-19 pandemic in a publicly funded versus privately funded North American tertiary cancer center.

Gynecol Oncol 2021 Apr 28. Epub 2021 Apr 28.

Division of Gynecologic Oncology, Department of Surgical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, ON, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada. Electronic address:

Objective: To compare gynecologic oncology surgical treatment modifications and delays during the first wave of the COVID-19 pandemic between a publicly funded Canadian versus a privately funded American cancer center.

Methods: This is a retrospective cohort study of all planned gynecologic oncology surgeries at University Health Network (UHN) in Toronto, Canada and Brigham and Women's Hospital (BWH) in Boston, USA, between March 22,020 and July 302,020. Surgical treatment delays and modifications at both centers were compared to standard recommendations. Read More

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Reuse and recycle: Integrating aquaculture and agricultural systems to increase production and reduce nutrient pollution.

Sci Total Environ 2021 Apr 20;785:146859. Epub 2021 Apr 20.

Bren School of Environmental Science and Management, University of California, Santa Barbara, CA 93106-5131, USA.

Integrated agriculture and aquaculture systems (IAAS) allow nutrients, energy, and water to flow throughout the components of the system, increasing the efficiency with which inputs are converted to food. Yet effectively designing an IAAS requires understanding how nutrients accumulate and alter the system's productivity. Here we developed a mechanistic model for nitrogen transport and utilization and parameterized it using the IAAS in He'eia, Hawai'i. Read More

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Risk factors for laminitis and nonsurvival in acute colitis: Retrospective study of 85 hospitalized horses (2011-2019).

J Vet Intern Med 2021 May 3. Epub 2021 May 3.

Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Background: Acute colitis is a serious cause of morbidity and death in horses. Recent studies have compared clinical features of coronavirus and salmonellosis, but no study has compared clinical features of enteric salmonellosis, coronavirus, and neorickettsiosis.

Hypothesis/objectives: To identify risk factors for laminitis and nonsurvival to discharge in horses with enteric salmonellosis, coronavirus, or neorickettsiosis. Read More

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Microplastics alone or co-exposed with copper induce neurotoxicity and behavioral alterations on zebrafish larvae after a subchronic exposure.

Aquat Toxicol 2021 Jun 26;235:105814. Epub 2021 Mar 26.

Centre for the Research and Technology of Agro-Environmental and Biological Sciences, CITAB, University of Trás-os-Montes and Alto Douro, Quinta de Prados 5000-801, Vila Real, Portugal; Institute for Research and Innovation in Health, Laboratory Animal Science, Institute of Molecular and Cell Biology, University of Porto, Rua Alfredo Allen, n° 208, 4200-135 Porto, Portugal.

Microplastics (MPs, <5 mm) have been frequently detected in aquatic ecosystems, representing both health and ecological concerns. However data about the combined effects of MPs and other contaminants is still limited. This study aimed to evaluate the impact of MPs and the heavy metal copper (Cu) on zebrafish (Danio rerio) larvae development and behavior. Read More

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Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis.

Clin Imaging 2021 Apr 28;79:104-109. Epub 2021 Apr 28.

Department of Medical Microbiology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Turkey.

Purpose: To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19.

Methods: Between July 1 and August 31, 2020, consecutive patients diagnosed with COVID-19 were analyzed. Among these patients, those who underwent chest computed tomography (CT) examination at the time of presentation, patients with follow-up CT due to clinical deterioration were included in the study. Read More

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The association between heart failure and incident cancer in women: An analysis of the Women's Health Initiative.

Eur J Heart Fail 2021 May 1. Epub 2021 May 1.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington State, USA.

Aims: There is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population-based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a cohort of mostly healthy males. We investigated the association of HF with incident cancer among a large cohort of post-menopausal women. Read More

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Effect of pre-pregnancy body mass index on neonatal outcomes in women undergoing autologous frozen-thawed embryo transfer.

Fertil Steril 2021 Apr 26. Epub 2021 Apr 26.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, People's Republic of China. Electronic address:

Objective: To investigate the associations between pre-pregnancy body mass index (BMI) and neonatal outcomes in women undergoing autologous frozen-thawed embryo transfer (FET).

Design: Retrospective cohort study.

Setting(s): University-affiliated reproductive medical center. Read More

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Patterns, Predictors, and Prognostic Value of Skeletal Muscle Mass Loss in Patients with Locally Advanced Head and Neck Cancer Undergoing Cisplatin-Based Chemoradiotherapy.

J Clin Med 2021 Apr 18;10(8). Epub 2021 Apr 18.

Department of Head and Neck Surgical Oncology, Division of Imaging and Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Low skeletal muscle mass (SMM) is associated with toxicities and decreased survival in head and neck cancer (HNC). Chemoradiotherapy (CRT) may exaggerate loss of SMM. We investigated the changes in SMM, their predictors, and prognostic impact of SMM in patients treated with CRT between 2012 and 2018. Read More

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Diffusion-Weighted Magnetic Resonance Imaging for Breast Cancer Screening in High-Risk Women: Design and Imaging Protocol of a Prospective Multicenter Study in Korea.

J Breast Cancer 2021 Apr;24(2):218-228

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Purpose: Interest in unenhanced magnetic resonance imaging (MRI) screening for breast cancer is growing due to concerns about gadolinium deposition in the brain and the high cost of contrast-enhanced MRI. The purpose of this report is to describe the protocol of the Diffusion-Weighted Magnetic Resonance Imaging Screening Trial (DWIST), which is a prospective, multicenter, intraindividual comparative cohort study designed to compare the performance of mammography, ultrasonography, dynamic contrast-enhanced (DCE) MRI, and diffusion-weighted (DW) MRI screening in women at high risk of developing breast cancer.

Methods: A total of 890 women with mutation or family history of breast cancer and lifetime risk ≥ 20% are enrolled. Read More

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Correlates of bullying perpetration among Lebanese adolescents: a national study.

BMC Pediatr 2021 Apr 28;21(1):204. Epub 2021 Apr 28.

INSPECT-LB: National Institute of Public Health, Clinical Epidemiology and Toxicology, Beirut, Lebanon.

Background: Presently, 1 in 4 Lebanese adolescents is involved in bullying, with 12% being perpetrators. In Lebanon, around 90% of bullying incidents occur in schools. Given the lack of studies tackling bullying perpetration in Lebanon, this study aims to identify and target risk factors of bullying perpetration among Lebanese adolescents, which would serve future prevention and intervention programs. Read More

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