15,929 results match your criteria total 142


Reoperation rate and implant survivorship compared between cementless and cemented bipolar hemiarthroplasty in femoral neck fracture patients with chronic kidney disease.

Injury 2021 Nov 14. Epub 2021 Nov 14.

Division of Adult Reconstructive Surgery, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. Electronic address:

Background: Chronic kidney disease (CKD) is commonly associated with aging and disorders of mineral and bone metabolism. Femoral neck fracture (FNF) is one of the most common fractures among older adults with coexisting CKD, and bipolar hemiarthroplasty (BHA) is a preferred treatment. However, the optimal method of stem fixation has not been conclusively determined. Read More

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November 2021

Effects of endplate coverage and intervertebral height change on heterotopic ossification following cervical disc replacement.

J Orthop Surg Res 2021 Nov 25;16(1):693. Epub 2021 Nov 25.

Department of Operation Room and Anesthesia Center, West China Hospital, Sichuan University, No. 37 Guo Xue Rd, Chengdu, 610041, China.

Background: Heterotopic ossification (HO) is a common complication after cervical disc replacement (CDR). Biomechanical factors including endplate coverage and intervertebral disc height change may be related to HO formation. However, there is a dearth of quantitative analysis for endplate coverage, intervertebral height change and their combined effects on HO. Read More

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November 2021

Measuring and predicting personal and household Black Carbon levels from 88 communities in eight countries.

Sci Total Environ 2021 Nov 22:151849. Epub 2021 Nov 22.

Madras Diabetes Research Foundation, Chennai, India.

Black Carbon (BC) is an important component of household air pollution (HAP) in low- and middle-income countries (LMICs), but levels and drivers of exposure are poorly understood. As part of the Prospective Urban and Rural Epidemiological (PURE) study, we analyzed 48-hour BC measurements for 1187 individual and 2242 household samples from 88 communities in 8 LMICs (Bangladesh, Chile, China, Colombia, India, Pakistan, Tanzania, and Zimbabwe). Light absorbance (10 m) of collected PM filters, a proxy for BC concentrations, was calculated via an image-based reflectance method. Read More

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November 2021

Low Dose of Direct Oral Anticoagulants after Left Atrial Appendage Occlusion.

J Cardiovasc Dev Dis 2021 Oct 28;8(11). Epub 2021 Oct 28.

Cardiology Department, Cardiovascular Institute (ICCV), Hospital Clinic, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.

The optimal antithrombotic strategy following left atrial appendage occlusion (LAAO) is not yet clearly established. Low-dose non-vitamin K antagonist oral anticoagulants (NOAC) might represent a valid alternative, but data regarding their usage is scarce. The aim of this study was to examine the efficacy and safety of low-dose NOAC compared to single (SAPT) or dual antiplatelet therapies (DAPT) after LAAO. Read More

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October 2021

A Study on the Prediction of Reproductive Outcomes in Frozen Embryo Transfer Cycles by Calculating the Volume of Uterine Junctional Zone with Three-Dimensional Ultrasound.

Ultraschall Med 2021 Nov 24. Epub 2021 Nov 24.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.

Purpose: To prospectively study the influence of the volume of the uterine junctional zone (JZ) as a novel predictor of reproductive outcomes in frozen embryo transfer cycles.

Methods: Among the first 30 patients, intra- and interobserver repeatability was evaluated and expressed as a coefficient of repeatability. The same classification system was used to evaluate the JZ of 142 infertility patients undergoing in vitro fertilization (IVF). Read More

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November 2021

Relationship between potential barriers to early mobilization in adult patients during intensive care stay using the Perme ICU Mobility score.

Can J Respir Ther 2021 22;57:148-153. Epub 2021 Nov 22.

Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo / Brazil.

Background: Identifying barriers to early mobilization is essential for the management of patients in the intensive care unit (ICU). Our objective was to identify the potential barriers to early mobilization in adult patients using the Perme ICU Mobility Score (Perme Score) and its relationship with days of mechanical ventilation (MV) and length of stay in ICU.

Methods: This was a pilot, observational, and prospective study. Read More

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November 2021

Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial.

Can Respir J 2021 15;2021:5570178. Epub 2021 Nov 15.

Department of Pediatrics, Kazakh Medical University of Continuing Education, Almaty 050040, Kazakhstan.

To evaluate the efficacy and safety of Ergoferon in combination with symptomatic therapy in children from 6 months to 6 years old with acute respiratory infections (ARI) in contemporary outpatient practice, an international, multicenter, double-blind, placebo-controlled, randomized, parallel-group clinical trial was performed. Derived by technological treatment of antibodies to interferon gamma, histamine, and CD4, Ergoferon was previously proved to modulate its molecular targets promoting effective antiviral protection. The data of 282 patients with oral temperature ≥38. Read More

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November 2021

Metabolic profile changes in serum of migraine patients detected using H-NMR spectroscopy.

J Headache Pain 2021 Nov 24;22(1):142. Epub 2021 Nov 24.

Departments of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Migraine is a common brain disorder but reliable diagnostic biomarkers in blood are still lacking. Our aim was to identify, using proton nuclear magnetic resonance (H-NMR) spectroscopy, metabolites in serum that are associated with lifetime and active migraine by comparing metabolic profiles of patients and controls.

Methods: Fasting serum samples from 313 migraine patients and 1512 controls from the Erasmus Rucphen Family (ERF) study were available for H-NMR spectroscopy. Read More

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November 2021

Risk and protective factors of acute kidney injury in decompensated cirrhotic patients with ascites on tolvaptan.

JGH Open 2021 Nov 1;5(11):1298-1305. Epub 2021 Nov 1.

Institute of Gastroenterology, Department of Internal Medicine Tokyo Women's Medical University Shinjuku-ku Tokyo Japan.

Background And Aim: Acute kidney injury (AKI) is a life-threatening complication of liver cirrhosis. Here, we evaluated the risk factors and characteristics of AKI in cirrhosis.

Patients/methods: This was a single-center retrospective study. Read More

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November 2021

[Association between body mass index changes and other risk factors for cardiovascular disease in patients with type 2 diabetes mellitus].

Zhonghua Liu Xing Bing Xue Za Zhi 2021 Jul;42(7):1194-1199

Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.

To investigate the association between body mass index (BMI) changes and other risk factors for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Based on the T2DM cohort in rural communities of Zhejiang province, baseline and follow up information of height, weight, blood pressure, glycated hemoglobin (HbA1c), TC, TG, LDL-C and HDL-C of the T2DM patients were collected. After excluding those who died during the follow-up period, lost follow-up or had incomplete information, a total of 8 953 T2DM patients were included in the final analysis. Read More

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Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: an observational cohort.

Elife 2021 Nov 23;10. Epub 2021 Nov 23.

ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, London, United Kingdom.

There is potentially considerable variation in the nature and duration of the care provided to hospitalised patients during an infectious disease epidemic or pandemic. Improvements in care and clinician confidence may shorten the time spent as an inpatient, or the need for admission to an intensive care unit (ICU) or high density unit (HDU). On the other hand, limited resources at times of high demand may lead to rationing. Read More

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November 2021

Newly established LC-MS/MS method for measurement of plasma BH4 as a predictive biomarker for kidney injury in diabetes.

Free Radic Biol Med 2021 Nov 19. Epub 2021 Nov 19.

Department of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, China. Electronic address:

Objective: The clinical research on BH4 is limited because of the difficulties on its measurement. In this study, we used our own established LC-MS/MS method to examine the plasma BH4 levels in diabetes to determine whether it could be used as a biomarker for the prediction of kidney injury in those patients.

Methods: Hospitalized diabetes patients in Renmin Hospital of Wuhan University from Jan to Aug 2021 were recruited. Read More

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November 2021

The epidemiology of COVID-19 in ten Southeast Asian countries.

Med J Malaysia 2021 11;76(6):783-791

Bangkokthonburi University, Faculty of Medicine, Bangkok, Thailand.

Introduction: Periodic benchmarking of the epidemiology of COVID-19 in the Association of Southeast Asian Nations (ASEAN) countries is critical for the continuous understanding of the transmission and control of COVID-19 in the region. The incidence, mortality, testing and vaccination rates within the ASEAN region from 1 January 2020 to 15 October 2021 is analysed in this paper.

Methods: COVID-19 data on cases, deaths, testing, and vaccinations were extracted from the Our World in Data (OWID) COVID-19 data repository for all the ten ASEAN countries. Read More

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November 2021

The association of blood urea nitrogen levels upon emergency admission with mortality in acute exacerbation of chronic obstructive pulmonary disease.

Chron Respir Dis 2021 Jan-Dec;18:14799731211060051

Department of Respiratory Medicine Affiliated Jinhua Hospital, RinggoldID:117946Zhejiang University School of Medicine, Jinhua Municipal Central Hospital, Jinhua, China.

Background And Purpose: High blood urea nitrogen (BUN) is associated with an elevated risk of mortality in various diseases, such as heart failure and pneumonia. Heart failure and pneumonia are common comorbidities of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, data on the relationship of BUN levels with mortality in patients with AECOPD are sparse. Read More

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November 2021

Prostate artery embolization for the treatment of urinary retention caused by large (>80 ​mL) benign prostatic hyperplasia: Results of 21 patients.

J Interv Med 2020 Sep 9;3(3):142-145. Epub 2020 Jul 9.

Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fu-xing Rd., Beijing, 100853, PR China.

Objective: A large prostate size (>80 ​mL) of benign prostatic hyperplasia (BPH) is technically challenging to treat surgically. This study aimed to investigate the safety and efficacy of super-selective prostatic artery embolization (PAE) for the treatment of urinary retention caused by large BPH.

Methods: A total of 21 patients with urinary retention, indwelling urinary catheter, or suprapubic cystostomy as a consequence of giant BPH (prostate volume [PV] ​> ​80 ​mL) who sought treatment between January 2013 and December 2017 were enrolled. Read More

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September 2020

Improved Outside-In Suture through the Joint Capsule to Repair the Palmer I-B Triangular Fibrocartilage Complex Superficial Injury.

Comput Math Methods Med 2021 10;2021:8387813. Epub 2021 Nov 10.

Medical College, Soochow University, Suzhou, China.

Background: The treatment of type I-B triangular fibrocartilage complex superficial injury is always a challenge to orthopedists. The traditional outside-in suture method often causes a risk of nervous irritation. We designed a modified outside-in suture through the joint capsule to repair the Palmer I-B triangular fibrocartilage complex superficial injury. Read More

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November 2021

[Single-phase Pulmonary Arteriovenous Separation CT Protocol with Estimated Time of Arrival Method Using 3rd Generation Dual Source CT: Its Success Rate of Pulmonary Arteriovenous Separation in Our Experience of 223 Cases].

Nihon Hoshasen Gijutsu Gakkai Zasshi 2021 ;77(11):1325-1333

Department of Radiology, Mie University Graduate School of Medicine.

We retrospectively investigated the success rate of pulmonary arteriovenous separation in a single-phase computed tomography (CT) protocol using the estimated time of arrival (ETA) method. A total of 223 patients who underwent a single-phase CT protocol using the ETA method for pulmonary arteriovenous separation were included in the analysis. Dual source CT (SOMATOM Force, SIEMENS) was used for imaging. Read More

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November 2021

Levels of pretreatment blood lipids are prognostic factors in advanced NSCLC patients treated with anlotinib.

Lipids Health Dis 2021 Nov 20;20(1):165. Epub 2021 Nov 20.

Department of Radiation Oncology, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.

Background: Anlotinib, a small molecule for multi-target tyrosine kinase inhibition, is the third or further line of defense for treatment of non-small cell lung cancer (NSCLC). Findings from an ALTER0303 phase III trial revealed that this drug confers significant survival benefits in patients. Although numerous inflammatory biomarkers have been shown to play vital roles in treatment, the clinical significance of blood lipid levels before treatment has not been evaluated. Read More

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November 2021

Effects of substrate organic composition on mesophilic and thermophilic anaerobic co-digestion of food waste and paper waste.

Chemosphere 2021 Nov 17:132933. Epub 2021 Nov 17.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

Facing the huge output of food waste (FW) and paper waste (PW), long-term semi-continuous experiments were carried out to investigate the effect of the substrate organic composition on mesophilic and thermophilic anaerobic co-digestions (Co-ADs) of their mixtures. The experimental results showed that the organic composition of the substrate affected the biogas and methane production and yield of the two Co-ADs of the FW and PW mixtures, and its effect on thermophilic Co-AD (Co-TAD) was lower than that on mesophilic Co-AD (Co-MAD). The two Co-ADs had similar biogas (2. Read More

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November 2021

Effect of injectable trace mineral supplementation on peripheral polymorphonuclear leukocyte function, antioxidant enzymes, health, and performance in dairy cows in semi-arid conditions.

J Dairy Sci 2021 Nov 16. Epub 2021 Nov 16.

Department of Veterinary Sciences, Texas Tech University, Lubbock 79415. Electronic address:

The objective of this study was to evaluate the effect of subcutaneous injections of 15 mg/mL Cu, 5 mg/mL Se, 60 mg/mL Zn, and 10 mg/mL Mn on health, performance, polymorphonuclear leukocyte (PMNL) function, circulating glutathione peroxidase (GPx) and superoxide dismutase (SOD) concentrations, and inflammation of dairy cows undergoing the transition period in high temperature-humidity index. A total of 923 multiparous cows from 2 commercial dairy farms were randomly allocated into 1 of 2 treatment groups as follows: control and injectable trace mineral supplementation (ITMS). Cows in the ITMS group received 7 mL of subcutaneous injections at dry-off (208 ± 3 d of gestation), 260 ± 3 d of gestation, and at 35 ± 3 d in milk (DIM). Read More

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November 2021

Protein-based engineering of the initial acquired enamel pellicle in vivo: Proteomic evaluation.

J Dent 2021 Nov 16;116:103874. Epub 2021 Nov 16.

Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. Electronic address:

Objective: To study the proteomic alterations in the initial AEP after rinsing with CaneCPI-5, StN15 or Hb or their combination.

Materials And Methods: In five crossover phases, after prophylaxis, 10 volunteers in 5 consecutive days, rinsed (10 mL, 1 min) with the following solutions: deionized water (HO- negative control- 1), 0.1 mg/mL CaneCPI-5 (2), 1. Read More

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November 2021

Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials.

Lancet Gastroenterol Hepatol 2021 Nov 16. Epub 2021 Nov 16.

Hospital Clinic of Barcelona, August Pi i Sunyer Biomedical Research Institute, Biomedical Research Networking Center in Hepatic and Digestive Diseases, Barcelona, Spain. Electronic address:

Background: Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In an earlier phase 2 induction study, etrolizumab significantly improved clinical remission relative to placebo in patients with moderately to severely active ulcerative colitis. The HIBISCUS studies aimed to compare the efficacy and safety of etrolizumab to adalimumab and placebo for induction of remission in patients with moderately to severely active ulcerative colitis. Read More

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November 2021

Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis.

J Org Chem 2021 Nov 19. Epub 2021 Nov 19.

Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimo-Adachi-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

A highly modular synthetic strategy for the heronamide C-type polyene macrolactams was established by synthesizing 8-deoxyheronamide C (). The developed strategy enabled not only the total synthesis of 8-deoxyheronamide C () but also the unified synthesis of four heronamide-like molecules named "heronamidoids" (-). Conformational and reactivity analysis of the heronamidoids clarified that (1) the C19 stereochemistry mainly affected the conformation of the amide linkage, resulting in the change of alignment of two polyene units and reactivity toward photochemical [6π + 6π] cycloaddition, and (2) the C8,C9-diol moiety is important for the conversion to the heronamide A-type skeleton from the heronamide C skeleton. Read More

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November 2021

The Role of Minimally Invasive Surgery in Gastric Cancer.

Cureus 2021 Nov 14;13(11):e19563. Epub 2021 Nov 14.

General and Colorectal Surgery, Koç University Hospital, Istanbul, TUR.

Objective: This study aims to investigate the efficacy and safety of minimally invasive surgery (MIS) in gastric cancer and to compare MIS versus open gastrectomy (OG) in terms of early mortality and morbidity, long-term oncological outcomes, and recurrence rates.

Methods: A total of 75 patients who underwent MIS or OG for gastric cancer at Koç University School of Medicine between December 2014 and December 2019 were retrospectively analyzed. Postoperative complications and disease-specific survival were compared between surgical approaches. Read More

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November 2021

Cost of illness of invasive meningococcal disease caused by serogroup B Neisseria meningitidis in Spain.

Vaccine 2021 Nov 15. Epub 2021 Nov 15.

GSK, Wavre, Belgium.

Introduction: Invasive meningococcal disease (IMD) is a severe infectious disease, mainly affecting children under 5 years, associated with long-term physical, neurological and psychological sequelae. In Spain, most IMD cases are caused by meningococcal serogroup B (MenB). This study estimates its economic burden from a societal perspective in Spain. Read More

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November 2021

[Application value of superb microvascular imaging for diagnosis of different size renal solid tumors].

Zhonghua Zhong Liu Za Zhi 2021 Nov;43(11):1215-1221

Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

To discuss the diagnostic value of superb microvacular imaging (SMI) in renal solid tumors of different sizes. A total of 142 patients with 146 renal tumors detected by ultrasound in Tianjin Medical University Cancer Institute and Hospital from September 2017 to March 2019 were retrospectively analyzed. The maximum diameter of lesions was 0. Read More

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November 2021

Is the Er: YAG Laser Effective in Reducing Pain, Edema and Trismus After Removal of Impacted Mandibular Third Molars? A Meta-Analysis.

J Oral Maxillofac Surg 2021 Oct 20. Epub 2021 Oct 20.

Full Professor, Department of Clinical and Preventive Dentistry, Federal University of Pernambuco (UFPE), Recife, PE, Brazil.

Purpose: Removal of impacted third molars, can be associated with complications such as pain, edema, trismus, that can increase the morbidity of this procedure. The purpose of this study is to determine whether the Er: YAG laser is effective in reducing pain, swelling and trismus compared to rotary instruments in removing impacted lower third molars (3 LM`s).

Methods: For this systematic review the searches were carried out independently by 2 researchers and the articles were selected according to the inclusion and exclusion criteria previously established. Read More

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October 2021

The Impact of a Baseline Exercise Test on Confidence to Perform Subsequent Incremental Shuttle Walk Tests, Walk at Home, and Manage Breathlessness.

J Cardiopulm Rehabil Prev 2021 Jun 9. Epub 2021 Jun 9.

Centre for Exercise & Rehabilitation Science, NIHR Biomedical Research Centre- Respiratory, Leicester, United Kingdom (Mss Stenson and Chaplin and Drs Houchen-Wolloff and Singh); and University of Leicester, Leicester, United Kingdom (Dr Singh).

Purpose: Incremental shuttle walk tests (ISWTs) are routinely conducted as outcome measures in pulmonary rehabilitation (PR) assessments and in clinical trials; however, there is a paucity of data describing the impact of simply conducting an exercise test and the change produced in the perceived ability of the individual to perform exercise subsequently, which may in turn influence therapy and study outcomes.

Methods: We conducted a prospective observational cohort study at Glenfield Hospital, Leicester, UK (University Hospitals of Leicester NHS Trust). At initial PR assessment, we asked patients pre- and post-practice ISWT to report confidence in three areas (walking at home [Q1], managing breathlessness [Q2], and performing an ISWT [Q3]) based on a visual analog scale (0-10). Read More

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¡Habla de VPH! An Educational Activity for College Students in Puerto Rico.

P R Health Sci J 2021 Sep;40(3):142-146

Puerto Rico Breast and Cervical Cancer Prevention and Early Detection Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR.

Objective: To evaluate human papillomavirus (HPV) infection knowledge, willingness to get vaccinated, and vaccination uptake, following a brief educational activity entitled ¡Habla de VPH! (Let's talk about HPV!) in a sample of college students at the University of Puerto Rico, Bayamón.

Methods: Participants completed a self-administered questionnaire developed by the research team, which gathered information regarding sociodemographic characteristics, HPV vaccination status, and willingness to receive the vaccine. Once the participant completed the survey, the staff of the Outreach Program conducted an educational activity. Read More

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September 2021

A randomized controlled trial of two dialysate sodium concentrations in hospitalized hemodialysis patients.

Nephrol Dial Transplant 2021 Nov 18. Epub 2021 Nov 18.

Renal Section, Boston Medical Center, Boston, MA.

Background: Several large dialysis organizations have lowered the dialysate sodium concentration (DNa) in an effort to ameliorate hypervolemia. The implications of lower DNa on intra-dialytic hypotension (IDH) during hospitalizations of hemodialysis (HD) patients is unclear.

Methods: In this double-blind single center randomized controlled trial, hospitalized maintenance HD patients were randomized to receive higher (142 mmol/L) or lower (138 mmol/L) DNa for up to six sessions. Read More

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November 2021