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Bilateral hydroureteronephrosis: A neonatal presentation of bladder duplication.

Radiol Case Rep 2021 Jun 26;16(6):1237-1241. Epub 2021 Mar 26.

Department of Paediatric Surgery and Urology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.

In a male neonate with bilateral hydroureteronephrosis, the most common surgical diagnosis is posterior urethral valves. This case report describes a male infant with the same presentation, but caused by a very uncommon congenital anomaly. The summation of different imaging modalities allowed a multidisciplinary team of colleagues to define the anatomy: bilateral duplex kidneys draining into separate urinary bladders. Read More

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Patient Perspectives on the Extent of Surgery and Radioactive Iodine Treatment for Low-Risk Differentiated Thyroid Cancer.

Endocr Pract 2021 Jan 16. Epub 2021 Jan 16.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Objective: To understand patient perspective regarding recommended changes in the 2015 American Thyroid Association (ATA) guidelines. Specifically, in regard to active surveillance (AS) of some small differentiated thyroid cancer (DTC), performance of less extensive surgery for low-risk DTC, and more selective administration of radioactive iodine (RAI).

Methods: An online survey was disseminated to thyroid cancer patient advocacy organizations and members of the ATA to distribute to the patients. Read More

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January 2021

Correlation of Seizure Increase and COVID-19 Outbreak in Adult Patients with Epilepsy: Findings and Suggestions from a Nationwide Multi-centre Survey in China.

Seizure 2021 Mar 31;88:102-108. Epub 2021 Mar 31.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Objectives: To investigate the impact of the COVID-19 outbreak on the behaviours, mental health and seizure control of adult patients with epilepsy (PWE) and to identify the correlation of seizure increase and the COVID-19 outbreak to guide the medical care of individuals with epilepsy during a public health crisis.

Methods: This study was conducted at 28 centres from February 2020 to April 2020. Participants filled out a 62-item online survey including sociodemographic, COVID-19-related, epilepsy-related and psychological variables and were divided into two groups based on whether their seizure frequency increased during the COVID-19 pandemic. Read More

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Medical Versus Surgical Treatment for the Management of Diabetic Foot Osteomyelitis: A Systematic Review.

J Clin Med 2021 Mar 17;10(6). Epub 2021 Mar 17.

Diabetic Foot Unit, Clínica Universitaria de Podología, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.

A systematic review and quality assessment was performed to assess the management of diabetic foot osteomyelitis by medical or surgical treatment. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist was used. All selected studies were evaluated using the Cochrane Risk of Bias Tool to assess the risk of bias for randomized controlled trials. Read More

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Lumpy skin disease outbreaks investigation in Egyptian cattle and buffaloes: Serological evidence and molecular characterization of genome termini.

Comp Immunol Microbiol Infect Dis 2021 Mar 9;76:101639. Epub 2021 Mar 9.

Department of Virology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Lumpy skin disease (LSD) is an endemic highly infectious viral disease affecting cattle in Egypt. This study aimed to identify and characterize the LSD virus (LSDV) outbreaks in Egypt between 2016 and 2018 and to determine the role of Egyptian buffaloes in the epidemiology of LSD. A total of 44 skin biopsies (41 from cattle and 3 from buffaloes) and 31 blood samples from asymptomatic buffaloes in contact with clinically infected cattle were collected from 7 Egyptian governorates and tested by real-time (rt)-PCR. Read More

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The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis.

Syst Rev 2021 03 20;10(1):80. Epub 2021 Mar 20.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: The coronavirus (COVID-19) pandemic was reported from Wuhan, China, on December 31, 2019, and the pandemic was spread to more than 212 countries in the globe. This meta-analysis aimed to assess the pooled incidence of COVID-19 complications and to identify the association between the incidence of complications and age.

Methods: Comprehensive databases, PubMed, Hinari, and Google Scholar, were used to locate potential articles for this review. Read More

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Effects of Austenitizing Temperature on Tensile and Impact Properties of a Martensitic Stainless Steel Containing Metastable Retained Austenite.

Materials (Basel) 2021 Feb 20;14(4). Epub 2021 Feb 20.

The State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819, China.

Austenitizing temperature is one decisive factor for the mechanical properties of medium carbon martensitic stainless steels (MCMSSs). In the present work, the effects of austenitizing temperature (1000, 1020, 1040 and 1060 °C) on the microstructure and mechanical properties of MCMSSs containing metastable retained austenite (RA) were investigated by means of electron microscopy, X-ray diffraction (XRD), as well as tensile and impact toughness tests. Results suggest that the microstructure including an area fraction of undissolved MC, carbon and chromium content in matrix, prior austenite grain size (PAGS), fraction and composition of RA in studied MCMSSs varies with employed austenitizing temperature. Read More

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February 2021

The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial.

Medicine (Baltimore) 2021 Feb;100(7):e24758

Department of Oncology, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Malignant pleural effusion (MPE) is one of the commonest causes of an exudative pleural effusion. Breathlessness, dyspnea and other symptoms often seriously distress and affect the quality of life. The external application of mirabilite and rhubarb (EAMR) combined with intrathoracic infusion of cisplatin, as an alternative treatment for MPE, is popular in China. Read More

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February 2021

Association of Lower Nutritional Status and Education Level with the Severity of Depression Symptoms in Older Adults-A Cross Sectional Survey.

Nutrients 2021 Feb 4;13(2). Epub 2021 Feb 4.

Department of Geriatrics, Healthy Ageing Research Centre, Medical University of Lodz, 92-115 Lodz, Poland.

The study analyzes the relationship between nutritional status and depression symptoms severity in the older population. A total of 1975 older outpatients (1457 women and 518 men, median age 75) were included in the study. Depression symptoms severity was assessed using the Geriatric Depression Scale (GDS). Read More

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February 2021

Visual Analysis of Biomarkers Reveals Differences in Lipid Profiles and Liver Enzymes before and after Gastric Sleeve and Bypass.

Obes Facts 2021 Feb 5:1-11. Epub 2021 Feb 5.

Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.

Introduction: Bariatric surgery results in both intentional and unintentional metabolic changes. In a high-volume bariatric center, extensive laboratory panels are used to monitor these changes pre- and postoperatively. Consecutive measurements of relevant biochemical markers allow exploration of the health state of bariatric patients and comparison of different patient groups. Read More

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February 2021

Effect of metabolic genetic variants on long-term disease comorbidity in patients with type 2 diabetes.

Sci Rep 2021 Feb 2;11(1):2794. Epub 2021 Feb 2.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Underlying genetic determinants contribute to developing type 2 diabetes (T2D) future diseases. The present study aimed to identify which genetic variants are associated with the incident of the major T2D co-morbid disease. First, we conducted a discovery study by investigating the genetic associations of comorbid diseases within the framework of the Utrecht Cardiovascular Pharmacogenetic studies by turning information of > 25 years follow-up data of 1237 subjects whom were genotyped and included in the discovery study. Read More

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February 2021

The prevalence of CRF55_01B among HIV-1 strain and its connection with traffic development in China.

Emerg Microbes Infect 2021 Dec;10(1):256-265

State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing 102206, China.

CRF55_01B is a relatively "young" HIV strain. At present, we do not know much about its transmission characteristics in China. So, to describe the transmission characteristics of CRF55_01B strain among provinces and HIV infected people, and to analyze the reasons for its rapid epidemic in China, a total of 1237 subjects infected with CRF55_01B from 31 provinces spanning a period of 12 years from 2007 to 2018 were enrolled in this study. Read More

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December 2021

Suitability of Video Consultations During the COVID-19 Pandemic Lockdown: Cross-sectional Survey Among Norwegian General Practitioners.

J Med Internet Res 2021 02 8;23(2):e26433. Epub 2021 Feb 8.

Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The COVID-19 pandemic imposed an acute, sharp rise in the use of video consultations (VCs) by general practitioners (GPs) in Norway.

Objective: This study aims to document GPs' experiences with the large-scale uptake of VCs in the natural experiment context of the pandemic.

Methods: A nationwide, cross-sectional online survey was conducted among Norwegian GPs during the pandemic lockdown (April 14-May 3, 2020). Read More

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February 2021

Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network.

Neurol Sci 2021 Apr 15;42(4):1237-1245. Epub 2021 Jan 15.

Dipartimento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS - UOC Neurologia, Rome, Italy.

Introduction: The COVID-19 outbreak highly impacted the acute ischemic stroke care management. The primary end point of the study was to evaluate the impact of the COVID-19 outbreak and the following lockdown measures on our hub-and-spoke network; the secondary end point was to evaluate if the impact of the COVID-19 outbreak was different in hub-and-spoke centers.

Methods: This was a retrospective multicenter observational study conducted at the Stroke Units of Policlinico Gemelli, Ospedale San Filippo Neri, Ospedale di Belcolle, and Ospedale San Camillo de Lellis. Read More

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A comparative study of the disease burden attributable to PM in China, Japan and South Korea from 1990 to 2017.

Ecotoxicol Environ Saf 2021 Feb 4;209:111856. Epub 2021 Jan 4.

Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA. Electronic address:

Background: Exposure to fine particulate matter (PM) is one of the leading contributors to disease burden. However, little is known about the spatial and temporal trends of the disease burden attributable to PM in the three major economies in East Asia. We aimed to estimate the patterns and temporal variations of the disease burden attributable to PM in China, Japan, and South Korea from 1990 to 2017. Read More

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February 2021

Quantitative Analysis of Biogenic Amines in Different Cheese Varieties Obtained from the Korean Domestic and Retail Markets.

Metabolites 2021 Jan 4;11(1). Epub 2021 Jan 4.

Animal Products Research and Development Division, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea.

To evaluate the safety and risk assessment of cheese consumption in the Republic of Korea, sixty cheese samples purchased from the farmstead and retails markets (imported) were analyzed for their biogenic amine (BA) contents. The BA profiles and quantities of eight amines (tryptamine, 2-phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine, and spermine) were determined using high-performance liquid chromatography (HPLC). Spermine was the only amine detectable in all the samples. Read More

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January 2021

Early factors related to mortality in children treated with bi-level noninvasive ventilation and CPAP.

Pediatr Pulmonol 2021 May 11;56(5):1237-1244. Epub 2021 Jan 11.

Department of Pediatric Intensive Care, Gregorio Marañón General University Hospital, Madrid, Spain.

Objective: To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children.

Study Design: A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical data and NIV parameters during the first 12 h of admission were collected. Read More

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Systematic Review and Meta-Analysis of Thiopurine Metabolite Levels and Biochemical Remission in Autoimmune Hepatitis.

Ther Drug Monit 2020 Dec 17;Publish Ahead of Print. Epub 2020 Dec 17.

Division of Pediatric Gastroenterology, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh Department of Community and Family Medicine, All India Institute of Medical Sciences, Jodhpur Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.

Objectives: and study: The utility of measuring thiopurine metabolites (TM) to individualize therapy in autoimmune hepatitis (AIH) has not been defined, and the evidence regarding its use in clinical practice is heterogeneous. This systematic review and meta-analysis aimed to compare the mean concentration of TM between patients in biochemical remission and those not in remission.

Methods: A systematic literature search was conducted using PubMed, Scopus, the Cochrane Library, and Google Scholar for keywords related to TM and AIH. Read More

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December 2020

Postoperative Nomogram for Predicting Cancer-Specific and Overall Survival among Patients with Medullary Thyroid Cancer.

Int J Endocrinol 2020 22;2020:8888677. Epub 2020 Nov 22.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.

Background: Medullary thyroid carcinoma (MTC) accounts for 1%-2% of thyroid cancer in the United States based on the latest Surveillance, Epidemiology, and End Results (SEER) data, and this study aimed to construct a comprehensive predictive nomogram based on various clinical variables in MTC patients who underwent total thyroidectomy and neck lymph nodes dissection.

Methods: Data regarding 1,237 MTC patients who underwent total thyroidectomy and neck lymph nodes dissection from 2004 to 2015 were obtained from the SEER database. Univariate and multivariate Cox regression analyses were used to screen for meaningful independent predictors. Read More

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November 2020

The comparison of analytical performances of Mindray CL-1000i and Beckman Coulter Access II Troponin I methods in the light of recent guidelines and the quality requirements.

Ann Transl Med 2020 Oct;8(19):1237

Department of Medical Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.

Background: The results of cardiac troponin I (cTnI) methods used in the diagnosis of acute myocardial infarction (AMI) are highly variable. In this study, it was aimed to compare the analytical performance of the Mindray CL-series TnI method with the Beckman Coulter-Access II AccuTnI+3 method.

Methods: Analytical performance and method comparison experiments for cTnI measurement with Mindray CL-1000i and Beckman Coulter-Access II instruments were with the Clinical and Laboratory Standards Institute (CLSI) documents EP15-A3 and EP9-A3. Read More

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October 2020

Opioid-Related Education Provided by Continuing Education Divisions at US Pharmacy Schools.

Am J Pharm Educ 2020 10;84(10):ajpe8001

The University of Texas at Austin College of Pharmacy, Austin, Texas.

To quantify the number and type of new opioid-related continuing pharmacy education (CPE) activities offered by continuing education divisions (CEDs) at US schools and colleges of pharmacy from 2015 through 2018, and to determine the number of pharmacists who completed opioid-related CPE activities. Data was derived from the database of CPE activities maintained by the Accreditation Council for Pharmacy Education (ACPE), which is the sole accreditation agency for all providers of CPE, including pharmacy schools. Data were filtered to include only pharmacy school CPE providers. Read More

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October 2020

[Survival time and related factors of antiretroviral therapy among HIV/AIDS patients in Liangshan Prefecture, during 2005-2015].

Zhonghua Yu Fang Yi Xue Za Zhi 2020 Nov;54(11):1237-1242

National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China.

To analyze the survival time and to explore the releated factors of antiretroviral therapy among HIV/AIDS patients in LiangShan Prefecture, Sichuan Province for reduction of AIDS death rate. The retrospective research method was used to collect relevant information from the Management Database of Antiviral Treatment from the National AIDS Comprehensive Prevention Information System. The Kaplan-Meier method was used to describe the survival distribution and to analyze the survival time by single factor and the model of Cox proportional riskanalysis was performed to analyze the survival time of HARRT by multi-factors analysis. Read More

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November 2020

Clinical phenotypes of extrapulmonary sarcoidosis: an analysis of a French, multi-ethnic, multicentre cohort.

Eur Respir J 2021 Apr 1;57(4). Epub 2021 Apr 1.

Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Lupus et Syndrome des Anticorps Antiphospholipides, Centre National de Référence Histiocytoses, Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Paris, France

Sarcoidosis is a rare disease of unknown cause with wide heterogeneity in clinical features and outcomes. We aimed to explore sarcoidosis phenotypes and their clinical relevance with particular attention to extrapulmonary subgroups.The Epidemiology of Sarcoidosis (EpiSarc) study is a French retrospective multicentre study. Read More

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Study on dosage range evaluation opioid analgesic for breakthrough pain in cancer patients: a retrospective study.

Ann Palliat Med 2021 Feb 24;10(2):1237-1243. Epub 2020 Sep 24.

Palliative Care and Relieved Pain Installation, Dr. Soetomo Hospital, Surabaya, East Java, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.

Background: Breakthrough pain is an exacerbation of pain occurring in patients with chronic pain who receive opioid therapy every day. Breakthrough pain has not been routinely recognized, evaluated and treated. This study aimed to analyze the utilization of opiates analgesics, including dose regimentation, frequency of use, and the actual adverse effects in cancer patients with breakthrough pain. Read More

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February 2021

The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants.

Pediatr Res 2021 Mar 10;89(4):869-877. Epub 2020 Oct 10.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Louis University, St. Louis, MO, USA.

Background: Previous studies describe a short-term decrease in cerebral oxygen saturation (StO2) after intraventricular hemorrhage (IVH) in premature infants; little is known about long-term implications.

Methods: Infants born <30 weeks gestational age (GA) were included. Clinical characteristics, hemoglobin measurements, the highest grade of IVH, and white matter injury (WMI) were noted. Read More

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Association Between Visceral Adipose Tissue and Estradiol with Bone Health among Obese Women with Metabolic Syndrome.

Pak J Biol Sci 2020 Jan;23(10):1237-1244

Background And Objective: Visceral Adipose Tissue (VAT) which is associated with a higher risk of Metabolic Syndrome (MS) shows adverse effects on bone health. Moreover, MS is associated with high concentrations of serum estradiol (E2), which is essential for bone, as it inhibits bone resorption. This study aimed to investigate the impact of visceral fat and serum E2 levels on bone health markers (vitamin D, C-terminal peptide, Ca and BMD) in obese women with and without MS. Read More

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January 2020

Single-Step Genomic Evaluation for Meat Quality Traits, Sensory Characteristics, and Fatty-Acid Composition in Duroc Pigs.

Genes (Basel) 2020 09 9;11(9). Epub 2020 Sep 9.

Department of Animal Science and Technology, Sunchon National University, Suncheon 57922, Korea.

Meat quality and carcass characteristics have gained the attention of breeders due to their increasing economic value. Thus, this study investigated the genomic prediction efficiencies of genomic best linear unbiased prediction (GBLUP) and single-step GBLUP (ssGBLUP) for traits associated with meat quality, sensory characteristics, and fatty-acid composition. A total of 1237 Duroc finishing pigs with 654 individuals genotyped using the Illumina Porcine SNP 60k marker panel were used in this study. Read More

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September 2020

Efficacy of Endoactivator, CanalBrush, and passive ultrasonic irrigation in the removal of calcium hydroxide paste with iodoform and p-chlorophenol from root canals.

Niger J Clin Pract 2020 Sep;23(9):1237-1242

Department of Endodontics, Faculty of Dentistry, Marmara University, Istanbul, Turkey.

Aims: We evaluated and compared EndoActivator, CanalBrush, and passive ultrasonic irrigation (PUI) in the removal of calcium hydroxide and calcium hydroxide with iodoform and p-chlorophenol paste (Calcipast Forte) from artificial standardized grooves in the apical third of root canals.

Materials And Methods: A total of 34 mandibular premolars were prepared and then split longitudinally. A standardized groove was prepared in the apical part of both segments. Read More

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September 2020

Comparison of the Clinical Outcomes Between Isoperistaltic and Antiperistaltic Anastomoses After Laparoscopic Distal Gastrectomy for Patients With Gastric Cancer.

Front Oncol 2020 31;10:1237. Epub 2020 Jul 31.

Department of Surgery, Korea University College of Medicine, Seoul, South Korea.

No consensus exists regarding the superiority of either of the two types of gastrointestinal anastomosis, which are isoperistaltic and antiperistaltic. This study aimed to compare the clinical outcomes between isoperistaltic and antiperistaltic anastomoses after total laparoscopic distal gastrectomy (TLDG) in patients with gastric cancer. We retrospectively reviewed the medical records of patients with gastric cancer who underwent TLDG with Billroth II anastomosis between January 2014 and December 2018. Read More

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Dental Health Services Response to COVID-19 in Norway.

Int J Environ Res Public Health 2020 08 12;17(16). Epub 2020 Aug 12.

Oral Health Centre of Expertise in Eastern Norway, Sørkedalsveien 10A, 0369 Oslo, Norway.

We aimed to investigate the management of urgent dental care, the perception of risk and workplace preparedness among dental staff in Norway during the COVID-19 pandemic. An electronic questionnaire regarding the strictest confinement period in Norway (13 March-17 April 2020) was distributed to dental staff. Among the 1237 respondents, 727 (59%) treated patients, of whom 170 (14%) worked in clinics designated to treat patients suspected or confirmed to have COVID-19. Read More

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