249 results match your criteria topically minimum


Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel for the prevention of heartworm disease in cats.

Parasite 2021 2;28:30. Epub 2021 Apr 2.

College of Veterinary Medicine, Cornell University, Ithaca, 14850 NY, USA.

NexGard Combo is a novel topical endectoparasiticide formulation for cats combining the insecticide/acaricide esafoxolaner, the nematodicide eprinomectin and the cestodicide praziquantel. The efficacy of this novel formulation for the prevention of heartworm disease in cats was tested in two experimental studies using an induced infection model and a randomized, blinded, placebo-controlled study design, and two USA isolates of Dirofilaria immitis. In each study, 20 naïve cats were each inoculated sub-cutaneously with 100 third-stage larvae of D. Read More

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Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Echinococcus multilocularis infections in cats.

Parasite 2021 2;28:29. Epub 2021 Apr 2.

Boehringer-Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, France.

NexGard Combo, a novel topical endectoparasiticide formulation for cats combining esafoxolaner, eprinomectin and praziquantel, for the treatment of internal and external parasite infestations, including arthropods, nematodes and cestodes, was tested for efficacy against induced infections of Echinococcus multilocularis in cats, in two experimental studies. The two studies were performed in the United States with the same E. multilocularis isolate sourced locally. Read More

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Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Amblyomma americanum in cats.

Parasite 2021 2;28:25. Epub 2021 Apr 2.

Boehringer-Ingelheim Animal Health, 29 avenue Tony Garnier, 69007 Lyon, France.

Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard Combo, a novel topical endectoparasiticide product for cats. The efficacy of this novel formulation was assessed in two experimental studies against induced infestations with Amblyomma americanum, a tick species of major importance, highly prevalent in a large southeastern quarter of the United States. In each study, 10 cats were randomly allocated to a placebo control group and 10 cats to a novel formulation treated group. Read More

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Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Rhipicephalus sanguineus in cats.

Parasite 2021 2;28:24. Epub 2021 Apr 2.

Clinvet International (Pty) Ltd., P.O. Box 11186, Universitas, Bloemfontein 9321, Republic of South Africa.

Esafoxolaner is a purified enantiomer of afoxolaner with insecticidal and acaricidal properties. It is combined with eprinomectin and praziquantel in a novel topical endectoparasiticide formulation for cats. The efficacy of this novel formulation was assessed in an experimental study against induced infestation of Rhipicephalus sanguineus ticks. Read More

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Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.

Cochrane Database Syst Rev 2021 03 23;3:CD013512. Epub 2021 Mar 23.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Keratoconus is the most common corneal dystrophy. It can cause loss of uncorrected and best-corrected visual acuity through ectasia (thinning) of the central or paracentral cornea, irregular corneal scarring, or corneal perforation. Disease onset usually occurs in the second to fourth decade of life, periods of peak educational attainment or career development. Read More

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Characterization of Ciprofloxacin Resistance Levels: Implications for Ototopical Therapy.

Otol Neurotol 2021 08;42(7):e887-e893

Dartmouth-Hitchcock Medical Center, Lebanon.

Hypothesis: Ciprofloxacin-resistant pathogens are inhibited by high concentrations of ciprofloxacin found in commercially-available ototopical solutions.

Background: Ciprofloxacin-resistant pathogens in otitis media are currently treated with ototopical ciprofloxacin suspensions. This is done irrespective of laboratory-reported ciprofloxacin susceptibility, under the assumption that the high concentration of ciprofloxacin applied topically is sufficient to overcome antimicrobial resistance. Read More

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Synthesis, Characterization, Antibacterial and Wound Healing Efficacy of Silver Nanoparticles From .

Front Microbiol 2021 19;12:611560. Epub 2021 Feb 19.

Plant Transformation and Tissue Culture, Temasek Life Sciences Laboratory, Singapore, Singapore.

Bacteria are the causative agents of numerous diseases. Ever increasing number of bacterial infections has generated the need to find new antibiotic materials and new ways to combat bacterial infections. Our study investigated (AI) as an alternate source of antibiotic compounds. Read More

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February 2021

Evaluation of local bioavailability of metronidazole from topical formulations using dermal microdialysis: Preliminary study in a Yucatan mini-pig model.

Eur J Pharm Sci 2021 Apr 1;159:105741. Epub 2021 Feb 1.

Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA. Electronic address:

Dermal microdialysis (dMD) can measure the rate and extent to which a topically administered active pharmaceutical ingredient (API) becomes available in the dermis. Using multiple test-sites on the same subject, and replicate probes at each test-site, it is feasible to compare the cutaneous pharmacokinetics of an API from different topical dermatological drug products in parallel on the same subject with this technique. This study design would help to reduce variability. Read More

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Effectiveness of Aqueous Extract of Marine Baitworm Idris, Hutchings and Arshad, 2014 (Annelida, Polychaeta), on Acute Wound Healing Using Sprague Dawley Rats.

Evid Based Complement Alternat Med 2020 25;2020:1408926. Epub 2020 Nov 25.

Cell Signaling and Biotechnology Research Group (CeSBTech), Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.

Wound healing is a well-coordinated process that restores skin integrity upon injury. However, some wound treatment poses harmful effects on the skin, which delay the normal wound healing process. , a marine baitworm or polychaete, represents unique ability to regenerate posterior segment after injury, which may be beneficial in the wound healing treatment. Read More

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November 2020

Rezafungin-Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins.

J Fungi (Basel) 2020 Nov 1;6(4). Epub 2020 Nov 1.

Laboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.P. 3000 Santa Fe, Argentina.

Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages over the already approved by the Food and Drug Administration (FDA) echinocandins as it has better tissue penetration, better pharmacokinetic/phamacodynamic (PK/PD) pharmacometrics, and a good safety profile. Read More

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November 2020

Efficacy of a topical combination of eprinomectin, praziquantel, fipronil and (S)-methoprene against developing and adult lungworms (Nematoda, Crenosomatidae) in cats.

Vet Parasitol X 2020 Dec 18;4:100032. Epub 2020 Sep 18.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany.

The efficacy of the eprinomectin, praziquantel, fipronil and (S)-methoprene combination parasiticide Broadline® (Boehringer Ingelheim Animal Health) was evaluated against developing larval and adult stages of , a metastrongyloid pulmonary nematode which is reported to parasitize domestic cats in southern Europe with increasing frequency. Twenty four purpose-bred cats were experimentally infected with 100 third-stage larvae each and randomly allocated to either remain untreated (control) or to be treated with the combination product when were developing larval (6 days post inoculation, dpi) or adult nematodes (28 dpi) (eight cats per group). Treatments were administered topically at the minimum label dose of 0. Read More

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December 2020

Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment.

Front Microbiol 2020 26;11:2053. Epub 2020 Aug 26.

Department of Cosmetic Science, Providence University, Taichung, Taiwan.

is the most common cause of fungal infection. The emergence of drug resistance leads to the need for novel antifungal agents. We aimed to design naphthofuranquinone analogs to treat drug-resistant for topical application on cutaneous candidiasis. Read More

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Efficacy of Broadline® in cats against induced infections with developing fourth-stage larval and adult hookworms.

Vet Parasitol X 2020 May 11;3:100025. Epub 2020 May 11.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.

hookworms parasitize dogs and cats in subtropical and tropical South East Asia and Pacific region, the Arab Peninsula, southern Africa and South America but cause patent infections in humans too. To evaluate the efficacy of Broadline®, a combination product comprising eprinomectin, fipronil, (S)-methoprene and praziquantel, against developing fourth-larval stage (L4) and adult in cats, a blinded, induced infection study was conducted. Following oral inoculation of 24 purpose bred cats with ˜300 infectious larvae each, cats were allocated to one of three groups of eight animals, each which served either as untreated controls or received Broadline® (once topically at the minimum label dose of 0. Read More

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Presbyopia Treatment With Eye Drops: An Eight Year Retrospective Study.

Transl Vis Sci Technol 2020 06 23;9(7):25. Epub 2020 Jun 23.

Pharmacology Unit, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires, Argentina.

Purpose: The purpose of this study was to evaluate the safety and efficacy across time, of patients topically treated with Benozzi's method for presbyopia.

Methods: A nonrandomized case series retrospective study was developed, including patients with emmetropia with binocular uncorrected distance visual acuity (UDVA) of 25/20 or better, and with uncorrected near visual acuity (UNVA) at least Jaeger 2 or worse. The study was set in Buenos Aires, Argentina, from January 2011 to June 2018, with at least 1-year follow-up. Read More

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Descemet Stripping Only Supplemented With Topical Ripasudil for Fuchs Endothelial Dystrophy 12-Month Outcomes of the Sydney Eye Hospital Study.

Cornea 2021 Mar;40(3):320-326

Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Sydney, Australia.

Purpose: To report early safety and efficacy of Descemet stripping only (DSO) supplemented with ripasudil.

Methods: A pre-post clinical trial with a historical control group for time to heal and cell count parameters. The study received ethics approval and was conducted with oversight of a data safety monitoring board. Read More

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Topical and oral minoxidil for hair disorders in pediatric patients: What do we know so far?

Dermatol Ther 2020 11 14;33(6):e13950. Epub 2020 Jul 14.

Department of Dermatology, São Paulo State University-UNESP, Botucatu, Brazil.

Minoxidil is a strong arterial vasodilator, first introduced as an antihypertensive medication. In dermatology, topical minoxidil (TMX) has been used for many types of alopecia. TMX is not FDA-approved in patients under 18 years old and there are no guidelines for its pediatric use. Read More

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November 2020

Preparation and in vitro-in vivo evaluation of novel ocular nanomicelle formulation of thymol based on glycyrrhizin.

Colloids Surf B Biointerfaces 2020 Oct 30;194:111157. Epub 2020 May 30.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

The development of an efficient ocular drug delivery system is helpful in improving the ocular diffusion of topically delivered drugs as well as enhancing drugs therapeutic efficacy. The objective of this study was to explore the potential of self-assembled nanomicelles based on glycyrrhizin in ocular topical applications. In brief, a dipotassium glycyrrhizinate (DG)-based nanomicelle ophthalmic solution encapsulating thymol (DG-THY) was developed using a simple thin-film dispersion method. Read More

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October 2020

Topical delivery of Tacrolimus using liposome containing gel: An emerging and synergistic approach in management of psoriasis.

Med Hypotheses 2020 Sep 15;142:109838. Epub 2020 May 15.

Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201313, India. Electronic address:

Psoriasis is a chronic relapsing inflammatory and hyperproliferative skin disease affecting quality of life. It affects an estimated 8 million Americans and more than 125 million people worldwide. The estimated cost to treat psoriasis in USA is over 13 billion US dollars per year. Read More

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September 2020

Safety and efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment and control of naturally occurring flea infestations in cats presented as veterinary patients in Australia.

Parasit Vectors 2020 May 6;13(1):227. Epub 2020 May 6.

Zoetis, Level 6, 5 Rider Boulevard, Rhodes, NSW, 2138, Australia.

Background: The safety and efficacy of a new spot-on formulation of selamectin plus sarolaner were evaluated for the treatment and control of natural flea infestations on cats in two non-randomised, multi-centre clinical trials conducted in 8 different locations in Queensland, Australia.

Methods: One hundred and four cats from 65 different households were enrolled across the two studies. Demographic characteristics of cats in the two studies were similar. Read More

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Preparation, and Assessment of Antidermatophyte Activity of Miconazole-Urea Water-Soluble Film.

Front Microbiol 2020 3;11:385. Epub 2020 Apr 3.

Department of Pharmaceutical Technology, Menoufia University, Shebeen El-Kom, Egypt.

Cutaneous mycoses, particularly tinea pedis caused by , are commonly known infections in humans. They are still considered as a major public health problem worldwide affecting the quality of life due to prolonged period of treatment and development of drug resistance, which leads to recurrence of infections. The objective of our study was to assess the effectiveness of miconazole in the presence and absence of urea, as a penetration enhancer, against and to formulate both of them in a water-soluble film to be applied topically for the purpose of treating tinea pedis caused by this fungus. Read More

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Sustained-release voriconazole-thermogel for subconjunctival injection in horses: ocular toxicity and in-vivo studies.

BMC Vet Res 2020 Apr 16;16(1):115. Epub 2020 Apr 16.

J. T. Vaughan Large Animal Teaching Hospital, Auburn University, Auburn, AL, USA.

Background: Keratomycosis is a relatively common, sight threatening condition in horses, where treatment is often prolonged and costly. Subconjunctival (SCo) injections offer less resistance to drug diffusion than the topical route, resulting in better penetration to the ocular anterior segment. Voriconazole, a second generation triazole antifungal, is effective against common fungal organisms causing keratomycosis. Read More

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Efficacy of Broadline® in cats against induced infections with developing fourth-stage larval and adult Ancylostoma ceylanicum hookworms.

Vet Parasitol 2020 11;277S:100025. Epub 2020 May 11.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.

Ancylostomaceylanicum hookworms parasitize dogs and cats in subtropical and tropical South East Asia and Pacific region, the Arab Peninsula, southern Africa and South America but cause patent infections in humans too. To evaluate the efficacy of Broadline®, a combination product comprising eprinomectin, fipronil, (S)-methoprene and praziquantel, against developing fourth-larval stage (L4) and adult A. ceylanicum in cats, a blinded, induced infection study was conducted. Read More

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Efficacy of a topical combination of eprinomectin, praziquantel, fipronil and (S)-methoprene against developing and adult Troglostrongylus brevior lungworms (Nematoda, Crenosomatidae) in cats.

Vet Parasitol 2020 18;277S:100032. Epub 2020 Sep 18.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany.

The efficacy of the eprinomectin, praziquantel, fipronil and (S)-methoprene combination parasiticide Broadline® (Boehringer Ingelheim Animal Health) was evaluated against developing larval and adult stages of Troglostrongylus brevior, a metastrongyloid pulmonary nematode which is reported to parasitize domestic cats in southern Europe with increasing frequency. Twenty four purpose-bred cats were experimentally infected with 100 third-stage T. brevior larvae each and randomly allocated to either remain untreated (control) or to be treated with the combination product when T. Read More

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September 2020

Coenzyme Q From Exhibits Drug-Resistant Bacteria Eradication and Keratinocyte Inflammation Mitigation to Ameliorate Infected Atopic Dermatitis in Mouse.

Front Pharmacol 2019 3;10:1445. Epub 2019 Dec 3.

Department of Cosmetic Science, Providence University, Taichung, Taiwan.

Atopic dermatitis (AD) is an inflammatory skin disease that is usually accompanied by infection due to cutaneous barrier-function damage. Benzenoid compounds from are known to exhibit antibacterial and anti-inflammatory activities. This study sought to investigate the potential of benzenoids for treating bacteria-infected AD. Read More

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December 2019

Comparative efficacy of topical treatments with Revolution Plus (selamectin and sarolaner) and Bravecto for Cats (fluralaner) against Ixodes scapularis ticks on cats.

Vet Parasitol 2019 Jun 3;270 Suppl 1:S58-S63. Epub 2019 Jun 3.

Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI, 49007, USA.

The efficacy of three consecutive monthly treatments with a novel topical product (Revolution Plus/Stronghold Plus, Zoetis) containing selamectin in combination with the isoxazoline, sarolaner, was compared with that of another topical isoxazoline, fluralaner [Bravecto (fluralaner topical solution) for Cats, Merck] against Ixodes scapularis ticks on cats. Twenty-four cats were ranked by pre-treatment tick counts to form groups of three and were randomly allocated to be treated with placebo, the minimum label dosage of Revolution Plus (6 mg/kg selamectin plus 1 mg/kg sarolaner) or the minimum label dosage of Bravecto for Cats (40 mg/kg fluralaner) within the groups. On Days 0, 30, and 60, each cat in the placebo and Revolution Plus-treated groups was treated topically, whereas cats in the Bravecto for Cats-treated group were treated topically once on Day 0 with fluralaner and, subsequently, these animals were treated with the placebo on Days 30 and 60 to maintain masking. Read More

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Effects of copaiba oil on dermonecrosis induced by venom.

J Venom Anim Toxins Incl Trop Dis 2019 25;25:e149318. Epub 2019 Apr 25.

Laboratory of Pharmacology; Department of Pharmacy and Pharmaceutical Administration; School of Pharmacy; Fluminense Federal University; Niterói - RJ, Brazil.

Background: Accidents caused by spiders of the genus constitute an important public health problem in Brazil. The venom of induces dermonecrosis at the bite site and systemic disease in severe cases. Traditional medicine based on plant-derived products has been proven to reduce the local effects of envenomation. Read More

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Efficacy and safety of a new topical formulation containing selamectin and sarolaner in the prevention of heartworm disease and the treatment of roundworm infection in cats presented as veterinary patients in Japan.

Vet Parasitol 2019 Jun 8;270 Suppl 1:S38-S44. Epub 2019 Apr 8.

Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI, 49007, USA.

The efficacy and safety of a new topical formulation containing selamectin plus sarolaner (Revolution® Plus / Stronghold® Plus, Zoetis) was evaluated for the prevention of heartworm (Dirofilaria immitis) disease and the treatment of roundworm infection in cats enrolled as veterinary patients in two field studies conducted in Japan. In the heartworm field study, 91 cats negative for D. immitis antigen and anti-D. Read More

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The Antimicrobial and Wound Healing Potential of Extracted Oil from Tunisia.

Evid Based Complement Alternat Med 2019 14;2019:9148782. Epub 2019 Apr 14.

Unité de Physiologie des Systèmes de Régulations et des Adaptations, Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunisia.

Introduction: (OFI) is used in traditional medicine pharmacopeia for its richness in natural bioactive compounds. It has been proven to be effective in the improvement of the healing of laser-induced skin burns. The aim of the present study was to investigate the wound healing effect of OFI extracted oil on full-thickness skin wound. Read More

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Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs.

BMC Microbiol 2019 04 25;19(1):81. Epub 2019 Apr 25.

Department of Clinical Sciences and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.

Background: Concern exists that frequent use of topically-applied fusidic acid (FA) and chlorhexidine (CHX) for canine pyoderma is driving clinically relevant resistance, despite rare description of FA and CHX genetic resistance determinants in canine-derived staphylococci. This study aimed to determine minimum inhibitory concentrations (MICs) and investigate presence of putative resistance determinants for FA and CHX in canine-derived methicillin-resistant (MR) and -susceptible (MS) staphylococci. Plasmid-mediated resistance genes (fusB, fusC, fusD, qacA/B, smr; PCR) and MICs (agar dilution) of FA and CHX were investigated in 578 staphylococci (50 MR S. Read More

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Topical application of povidone-iodine/dimethylsulfoxide ophthalmic gel preparation in Dutch-Belted rabbits.

Cutan Ocul Toxicol 2019 Sep 22;38(3):221-226. Epub 2019 Mar 22.

a Veloce BioPharma LLC , Fort Lauderdale , FL , USA.

To determine the ocular and systemic toxicity of a novel, topically applied ophthalmic gel preparation of povidone-iodine (PVP-I) and dimethylsulfoxide (DMSO) in Dutch-Belted rabbits. Rabbits were administered doses of the test material or control by ocular instillation four times/eye/day, 7 d/week, for a minimum of 14 consecutive days. Dosing consisted of instillation of 50 µl of the appropriate test material solution or control material (saline) into each eye of the rabbit. Read More

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September 2019