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Clothes4all: A Novel Resource for Studying and Improving Web Accessibility.

Stud Health Technol Inform 2021 Jun;282:201-209

Webstep AS (webstep.no).

We present a novel and versatile online resource named Clothes4all which is a website, web application, and tool likewise, and which can be used to study various aspects of web accessibility. The article elaborates on the tool's development, its features and possibilities, as well as use and potential methodology. Clothes4all mimics a web shop for clothes and consists as such of a set of coherent web pages that can be freely used, studied, and extended as desired, in particular aiming at user trials. Read More

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Development and evaluation of an online, patient-driven, family outreach intervention to facilitate sharing of genetic risk information in families with Lynch syndrome.

J Med Genet 2021 May 18. Epub 2021 May 18.

Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Identifying at-risk relatives of individuals with genetic conditions facilitates 'cascade' genetic testing and cancer prevention. Although current standards of care give mutation-positive (index) patients the responsibility of sharing genetic risk information with relatives, the communication is suboptimal, limited largely to close relatives. We developed FamilyCONNECT, a provider-mediated, patient-navigated online tool to facilitate family outreach, and assessed its feasibility, usability and acceptability. Read More

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Sequence2Script: A Web-Based Tool for Translation of Pharmacogenetic Data Into Evidence-Based Prescribing Recommendations.

Front Pharmacol 2021 18;12:636650. Epub 2021 Mar 18.

Ushiosoft Corporation, Calgary, AB, Canada.

Pharmacogenomic (PGx) testing has emerged as an effective strategy for informing drug selection and dosing. This has led to an increase in the use of PGx testing in the clinic and has catalyzed the emergence of a burgeoning commercial PGx testing industry. However, not all PGx tests are equivalent in their approach to translating testing results into prescribing recommendations, due to an absence of regulatory standards. Read More

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Blood donation support application: contributions from experts on the tool's functionality.

Cien Saude Colet 2021 Feb 24;26(2):493-503. Epub 2020 Apr 24.

Curso de Graduação em Medicina, Unifor. Fortaleza CE Brasil.

Blood donation is a social practice that helps treat diseases and maintain public health. The DoeSangue application was designed and developed to support donor recruitment and loyalty, strengthening health promotion and social engagement. We aimed to assess the DoeSangue application from the perspective of hematology and hemotherapy experts. Read More

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February 2021

Combined Use of Color Doppler Ultrasound and Contrast-Enhanced Ultrasound in the Intraoperative Armamentarium for Arteriovenous Malformation Surgery.

World Neurosurg 2021 Mar 5;147:150-156. Epub 2021 Jan 5.

Department of Neurosurgery, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy; Institute of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy.

Background: Safety and efficacy in surgical treatment of cerebral arteriovenous malformations (AVMs) are dictated by thorough understanding of angioarchitectural features, intraoperative identification of feeding vessels, and appreciation of surrounding eloquent areas. Our aim was to describe the preliminary results of combined application of color Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in a consecutive surgical series of AVM. We pointed out the tool's efficacy in distinguishing feeding from bystander vessels and in identifying pattern of venous drainage. Read More

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VISTA: VIsual Semantic Tissue Analysis for pancreatic disease quantification in murine cohorts.

Sci Rep 2020 12 1;10(1):20904. Epub 2020 Dec 1.

Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine (OCSSB), Portland, OR, USA.

Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone to misinterpretation and investigator bias. We developed an automated semantic segmentation tool utilizing deep learning for rapid and objective quantification of histologic features relying solely on hematoxylin and eosin stained pancreatic tissue sections. Read More

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December 2020

Automatized analysis of children's exposure to child-directed speech in reschool settings: Validation and application.

PLoS One 2020 25;15(11):e0242511. Epub 2020 Nov 25.

Crane Center for Early Childhood Research and Policy, The Ohio State University, Columbus, OH, United States of America.

The present study explored whether a tool for automatic detection and recognition of interactions and child-directed speech (CDS) in preschool classrooms could be developed, validated, and applied to non-coded video recordings representing children's classroom experiences. Using first-person video recordings collected by 13 preschool children during a morning in their classrooms, we extracted high-level audiovisual features from recordings using automatic speech recognition and computer vision services from a cloud computing provider. Using manual coding for interactions and transcriptions of CDS as reference, we trained and tested supervised classifiers and linear mappings to measure five variables of interest. Read More

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January 2021

Patient and Provider Perspectives on a Novel Mobile Health Intervention for Low-Income Pregnant Women With Gestational or Type 2 Diabetes Mellitus.

J Diabetes Sci Technol 2020 Jul 5:1932296820937347. Epub 2020 Jul 5.

Departments of Obstetrics and Gynecology and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Management of diabetes mellitus (DM) during pregnancy is burdensome given the intensity of required patient engagement and skills, especially for women with greater social disadvantage. Mobile health (mHealth) technology is a promising avenue for DM health promotion, but few evidence-based mHealth tools exist for pregnancy. Thus, we designed a theory-driven mHealth tool called SweetMama, and planned a priori to gather usability and acceptability feedback from patients and providers to ensure a user-centered design. Read More

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Fostering Responsible Innovation in Health: An Evidence-Informed Assessment Tool for Innovation Stakeholders.

Int J Health Policy Manag 2021 Mar 14;10(4):181-191. Epub 2021 Mar 14.

Public Health Research Institute, University of Montreal, Montreal, QC, Canada.

Background: Responsible innovation in health (RIH) emphasizes the importance of developing technologies that are responsive to system-level challenges and support equitable and sustainable healthcare. To help decision-makers identify whether an innovation fulfills RIH requirements, we developed and validated an evidence-informed assessment tool comprised of 4 inclusion and exclusion criteria, 9 assessment attributes and a scoring system.

Methods: We conducted an inter-rater reliability assessment to establish the extent to which 2 raters agree when applying the RIH Tool to a diversified sample of health innovations (n=25). Read More

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PEMA: a flexible Pipeline for Environmental DNA Metabarcoding Analysis of the 16S/18S ribosomal RNA, ITS, and COI marker genes.

Gigascience 2020 03;9(3)

Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Hellenic Centre for Marine Research (HCMR), Former U.S. Base of Gournes P.O. Box 2214, 71003, Heraklion, Crete, Greece.

Background: Environmental DNA and metabarcoding allow the identification of a mixture of species and launch a new era in bio- and eco-assessment. Many steps are required to obtain taxonomically assigned matrices from raw data. For most of these, a plethora of tools are available; each tool's execution parameters need to be tailored to reflect each experiment's idiosyncrasy. Read More

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[ADI-R and ADOS and the differential diagnosis of autism spectrum disorders: Interests, limits and openings].

Encephale 2019 Nov 5;45(5):441-448. Epub 2019 Sep 5.

Laboratoire INTERPSY EA 4432, université de Lorraine, 23, boulevard Albert-1er, BP 13397, 54015 Nancy cedex, France.

Introduction: Current developments in international public health are leading qualified authorities to release clinical practice guidelines for Autism Spectrum Disorders (ASD) assessment and diagnosis. Such documents incorporate procedures that rely on the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) which are considered to be the "gold standard" assessment measures in the evaluation of ASD. Although these tools do prove their effectiveness in the evaluation of autistic symptomatology, they nevertheless stumble whenever the situation becomes more complex and reveal differential diagnostic issues in infantile and adult autism cases. Read More

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November 2019

A systematic assessment of current genome-scale metabolic reconstruction tools.

Genome Biol 2019 08 7;20(1):158. Epub 2019 Aug 7.

Systems Bioinformatics, AIMMS, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: Several genome-scale metabolic reconstruction software platforms have been developed and are being continuously updated. These tools have been widely applied to reconstruct metabolic models for hundreds of microorganisms ranging from important human pathogens to species of industrial relevance. However, these platforms, as yet, have not been systematically evaluated with respect to software quality, best potential uses and intrinsic capacity to generate high-quality, genome-scale metabolic models. Read More

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Sentiment Analysis for Words and Fiction Characters From the Perspective of Computational (Neuro-)Poetics.

Arthur M Jacobs

Front Robot AI 2019 17;6:53. Epub 2019 Jul 17.

Department of Experimental and Neurocognitive Psychology, Freie Universität Berlin, Berlin, Germany.

Two computational studies provide different sentiment analyses for text segments (e.g., "fearful" passages) and figures (e. Read More

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Dissemination of a Web-Based Tool for Supporting Health Insurance Plan Decisions (Show Me Health Plans): Cross-Sectional Observational Study.

J Med Internet Res 2018 06 20;20(6):e209. Epub 2018 Jun 20.

Division of Public Health Sciences, Department of Surgery, Washington University in Saint Louis, St. Louis, MO, United States.

Background: The rate of uninsured people has decreased dramatically since the Affordable Care Act was passed. To make an informed decision, consumers need assistance to understand the advantages and disadvantages of health insurance plans. The Show Me Health Plans Web-based decision support tool was developed to improve the quality of health insurance selection. Read More

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A Decision Support Tool Facilitating Medicine Design for Optimal Acceptability in The Older Population.

Pharm Res 2018 May 7;35(7):136. Epub 2018 May 7.

Département Recherche et Développement Pharmaceutique, Agence Générale des Equipements et Produits de Santé (AGEPS), Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Purpose: Medicine acceptability, which is of the utmost importance for vulnerable patients' adherence, is driven by both user and product characteristics. Herein, a novel multivariate approach integrating the many aspects of acceptability is used to discriminate positively and negatively accepted medicines in the older population.

Methods: An observational study was carried out in eight hospitals and eight nursing homes to collect a large set of real-life data on medicines uses in older patients (≥65 years). Read More

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Diabetes-Related Behavior Change Knowledge Transfer to Primary Care Practitioners and Patients: Implementation and Evaluation of a Digital Health Platform.

JMIR Med Inform 2018 Apr 18;6(2):e25. Epub 2018 Apr 18.

Knowledge Intensive Computing for Healthcare Enterprises Research Group, Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.

Background: Behavioral science is now being integrated into diabetes self-management interventions. However, the challenge that presents itself is how to translate these knowledge resources during care so that primary care practitioners can use them to offer evidence-informed behavior change support and diabetes management recommendations to patients with diabetes.

Objective: The aim of this study was to develop and evaluate a computerized decision support platform called "Diabetes Web-Centric Information and Support Environment" (DWISE) that assists primary care practitioners in applying standardized behavior change strategies and clinical practice guidelines-based recommendations to an individual patient and empower the patient with the skills and knowledge required to self-manage their diabetes through planned, personalized, and pervasive behavior change strategies. Read More

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The Norwegian National Summary Care Record: a qualitative analysis of doctors' use of and trust in shared patient information.

BMC Health Serv Res 2018 04 6;18(1):252. Epub 2018 Apr 6.

Norwegian Centre for E-health Research, Siva Innovation Centre Breivika, Sykehusveien. 23, 9019, Tromsø, Norway.

Background: This paper explores Norwegian doctors' use of and experiences with a national tool for sharing core patient health information. The summary care record (SCR; the Kjernejournal in Norwegian) is the first national system for sharing patient information among the various levels and institutions of health care throughout the country. The health authorities have invested heavily in the development, implementation and deployment of this tool, and as of 2017 all Norwegian citizens have a personalised SCR. Read More

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Utility of the Hospital Admission Risk Programme diabetes risk calculator in identifying patients with type 2 diabetes at risk of unplanned hospital presentations.

Intern Med J 2018 Oct;48(10):1198-1205

Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Background: Prevention of hospitalisation is an important aspect of type 2 diabetes (T2D) management.

Aims: We retrospectively determined the utility of the Hospital Admission Risk Programme (HARP) diabetes risk calculator (HARP tool) in identifying patients with T2D more likely to have unplanned hospital presentations.

Methods: The HARP tool includes a clinical assessment score (Part A) and a psychosocial and self-management impact score (Part B), and categorises patients into low, medium, high or urgent risk of acute hospitalisation. Read More

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October 2018

Novel Methods for Environmental Assessment of Pedestrian Injury: Creation and Validation of the Inventory for Pedestrian Safety Infrastructure.

J Urban Health 2018 04;95(2):208-221

Department of Epidemiology and Biostatistics, Michigan State University College of Human Medicine, 200 East First Street, Flint, MI, 48502, USA.

Nationally, 80% of pedestrian fatalities occur in urban environments, yet the distribution of injuries across urban areas is not uniform. Identifying street-level risk factors for pedestrian injury is essential for urban planning and improvement projects, as well as targeted injury prevention efforts. However, creating and maintaining a comprehensive database of a city's traffic safety infrastructure can be cumbersome and costly. Read More

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METLIN: A Technology Platform for Identifying Knowns and Unknowns.

Anal Chem 2018 03 9;90(5):3156-3164. Epub 2018 Feb 9.

ISOtopic Solutions , Waehringerstrasse 38 , Vienna 1090 , Austria.

METLIN originated as a database to characterize known metabolites and has since expanded into a technology platform for the identification of known and unknown metabolites and other chemical entities. Through this effort it has become a comprehensive resource containing over 1 million molecules including lipids, amino acids, carbohydrates, toxins, small peptides, and natural products, among other classes. METLIN's high-resolution tandem mass spectrometry (MS/MS) database, which plays a key role in the identification process, has data generated from both reference standards and their labeled stable isotope analogues, facilitated by METLIN-guided analysis of isotope-labeled microorganisms. Read More

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Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.

ChemMedChem 2017 11 9;12(22):1828-1838. Epub 2017 Oct 9.

Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

Chemical tools have been valuable for establishing a better understanding of the relationships between metal ion dyshomeostasis, the abnormal aggregation and accumulation of amyloid-β (Aβ), and oxidative stress in Alzheimer's disease (AD). Still, very little information is available to correlate the structures of chemical tools with specific reactivities used to uncover such relationships. Recently, slight structural variations to the framework of a chemical tool were found to drastically determine the tool's reactivities toward multiple pathological facets to various extents. Read More

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November 2017

The effect of impact tool geometry and soft material covering on long bone fracture patterns in children.

Int J Legal Med 2017 Jul 2;131(4):1011-1021. Epub 2017 Feb 2.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.

Introduction: The effect of impact tool geometry and soft material covering on bone fracture patterns plays a major role in fracture patterns. However, the literature is nearly void of such studies and only general correlations between the fracture pattern and the mechanism underlying the insult were reported.

Purpose: The aim of this study is to reveal the association between the geometry of the impact tool and the presence of soft material covering on bone fracture patterns. Read More

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Adapting a weight management tool for Latina women: a usability study of the Veteran Health Administration's MOVE!23 tool.

BMC Med Inform Decis Mak 2016 10 5;16(1):128. Epub 2016 Oct 5.

Research, VA NY Harbor Healthcare System, 423 East 23rd Street, 15161N, New York, NY, 10010, USA.

Background: Obesity disproportionately affects Latina women, but few targeted, technology-assisted interventions that incorporate tailored health information exist for this population. The Veterans Health Administration (VHA) uses an online weight management tool (MOVE!23) which is publicly available, but was not designed for use in non-VHA populations.

Methods: We conducted a qualitative study to determine how interactions between the tool and other contextual elements impacted task performance when the target Latina users interacted with MOVE!23. Read More

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October 2016

Applying a Participatory Design Approach to Define Objectives and Properties of a "Data Profiling" Tool for Electronic Health Data.

AMIA Jt Summits Transl Sci Proc 2016 20;2016:60-7. Epub 2016 Jul 20.

Institute of Translational Health Sciences, University of Washington, Seattle, WA; Department of Biomedical Informatics & Medical Education, University of Washington, Seattle, WA; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA.

We applied a participatory design approach to define the objectives, characteristics, and features of a "data profiling" tool for primary care Electronic Health Data (EHD). Through three participatory design workshops, we collected input from potential tool users who had experience working with EHD. We present 15 recommended features and characteristics for the data profiling tool. Read More

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Key stakeholders' perspectives on a Web-based advance care planning tool for advanced lung disease.

J Crit Care 2015 Dec 3;30(6):1418.e7-1418.e12. Epub 2015 Sep 3.

Center for Bioethics and Health Law, University of Pittsburgh, Pittsburgh PA; Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA; Program on Ethics and Decision Making in Critical Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

Purpose: There is a paucity of scalable advance care planning strategies that achieve the diverse goals of patients, families, and clinicians. We convened key stakeholders to gain their perspectives on developing a Web-based advance care planning tool for lung disease.

Materials And Methods: We conducted semistructured interviews with 50 stakeholders: 21 patients with lung disease, 18 surrogates, and 11 clinicians. Read More

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December 2015

Do human brain areas involved in visuomotor actions show a preference for real tools over visually similar non-tools?

Neuropsychologia 2015 Oct 5;77:35-41. Epub 2015 Aug 5.

Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; Brain and Mind Institute, University of Western Ontario, London, Ontario, Canada; Department of Psychology, University of Western Ontario, London, Ontario, Canada. Electronic address:

Neuroimaging has revealed a left-lateralized network of brain areas implicated in understanding the conceptual and sensorimotor aspects of tool perception and tool use. Often this network of areas is identified by contrasting brain activity when participants view pictures of tools vs. pictures of non-tools (e. Read More

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October 2015

Development of an interpretive simulation tool for the proton radiography technique.

Rev Sci Instrum 2015 Mar;86(3):033302

Lawrence Livermore National Laboratory, Livermore, California 94551, USA.

Proton radiography is a useful diagnostic of high energy density (HED) plasmas under active theoretical and experimental development. In this paper, we describe a new simulation tool that interacts realistic laser-driven point-like proton sources with three dimensional electromagnetic fields of arbitrary strength and structure and synthesizes the associated high resolution proton radiograph. The present tool's numerical approach captures all relevant physics effects, including effects related to the formation of caustics. Read More

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Development and early application of the Scottish Community Nursing Workload Measurement Tool.

Br J Community Nurs 2015 Feb;20(2):89-92

Workload Programme Advisor, Nursing and Midwifery Workload and Workforce Planning Programme, c/o Directorate for Chief Nursing Officer, Patients, Public and Health Professions.

This article describes the development and early application of the Scottish Community Nursing Workload Measurement Tool, part of a suite of tools aiming to ensure a consistent approach to measuring nursing workload across NHS Scotland. The tool, which enables community nurses to record and report their actual workload by collecting information on six categories of activity, is now being used by all NHS boards as part of a triangulated approach. Data being generated by the tool at national level include indications that approximately 50% of band 6 district nurses' time is spent in face-to-face and non-face-to-face contact and planned sessions with patients, and that over 60% of face-to-face contacts are at 'moderate' and 'complex' levels of intervention (2012 data). Read More

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February 2015

Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis.

PLoS One 2014 31;9(12):e116037. Epub 2014 Dec 31.

Department Of Pediatric Newborn Medicine and Department of Medicine, Division of Genetics, Brigham and Women's Hospital; Harvard Medical School; Harvard Stem Cell Institute, Boston, Massachusetts, United States of America.

Human pluripotent stem (hPS) cells are a potential source of cells for medical therapy and an ideal system to study fate decisions in early development. However, hPS cells cultured in vitro exhibit a high degree of heterogeneity, presenting an obstacle to clinical translation. hPS cells grow in spatially patterned colony structures, necessitating quantitative single-cell image analysis. Read More

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October 2015

An evaluation of the performance of the Opioid Manager clinical tool in primary care: a qualitative study.

J Opioid Manag 2014 May-Jun;10(3):187-99

Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada; Department of Medicine, Division of Physiatry, University of Toronto, Toronto, Ontario, Canada; Institute for Work & Health, Toronto, Ontario, Canada.

Aims: The Opioid Manager (OM) is a point-of-care paper tool for physicians, which summarizes the Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain. To evaluate the efficacy of the OM, there is a need to better understand how physicians are using the OM, and how it is relevant to their practice.

Methods: Semistructured interviews were conducted with six family physicians in Ontario with clinical pain management experience. Read More

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September 2014