88 results match your criteria tonic irritability

Examining the influence of irritability and ADHD on domains of parenting stress.

Eur Child Adolesc Psychiatry 2021 Sep 12. Epub 2021 Sep 12.

University of Louisville, Louisville, USA.

Parents of children with ADHD typically report higher levels of parenting stress than parents of typically developing children. Children with ADHD display developmentally inappropriate levels of hyperactivity, impulsivity, and inattention. Some children with ADHD are also prone to particularly high levels of tonic irritability that may explain some of the impairments typically found in ADHD. Read More

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September 2021

Severe Perampanel Toxicity in a Pediatric Patient With Prolonged Symptoms.

J Emerg Med 2021 Aug 31. Epub 2021 Aug 31.

Division of Medical Toxicology, Department of Emergency Medicine, University of California at San Diego Medical Center, San Diego, CA.

Background: Perampanel is a new antiepileptic used to treat partial-onset seizures and generalized tonic-clonic seizures in people older than 12 years old. Perampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, with a prolonged half-life of approximately 105 hours. Few cases of significant toxicity have been reported, and effects in overdose are poorly understood. Read More

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Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial.

JAMA Netw Open 2021 Sep 1;4(9):e2123930. Epub 2021 Sep 1.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Importance: Developmental and epileptic encephalopathies (DEEs) are the most severe group of drug-resistant epilepsies. Alternatives to oral therapies are urgently needed to reduce seizures and improve developmental outcomes and comorbidities in this medically complex population.

Objective: To assess the safety and tolerability of cannabidiol (CBD) transdermal gel in children with DEEs and to evaluate seizure frequency, sleep, and quality of life. Read More

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September 2021

Therapeutic effects of traditional Thai herbal blood and wind tonic formulations for treatment of menopausal symptoms.

Explore (NY) 2021 Sep-Oct;17(5):469-474. Epub 2021 Jun 12.

Excellence Research Laboratory on Natural Products, Division of Biological Science, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Introduction: Traditional Thai herbal medicine formulations have been used as alternative therapies for menopausal symptoms due to concerns from adverse effects associated with hormone therapy. This study aimed to demonstrate the effects of traditional Thai herbal blood and wind tonic formulations used by a traditional Thai medicine doctor, Mr. Somporn Chanwanitsakul, in postmenopausal women. Read More

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A Case Series of Severe Dengue with Neurological Presentation in Children from a Colombian Hyperendemic Area.

Case Rep Med 2021 1;2021:6643738. Epub 2021 Jun 1.

Grupo de Virología, Universidad El Bosque, Bogotá, Colombia.

Dengue transmission is sustained in Colombia with increasing prevalence mainly in children. This work aimed to describe a case series of children diagnosed with dengue presenting neurological disease in Huila Province of Colombia. Eleven pediatric febrile patients confirmed for dengue disease and presenting neurological signs were studied in the University Hospital of Neiva, Huila Province. Read More

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The association of phasic irritability (aggressive outbursts) and tonic irritability (irritable mood) to depression occurrences, symptoms, and subtypes.

J Affect Disord 2021 10 11;293:9-18. Epub 2021 Jun 11.

Vanderbilt University, Nashville, Tennessee.

Background: Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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October 2021

Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Serum Anti-Thyroid Antibodies: A Case Report and Literature Review.

Am J Case Rep 2021 May 17;22:e931104. Epub 2021 May 17.

Department of Biomedical Sciences and Human Oncology, University Hospital of Bari, Bari, Italy.

BACKGROUND Anti-N methyl D-aspartate receptor encephalitis (anti-NMDArE) is a disorder in which triggers such as infectious agents or neoplastic disease can lead to an autoimmune response against the nervous system, although this disorder is usually idiopathic. Some patients with anti-NMDArE have evidence of other autoimmune alterations. Here, we present a case of non-paraneoplastic anti-NMDArE with elevation of serum anti-thyroid antibodies and a literature review of this association. Read More

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[Efficacy and tolerability of perampanel as adjunctive treatment of focal and generalized tonic-clonic epileptic seizures in children over 4 years of age].

E D Belousova

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):116-120

Veltischev Research Clinical Institute of Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russia.

The article is a short review of an observational study that proves the good efficacy and tolerability of perampanel suspension in the adjunctive treatment of epilepsy in children over 4 years of age. The study demonstrated a high level of 50% responders: 47% with focal seizures, 65% with transition of focal seizures to bilateral tonic-clonic seizures, 65% with primary generalized tonic-clonic seizures. Cessation of seizures was achieved in 12%, 19% and 55% of patients, respectively. Read More

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Differential outcomes of tonic and phasic irritability in adolescent girls.

J Child Psychol Psychiatry 2021 Mar 14. Epub 2021 Mar 14.

Department of Psychology, Stony Brook University, Stony Brook, NY, USA.

Background: Irritable mood is a transdiagnostic clinical feature that is present in multiple psychiatric disorders. Although irritability is frequently examined as a unitary construct, two dimensions of irritability, tonic (i.e. Read More

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Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients.

Orphanet J Rare Dis 2021 03 5;16(1):118. Epub 2021 Mar 5.

Mastocytosis National Expert Centre (CEREMAST), Department of Dermatology, Toulouse University Hospital, 24 Chemin de Pouvourville, 31059, Toulouse, France.

Background: Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ systems. The current study aims to assess the prevalence of MC mediator-related symptoms in a cohort of mastocytosis patients with a specific focus on neurological, psychiatric, cognitive and sexual symptoms. Read More

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Editorial: Moving From Concept to Proof in the Distinction Between Phasic and Tonic Irritability.

J Am Acad Child Adolesc Psychiatry 2021 Feb 15. Epub 2021 Feb 15.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address:

In child and adolescent psychiatry, irritability is listed as a cardinal or associated symptom in nearly every emotional, behavioral, and neurodevelopmental disorder in the DSM-5. Despite the omnipresence of irritability in distinct psychiatric disorders, its manifestation is highly heterogeneous, across and within individuals. Part of that heterogeneity has to do with its temporal dynamics. Read More

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February 2021

Levetiracetam monotherapy in children with epilepsy: Experience from a tertiary pediatric neurology center.

Epilepsy Behav 2021 03 25;116:107745. Epub 2021 Jan 25.

Department of Pediatric Neurology, Ankara University Faculty of Medicine, Ankara, Turkey. Electronic address:

Objectives: Levetiracetam (LEV) is a second-generation antiepileptic drug with high efficacy and tolerability in children and adults with epilepsy. We aimed to retrospectively assess the long-term efficacy, tolerability, and safety of LEV monotherapy in children with epilepsy.

Methods: All patients who received LEV monotherapy at the Ankara University Children Hospital between January 2010 and June 2020 were evaluated. Read More

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Levetiracetam as first-line monotherapy for Idiopathic Generalized Epilepsy in women.

Acta Neurol Scand 2021 Apr 15;143(4):407-412. Epub 2021 Jan 15.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: Levetiracetam (LEV) is effective in Idiopathic Generalized Epilepsy (IGE) and seems to be a good alternative to valproic acid in women of childbearing age. However, there is lack of approval for this indication as monotherapy. The aim of this study is to assess the efficacy of LEV as a first-line therapy in this population. Read More

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Phasic Versus Tonic Irritability: Differential Associations With Attention-Deficit/Hyperactivity Disorder Symptoms.

J Am Acad Child Adolesc Psychiatry 2021 Jan 10. Epub 2021 Jan 10.

Emotion and Development Branch, National Institute of Mental Health, Bethesda, Maryland.

Objective: Irritability is a multifaceted construct in pediatric psychopathology. It has been conceptualized as having a phasic dimension and a tonic dimension. Disruptive mood dysregulation disorder is defined by the presence of both dimensions. Read More

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January 2021

Topiramate Effectiveness as Add-on Therapy in Bulgarian Patients with Drug-resistant Epilepsy.

Folia Med (Plovdiv) 2020 Dec;62(4):712-722

Medical University of Plovdiv, Plovdiv, Bulgaria.

Introduction: There are no reliable prospective studies on the effectiveness of topiramate in Bulgarian adult patients with drug-resistant epilepsy.

Aim: The aim of the study was to conduct an open, prospective study on various aspects of topiramate (TPM) effectiveness in Bulgarian patients with drug-resistant epilepsy.

Patients And Methods: The study included patients with epilepsy who attended the Clinic of Neurology at the University Hospital in Plovdiv, Bulgaria. Read More

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December 2020

Complications and Sequelae in Patients With Congenital Microcephaly Associated With Zika Virus Infection: Two-Year Follow-Up.

J Child Neurol 2021 06 7;36(7):537-544. Epub 2021 Jan 7.

28125Universidade Federal do Rio de Janeiro, v. Pedro Calmon, Rio de Janeiro, Brazil.

Background: We aim to describe the long term follow-up of a cohort of children exposed in utero to the Zika virus.

Methods: Descriptive study of a cohort of microcephalic children due to Zika virus. Logistic regression was used to evaluate variables associated with worse prognosis epilepsy. Read More

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Irritability as a Transdiagnostic Vulnerability Trait:Current Issues and Future Directions.

Behav Ther 2020 03 27;51(2):350-364. Epub 2019 Nov 27.

Northwestern University.

In recent years, irritability has received increasing attention among mental health professionals given its transdiagnostic associations with diverse forms of psychopathology. In contrast to other emotional states and traits, however, literature addressing associations between irritability and related temperament and personality constructs is limited. In addition, those who study irritability have diverse perspectives on its neurobiological substrates. Read More

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A case report of several intraoperative convulsions while using the Narcotrend monitor: Significance and predictive use.

Medicine (Baltimore) 2019 Nov;98(47):e18004

Department of Anaesthesiology and Pain Medicine.

Introduction: Intraoperative seizures under general anesthesia are rare and our observation is the first to demonstrate a distinct electroencephalogram (EEG) pattern on the Narcotrend monitor.

Patient Concerns: We present the case of a 30-year-old man undergoing craniotomy for glioblastoma resection under general anesthesia who suffered tonic-clonic seizures captured in a specific pattern by the intraoperative EEG.

Diagnoses: Our depth of anesthesia monitor recorded, before the seizure, a widening of the beta-wave performance in a distinct "triangular-shaped" pattern. Read More

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November 2019

Traumatic Hystero-Neurasthenia in Professor Charcot's Leçons du Mardi.

J Nerv Ment Dis 2019 Sep;207(9):799-804

Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS Toulouse, France.

At the end of the 19th century, several authors became interested in the physical and psychological symptoms resulting from traumatic life events. Oppenheim presented 42 detailed clinical observations. He suggested the term "traumatic neurosis. Read More

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September 2019

Atropine toxicity caused by erroneous intranasal administration in a pediatric patient: case report.

Ann Saudi Med 2019 Jul-Aug;39(4):279-282. Epub 2019 Aug 5.

From the Department of Surgery, Division of Otorhinolaryngology-Head and Neck Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

A 28-month-old boy mistakenly received intranasal atropine sulfate instead of Otrivin (xylometazoline hydrochloride) for the treatment of adenoid hypertrophy. Later on, he came to the emergency department with anticholinergic manifestations after the administration of multiple drops. The child presented with a tonic-clonic seizure lasting for a few minutes, followed by a brief loss of consciousness, vomiting, agitation, and irritability, all of which were stabilized by a dose of intravenous lorazepam. Read More

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January 2020

Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome.

Front Behav Neurosci 2019 25;13:141. Epub 2019 Jun 25.

Ovid Therapeutics, New York, NY, United States.

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent work supports the role of γ-aminobutyric-acid (GABA), the primary inhibitory neurotransmitter in the brain, in mediating symptoms of FXS. Read More

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Heritability, stability, and prevalence of tonic and phasic irritability as indicators of disruptive mood dysregulation disorder.

J Child Psychol Psychiatry 2019 09 17;60(9):1032-1041. Epub 2019 Apr 17.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.

Background: Little is known about genetic and environmental influences on the components of disruptive mood dysregulation disorder (DMDD), tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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September 2019

Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.

Epilepsy Behav 2019 05 18;94:82-86. Epub 2019 Mar 18.

Department of Pediatrics, Hiroshima University Hospital, Japan.

Background: Perampanel (PER) is a new antiepileptic drug (AED) with a novel mechanism of action. Investigations of the efficacy and safety of PER in pediatric and adult patients have increased recently. Although the clinical usefulness and pharmacokinetics of PER have been investigated in adolescent and adult populations, similar studies have not been performed in children. Read More

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Efficacy and safety of perampanel in generalized and focal to bilateral tonic-clonic seizures: A comparative study of Asian and non-Asian populations.

Epilepsia 2019 03;60 Suppl 1:47-59

Eisai Singapore Pte. Ltd., Singapore.

Perampanel is an approved adjunctive treatment for focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures and generalized tonic-clonic (GTC) seizures. We compared efficacy and safety of perampanel vs placebo in Asian and non-Asian populations in a post hoc analysis of pooled data from 5 randomized phase 3 studies. Patients (≥12 years old) with focal + FBTC seizures received perampanel 2, 4, 8, or 12 mg or placebo; patients with GTC seizures received perampanel 8 mg or placebo (titration: 4-6 weeks; maintenance: 13 weeks). Read More

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Efficacy, safety, and tolerability of perampanel in Asian and non-Asian patients with epilepsy.

Epilepsia 2019 03;60 Suppl 1:37-46

Eisai Singapore Pte. Ltd., Singapore.

People of different ethnic or racial backgrounds may experience variations in pharmacokinetic and pharmacodynamic responses to drug therapies. Our post hoc analysis evaluated the efficacy, safety, and tolerability of perampanel in Asian and non-Asian populations with refractory focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures. This analysis pooled data from 4 randomized, placebo-controlled, phase-3 studies involving patients aged ≥12 years who have focal seizures with or without FBTC seizures. Read More

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Hypocalcemia in an 11 Year Old Child: .

Indian J Clin Biochem 2018 Oct 3;33(4):489-490. Epub 2018 Mar 3.

2Department of Pediatrics, AIIMS Jodhpur, Jodhpur, India.

Hypocalcemia is a laboratory and clinical abnormality that is observed especially in neonates and paediatric patients. Laboratory hypocalcaemia is often asymptomatic but it can manifest as central nervous system irritability, paraesthesia, tetany (i.e. Read More

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October 2018

Sulthiame add-on therapy in children with Lennox-Gastaut syndrome: A study of 44 patients.

Seizure 2018 Nov 27;62:55-58. Epub 2018 Sep 27.

Hospital de Pediatría A Fleming, Mendoza, Argentina.

Purpose: The aim of this study was to evaluate efficacy and tolerability of sulthiame as an add-on treatment in 44 patients with Lennox-Gastaut syndrome (LGS) refractory to other antiepileptic drugs and/or non-pharmacological treatment.

Methods: Patients were selected according to the following criteria: (1) age 4 years or older, (2) a diagnosis of LGS refractory to at least four previous antiepileptic drugs, alone or in combination. Neurologic examinations, brain magnetic resonance imaging, and repeated prolonged electroencephalography (EEG) or video-EEG studies were performed in all cases. Read More

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November 2018

The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review.

J Ethnopharmacol 2018 Nov 18;226:143-167. Epub 2018 Aug 18.

School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Ethnopharmacological Relevance: Atractylodes macrocephala Koidz. (called Baizhu in China) is a medicinal plant that has long been used as a tonic agent in various ethno-medical systems in East Asia, especially in China, for the treatment of gastrointestinal dysfunction, cancer, osteoporosis, obesity, and fetal irritability.

Aim Of The Review: This review aims to provide a systematic summary on the botany, traditional uses, phytochemistry, pharmacology, pharmacokinetics, and toxicology of A. Read More

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November 2018

Perampanel in routine clinical use in idiopathic generalized epilepsy: The 12-month GENERAL study.

Epilepsia 2018 09 31;59(9):1740-1752. Epub 2018 Jul 31.

University Hospital Vall d'Hebrón, Barcelona, Spain.

Objective: To analyze the effectiveness and tolerability of perampanel across different seizure types in routine clinical care of patients with idiopathic generalized epilepsy (IGE).

Methods: This multicenter, retrospective, 1-year observational study collected data from patient records at 21 specialist epilepsy units in Spain. All patients who were aged ≥12 years, prescribed perampanel before December 2016, and had a confirmed diagnosis of IGE were included. Read More

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September 2018