28,292 results match your criteria tolerance tests


Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System.

JAMA Netw Open 2021 Sep 1;4(9):e2125524. Epub 2021 Sep 1.

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, California.

Importance: As of May 2021, more than 32 million cases of COVID-19 have been confirmed in the United States, resulting in more than 615 000 deaths. Anaphylactic reactions associated with the Food and Drug Administration (FDA)-authorized mRNA COVID-19 vaccines have been reported.

Objective: To characterize the immunologic mechanisms underlying allergic reactions to these vaccines. Read More

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September 2021

Germination of small tropical seeds has distinct light quality and temperature requirements, depending on microhabitat.

Plant Biol (Stuttg) 2021 Sep 16. Epub 2021 Sep 16.

Seed Laboratory, Instituto de Pesquisas Jardim Botânico do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

The coexistence of plant species in tropical rainforests is related to specific abiotic resources, varying according to the occurrence microhabitat of each species. Light quality is the main abiotic factor influencing germination of small seeds; however, studies often do not discriminate its effect from that of light irradiance. This study compared specific requirements for seed germination of ten small-seeded species, with restricted occurrence in only one of three contrasting microhabitats: forest understorey, edge of clearings and open areas. Read More

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September 2021

Factors Associated With Gestational Diabetes Mellitus: A Cross-Sectional Study.

Cureus 2021 Aug 11;13(8):e17113. Epub 2021 Aug 11.

Obstetrics and Gynaecology, Isra University, Hyderabad, PAK.

Introduction The absence of tolerance in the levels of carbohydrates at the onset or at the time of pregnancy amongst females is known as gestational diabetes mellitus (GDM). This study is designed to determine the frequency of GDM and factors responsible for GDM to assess the actual magnitude of the outcome. Furthermore, it allows for developing strategies to minimize morbidities and improve the pregnancy outcome by early diagnosis and timely management, which can help reduce the frequency of GDM. Read More

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Follow-up on the therapeutic effects of a budesonide, azithromycin, montelukast, and acetylcysteine (BAMA) regimen in children with post-infectious bronchiolitis obliterans.

J Thorac Dis 2021 Aug;13(8):4775-4784

Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Post-infectious bronchiolitis obliterans (PIBO) is a rare, severe chronic lung disease without optimal treatment. Currently, treatment in children mainly relies on systemic corticosteroids, but long-term use of these drugs may lead to adverse reactions. This study aimed to evaluate the short-term efficacy of the budesonide, azithromycin, montelukast, and acetylcysteine (BAMA) regimen in paediatric PIBO patients and whether it can reduce systemic corticosteroid use. Read More

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Role of myeloid cell leptin signaling in the regulation of glucose metabolism.

Sci Rep 2021 Sep 15;11(1):18394. Epub 2021 Sep 15.

Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodology to determine the effect of myeloid cell-specific leptin receptor (Lepr) reconstitution and Lepr knockdown on in vivo glucose metabolism. Male mice with myeloid cell-specific Lepr reconstitution (Lyz2CreLepr) had better glycemic control as they aged compared to male mice with whole-body transcriptional blockade of Lepr (Lyz2CreLepr). Read More

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September 2021

Pharmacological blockade of neurokinin1 receptor restricts morphine-induced tolerance and hyperalgesia in the rat.

Scand J Pain 2021 Sep 16. Epub 2021 Sep 16.

Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: The most notable adverse side effects of chronic morphine administration include tolerance and hyperalgesia. This study investigated the involvement of dorsal root ganglion (DRG) protein kinase Cɛ (PKCɛ) expression during chronic morphine administration and also considered the relationship between DRG PKCɛ expression and the substance P- neurokinin1 receptor SP- NK1R) activity.

Methods: Thirty-six animals were divided into six groups (n=6) in this study. Read More

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September 2021

Hydrokinetic pancreatic function and insulin secretion are moduled by Cl uniporter Slc26a9 in mice.

Acta Physiol (Oxf) 2021 Sep 15:e13729. Epub 2021 Sep 15.

Dept. of Gastroenterology, Hannover Medical School, Hannover, Germany.

Aim: Slc26a9 is a member of the Slc26 multifunctional anion transporter family. Polymorphisms in Slc26a9 are associated with an increased incidence of meconium ileus and diabetes in cystic fibrosis patients. We investigated the expression of Slc26a9 in the murine pancreatic ducts, islets and parenchyma, and elucidated its role in pancreatic ductal electrolyte and fluid secretion and endocrine function. Read More

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September 2021

Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques.

Am J Physiol Regul Integr Comp Physiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Physiology, grid.279863.1Louisiana State University Health Sciences Center New Orleans, New Orleans, Louisiana, United States.

Objective: Aging people living with HIV (PLWH), especially post-menopausal women may be at higher risk of comorbidities associated with HIV, ART, hypogonadism and at-risk alcohol use. Our studies in simian immunodeficiency virus (SIV)-infected male macaques demonstrated that chronic binge alcohol (CBA) reduced acute insulin response to glucose (AIRG), and at-risk alcohol use decreased HOMA-β in PLWH. The objective of this study was to examine the impact of ovariectomy (OVX), on glucose-insulin dynamics and integrity of pancreatic endocrine function in CBA/SIV-infected female macaques. Read More

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September 2021

L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis.

Mol Metab 2021 Sep 11:101340. Epub 2021 Sep 11.

Department of Physiology, University of Toronto; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Objectives: Recent studies using whole-body clock-disrupted animals identified a disruption in the circadian rhythm of the intestinal L-cell incretin hormone, glucagon-like peptide-1 (GLP-1). Although GLP-1 plays an essential role in metabolism, through enhancement of both glucose-stimulated insulin secretion and satiety, recent evidenced has also demonstrated its importance in regulating intestinal and microbial homeostasis. Therefore, using in vivo and in vitro models, this study assessed the requirement for the core circadian clock gene Arntl in the regulation of GLP-1 secretion and its impact on the intestinal environment. Read More

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September 2021

A novel nanosphere-in-nanotube iron phosphide Li-ion battery anode displaying a long cycle life, recoverable rate-performance, and temperature tolerance.

Nanoscale 2021 Sep 13. Epub 2021 Sep 13.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, P. R. China.

Currently, non-ideal anodes restricts the development of long-term stable Li-ion batteries. Several currently available high-capacity anode candidates are suffering from a large volumetric change during charge and discharge and non-stable solid interphase formation. Here, we develop a novel nanosphere-confined one-dimensional yolk-shell anode taking iron phosphide (FeP) as a demonstrating case study. Read More

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September 2021

The Dual Targeting of FcRn and FcγRs Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies.

Front Immunol 2021 26;12:728322. Epub 2021 Aug 26.

LFB Biotechnologies, Innovation Department, Les Ulis, France.

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development and hold promise for reducing the levels of circulating IgG. Additionally, engineered structures containing multimeric Fc regions allow the dual targeting of FcRn and FcγRs; however, their tolerance needs to first be validated in phase I clinical studies. Read More

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Hepatogenous Diabetes: A Primer.

J Clin Exp Hepatol 2021 Sep-Oct;11(5):603-615. Epub 2021 May 1.

Department of Gastroenterology & Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha 751024, India.

As liver is one of the primary organs involved in glucose homeostasis, it is not surprising that patients with liver dysfunction in chronic liver disease usually develop impaired glucose tolerance and subsequently overt diabetes later in their natural course. Diabetes that develops after the onset of cirrhosis of liver is usually referred to as hepatogenous diabetes (HD). It is an underrecognized and a hallmark endocrinological event in chronic liver disease. Read More

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A Polysulfides-Confined All-in-One Porous Microcapsule Lithium-Sulfur Battery Cathode.

Small 2021 Sep 12:e2103051. Epub 2021 Sep 12.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China.

Developing emerging materials for high energy-density lithium-sulfur (Li-S) batteries is of great significance to suppress the shuttle effect of polysulfides and to accommodate the volumetric change of sulfur. Here, a novel porous microcapsule system containing a carbon nanotubes/tin dioxide quantum dots/S (CNTs/QDs/S) composite core and a porous shell prepared through a liquid-driven coaxial microfluidic method as Li-S battery cathode is developed. The encapsulated CNTs in the microcapsules provide pathways for electron transport; SnO QDs on CNTs immobilize the polysulfides by strong adsorption, which is verified by using density functional theory calculations on binding energies. Read More

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September 2021

Long-term dysglycemia as a risk factor for faster cognitive decline during aging: a 12-year follow-up study.

Diabetes Res Clin Pract 2021 Sep 8:109045. Epub 2021 Sep 8.

Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Finland; Unit of Primary Care, Oulu University Hospital and Medical Research Center Oulu, Oulu, Finland; Healthcare and Social Services of Selänne, Pyhäjärvi, Finland.

Aims: This longitudinal study evaluated associations between glucose metabolism and cognitive performance during a 12-year follow-up.

Methods: We included 714 subjects, which were followedfrom the age 55 to 70 years. Using oral glucose tolerance tests the population was classified as normoglycemic (NGT) and based on WHO diagnostic criteria for diabetes and prediabetes. Read More

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September 2021

Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of Β-cell function.

J Diabetes Complications 2021 Aug 30:108028. Epub 2021 Aug 30.

Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

Aims: Identifying and modulating risk factors is essential to prevent visual impairment due to diabetic retinopathy (DR). This study examines incident DR with metabolic and hormonal factors in newly-diagnosed, treatment naïve, individuals with Type2 Diabetes Mellitus (T2DM), over a 5 year period from diagnosis.

Methods: 233 T2DM subjects underwent serial DR screening using digital photography and standardised Meal Tolerance Tests at diagnosis and after 1, 2 and 5 years. Read More

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Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus.

Int J Mol Sci 2021 Sep 2;22(17). Epub 2021 Sep 2.

Laboratory of Mitochondrial Transport, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.

Diabetes mellitus is a systemic metabolic disorder associated with mitochondrial dysfunction, with mitochondrial permeability transition (MPT) pore opening being recognized as one of its pathogenic mechanisms. Alisporivir has been recently identified as a non-immunosuppressive analogue of the MPT pore blocker cyclosporin A and has broad therapeutic potential. The purpose of the present work was to study the effect of alisporivir (2. Read More

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September 2021

Quantitative trait loci for yellow rust resistance in spring wheat doubled haploid populations developed from the German Federal ex situ genebank genetic resources.

Plant Genome 2021 Sep 9:e20142. Epub 2021 Sep 9.

Leibniz Institute of Plant Genetics and Crop Plant Research, Corrensstraße 3, 06466, Stadt Seeland OT, Gatersleben, Germany.

Novel resistance sources to the pathogen Puccinia striiformis f. sp. tritici, which causes yellow rust (stripe rust), a widespread devastating foliar disease in wheat (Triticum aestivum L. Read More

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September 2021

SGLT2 inhibitor ipragliflozin poses a low risk of hypoglycemia owing to its blood glucose-dependent urinary glucose excretion mechanism in mice.

Authors:
Atsuo Tahara

Clin Exp Pharmacol Physiol 2021 Sep 8. Epub 2021 Sep 8.

Candidate Discovery Science Laboratories, Astellas Pharma Inc, Ibaraki, Japan.

Sodium-glucose cotransporter (SGLT) 2 inhibitors, which inhibit renal reabsorption of glucose and stimulate urinary glucose excretion, have been proposed as useful drugs for treating diabetes. This study examined the effects of the SGLT2 inhibitor ipragliflozin on blood glucose-dependent urinary glucose excretion in mice. To investigate the antihyperglycemic effects of ipragliflozin, several oral glucose tolerance tests (glucose load: 1-4 g/kg) were performed. Read More

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September 2021

Polyguanidine-modified adsorbent to enhance marine applicability for uranium recovery from seawater.

J Hazard Mater 2021 08 25;416:126192. Epub 2021 May 25.

China Academy of Engineering Physics, Mianyang 621900, China. Electronic address:

The marine applicability of adsorbents intended for recovering uranium from seawater is crucial. For such applicability, the materials must exhibit anti-biofouling properties, seawater pH adaptability (pH~8), and salt tolerance. Extracting uranium from seawater is a long-term project; hence, biofouling, high salt concentrations, and weak alkaline environments negatively affect the adsorption of uranium and damage the recovered materials. Read More

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First Report of Leaf Blight Caused by Nigrospora oryzae on Poplar in China.

Plant Dis 2021 Sep 7. Epub 2021 Sep 7.

Shenyang Agricultural University, 98428, College of Forestry, Shenyang, Liaoning, China.

Populus alba L. × P. berolinensis Dipp. Read More

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September 2021

Intra-session repeatability of anterior chamber depth across the chamber width using Pentacam Scheimpflug imaging in healthy subjects.

Ophthalmic Physiol Opt 2021 Sep 7. Epub 2021 Sep 7.

Centre for Eye Health, University of New South Wales, Kensington, New South Wales, Australia.

Purpose: Despite the importance of anterior chamber depth (ACD) measurements in disease and ageing, the repeatability and their threshold for change is not known. Our purpose was to determine the intra-session repeatability of Pentacam Scheimpflug photography for measuring the ACD across the chamber width in healthy subjects and thus inform expected limits of normality.

Methods: Pentacam Scheimpflug photography was used to obtain ACD measurements at 57 points across the central 8mm of the chamber width from one randomly selected eye of 130 healthy (normal vision and no ocular diseases, except age-normal cataracts) subjects (median age 58. Read More

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September 2021

From the factory to the field: considerations of product characteristics for insecticide-treated net (ITN) bioefficacy testing.

Malar J 2021 Sep 6;20(1):363. Epub 2021 Sep 6.

Vector Control Product Testing Unit, Ifakara Health Institute, P.O. Box 74, Bagamoyo, Tanzania.

Background: Insecticide-treated nets (ITNs) undergo a series of tests to obtain listing by World Health Organization (WHO) Prequalification. These tests characterize the bioefficacy, physical and chemical properties of the ITN. ITN procurers assume that product specifications relate to product performance. Read More

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September 2021

Obesity management in polycystic ovary syndrome: disparity in knowledge between obstetrician-gynecologists and reproductive endocrinologists in China.

BMC Endocr Disord 2021 Sep 6;21(1):182. Epub 2021 Sep 6.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Background: Obesity is associated with the development of polycystic ovary syndrome (PCOS) and contributes substantially to metabolic abnormalities in women with PCOS. The study aimed to describe and compare the practices of physicians in the diagnosis, evaluation, and treatment of obesity in patients with PCOS.

Methods: Reproductive endocrinologists (Repro-Endo) and obstetrician-gynecologists (non-reproductive medicine specialty, OB-Gyn) in China participated in a survey, and their responses were analyzed using χ tests, Fisher exact tests, and multivariable logistic regression analysis. Read More

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September 2021

A rice mTERF protein V14 sustains photosynthesis establishment and temperature acclimation in early seedling leaves.

BMC Plant Biol 2021 Sep 6;21(1):406. Epub 2021 Sep 6.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, China.

Background: Plant mitochondrial transcription termination factor (mTERF) family members play important roles in development and stress tolerance through regulation of organellar gene expression. However, their molecular functions have yet to be clearly defined.

Results: Here an mTERF gene V14 was identified by fine mapping using a conditional albino mutant v14 that displayed albinism only in the first two true leaves, which was confirmed by transgenic complementation tests. Read More

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September 2021

SGLT2 inhibitor ipragliflozin exerts antihyperglycemic effects via the blood glucose-dependent increase in urinary glucose excretion in type 2 diabetic mice.

Authors:
Atsuo Tahara

Eur J Pharmacol 2021 Sep 3;910:174486. Epub 2021 Sep 3.

Candidate Discovery Science Laboratories, Astellas Pharma Inc., Ibaraki, Japan. Electronic address:

This study investigated the antihyperglycemic effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin via the blood glucose-dependent increase in urinary glucose excretion in KK/A type 2 diabetic mice. In oral glucose tolerance tests (glucose load: 1, 2, or 4 g/kg) in 24-h-fasted mice, blood glucose levels increased in a glucose-loading dose-dependent manner. Oral administration of ipragliflozin (1 mg/kg) significantly inhibited the increase in blood glucose concomitant with urinary glucose excretion. Read More

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September 2021

Home-Based Up-Dosing in Build-Up Phase of Oral Immunotherapy of Egg Allergy Is Safe and Feasible in Real-World Practice.

Allergy Asthma Immunol Res 2021 Sep;13(5):791-798

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Oral immunotherapy (OIT) has emerged to build sustained unresponsiveness or tolerance in patients with egg allergy. However, it is important to increase compliance and ensure safety because OIT requires an extended period of time and has a risk of side effects like anaphylaxis. We aimed to show the feasibility and safety of OIT during the build-up phase using a home-based, up-dosing method in children with egg allergy. Read More

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September 2021

Probiotic Properties of Isolated From Tibetan Yaks, China.

Front Microbiol 2021 17;12:649207. Epub 2021 Aug 17.

College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Yaks () live primarily in high-altitude hypoxic conditions and have a unique intestinal micro-ecosystem, remarkable adaptability, and strong climatic resistance. Accumulating evidence revealed the importance of probiotics in host metabolism, gut microbiota, growth performance, and health. The goal of this study was to screen out probiotics with excellent probiotic potential for clinical application. Read More

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Limitations of current alpine touring ski bindings.

J Sci Med Sport 2021 May 28. Epub 2021 May 28.

TUM Technical University of Munich, School of Engineering and Design, Sport Equipment and Materials, Germany.

Objectives: Quantify various parameters of safety and performance of modern alpine touring bindings in particular their release characteristics.

Design: For n = 16 alpine touring bindings from season 2018/19 and 2019/20, we performed multiple tests under standardized conditions using identical test soles built from one market relevant alpine touring boot.

Methods: Referring to the standard of the International Organization for Standardization for alpine touring bindings ISO 13992 we measured both the impact tolerance as well as the influence of forward and backward lean on the bindings' twist release behavior. Read More

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Coral adaptation to climate change: Meta-analysis reveals high heritability across multiple traits.

Glob Chang Biol 2021 Sep 5. Epub 2021 Sep 5.

College of Science and Engineering and ARCCOE for Coral Reef Studies, James Cook University, Townsville, Queensland, Australia.

Anthropogenic climate change is a rapidly intensifying selection pressure on biodiversity across the globe and, particularly, on the world's coral reefs. The rate of adaptation to climate change is proportional to the amount of phenotypic variation that can be inherited by subsequent generations (i.e. Read More

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September 2021

Interaction of myxobacteria-derived outer membrane vesicles with biofilms: antiadhesive and antibacterial effects.

Nanoscale 2021 Sep 2;13(34):14287-14296. Epub 2021 Aug 2.

Helmholtz Centre for Infection Research (HZI), Biogenic Nanotherapeutics Group (BION), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123 Saarbrücken, Germany.

Bacterial biofilms are widespread in nature and in medical settings and display a high tolerance to antibiotics and disinfectants. Extracellular vesicles have been increasingly studied to characterise their origins and assess their potential for use as a versatile drug delivery system; however, it remains unclear whether they also have antibiofilm effects. Outer membrane vesicles are lipid vesicles shed by Gram-negative bacteria and, in the case of myxobacteria, carry natural antimicrobial compounds produced by these microorganisms. Read More

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September 2021