758 results match your criteria tocopherols tocotrienols

Red Raspberry ( L.) Seed Oil: A Review.

Plants (Basel) 2021 May 9;10(5). Epub 2021 May 9.

Lithuanian Research Centre for Agriculture and Forestry, Institute of Horticulture, Kauno str. 30, Kaunas District, LT-54333 Babtai, Lithuania.

Raspberry ( L.) seed oil (RSO) is considered as a source of high value bioactive compounds as fatty acids, tocopherols, tocotrienols, carotenoids, flavonoids, phytosterols, antioxidants, monoterpenes and many other chemical constituents. These compounds are appreciated as a source of nutrition for humans, as additives in cosmetic production, has immense therapeutic potential. Read More

View Article and Full-Text PDF

Phytoprostanes, phytofurans, tocopherols, tocotrienols, carotenoids and free amino acids and biological potential of sea buckthorn juices.

J Sci Food Agric 2021 Jun 1. Epub 2021 Jun 1.

Department of Fruit, Vegetable and Plant Nutraceutical Technology, The Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 37 ChełmoŃskiego Street, 51-630, Wrocław, Poland.

Background: Juices are currently the fast growing segment in the fruit and vegetable industry sector. However, there are still no reports on the diversity of phytochemical profile and health-promoting properties of commercial sea buckthorn (Hippophaë rhamnoides) juices. This study aimed to identify and quantify phytoprostanes, phytofurans (UHPLC-QqQ-MS/MS), tocopherols, tocotrienols (UPLC-FL), carotenoids and free amino acids (UPLC-PDA-Q/TOF-MS) and assess the anti-cholinergic, anti-diabetic, anti-obesity, anti-inflammatory and antioxidant potential by in vitro assays of commercial sea buckthorn juices. Read More

View Article and Full-Text PDF

Redox Pioneer: Professor Regina Brigelius-Flohé.

Matilde Maiorino

Antioxid Redox Signal 2021 May 26. Epub 2021 May 26.

University of Padua, 9308, Molecular Medicine, Padova, Veneto, Italy;

Dr. Regina Brigelius-Flohé (Ph.D. Read More

View Article and Full-Text PDF

Vitamin E beyond Its Antioxidant Label.

Antioxidants (Basel) 2021 Apr 21;10(5). Epub 2021 Apr 21.

Department of Biochemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, 020956 Bucharest, Romania.

Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The aim of this review is to summarize the molecular mechanisms and signaling pathways linked to inflammation and malignancy modulated by its vitamers. Preclinical reports highlighted a myriad of cellular effects like modulating the synthesis of pro-inflammatory molecules and oxidative stress response, inhibiting the NF-κB pathway, regulating cell cycle, and apoptosis. Read More

View Article and Full-Text PDF

Dehiscence and prolonged storage of 'Kerman' Pistachios: Effects on morphometry and nutraceutical value.

J Food Sci Technol 2021 May 19;58(5):1958-1968. Epub 2020 Aug 19.

Departamento de Ciencias Químico-Biológicas/Ciencias de La Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, 32310 Ciudad Juárez, Chihuahua, Mexico.

'Kerman' pistachios (KP; L.) are an important crop for several countries but their commercial value is diminished by their shell dehiscence status and prolonged storage in popular marketplaces. The aim was to evaluate the independent/synergistic effect of prolonged storage (1-4 year) and dehiscence status (split/unsplit) on KP's morphometry and chemical composition. Read More

View Article and Full-Text PDF

Effect of vitamin E on periodontitis: Evidence and proposed mechanisms of action.

J Oral Biosci 2021 Jun 20;63(2):97-103. Epub 2021 Apr 20.

Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. Electronic address:

Background: Periodontitis is a noncommunicable inflammatory disease of the soft tissue and bone surrounding the teeth in the jaw, which affects susceptible individuals with poor oral hygiene. A growing interest has been seen in the use of dietary supplements and natural products for the treatment and prevention of periodontitis. Vitamin E consists of two major groups, namely tocopherols and tocotrienols, which are botanical lipophilic compounds with excellent anti-inflammatory and antioxidant properties. Read More

View Article and Full-Text PDF

Protective Activity and Underlying Mechanism of Ginseng Seeds against UVB-Induced Damage in Human Fibroblasts.

Antioxidants (Basel) 2021 Mar 8;10(3). Epub 2021 Mar 8.

Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Korea.

Ginseng seeds are rich in phytosterols, ginsenosides, and fatty acids, and can therefore be used in skincare to delay the aging process. Ginseng seed embryo (GSE) and ginseng seed coat (GSC) were separated from ginseng seeds (Panax ginseng Meyer). This study evaluated the protective activity and underlying mechanism of GSE and GSC on UVB irradiation-induced skin photoaging using Hs68 cells. Read More

View Article and Full-Text PDF

Influence of enzyme concentrations in enzymatic bioprocessing of red rice bran: A detailed study on nutraceutical compositions, antioxidant and human LDL oxidation inhibition properties.

I Sapna A Jayadeep

Food Chem 2021 Jul 9;351:129272. Epub 2021 Feb 9.

Department of Grain Science and Technology, CSIR - Central Food Technological Research Institute, Mysore 570020, Karnataka, India. Electronic address:

Enzymes and their concentrations are crucial factors in improving the release of nutraceuticals bounded to rice bran's cell wall matrix. This study aims to investigate the optimal concentrations of Viscozyme and Fiberzyme at 3-30 beta-glucanase units/2 g in improving the release of phenolics, tocopherols, tocotrienols, and γ-oryzanol fractions and enhancing the bioactivities of red rice bran. At specific concentrations, Fiberzyme increased ferulic (301%) and caffeic acid (691%) in soluble phenolics, p-coumaric acid (98%), and catechin (161%) in bound phenolics as well as γ-oryzanol fractions(32%-134%) and increased ferric reducing power (90%), DPPH (41%), and hydroxyl (25%) radical scavenging activities. Read More

View Article and Full-Text PDF

The characterization of tocols in different plants parts of six Japanese rice cultivars relating to their UVB-sensitivity.

Plant Physiol Biochem 2021 Apr 1;161:48-53. Epub 2021 Feb 1.

Research Institute of University‒Community Collaborations, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai-City, Osaka, 599-8531, Japan.

There has been significant interest in the photosensitivity, or photo-resistance, of Japanese rice cultivars, which synthesize tocols (Vitamin E), a class of phytochemicals including tocol derivatives tocopherol (T) and tocotrienol (T3). In the present study, the distribution of tocols in the leaves, seeds, stems, and roots of six Japanese rice cultivars was investigated. The relationship between the different tocols in cultivars and their ultraviolet B sensitivity index (USB-SI) was analyzed. Read More

View Article and Full-Text PDF

Beneficial effect of rice bran extract against rotenone-induced experimental Parkinson's disease in rats.

Curr Mol Pharmacol 2021 Jan 25. Epub 2021 Jan 25.

Department of Pharmaceutical Sciences & Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab. India.

Background: Neurodegenerative diseases have become the rising cause of various disabilities worldwide, followed by aging, including Parkinson's disease (PD). Parkinson's disease is a degenerative brain disorder distinguished by growing motor & non-motor failure due to the degeneration of medium-sized spiked neurons in the striatum region. Rotenone is often employed to originate the animal model of PD. Read More

View Article and Full-Text PDF
January 2021

Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice.

Foods 2021 Feb 7;10(2). Epub 2021 Feb 7.

Department of Food Science and Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea.

Macrophages are involved in all inflammatory processes from killing pathogens to repairing damaged tissue. In the obese state, macrophages infiltrate into enlarged adipose tissue and polarize into pro-inflammatory M1 macrophages, resulting in chronic low-grade inflammation due to the secretion of inflammatory mediators. Rice bran oil (RBO) is an edible oil containing tocopherols, tocotrienols, and γ-oryzanol. Read More

View Article and Full-Text PDF
February 2021

Production of tocotrienols in seeds of cotton (Gossypium hirsutum L.) enhances oxidative stability and offers nutraceutical potential.

Plant Biotechnol J 2021 Jun 17;19(6):1268-1282. Epub 2021 Feb 17.

Department of Biological Sciences, BioDiscovery Institute, University of North Texas, Denton, TX, USA.

Upland cotton (Gossypium hirsutum L.) is an economically important multi-purpose crop cultivated globally for fibre, seed oil and protein. Cottonseed oil also is naturally rich in vitamin E components (collectively known as tocochromanols), with α- and γ-tocopherols comprising nearly all of the vitamin E components. Read More

View Article and Full-Text PDF

[Eight vitamin E congeners in seafood and aquatic products in Zhejiang Province].

Wei Sheng Yan Jiu 2020 Nov;49(6):990-997

Zhejiang Province Center for Disease Control and Prevention, Hangzhou 310051, China.

Objective: Comparison and analysis of α-, β-, γ-, δ-tocopherol(T) and α-, β-, γ-, δ-tocotrienol(T3) in 44 species of seafood and aquatic products is under processed to enrich the database of food composition in China and provide a scientific reference for dietary intake choice.

Methods: Quantitative and correlation analysis of eight vitamin E isomers were based on external calibration method with reversed-phase high-performance liquid chromatography-fluorescence detector, after hot saponification with alkaline and liquid-liquid extraction.

Results: The content of α-tocopherol equivalent(α-TE) in seafood and aquatic products varied greatly(from 0. Read More

View Article and Full-Text PDF
November 2020

Nutlets of Tilia cordata Mill. and Tilia platyphyllos Scop. - Source of bioactive compounds.

Food Chem 2021 Jun 29;346:128888. Epub 2020 Dec 29.

Institute of Food Technology, Poznań University of Life Sciences, Wojska Polskiego 28, 60-637 Poznań, Poland.

The aim of this study was to analyse contents of phytosterols, carotenoids, tocochromanols and fatty acid composition in oil from nutlets of linden. Standard determination methods for these compounds were applied using liquid and gas chromatography. In the analysed oils from small and large-leaved lime the dominant acids included linoleic (53. Read More

View Article and Full-Text PDF

Pharmacology and Pharmacokinetics of Vitamin E: Nanoformulations to Enhance Bioavailability.

Int J Nanomedicine 2020 8;15:9961-9974. Epub 2020 Dec 8.

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. Read More

View Article and Full-Text PDF
December 2020

Stability of B vitamins, vitamin E, xanthophylls and flavonoids during germination and maceration of sorghum (Sorghum bicolor L.).

Food Chem 2021 May 3;345:128775. Epub 2020 Dec 3.

Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Avenida P.H. Rolfs, s/n, 36570-900 Viçosa, Minas Gerais, Brazil.

The impact of maceration and germination on the concentration of bioactive compounds still needs to be evaluated. The stability of B complex vitamins (thiamine, riboflavin, pyridoxine), vitamin E (α, β, γ, δ tocopherols and tocotrienols), xanthophylls (lutein and zeaxanthin) and flavonoids (3-deoxyanthocyanidins-3-DXAs, flavones and flavanones) was evaluated in sorghum grains subjected to maceration and germination, using High Performance Liquid Chromatography. Maceration and germination reduced thiamine and pyridoxine concentrations (retentions ranging from 3. Read More

View Article and Full-Text PDF

Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization.

Mar Drugs 2020 Dec 7;18(12). Epub 2020 Dec 7.

Unit of Chemical-Physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products can represent an interesting source of high added value bioactive compounds, such as proteins, carbohydrates, collagen, polyunsaturated fatty acids, chitin, polyphenolic constituents, carotenoids, vitamins, alkaloids, tocopherols, tocotrienols, toxins; nevertheless, their biotechnological potential is still largely underutilized. Read More

View Article and Full-Text PDF
December 2020

Synthesis of [F]F-γ-T-3, a Redox-Silent γ-Tocotrienol (γ-T-3) Vitamin E Analogue for Image-Based In Vivo Studies of Vitamin E Biodistribution and Dynamics.

Molecules 2020 Dec 3;25(23). Epub 2020 Dec 3.

Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Vitamin E, a natural antioxidant, is of interest to scientists, health care pundits and faddists; its nutritional and biomedical attributes may be validated, anecdotal or fantasy. Vitamin E is a mixture of tocopherols (TPs) and tocotrienols (T-3s), each class having four substitutional isomers (α-, β-, γ-, δ-). Vitamin E analogues attain only low concentrations in most tissues, necessitating exacting invasive techniques for analytical research. Read More

View Article and Full-Text PDF
December 2020

Investigation of Wheat Germ and Oil Characteristics with Regard to Different Stabilization Techniques.

Food Technol Biotechnol 2020 Sep;58(3):348-355

Department of Chemistry, Faculty of Science, Karamanoğlu Mehmetbey University, Karaman, Turkey.

Research Background: Utilization of wheat germ and wheat germ oil is limited due to high enzymatic activity and the presence of unsaturated fatty acids, which require stabilization techniques to overcome this problem.

Experimental Approach: In this study, the effects of stabilization methods (dry convective oven heating at 90 and 160 °C, microwave radiation at 180 and 360 W, and autoclave steaming) on both wheat germ and its oil were evaluated.

Results And Conclusions: Steaming caused the most dramatic changes in lipoxygenase activity, free fatty acid content, DPPH radical scavenging activity, and mass fractions of tocopherols and tocotrienols. Read More

View Article and Full-Text PDF
September 2020

Corn Bioethanol Side Streams: A Potential Sustainable Source of Fat-Soluble Bioactive Molecules for High-Value Applications.

Foods 2020 Dec 2;9(12). Epub 2020 Dec 2.

CREA Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy.

This paper reports data from a characterization study conducted on the unsaponifiable lipid fraction of dry-grind corn bioethanol side streams. Phytosterols, squalene, tocopherols, tocotrienols, and carotenoids were quantified by High Performance Liquid Chromatography with Diode-Array Detector (HPLC-DAD) and Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) in different lots of post-fermentation corn oil and thin stillage collected from a bioethanol plant over a time-span of one year. Fat-soluble bioactives were present at high levels in corn oil, with a prevalence of plant sterols over tocols and squalene. Read More

View Article and Full-Text PDF
December 2020

Analysis of expression of vitamin E-binding proteins in H2O2 induced SK-N-SH neuronal cells supplemented with α-tocopherol and tocotrienol-rich fraction.

PLoS One 2020 24;15(11):e0241112. Epub 2020 Nov 24.

Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, Selangor, Malaysia.

Natural α-tocopherol (α-TCP), but not tocotrienol, is preferentially retained in the human body. α-Tocopherol transfer protein (α-TTP) is responsible for binding α-TCP for cellular uptake and has high affinity and specificity for α-TCP but not α-tocotrienol. The purpose of this study was to examine the modification of α-TTP together with other related vitamin E-binding genes (i. Read More

View Article and Full-Text PDF
December 2020

The journey from white rice to ultra-high hydrostatic pressurized brown rice: an excellent endeavor for ideal nutrition from staple food.

Crit Rev Food Sci Nutr 2020 Nov 16:1-19. Epub 2020 Nov 16.

Shimane Institute for Industrial Technology, Matsue, Japan.

Although brown rice (BR) contains significantly higher levels of nutrients than the traditionally used polished white rice (WR), its consumption among the population is still not noteworthy. WR and BR are essentially same grain. The only difference between the two is the application of an exhaustive milling procedure during the processing of WR that removes all other layers of the grain except the portion of its white endosperm. Read More

View Article and Full-Text PDF
November 2020

Evaluation of bioactive compounds in cereals. Study of wheat, barley, oat and selected grain products.

Acta Sci Pol Technol Aliment 2020 Oct-Dec;19(4):405-423

Department of Food Biochemistry and Analysis, Poznań University of Life Sciences, Poland.

Background: One of the requirements for proper nutrition and maintenance of good health is to supply the body, through diet, with an appropriately increased quantity of bioactive compounds. With this in mind, modern milling and baking industries keep introducing new types of products. The use of such additives as wholegrain flours and bran in baked products provided the basis for research in this paper. Read More

View Article and Full-Text PDF
November 2020

Validated MAGIC and GWAS population mapping reveals the link between vitamin E content and natural variation in chorismate metabolism in tomato.

Plant J 2021 02 22;105(4):907-923. Epub 2020 Dec 22.

Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina.

Tocochromanols constitute the different forms of vitamin E (VTE), essential components of the human diet, and display a high membrane protectant activity. By combining interval mapping and genome-wide association studies (GWAS), we unveiled the genetic determinants of tocochromanol accumulation in tomato (Solanum lycopersicum) fruits. To enhance the nutritional value of this highly consumed vegetable, we dissected the natural intraspecific variability of tocochromanols in tomato fruits and genetically engineered their biosynthetic pathway. Read More

View Article and Full-Text PDF
February 2021

Assessing the Impact of Oil Types and Grades on Tocopherol and Tocotrienol Contents in Vegetable Oils with Chemometric Methods.

Molecules 2020 Nov 1;25(21). Epub 2020 Nov 1.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

The consumption of vegetable oil is an important way for the body to obtain tocols. However, the impact of oil types and grades on the tocopherol and tocotrienol contents in vegetable oils is unclear. In this study, nine types of traditional edible oils and ten types of self-produced new types of vegetable oil were used to analyze eight kinds of tocols. Read More

View Article and Full-Text PDF
November 2020

Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies.

Dermatology 2020 Oct 16:1-12. Epub 2020 Oct 16.

Research and Development Department, Davos Life Science, Singapore, Singapore.

Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Read More

View Article and Full-Text PDF
October 2020

Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.

Kilmer S McCully

Ann Clin Lab Sci 2020 Sep;50(5):567-577

Pathology and Laboratory Medicine Service, Boston Veterans Affairs Medical Center, and Department of Pathology, Harvard Medical School, Boston, MA, USA

A century ago a fat-soluble vitamin from leafy vegetables, later named vitamin E, was discovered to enhance fertility in animals. Vitamin E consists of 8 isomers of tocopherols and tocotrienols, each containing chromanol groups that confer antioxidant properties and differ only in the 15-carbon saturated phytyl poly-isoprenoid side chain of tocopherols and the 15-carbon unsaturated farnesyl poly-isoprenoid side chain of tocotrienols. Although tocotrienol was first isolated from rubber plants in 1964, its importance in multiple disease processes was not recognized until two decades later, when the cholesterol-lowering and anti-cancer effects were first reported. Read More

View Article and Full-Text PDF
September 2020

Cambess. Pulp Oil Supplementation Reduces Total Cholesterol, LDL-c, and Non-HDL-c in Animals.

Molecules 2020 Oct 3;25(19). Epub 2020 Oct 3.

Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.

The fruit of Cambess. is a source of oil with active compounds that are protective to the organism. In our work, we analyzed the physicochemical characteristics and evaluated the effects of supplementation with oil in an animal model. Read More

View Article and Full-Text PDF
October 2020

Cellular uptake and anti-inflammatory effects of palm oil-derived delta (δ)-tocotrienol in microglia.

Cell Immunol 2020 11 28;357:104200. Epub 2020 Aug 28.

Neuroinflammation Group, Immunology Laboratory, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. Electronic address:

Tocopherols long dominated studies on vitamin E, although interest has shifted to tocotrienols. It was previously shown that δ-tocotrienol derived from palm oil reduced nitric oxide released by BV2 microglia as early as 18 h after lipopolysaccharide stimulation. The current study measured δ-tocotrienol uptake by BV2 over a 24 h incubation period and its anti-inflammatory effects on primary microglia. Read More

View Article and Full-Text PDF
November 2020

From By-Product to the Food Chain: Melon ( L.) Seeds as Potential Source for Oils.

Foods 2020 Sep 23;9(10). Epub 2020 Sep 23.

Higher Technical School of Agricultural and Forestry Engineering, University of Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.

Fruit-processing industries annually discard large volumes of fruit by-products. Thousands of tons of melon seeds could be recovered through the year from melon production. These seeds are an excellent source of vegetable oil with significant health-promoting properties due to their unsaturated fatty acid profile and high content of specific bioactive compounds. Read More

View Article and Full-Text PDF
September 2020