297 results match your criteria tms-eeg

Does pericentral mu-rhythm "power" corticomotor excitability? - a matter of EEG perspective.

Brain Stimul 2021 Apr 10. Epub 2021 Apr 10.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Electroencephalography (EEG) and single-pulse transcranial magnetic stimulation (spTMS) of the primary motor hand area (M1-HAND) have been combined to explore whether the instantaneous expression of pericentral mu-rhythm drives fluctuations in corticomotor excitability, but this line of research has yielded diverging results.

Objectives: To re-assess the relationship between the mu-rhythm power expressed in left pericentral cortex and the amplitude of motor potentials (MEP) evoked with spTMS in left M1-HAND.

Methods: 15 non-preselected healthy young participants received spTMS to the motor hot spot of left M1-HAND. Read More

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Cortical excitability measures from TMS-EEG and TMS-EMG - Two sides of the same story?

J Physiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

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Contribution of TMS and TMS-EEG to the Understanding of Mechanisms Underlying Physiological Brain Aging.

Brain Sci 2021 Mar 22;11(3). Epub 2021 Mar 22.

Department of Neuroscience, University of Padua, 35122 Padua, Italy.

In the human brain, aging is characterized by progressive neuronal loss, leading to disruption of synapses and to a degree of failure in neurotransmission. However, there is increasing evidence to support the notion that the aged brain has a remarkable ability to reorganize itself, with the aim of preserving its physiological activity. It is important to develop objective markers able to characterize the biological processes underlying brain aging in the intact human, and to distinguish them from brain degeneration associated with many neurological diseases. Read More

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Preconditioning Stimulus Intensity Alters Paired-Pulse TMS Evoked Potentials.

Brain Sci 2021 Mar 4;11(3). Epub 2021 Mar 4.

Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Motor cortex (M1) paired-pulse TMS (ppTMS) probes excitatory and inhibitory intracortical dynamics by measurement of motor-evoked potentials (MEPs). However, MEPs reflect cortical and spinal excitabilities and therefore cannot isolate cortical function. Concurrent TMS-EEG has the ability to measure cortical function, while limiting peripheral confounds; TMS stimulates M1, whilst EEG acts as the readout: the TMS-evoked potential (TEP). Read More

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Single-Pulse TMS to the Temporo-Occipital and Dorsolateral Prefrontal Cortex Evokes Lateralized Long Latency EEG Responses at the Stimulation Site.

Front Neurosci 2021 12;15:616667. Epub 2021 Mar 12.

Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Introduction: Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) allow for probing cortical functions in health and pathology. However, there is uncertainty whether long-latency TMS-evoked potentials reflect functioning of the targeted cortical area. It has been suggested that components such as the TMS-evoked N100 are stereotypical and related to nonspecific sensory processes rather than transcranial effects of the changing magnetic field. Read More

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Assessing cerebellar-cortical connectivity using concurrent TMS-EEG: a feasibility study.

J Neurophysiol 2021 Mar 31. Epub 2021 Mar 31.

Deakin University, Australia.

Combined single-pulse transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been used to probe the features of local networks in the cerebral cortex. Here we investigate whether we can use this approach to explore long-range connections between the cerebellum and cerebral cortex. Ten healthy adults received single-pulse suprathreshold TMS to the cerebellum and an occipital/parietal control site with double-cone and figure-of-eight coils while cerebral activity was recorded. Read More

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Characterizing Cortical Oscillatory Responses in Major Depressive Disorder Before and After Convulsive Therapy: A TMS-EEG Study.

J Affect Disord 2021 Mar 8;287:78-88. Epub 2021 Mar 8.

Department of Psychiatry, Faculty of Health, University of California San Diego, La Jolla, CA 92093-0603, United States. Electronic address:

Background: Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a powerful technique for interrogating neural circuit dysfunction in psychiatric disorders. Here, we utilized time-frequency analyses to characterize differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC). We further examined changes in TMS-related oscillatory power following convulsive therapy. Read More

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Time course of cortical response complexity during extended wakefulness and its differential association with vigilance in young and older individuals.

Biochem Pharmacol 2021 Mar 15:114518. Epub 2021 Mar 15.

Centre for Biomedical Engineering, Dept. Of Mechanical Engineering Sciences, University of Surrey, Guildford, UK; Joint last authors.

Characterization of the complexity of electroencephalogram (EEG) responses has provided important insights in cognitive function as well as in the brain bases of consciousness and vigilance. Whether brain response complexity changes during prolonged wakefulness and sleep deprivation -when vigilance level considerably varies- is not fully elucidated yet. In the present study, we repeatedly assessed EEG responses to transcranial magnetic stimulation (TMS) over 34 h of sleep deprivation under constant routine conditions in healthy younger (N = 13; 5 women; 18-30 y) and older (N = 12; 6 women; 50-70 y) individuals, while they were performing a vigilance task. Read More

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Local Differences in Cortical Excitability - A Systematic Mapping Study of the TMS-Evoked N100 Component.

Front Neurosci 2021 25;15:623692. Epub 2021 Feb 25.

Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Transcranial magnetic stimulation (TMS) with simultaneous electroencephalography applied to the primary motor cortex provides two parameters for cortical excitability: motor evoked potentials (MEPs) and TMS-evoked potentials (TEPs). This study aimed to evaluate the effects of systematic coil shifts on both the TEP N100 component and MEPs in addition to the relationship between both parameters. In 12 healthy adults, the center of a standardized grid was fixed above the hot spot of the target muscle of the left primary motor cortex. Read More

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February 2021

TMS-EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias: A Systematic Review.

Brain Sci 2021 Feb 27;11(3). Epub 2021 Feb 27.

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 5020 Salzburg, Austria.

An established method to assess effective brain connectivity is the combined use of transcranial magnetic stimulation with simultaneous electroencephalography (TMS-EEG) because TMS-induced cortical responses propagate to distant anatomically connected brain areas. Alzheimer's disease (AD) and other dementias are associated with changes in brain networks and connectivity, but the underlying pathophysiology of these processes is poorly defined. We performed here a systematic review of the studies employing TMS-EEG co-registration in patients with dementias. Read More

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February 2021

Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments.

Am J Psychiatry 2021 Mar 3:appiajp202020071050. Epub 2021 Mar 3.

Department of Psychiatry, University of Pittsburgh School of Medicine.

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique uniquely equipped to both examine and modulate neural systems and related cognitive and behavioral functions in humans. As an examination tool, TMS can be used in combination with EEG (TMS-EEG) to elucidate directly, objectively, and noninvasively the intrinsic properties of a specific cortical region, including excitation, inhibition, reactivity, and oscillatory activity, irrespective of the individual's conscious effort. Additionally, when applied in repetitive patterns, TMS has been shown to modulate brain networks in healthy individuals, as well as ameliorate symptoms in individuals with psychiatric disorders. Read More

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Connectivity Analysis during Rubber Hand Illusion-A Pilot TMS-EEG Study in a Patient with SCI.

Neural Plast 2021 8;2021:6695530. Epub 2021 Feb 8.

Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Austria.

Background: Bodily self-perception is an important concept for several neurological disorders, including spinal cord injury (SCI). Changing one's bodily self-perception, e.g. Read More

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February 2021

The correspondence between EMG and EEG measures of changes in cortical excitability following transcranial magnetic stimulation.

J Physiol 2021 Feb 18. Epub 2021 Feb 18.

The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Victoria, Australia.

Key Points: TMS is commonly used to study excitatory/inhibitory neurotransmission in cortical circuits. Changes in cortical excitability following TMS are typically measured from hand (using EMG; limited to motor cortex) or scalp (using EEG); however, it is unclear whether these two measures represent the same activity when assessing motor cortex. We found that TMS-EMG and TMS-EEG measures of motor cortex excitability are differentially affected by sensory confounds at different time points, masking any actual relationship between them in the time domain. Read More

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February 2021

Asymmetric transcallosal conduction delay leads to finer bimanual coordination.

Brain Stimul 2021 Mar-Apr;14(2):379-388. Epub 2021 Feb 10.

Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy; Ospedale Policlinico San Martino-IRCCS, Genoa, Italy. Electronic address:

It has been theorized that hemispheric dominance and more segregated information processing have evolved to overcome long conduction delays through the corpus callosum (transcallosal conduction delay - TCD) but that this may still impact behavioral performance, mostly in tasks requiring high timing accuracy. Nevertheless, a thorough understanding of the temporal features of interhemispheric communication is lacking. Here, we aimed to assess the relationship between TCD and behavioral performance with a noninvasive directional cortical measure of TCD obtained from transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) in the motor system. Read More

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February 2021

Neural correlates of anger expression in patients with PTSD.

Neuropsychopharmacology 2021 Jan 26. Epub 2021 Jan 26.

Department of Psychiatry, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Anger is a common and debilitating symptom of post-traumatic stress disorder (PTSD). Although studies have identified brain circuits underlying anger experience and expression in healthy individuals, how these circuits interact with trauma remains unclear. Here, we performed the first study examining the neural correlates of anger in patients with PTSD. Read More

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January 2021

Transcranial Evoked Potentials Can Be Reliably Recorded with Active Electrodes.

Brain Sci 2021 Jan 22;11(2). Epub 2021 Jan 22.

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Electroencephalographic (EEG) signals evoked by transcranial magnetic stimulation (TMS) are usually recorded with passive electrodes (PE). Active electrode (AE) systems have recently become widely available; compared to PE, they allow for easier electrode preparation and a higher-quality signal, due to the preamplification at the electrode stage, which reduces electrical line noise. The performance between the AE and PE can differ, especially with fast EEG voltage changes, which can easily occur with TMS-EEG; however, a systematic comparison in the TMS-EEG setting has not been made. Read More

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January 2021

Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants.

Yoshihiro Noda

J Pers Med 2021 Jan 24;11(2). Epub 2021 Jan 24.

Department of Neuropsychiatry, Graduate School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Background: The present study aimed to examine the acute neurophysiological effects of 1Hz transcranial magnetic stimulation (TMS) administered to the right dorsolateral prefrontal cortex (DLPFC) in healthy participants.

Methods: TMS combined with simultaneous electroencephalography (EEG) recording was conducted for 21 healthy participants. For the right DLPFC, 1Hz-TMS (100 pulses/block × 17 sessions) was applied in the resting-state, while for the left DLPFC, 1Hz-TMS (100 pulses/block × 2 sessions) was administered during the verbal fluency tasks (VFTs). Read More

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January 2021

Real-Time Artifacts Reduction during TMS-EEG Co-Registration: A Comprehensive Review on Technologies and Procedures.

Sensors (Basel) 2021 Jan 18;21(2). Epub 2021 Jan 18.

School of Computing, Edinburgh Napier University, Edinburgh EH11 4BN, UK.

Transcranial magnetic stimulation (TMS) excites neurons in the cortex, and neural activity can be simultaneously recorded using electroencephalography (EEG). However, TMS-evoked EEG potentials (TEPs) do not only reflect transcranial neural stimulation as they can be contaminated by artifacts. Over the last two decades, significant developments in EEG amplifiers, TMS-compatible technology, customized hardware and open source software have enabled researchers to develop approaches which can substantially reduce TMS-induced artifacts. Read More

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January 2021

Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients.

J Pers Med 2021 Jan 17;11(1). Epub 2021 Jan 17.

Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.

Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ).

Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. Read More

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January 2021

Evaluation of White Matter Integrity Utilizing the DELPHI (TMS-EEG) System.

Front Neurosci 2020 21;14:589107. Epub 2020 Dec 21.

QuantalX Neuroscience, Beer-Yaacov, Israel.

Objective: The aim of this study was to evaluate brain white matter (WM) fibers connectivity damage in stroke and traumatic brain injury (TBI) subjects by direct electrophysiological imaging (DELPHI) that analyzes transcranial magnetic stimulation (TMS)-evoked potentials (TEPs).

Methods: The study included 123 participants, out of which 53 subjects with WM-related pathologies (39 stroke, 14 TBI) and 70 healthy age-related controls. All subjects underwent DELPHI brain network evaluations of TMS-electroencephalogram (EEG)-evoked potentials and diffusion tensor imaging (DTI) scans for quantification of WM microstructure fractional anisotropy (FA). Read More

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December 2020

tDCS over posterior parietal cortex increases cortical excitability but decreases learning: An ERPs and TMS-EEG study.

Brain Res 2021 Feb 30;1753:147227. Epub 2020 Dec 30.

Center for Mind/Brain Sciences - CIMeC, University of Trento, Rovereto, TN, Italy. Electronic address:

The application of anodal transcranial direct current stimulation (AtDCS) is generally associated with increased neuronal excitability and enhanced cognitive functioning. Nevertheless, previous work showed that applying this straight reasoning does not always lead to the desired results at behavioural level. Here, we investigated electrophysiological markers of AtDCS-mediated effects on visuo-spatial contextual learning (VSCL). Read More

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February 2021

Increased cortical excitability but stable effective connectivity index during attentional lapses.

Sleep 2020 Dec 23. Epub 2020 Dec 23.

Sleep and Chronobiology lab, GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium.

Modern lifestyle curtails sleep and increases night-time work and leisure activities. This has a deleterious impact on vigilance and attention, exacerbating chances of committing attentional lapses, with potential dramatic outcomes. Here, we investigated the brain signature of attentional lapses and assessed whether cortical excitability and brain response propagation were modified during lapses and whether these modifications changed with aging. Read More

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December 2020

The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.

Brain Stimul 2021 Jan-Feb;14(1):161-169. Epub 2020 Dec 17.

Department of Social and Behavioral Sciences, City University of Hong Kong, Hong Kong SAR, China. Electronic address:

Background: The prediction violation account of automatic or pre-attentive change detection assumed that the inferior frontal cortex (IFC) is involved in establishing a prediction model for detecting unexpected changes. Evidence supporting the IFC's contribution to prediction model is mainly based on the Mismatch Negativity (MMN) to deviants violating predictions that are established based on the frequently presented standard events. However, deviant detection involves processes, such as events comparison, other than prediction model establishment. Read More

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December 2020

Natural oscillation frequencies in the two lateral prefrontal cortices induced by Transcranial Magnetic Stimulation.

Neuroimage 2021 02 15;227:117655. Epub 2020 Dec 15.

Padova Neuroscience Center, University of Padua, Padua, Italy; Department of Neuroscience, University of Padua, Padua, Italy; Department of General Psychology, University of Padua, Padua, Italy. Electronic address:

Different cortical regions respond with distinct rhythmic patterns of neural oscillations to Transcranial Magnetic Stimulation (TMS). We investigated natural frequencies induced by TMS in left and right homologous dorsolateral prefrontal cortices (DLPFC) and related hemispheric differences. In 12 healthy young adults, single-pulse TMS was delivered in different blocks close to F3 and F4 channels to target left and right DLPFC. Read More

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February 2021

Detecting the Potential for Consciousness in Unresponsive Patients Using the Perturbational Complexity Index.

Brain Sci 2020 Nov 27;10(12). Epub 2020 Nov 27.

Research Center of Neurology, Volokolamskoe Shosse, 80, Moscow 125367, Russia.

The difficulties of behavioral evaluation of prolonged disorders of consciousness (DOC) motivate the development of brain-based diagnostic approaches. The perturbational complexity index (PCI), which measures the complexity of electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS), showed a remarkable sensitivity in detecting minimal signs of consciousness in previous studies. Here, we tested the reliability of PCI in an independently collected sample of 24 severely brain-injured patients, including 11 unresponsive wakefulness syndrome (UWS), 12 minimally conscious state (MCS) patients, and 1 emergence from MCS patient. Read More

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November 2020

Effects of repetitive paired associative stimulation on brain plasticity and working memory in Alzheimer's disease: a pilot randomized double-blind-controlled trial.

Int Psychogeriatr 2020 Nov 16:1-13. Epub 2020 Nov 16.

Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Design: Pilot randomized double-blind-controlled trial of repetitive paired associative stimulation (rPAS), a paradigm that combines transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) with peripheral median nerve stimulation.

Objectives: To study the impact of rPAS on DLPFC plasticity and working memory performance in Alzheimer's disease (AD).

Methods: Thirty-two patients with AD (females = 16), mean (SD) age = 76. Read More

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November 2020

Local sleep-like cortical reactivity in the awake brain after focal injury.

Brain 2020 12;143(12):3672-3684

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano, Milan, Italy.

The functional consequences of focal brain injury are thought to be contingent on neuronal alterations extending beyond the area of structural damage. This phenomenon, also known as diaschisis, has clinical and metabolic correlates but lacks a clear electrophysiological counterpart, except for the long-standing evidence of a relative EEG slowing over the injured hemisphere. Here, we aim at testing whether this EEG slowing is linked to the pathological intrusion of sleep-like cortical dynamics within an awake brain. Read More

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December 2020

Subgenual cingulate connectivity and hippocampal activation are related to MST therapeutic and adverse effects.

Transl Psychiatry 2020 11 10;10(1):392. Epub 2020 Nov 10.

Department of Psychiatry, Faculty of Health, University of California San Diego, La Jolla, CA, 92093-0603, USA.

Aberrant connectivity between the dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate cortex (SGC) has been linked to the pathophysiology of depression. Indirect evidence also links hippocampal activation to the cognitive side effects of seizure treatments. Magnetic seizure therapy (MST) is a novel treatment for patients with treatment resistant depression (TRD). Read More

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November 2020

Disentangling EEG responses to TMS due to cortical and peripheral activations.

Brain Stimul 2021 Jan-Feb;14(1):4-18. Epub 2020 Oct 28.

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom.

Background: the use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation of the cerebral cortex in health and disease is becoming increasingly common. However, there is still some ambiguity regarding the extent to which brain responses to auditory and somatosensory stimulation contribute to the TMS-evoked potential (TEP).

Objective/hypothesis: to measure separately the contribution of auditory and somatosensory stimulation caused by TMS, and to assess their contribution to the TEP waveform, when stimulating the motor cortex (M1). Read More

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October 2020