11,707 results match your criteria tmd

Validation of the Temporomandibular Disorder Pain Screener in a Specialized Headache Center.

J Oral Facial Pain Headache 2021 Spring;35(2):150-156

Aims: To investigate the sensitivity and specificity of the TMD pain screener in a headache population.

Methods: A cross-sectional study was conducted at the Danish Headache Center (DHC). Patients were included if they had primary or secondary headache, trigeminal neuralgia, or facial pain. Read More

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Headache Attributed to Temporomandibular Disorders: Axis I and II Findings According to the Diagnostic Criteria for Temporomandibular Disorders.

J Oral Facial Pain Headache 2021 Spring;35(2):119-128

Aims: To analyze Axis I and II findings of patients diagnosed as having painful temporomandibular disorder (TMD) with headache attributed to TMD (HAattrTMD) in order to assess whether HAattrTMD is associated with a specific Axis I and II profile suggestive of the central sensitization process.

Methods: This retrospective study included 220 patients with painful TMD divided into those with (n = 60) and those without (n = 160) HAattrTMD, and the patients were compared for Axis I and II results according to the Diagnostic Criteria for TMD (DC/TMD). A P value < . Read More

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Association of Hormonal Contraceptive Use with Headache and Temporomandibular Pain: The OPPERA Study.

J Oral Facial Pain Headache 2021 Spring;35(2):105-112

Aims: To determine the relationship between hormonal contraceptive (HC) use and painful symptoms, particularly those associated with headache and painful temporomandibular disorders (TMD).

Methods: Data from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) prospective cohort study were used. During the 2. Read More

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An investigation of biomechanics, muscle performance, and disability level of craniocervical region of individuals with temporomandibular disorder.

Cranio 2021 Jun 15:1-11. Epub 2021 Jun 15.

Department of Physical Medicine & Rehabilitation, Ankara Yildirim Beyazit University Medical School, Ankara, Turkey.

Objective: To investigate biomechanics, muscle performance, and disability of the craniocervical region in temporomandibular disorder (TMD) patients and compare them with controls.

Methods: Craniocervical posture was evaluated using lateral photography and radiography. Range of motion, muscle performance, disability, and TMD severity were assessed using an inclinometer, Functional Strength Testing of Cervical Spine, Neck Disability Index, and Fonseca Anamnestic Index, respectively. Read More

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Study of the Protocol Used to Evaluate Skin-Flap Perfusion in Mastectomy Based on the Characteristics of Indocyanine Green.

Photodiagnosis Photodyn Ther 2021 Jun 11:102401. Epub 2021 Jun 11.

Department of Specialized Surgeries, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.

Background: Indocyanine green angiography enables real-time visualization of blood vessels at depths of up to 10 mm beneath the body surface, thereby aiding the evaluation of the viability of skin flaps and predicting necrosis in surgical fields requiring good tissue perfusion. Although skin-flap necrosis also occurs in mastectomy without reconstruction, most studies have focused on reconstructive plastic surgery. Several patients undergoing mastectomy are eligible for postoperative adjuvant therapy, but complications can lead to delays in treatment and thus require prevention. Read More

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Mineral deposition intervention through reduction of phosphorus intake suppresses osteoarthritic lesions in temporomandibular joint.

Osteoarthritis Cartilage 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University. Electronic address:

Objective: To explore the suppressing impact of low phosphorus intake on osteoarthritic temporomandibular joint and the possible mechanisms of nuclear acid injury in the insulted chondrocytes.

Design: Chondrocytes were loaded with fluid flow shear stress (FFSS) with or without low phosphorus medium. Seventy-two mice (sampled at 3-, 7- and 11-wk, n = 6) and forty-eight rats (sampled at 12-wks for different testing purpose, n = 6) were applied with unilateral anterior crossbite (UAC) with or without low phosphorus diet. Read More

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Impact of Preoperative Time Interval on Survival in Patients With Gastric Cancer.

World J Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: A time interval between diagnosis and surgery for gastric cancer is necessary, although its impact on survival remains controversial. We evaluated the impact of preoperative time interval on survival in gastric cancer patients.

Methods: We enrolled 332 patients who underwent curative gastrectomy for clinical stage (cStage) I-III gastric cancer between 2012 and 2015. Read More

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Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: A case report.

J Orthop Sci 2021 Jun 10. Epub 2021 Jun 10.

Center for Stem Cells and Regenerative Medicine, Tokyo Medical and Dental University, Japan.

Background: The purpose of this study was to compare arthroscopic findings of a degenerative flap and radial tear of the medial meniscus (MM) before and one year after treatment by meniscus repair and synovial mesenchymal stem cell (MSC) transplantation.

Methods: Patients with a degenerative flap and radial MM tear that would generally be treated by meniscectomy were included. The patients ranged in age from 45 to 62 years and all underwent meniscus repair and synovium harvest at time 0. Read More

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Pediatric patients' reasons for visiting dentists in all WHO regions.

Health Qual Life Outcomes 2021 Jun 13;19(1):165. Epub 2021 Jun 13.

Oral Surgery Department, Faculty of Dentistry of Rabat, Mohammed V University in Rabat, Rabat, Morocco.

Background: Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact are the four oral health-related quality of life (OHRQoL) dimensions (4D) or areas in which oral disorders impact pediatric patients. Using their dentists' assessment, the study aimed to evaluate whether pediatric dental patients' oral health concerns fit into the 4D of the Oral Health-Related Quality of Life (OHRQoL) construct.

Methods: Dentists who treat children from 32 countries and all WHO regions were selected from a web-based survey of 1580 international dentists. Read More

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Usefulness of texture features of apparent diffusion coefficient maps in predicting chemoradiotherapy response in muscle-invasive bladder cancer.

Eur Radiol 2021 Jun 13. Epub 2021 Jun 13.

Department of Urology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.

Objectives: To examine the usefulness of the texture analysis (TA) of apparent diffusion coefficient (ADC) maps in predicting the chemoradiotherapy (CRT) response of muscle-invasive bladder cancer (MIBC).

Methods: We reviewed 45 MIBC patients who underwent cystectomy after CRT. CRT response was assessed through histologic evaluation of cystectomy specimens. Read More

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Probing the Chiral Domains and Excitonic States in Individual WS Tubes by Second-Harmonic Generation.

Nano Lett 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (MOE), and Department of Physics, Fudan University, Shanghai 200433, People's Republic of China.

Distinct from carbon nanotubes, transition-metal dichalcogenide (TMD) nanotubes are noncentrosymmetric and polar and can exhibit some intriguing phenomena such as nonreciprocal superconductivity, chiral shift current, bulk photovoltaic effect, and exciton-polaritons. However, basic characterizations of individual TMD nanotubes are still quite limited, and much remains unclear about their structural chirality and electronic properties. Here we report an optical second-harmonic generation (SHG) study on multiwalled WS nanotubes on a single-tube level. Read More

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External ears for non-invasive and stable monitoring of volatile organic compounds in human blood.

Sci Rep 2021 Jun 10;11(1):10415. Epub 2021 Jun 10.

Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.

Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement is essential. In this study, we have investigated the possibility of external ears for stable and real-time measurement of ethanol vapour by developing a monitoring system that consisted with an over-ear gas collection cell and a biochemical gas sensor (bio-sniffer). Read More

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Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients.

BMC Oral Health 2021 Jun 10;21(1):298. Epub 2021 Jun 10.

Department of Oral and Maxillofacial Surgery, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear.

Methods: We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. Read More

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[Control study of forward head posture between patients with temporomandibular disorders and healthy people].

Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):173-176

Department of Rehabilitation Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.

Purpose: To investigate the difference of forward head posture between patients with temporomandibular disorders(TMD) and healthy people.

Methods: Ninety-one TMD patients (18 males and 73 females) were recruited from the Department of Rehabilitation; Meanwhile, eighty-three healthy participants(20 males and 63 females)were recruited. A digital camera was used to capture images of the sagittal plane of the head and neck and upper thorax. Read More

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Botulinum toxin type A and acupuncture for masticatory myofascial pain: a randomized clinical trial.

J Appl Oral Sci 2021 4;29:e20201035. Epub 2021 Jun 4.

Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Departamento de Prótese e Periodontia, Piracicaba, SP, Brasil.

Background: BoNT-A has been widely used for TMD therapy. However, the potential benefits compared to dry needling techniques are not clear.

Objective: this study aimed to compare the immediate effects of botulinum toxin type A (BoNT-A) injections and Acupuncture in myofascial temporomandibular disorders (TMD) patients. Read More

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Effects of acute mental stress on conditioned pain modulation in temporomandibular disorders patients and healthy individuals.

J Appl Oral Sci 2021 4;29:e20200952. Epub 2021 Jun 4.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia, Bauru, Brasil.

Background: Stress is a contributing factor to painful temporomandibular disorders (TMD). Nevertheless, the underpinnings of this relationship are not fully understood.

Objective: To investigate the effects of acute mental stress on conditioned pain modulation (CPM) in TMD patients compared with healthy individuals. Read More

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Effects of photobiomodulation associated with orofacial myofactional therapy on temporomandibular joint dysfunction.

Codas 2021 4;33(6):e20200193. Epub 2021 Jun 4.

Programa de Pós-graduação em Saúde da Comunicação Humana, Universidade Federal de Pernambuco - UFPE - Recife (PE), Brasil.

Purpose: To investigate the influence of photobiomodulation associated with orofacial myofunctional therapy (OMT) in patients with temporomandibular muscle disorders (TMD).

Methods: Randomized, blinded trial clinical study with a sample of eleven women with muscle TMD divided into two groups. The experimental group (EG) consisted of five women submitted to orofacial myofunctional therapy associated with photobiomodulation, and the control group (CG) consisted of six women submitted to orofacial myofunctional therapy associated with inactive photobiomodulation (placebo). Read More

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Highly Sensitive, Ultrafast, and Broadband Photo-Detecting Field-Effect Transistor with Transition-Metal Dichalcogenide van der Waals Heterostructures of MoTe and PdSe.

Adv Sci (Weinh) 2021 Jun 16;8(11):e2003713. Epub 2021 Mar 16.

Department of Electrical and Biological Physics, Kwangwoon University, Wolgye-Dong, Seoul, 01897, South Korea.

Recently, van der Waals heterostructures (vdWHs) based on transition-metal dichalcogenides (TMDs) have attracted significant attention owing to their superior capabilities and multiple functionalities. Herein, a novel vdWH field-effect transistor (FET) composed of molybdenum ditelluride (MoTe ) and palladium diselenide (PdSe ) is studied for highly sensitive photodetection performance in the broad visible and near-infrared (VNIR) region. A high rectification ratio of 6. Read More

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Study comparing different airway assessment tests in predicting difficult laryngoscopy: A prospective study in geriatric patients.

Indian J Anaesth 2021 Apr 15;65(4):309-315. Epub 2021 Apr 15.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Background And Aims: Limited studies are available comparing diagnostic accuracy of various airway predictors in geriatric patients. We conducted this study with primary aim to evaluate and validate the predictive value of 'standard airway predictors' like modified Mallampati test, thyromental distance (TMD), sternomental distance, neck movement (NM), mouth opening (MO), dentition and 'new airway predictors' like upper lip bite test (ULBT), ratio of height to thyromental distance and thyromental height test (TMHT) for predicting difficult laryngoscopy in geriatric patients.

Methods: This prospective, observational study was conducted on 140 patients above 65 years of age of either sex, scheduled for elective surgery under general anaesthesia requiring endotracheal intubation. Read More

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One-step synthesis of benzo[]thiophenes by aryne reaction with alkynyl sulfides.

Chem Sci 2020 Sep 1;11(35):9691-9696. Epub 2020 Sep 1.

Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) 2-3-10 Kanda-Surugadai Chiyoda-ku Tokyo 101-0062 Japan

An aryne reaction with alkynyl sulfides affording benzo[]thiophenes is disclosed. A wide range of 3-substituted benzothiophenes were synthesized from easily available -silylaryl triflates and alkynyl sulfides in a one-step intermolecular manner. The synthesis of diverse multisubstituted benzothiophene derivatives involving a pentacyclic compound was achieved by virtue of the good functional group tolerance and versatile C2 functionalizations. Read More

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September 2020

The repertoire of ABC proteins in .

Comput Struct Biotechnol J 2021 8;19:2905-2920. Epub 2021 May 8.

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

ATP-binding cassette (ABC) transporters belong to one of the largest membrane protein superfamilies, which function in translocating substrates across biological membranes using energy from ATP hydrolysis. Currently, the classification of ABC transporters in is not complete. Therefore, the sequence-function relationship of all ABC proteins encoded within the genome was analyzed. Read More

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Is Tele-Dentistry an Effective Approach for Patient Follow-up in Maxillofacial Surgery.

J Maxillofac Oral Surg 2021 May 31:1-7. Epub 2021 May 31.

Department of Prosthodontics, Ordu University, 52200 Ordu, Turkey.

Purpose: To explore the feasibility and diagnostic accuracy of the tele-dentistry for the follow-up of different diagnostic groups of Turkish patients in maxillofacial surgery.

Materials And Methods: In this study, follow-up patients were allocated to four groups as dental implant, minor surgical procedure, infection-medication-related osteonecrosis of the jaws (MRONJ) and temporomandibular joint disorder (TMD). In all groups, remote examination via video call and subsequently face-to-face clinic examination were performed. Read More

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Sleep bruxism and temporomandibular disorders: A scoping review of the literature.

J Dent 2021 Jun 6;111:103711. Epub 2021 Jun 6.

Professor and Chair, Department of Orofacial pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Objective: To provide a scoping review of the literature by assessing all the English-language papers that investigated the relationship between sleep bruxism (SB) and temporomandibular disorders (TMDs).

Study Data And Sources: A search was performed in the National Library of Medicine (PubMed) and Scopus databases, in order to identify all the articles published assessing the relationship between SB and TMDs, by several different approaches. The selected articles were then structurally read and summarized in PICO tables. Read More

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Development of nanobody-based POLArIS orientation probes enabled multi-color/multi-target orientation imaging in living cells.

Biochem Biophys Res Commun 2021 Aug 2;565:50-56. Epub 2021 Jun 2.

Department of Neuroanatomy and Cellular Neurobiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, 113-8519, Japan; Center for Brain Integration Research, TMDU, Bunkyo-ku, Tokyo, 113-8519, Japan. Electronic address:

Fluorescence polarization microscopy (FPM) can visualize the dipole orientation of fluorescent molecules and has been used for analyzing architectural dynamics of biomolecules including cytoskeletal proteins. To monitor the orientation of target molecules by FPM, target molecules need to be labeled with fluorophores in a sterically constrained manner, so that the fluorophores do not freely rotate. Recently, a versatile probe for such labeling using fluorescent proteins, POLArIS (Probe for Orientation and Localization Assessment, recognizing specific Intracellular Structures of interest), was reported. Read More

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Cancer-associated miRNAs and their therapeutic potential.

J Hum Genet 2021 Jun 4. Epub 2021 Jun 4.

Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

MicroRNA (miRNA; miR) is a functionally small non-coding RNA and can negatively regulate gene expression by directly binding to the target gene. Some miRNAs are closely involved in the development and progression of cancer and are abnormally expressed in many cancer types. Therefore, control of the expression of cancer-associated miRNAs is expected as a next-generation drug modality to treat advanced types of cancers with high unmet medical needs. Read More

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A Trimeric Hydrophobic Zipper Mediates the Intramembrane Assembly of SARS-CoV-2 Spike.

J Am Chem Soc 2021 Jun 4;143(23):8543-8546. Epub 2021 Jun 4.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

The S protein of SARS-CoV-2 is a type I membrane protein that mediates membrane fusion and viral entry. A vast amount of structural information is available for the ectodomain of S, a primary target by the host immune system, but much less is known regarding its transmembrane domain (TMD) and its membrane-proximal regions. Here, we determined the NMR structure of the S protein TMD in bicelles that closely mimic a lipid bilayer. Read More

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Monckeberg's Medial Sclerosis as a Cause for Headache and Facial Pain.

Curr Pain Headache Rep 2021 Jun 4;25(8):50. Epub 2021 Jun 4.

Professional Program for International Dentists, University of California Los A ngeles School of Dentistry, Los Angeles, CA, USA.

Purpose Of Review: Mönckeberg's medial sclerosis (MMS) is a chronic, non-inflammatory degenerative condition affecting primarily the tunica media of muscular arteries resulting in their calcification. The purpose of this comprehensive review is to describe MMS as it appears in the literature, in the context of headache and facial pain. Understanding the etiopathology, the associated conditions, and the differential diagnoses is important in managing MMS. Read More

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Visualization of Radiation-Induced Cell Cycle Kinetics with a Fluorescent Ubiquitination-Based Cell Cycle Indicator (Fucci).

Methods Mol Biol 2021 ;2329:223-236

Division of Oral Health Sciences, Department of Oral Radiation Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Among the methods for detecting cell cycle kinetics in tumor cells, fluorescent ubiquitination-based cell cycle indicator (Fucci) is innovative because it allows observation in live cells without losing spatiotemporal information. We succeeded in using the Fucci system to visualize radiation-induced G2 arrest in tumor cells with deficient p53 function. Here we describe protocols for establishing Fucci-expressing cell lines and analyzing radiation-induced G2 arrest kinetics in three different models: monolayer cell cultures, spheroids, and xenografted solid tumors in mice. Read More

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January 2021

Active participation of membrane lipids in inhibition of multidrug transporter P-glycoprotein.

Chem Sci 2021 Apr 9;12(18):6293-6306. Epub 2021 Apr 9.

NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign Urbana IL 61801 USA

P-glycoprotein (Pgp) is a major efflux pump in humans, overexpressed in a variety of cancers and associated with the development of multi-drug resistance. Allosteric modulation by various ligands (, transport substrates, inhibitors, and ATP) has been biochemically shown to directly influence structural dynamics, and thereby, the function of Pgp. However, the molecular details of such effects, particularly with respect to the role and involvement of the surrounding lipids, are not well established. Read More

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Role of thermography in the assessment of temporomandibular disorders and other musculoskeletal conditions: A systematic review.

Proc Inst Mech Eng H 2021 Jun 3:9544119211023616. Epub 2021 Jun 3.

Department of Prosthodontics, Faculty of Dental Medicine, University of Porto, Porto, Portugal.

The aim of this review was to evaluate whether thermal imaging may constitute a reliable assessment method of musculoskeletal and temporomandibular disorders (TMD/MSD). A systematic review was conducted in the Pubmed, Scopus, Cochrane library, Web of Science, and Lilacs databases. The search terms were "musculoskeletal disorders,"temporomandibular disorders,"infrared thermography,"thermography," and "infrared imaging. Read More

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