Biomed Mater 2021 Jun 18. Epub 2021 Jun 18.
Department of Medical Physics, Tarbiat Modares University, Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Tehran, 14115116, IRAN, ISLAMIC REPUBLIC OF.
Objective: Mesenchymal stem cells (MSCs) on injectable hydrogels are mostly used to regenerate articular cartilage, which would have a variety of outcomes. Chondrocyte extracellular vesicles (EVs) have attracted many attentions for their chondrogenic differentiation capacity; however, the roles of EVs in both chondrogenic differentiation of MSCs and cartilage regeneration are poorly understood yet.
Methods: In the current study, to investigate the differentiation effects of human articular chondrocyte EVs on Adipose-derived MSCs, they were cultured in injectable chitosan-hyaluronic acid (CS-HA) hydrogel and then treated with chondrocyte EVs for 21 days. Read More