205,415 results match your criteria tissue injuries


Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture.

FASEB J 2021 Jul;35(7):e21733

Center for Musculoskeletal Research, Department of Orthopaedics & Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA.

Tendon injuries are common and heal poorly, due in part to a lack of understanding of fundamental tendon cell biology. A major impediment to the study of tendon cells is the absence of robust, well-characterized in vitro models. Unlike other tissue systems, current tendon cell models do not account for how differences in isolation methodology may affect the activation state of tendon cells or the presence of various tendon cell subpopulations. Read More

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The contribution of TFPIα to the hemostatic response to injury in mice.

J Thromb Haemost 2021 Jun 23. Epub 2021 Jun 23.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania.

Background: TFPI is an essential regulator of coagulation, limiting thrombin generation and preventing thrombosis. In humans and mice, TFPIα is the sole isoform present in platelets.

Objective: Here we asked whether TFPIα, because of its release from platelets at sites of injury, has a unique role in limiting the hemostatic response. Read More

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EFFECTIVENESS OF CORRECTION OF PSYCHO-EMOTIONAL STRESS IN CHILDREN WITH TRAUMATIC INJURY TO SOFT TISSUES AND FACIAL BONES.

Wiad Lek 2021 ;74(6):1463-1468

POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.

Objective: The aim: To study the effectiveness of correction of psycho-emotional stress in children with traumatic injuries of the tissues of the maxillofacial area.

Patients And Methods: Materials and methods: A comprehensive examination and treatment of 58 children aged 3 to 15 years with traumatic injuries of the maxillofacial area were conducted during the period of 5 years. This applied to soft tissue injuries in 51. Read More

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3',4'-Dihydroxyflavonol (DiOHF) prevents DNA damage, lipid peroxidation and inflammation in ovarian ischaemia-reperfusion injury of rats.

J Obstet Gynaecol 2021 Jun 23:1-8. Epub 2021 Jun 23.

Department of Pathology, Meram Medical School, Necmettin Erbakan University, Konya, Turkey.

This study aimed to determine the effect of 3',4'-Dihydroxyflavonol (DiOHF) on lipid peroxidation, DNA damage and inflammation in ovarian ischaemia (I)-reperfusion (R) injury. This study was performed on 44 Wistar-albino female rats. Groups were designed as Control; Sham; I/R (the left ovary was ligated for 2 h and then reperfused for 2 h); I/R + DiOHF (after 2 h ischaemia and 2 h reperfusion, 30 mg/kg of DiOHF was given intraperitoneally and reperfusion was allowed for 2 h more); I + DiOHF + R (after 2 h I, 30 mg/kg of DiOHF was given at the beginning of 2 h reperfusion); DiOHF + I/R (2 h after DiOHF administration, the left ovary was ligated for 2 h and then reperfused for 2 h). Read More

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A novel Veress needle mechanism that reduces overshooting after puncturing the abdominal wall.

Surg Endosc 2021 Jun 22. Epub 2021 Jun 22.

Department of BioMechanical Engineering, Faculty of Biomedical Engineering, University of Technology Delft, Mekelweg 2, 2628 CD, Delft, The Netherlands.

Background: Complications that occur in laparoscopic surgery are often associated with the initial entry into the peritoneal cavity. The literature reported incidences of Veress needle (VN) injuries of e.g. Read More

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Extravasation Injuries of the Limbs in Neonates and Children-Development of a Treatment Algorithm.

Dtsch Arztebl Int 2021 Aug 23(Forthcoming). Epub 2021 Aug 23.

Background: Hospitalized children and neonates very often receive intravenous treatment. There has not yet been any systematic study of the incidence of extravasation injuries in this age group. In a few studies of neonates in intensive care receiving intravenous treatment, incidence figures in the range of 18-46% have been reported; 2. Read More

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How often does it happen? A review of unintended, unnecessary and unavoidable high-dose radiation exposures.

J Radiol Prot 2021 Jun 22. Epub 2021 Jun 22.

Radiation Safety and Monitoring Section, International Atomic Energy Agency (IAEA), Vienna, AUSTRIA.

High-dose radiation exposures of humans occur every year around the world, and may lead to harmful tissue reactions. This review aims to look at the available information sources that can help answering the question of how often these events occur yearly on a global scale. In the absence of comprehensive databases of global occurrence, publications on radiation accidents in all uses of radiation and on rates of high-dose events in different medical uses of radiation have been reviewed. Read More

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Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers.

Clin Exp Pharmacol Physiol 2021 Jun 22. Epub 2021 Jun 22.

Departments of Physiology Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt.

Cholestasis caused by slowing or blockage of bile flow is a serious liver disease that can lead to liver fibrosis and cirrhosis. The link between transforming growth factor beta 1 (TGFβ1), Smad family member 3 (Smad3), and microRNA 21 (miR21) in bile duct ligation (BDL)-induced liver fibrosis in the presence and absence of the anti-inflammatory and antioxidant compound, resveratrol (RSV) has not been previously studied. Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. Read More

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Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration.

Elife 2021 Jun 22;10. Epub 2021 Jun 22.

Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, United States.

In order to regenerate tissues successfully, stem cells must detect injuries and restore missing cell types through largely unknown mechanisms. Planarian flatworms have an extensive stem cell population responsible for regenerating any organ after amputation. Here, we compare planarian stem cell responses to different injuries by either amputation of a single organ, the pharynx, or removal of tissues from other organs by decapitation. Read More

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Incidence and risk factors of medical device-related pressure injuries among patients undergoing prone position spine surgery in the operating room.

J Tissue Viability 2021 Jun 13. Epub 2021 Jun 13.

Orthopaedic Surgeon, Department of Orthopaedic Surgery, Spine Center, Busan Korea Hospital, Busan, South Korea.

Aim: We aimed to investigate the incidence rate and risk factors of medical device-related pressure injuries (MDRPIs) among patients undergoing prone position spine surgery.

Materials And Methods: This was a prospective observational study of 147 patients who underwent spine surgery in an orthopaedic hospital in Korea. The incidence of MDRPI according to intrinsic and extrinsic factors was assessed using the independent t-, χ -, or Fisher's exact tests. Read More

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Large traumatic vulvar hematoma managed with a simple incision: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106080. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Medical Faculty, Universitas Airlangga, Surabaya, Indonesia. Electronic address:

Introduction And Importance: Non-obstetric vulvar hematoma is a rare condition. With only few cases reported, no standard consensus exists on the best management of vulvar hematomas. Herein, we report the successful management of a large trauma-induced vulvar hematoma through a simple incision under local anesthesia. Read More

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Effect of supersaturated oxygen emulsion treatment on chloropicrin-induced chemical injury in ex vivo rabbit cornea.

Toxicol Lett 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmacology and Toxicology, Michigan State University, 1355 Bogue Street, East Lansing, MI, 48824, United States. Electronic address:

With a possibility for the use of chemical weapons in battlefield or in terrorist activities, effective therapies against the devastating ocular injuries, from their exposure, are needed. Oxygen plays a vital role in ocular tissue preservation and wound repair. We tested the efficacy of supersaturated oxygen emulsion (SSOE) in reducing ex vivo corneal and keratocyte injury from chloropicrin (CP). Read More

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Joining soft tissues to bone: Insights from modeling and simulations.

Bone Rep 2021 Jun 23;14:100742. Epub 2020 Dec 23.

Mechanics of Biological and Bioinspired Materials Laboratory, Department of Aerospace and Mechanical Engineering, University of Liège, Liège, Belgium.

Entheses are complex multi-tissue regions of the musculoskeletal system serving the challenging task of connecting highly dissimilar materials such as the compliant tendon to the much stiffer bone, over a very small region. The first aim of this review is to highlight mathematical and computational models that have been developed to investigate the many attachment strategies present at entheses at different length scales. Entheses are also relevant in the medical context due to the high prevalence of orthopedic injuries requiring the reattachment of tendons or ligaments to bone, which are associated with a rather poor long-term clinical outcome. Read More

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Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review.

Front Bioeng Biotechnol 2021 3;9:654087. Epub 2021 Jun 3.

Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, China.

The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g. Read More

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The protective role of the miR-25-mediated notch signaling pathway in the memory capacity and brain tissue of mice with central nervous system infections.

Am J Transl Res 2021 15;13(5):4835-4843. Epub 2021 May 15.

Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University Guiyang, Guizhou Province, China.

Objective: The study aimed to explore the role of miR-25 and the notch signaling pathway in the memory capacity and brain tissue of mice with central nervous system (CNS) infections.

Methods: A bioinformatics website and the dual-luciferase reporter assay were used to analyze the targeting relationship between miR-25 and Notch1. The mice were randomized into 7 groups (n=10 per group), including the normal group, the model group (lipopolysaccharide at a dose of 500 μg/kg for the model establishment), the NC group, the miR-25 mimic group, the miR-25 inhibitor group, the DAPT group, and the miR-25 inhibitor + DAPT group. Read More

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Outcomes and rate of return to play in elite athletes following arthroscopic surgery of the hip.

Int Orthop 2021 Jun 19. Epub 2021 Jun 19.

Young Adult Hip Service, Department of Trauma and Orthopaedics, Addenbrooke's - Cambridge University Hospitals NHS Foundation Trust, Box 37, Hills Road, CB2 0QQ, Cambridge, UK.

Background: The tremendous physical demands of elite performance increase the risk of elite athletes sustaining various orthopaedic injuries. Hip pain is common in high-level athletes representing up to 6% of all athletic injuries. Expedient diagnosis and effective treatment are paramount for their future sporting careers and to prevent subsequent joint degeneration. Read More

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Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms.

Life Sci 2021 Jun 17:119730. Epub 2021 Jun 17.

Department of Chemistry, Faculty of Science and Literature, 12000-Bingol University, Bingol, Turkey.

Aim: High dose of fluoride intake is associated with toxic effects on liver and kidney tissues. One approach to tackle these toxicities is using natural antioxidants as supplements. This study evaluated the ameliorative effects of hesperidin (HSP) against sodium fluoride (NaF)-induced hepatotoxicity and nephrotoxicity in wistar albino rats. Read More

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Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation.

Chin Med 2021 Jun 19;16(1):45. Epub 2021 Jun 19.

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 West Chunrong Road, Chenggong, Kunming, Yunnan, 650500, PR China.

Background: Panax notoginseng (Burk.) F. H. Read More

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Cell death due to electroporation - A review.

Bioelectrochemistry 2021 Jun 6;141:107871. Epub 2021 Jun 6.

University of Ljubljana, Faculty of Electrical Engineering, Tržaška cesta 25, 1000 Ljubljana, Slovenia. Electronic address:

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer and enhanced drug delivery but can also lead to cell death. Electroporation resulting in cell death (termed as irreversible electroporation) has been successfully used as a new non-thermal ablation method of soft tissue such as tumours or arrhythmogenic heart tissue. Read More

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[Role of ski injury treatment system between the ski resort medical station of Winter Olympics and the nearby medical care hospital].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):580-585

Department of Sports Medicine, Peking University Third Hospital; Institute of Sports Medicine of Peking University; Beijing Key Laboratory of Sports Injuries; Beijing 100191, China.

Objective: To make a retrospective analysis of the situation and process of treating skiers' injuries in the medical station of the Wanlong ski resort in Chongli and the nearest treatment hospital, and to provide a basis for the establishment and optimization of the treatment process between the medical station of the Winter Olympics ski resort and the nearest treatment hospital, and to gain experience for medical security of mass skiing.

Methods: The data of all ski injuries in Chongli District were collected from the medical station of the Wanlong ski resort during the 2018-2019 snow season (November 2018 to April 2019) and the nearest treatment hospital during two periods (March 2019, and November 2019 to January 2020). The differences of injury causes, injury types, injury sites, and treatment effects of the injured skiers were analyzed. Read More

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A 64-Year-Old Man with Traumatic Right Middle Lobe Lung Herniation Successfully Managed Conservatively.

Am J Case Rep 2021 Jun 19;22:e931446. Epub 2021 Jun 19.

Section of Diagnostic Radiology, School of Medicine, University of Puerto Rico (UPR) Medical Sciences Campus, San Juan, Puerto Rico.

BACKGROUND Intercostal lung hernias can be congenital or acquired and involve a protrusion of lung tissue beyond the thoracic cage. Post-traumatic intercostal lung hernias can present with symptoms of pain and dyspnea or can be asymptomatic. This report is of a case of traumatic right middle lobe lung herniation through the intercostal junction of the fourth and fifth ribs in a 64-year-old man that was successfully managed conservatively. Read More

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Strain patterns in normal anterior talofibular and calcaneofibular ligaments and after anatomical reconstruction using gracilis tendon grafts: A cadaver study.

BMC Musculoskelet Disord 2021 Jun 18;22(1):558. Epub 2021 Jun 18.

Division of Orthopaedic Surgery, Dalhousie University, Queen Elizabeth II Health Sciences Center Halifax Infirmary (Suite 4867), 1796 Summer Street, Halifax, NS, B3H3A7, Canada.

Background: Inversion ankle sprains, or lateral ankle sprains, often result in symptomatic lateral ankle instability, and some patients need lateral ankle ligament reconstruction to reduce pain, improve function, and prevent subsequent injuries. Although anatomically reconstructed ligaments should behave in a biomechanically normal manner, previous studies have not measured the strain patterns of the anterior talofibular ligament (ATFL) and calcaneofibular ligament (CFL) after anatomical reconstruction. This study aimed to measure the strain patterns of normal and reconstructed ATFL and CFLs using the miniaturization ligament performance probe (MLPP) system. Read More

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Cartilage tissue engineering by co-transplantation of chondrocyte extracellular vesicles and mesenchymal stem cells, entrapped in chitosan-hyaluronic acid hydrogel.

Biomed Mater 2021 Jun 18. Epub 2021 Jun 18.

Department of Medical Physics, Tarbiat Modares University, Department of Cell Therapy and Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Tehran, 14115116, IRAN, ISLAMIC REPUBLIC OF.

Objective: Mesenchymal stem cells (MSCs) on injectable hydrogels are mostly used to regenerate articular cartilage, which would have a variety of outcomes. Chondrocyte extracellular vesicles (EVs) have attracted many attentions for their chondrogenic differentiation capacity; however, the roles of EVs in both chondrogenic differentiation of MSCs and cartilage regeneration are poorly understood yet.

Methods: In the current study, to investigate the differentiation effects of human articular chondrocyte EVs on Adipose-derived MSCs, they were cultured in injectable chitosan-hyaluronic acid (CS-HA) hydrogel and then treated with chondrocyte EVs for 21 days. Read More

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Return to Play After a Hamstring Strain Injury: It is Time to Consider Natural Healing.

Sports Med 2021 Jun 18. Epub 2021 Jun 18.

Department of Rehabilitation Sciences, Ghent University, University Hospital, Corneel Heymanslaan 10, 3B3, 9000, Ghent, Belgium.

Return to play (RTP) criteria after hamstring strain injuries (HSIs) help clinicians in deciding whether an athlete is ready to safely resume previous sport activities. Today, functional and sport-specific training tests are the gold standard in the decision-making process. These criteria lead to an average RTP time between 11 and 25 days after a grade 1 or 2 HSI. Read More

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Fibular Rod Osteosynthesis in Ankle Fractures With Compromised Soft Tissue.

Foot Ankle Spec 2021 Jun 18:19386400211018075. Epub 2021 Jun 18.

Department of Orthopaedic Surgery, Ostfold Hospital Trust, Graalum, Norway.

Background: Complications after plate and screw fixation of ankle fractures are frequently reported in the literature, with a higher rate in patients with advanced age, comorbidities, and poor skin conditions. A reduced complication rate has been reported with intramedullary nailing (IMN) of the fibula; however, the indication has been based on the surgeon's preferences. We report the results after IMN in patients with compromised soft tissue exclusively. Read More

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[Clinical application of free peroneal artery perforator flap in soft tissue defect of foot and ankle].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):756-760

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R.China.

Objective: To investigate clinical application of the free peroneal artery perforator flap in soft tissue defect of foot and ankle.

Methods: The clinical data of 18 patients with soft tissue defects of foot and ankle who were repaired with free peroneal artery perforator flaps between March 2019 and March 2020 were retrospectively analyzed. Among them, there were 11 males and 7 females; the age ranged from 21 to 58 years, with an average age of 45 years. Read More

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[Clinical study of modified technique to reduce partial necrosis rate of distally pedicled sural flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):750-755

Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha Hunan, 410001, P.R.China.

Objective: To investigate whether the technical modifications regarding the risk factors related to the partial necrosis of the distally pedicled sural flap could reduce the partial necrosis rate of the flap.

Methods: A clinical data of 254 patients (256 sites) (modified group), who used modified technique to design and cut distally pedicled sural flaps to repair the distal soft tissue defects of the lower limbs between April 2010 and December 2019, was retrospectively analyzed. Between April 2001 and March 2010, 175 patients (179 sites) (control group) who used the traditional method to design and cut the skin flap to repair the distal soft tissue defects of the lower limbs were compared. Read More

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[Modified induced membrane technique and pedicled skin (myocutaneous) flap for chronic tibial osteomyelitis in patients with diabetes].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):716-721

Department of Wound Repair Surgery, Wuxi 9th Affiliated Hospital of Soochow University, Wuxi Jiangsu, 214062, P.R.China.

Objective: To investigate the effectiveness of modified induced membrane technique and pedicled skin (myocutaneous) flap for chronic tibial osteomyelitis in patients with diabetes.

Methods: A clinical data of 22 diabetic patients with chronic tibial osteomyelitis between January 2017 and March 2019 was retrospectively analyzed. There were 15 males and 7 females with an average age of 52 years (range, 44-65 years). Read More

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[Indirect reduction technique via Nice knot for transverse fracture of patella].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):710-715

Fujian Orthopaedics Research Institute, Department of Orthopaedic Trauma, the First Affiliated Hospital of Fujian Medical University, Fuzhou Fujian, 350005, P.R.China.

Objective: To assess the outcomes in indirect reduction technique via Nice knot for transverse patellar fractures.

Methods: The clinical data of 25 patients with transverse patellar fractures meeting the inclusion criteria between January 2017 and December 2018 were retrospectively analyzed. The patients were divided into trial group ( =13) and control group ( =12) according to different intraoperative reduction methods. Read More

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[Influence of lateral posterior tibial slope on tibial tunnel expansion after anatomical single-bundle anterior cruciate ligament reconstruction].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):697-703

Department of Sports Medicine, Affiliated Xinhuan Hospital of Dalian University, Dalian Liaoning, 116001, P.R.China.

Objective: To investigate the influence of lateral posterior tibial slope (LPTS) on tibial tunnel expansion after anatomical single-bundle anterior cruciate ligament (ACL) reconstruction and the effect of tibial tunnel expansion on knee joint function.

Methods: A clinical data of 52 patients with ACL rupture, who underwent arthroscopic anatomical single-bundle reconstruction between November 2018 and December 2019, was retrospectively analyzed. There were 32 males and 20 females with an average age of 34. Read More

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