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Bioelectrochemistry 2021 Mar 31;140:107810. Epub 2021 Mar 31.

Heart Center, Department of Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.

Mammalian heart cells and cells of leaves of Dionaea muscipula share the ability to generate propagated action potentials, because the excitable cells are electrically coupled. In the heart the propagated action potential causes synchronized contraction of the heart muscle after automatic generation of the impulse in the sinus node. In Dionaea propagation results in closure of the trap after activation of trigger hairs by an insect. Read More

Int J Cancer 2021 Apr 12. Epub 2021 Apr 12.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai, China.

Previous studies have suggested that gut microbiota plays a critical role in colorectal cancer (CRC). Although preliminary comparisons of the oral and gut microbiota between CRC and healthy control (HC) patients have been made, the association between microbiome abundance and host clinical factors has not been fully illustrated, especially oral health conditions. Matching samples of unstimulated saliva, cancer tissues or biopsies and stools were collected from 30 CRC and 30 HC patients from Shanghai Jiao Tong University affiliated Renji Hospital for 16S rRNA sequencing analysis. Read More

Brain 2021 Apr;144(3):989-998

Department of Neuropsychology, NHNN, University College London Hospitals NHS Foundation Trust, London, UK.

The clinical effectiveness of any disease-modifying treatment for prion disease, as for other neurodegenerative disorders, will depend on early treatment before damage to neural tissue is irrevocable. Thus, there is a need to identify markers that predict disease onset in healthy at-risk individuals. Whilst imaging and neurophysiological biomarkers have shown limited use in this regard, we recently reported progressive neurophysiological changes in individuals with the inherited prion disease mutation P102L. Read More

Rev Med Chil 2020 Nov;148(11):1679-1683

Facultad de Medicina, Universidad de Antofagasta, Antofagasta, Chile.

We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. Read More

Arthritis Rheumatol 2021 Apr 12. Epub 2021 Apr 12.

University of Pittsburgh, Pittsburgh, PA, USA.

Objective: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin in which the pathogenesis is not well understood due to its rarity. Our goal was to determine the skin transcriptome of LS tissue compared with healthy controls to identify molecular targets using RNA sequencing (RNAseq). Differentially expressed genes (DEGs) identified in jLS patients were compared with histopathological features, clinical features and used to cluster jLS patients. Read More

J Clin Monit Comput 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, University of Groningen, BA60, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Purpose: Hyperspectral imaging (HSI) is a noninvasive spectroscopy technique for determining superficial tissue oxygenation. The HyperView™ system is a hand-held camera that enables perfusion image acquisition. The evaluation of superficial tissue oxygenation is warranted in the evaluation of patients with peripheral arterial disease. Read More

Wiad Lek 2021 ;74(3 cz 2):702-707

SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.

Objective: The aim: Is to characterize the «Medico-sociological map» developed by us to identify systemic and local risk factors for periodontal disease in patients with type I and II diabetes mellitus as a resource to improve the treatment of generalized periodontitis.

Patients And Methods: Materials and methods: We have developed a Medic-sociological map to identify systemic and local risk factors for periodontal disease in patients with type I and type II diabetes mellitus. Methods of accumulation of primary dental and endocrinological information, review and analytical methods. Read More

Bioengineered 2021 Dec;12(1):1212-1225

Department of Dermatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. Read More

Am J Physiol Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Turku PET Centre, University of Turku, Finland.

Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Read More

Am J Ophthalmol Case Rep 2021 Jun 18;22:101063. Epub 2021 Mar 18.

Eye Institute, Cleveland Clinic Abu Dhabi, C7-257 Swing Wing, Al Maryah Island, Abu Dhabi, 112412, United Arab Emirates.

Purpose: Over the last decade, injectable soft tissue fillers have become an essential part of facial plastic surgery practice. We report here a tragic complication of hyaluronic acid filler injection in a young healthy woman, management offered, and the outcome.

Observations: A 32-year-old woman developed unilateral acute blindness, orbital pain, total ophthalmoplegia, and anterior and posterior segment ischemia immediately following hyaluronic acid injection. Read More

Front Vet Sci 2021 24;8:603262. Epub 2021 Mar 24.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Lithium (Li) is prescribed against a wide range of neurological disorders. Besides its excellent therapeutic properties, there are several adverse effects associated with Li. The impact of Li on renal function and diabetes insipidus is the most common adverse effect of this drug. Read More

Front Cell Dev Biol 2021 25;9:628128. Epub 2021 Mar 25.

Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China.

Background: Dermatomyositis (DM) associated rapidly progressive interstitial lung disease (RP-ILD) has high mortality rate and poor prognosis. Galectin-9 (Gal-9) plays multiple functions in immune regulation. We investigated Gal-9 expression in DM patients and its association with DM-ILD. Read More

Front Oncol 2021 25;11:654185. Epub 2021 Mar 25.

Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China.

Purpose: Our research was aimed to identify the expression, clinical value and biological significance of GINS complex subunit 4 (GINS4) in hepatocellular carcinoma (HCC).

Materials And Methods: GINS4 was initially screened through weighted gene co-expression network analysis (WGCNA). The TCGA, GEO, and TIMER databases were applied for analyzing the GINS4 mRNA expression in HCC. Read More

Am J Transl Res 2021 15;13(3):1037-1050. Epub 2021 Mar 15.

Pancreatic Disease Center, Shanghai Ruijin Hospital Shanghai, China.

Objective: Long non-coding RNA (lncRNA) SNHG17 has been shown to modulate the biological behavior of multiple cancers (e.g., colorectal and lung cancers). Read More

Front Immunol 2021 25;12:591236. Epub 2021 Mar 25.

Discipline of Periodontics, Department of Prosthodontics and Periodontics, School of Dentistry at Bauru, University of São Paulo, Bauru, Brazil.

Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease characterized by tissue damage and widespread inflammation in response to environmental challenges. Deposition of immune complexes in kidneys glomeruli are associated with lupus nephritis, determining SLE diagnosis. Periodontitis is a chronic inflammatory disease characterized by clinical attachment and bone loss, caused by a microbial challenge - host response interaction. Read More

Front Neurol 2021 24;12:645925. Epub 2021 Mar 24.

Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, University Utrecht, Utrecht, Netherlands.

Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy and is often associated with hippocampal sclerosis (HS) and cognitive disturbances. Over the last decade, high frequency oscillations (HFOs) in the intraoperative electrocorticography (ioECoG) have been proposed to be biomarkers for the delineation of epileptic tissue but hippocampal ripples have also been associated with memory consolidation. Healthy hippocampi can show prolonged ripple activity in stereo- EEG. Read More

Front Physiol 2021 24;12:649794. Epub 2021 Mar 24.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

Polycystic ovary syndrome (PCOS) and metabolic inflexibility are linked to insulin resistance, and women with PCOS appear to be metabolic inflexible in the rested, insulin-stimulated state. Exercise training is a primary lifestyle intervention in PCOS. Exercise training improves whole-body fat oxidation during submaximal exercise in healthy women, yet little is known about the effect on this outcome in women with PCOS. Read More

Front Cell Neurosci 2021 26;15:661412. Epub 2021 Mar 26.

Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, NL, Canada.

Pharmacological upregulation of glutamate transporter-1 (GLT-1), commonly achieved using the beta-lactam antibiotic ceftriaxone, represents a promising therapeutic strategy to accelerate glutamate uptake and prevent excitotoxic damage in neurological conditions. While excitotoxicity is indeed implicated in numerous brain diseases, it is typically restricted to select vulnerable brain regions, particularly in early disease stages. In healthy brain tissue, the speed of glutamate uptake is not constant and rather varies in both an activity- and region-dependent manner. Read More

Proc SPIE Int Soc Opt Eng 2020 Feb 16;11315. Epub 2020 Mar 16.

Harvard Medical School, Boston, MA, USA.

Brain shift is a non-rigid deformation of brain tissue that is affected by loss of cerebrospinal fluid, tissue manipulation and gravity among other phenomena. This deformation can negatively influence the outcome of a surgical procedure since surgical planning based on pre-operative image becomes less valid. We present a novel method to compensate for brain shift that maps preoperative image data to the deformed brain during intra-operative neurosurgical procedures and thus increases the likelihood of achieving a gross total resection while decreasing the risk to healthy tissue surrounding the tumor. Read More

Vet J 2021 May 6;271:105653. Epub 2021 Mar 6.

Department of Clinical Diagnostics and Services, Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Ten healthy Beagle dogs were used to compare selected echocardiographic parameters of right ventricular (RV) systolic function with high field cardiac magnetic resonance imaging (MRI). All dogs underwent complete transthoracic echocardiography before and during anesthesia, as well as cardiac MRI with determination of morphology-based ejection fraction, and phase contrast angiography-derived stroke volume. A correlation analysis was carried out between echocardiographic and MRI parameters. Read More

Fertil Steril 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan.

Objective: To describe the anatomic and technical highlights of a novel nerve-sparing surgery in deep endometriosis (DE) using near-infrared (NIR) fluorescence technology and indocyanine green (ICG).

Design: Stepwise demonstration of this method with narrated video footage.

Setting: An urban general hospital. Read More

Inflammation 2021 Apr 11. Epub 2021 Apr 11.

Qingdao Stomatological Hospital Affiliated to Qingdao University, No.17 Dexian Road, Shinan District, Qingdao, 266001, Shandong Province, China.

To study the effects of psoralen on the intestinal barrier and alveolar bone loss (ABL) in rats with chronic periodontitis. Fifty-two 8-week-old specific pathogen-free (SPF) male Sprague-Dawley (SD) rats were randomly divided into the following four groups: Control group (Control), psoralen group of healthy rats (Pso), periodontitis model group (Model), and psoralen group of periodontitis rats (Peri+Pso). The alveolar bone resorption of maxillary molars was observed via haematoxylin-eosin staining and micro-computed tomography. Read More

Eur J Trauma Emerg Surg 2021 Apr 11. Epub 2021 Apr 11.

Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany.

Objective: Trauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a potent immunomodulator of the post-traumatic response to tissue injury. Polytraumatized patients are frequently at risk to developing infectious complications, which may be aggravated by alcohol-induced immunosuppression. Read More

J Vasc Res 2021 Apr 9:1-24. Epub 2021 Apr 9.

Space Biology Division, Space Technology Mission Directorate, Ames Research Center, National Aeronautics and Space Administration, Moffett Field, California, USA.

The molecular signaling cascades that regulate angiogenesis and microvascular remodeling are fundamental to normal development, healthy physiology, and pathologies such as inflammation and cancer. Yet quantifying such complex, fractally branching vascular patterns remains difficult. We review application of NASA's globally available, freely downloadable VESsel GENeration (VESGEN) Analysis software to numerous examples of 2D vascular trees, networks, and tree-network composites. Read More

Biochim Biophys Acta Proteins Proteom 2021 Apr 8:140659. Epub 2021 Apr 8.

Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, São Paulo, Brazil. Electronic address:

Saliva is a biofluid that maintains the health of oral tissues and the homeostasis of oral microbiota. Studies have demonstrated that Oral squamous cell carcinoma (OSCC) patients have different salivary microbiota than healthy individuals. However, the relationship between these microbial differences and clinicopathological outcomes is still far from conclusive. Read More

J Minim Invasive Gynecol 2021 Apr 8. Epub 2021 Apr 8.

OmicsWay Corp., Walnut, CA, 91789, USA; I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, 141701 Moscow, Russia Federation; World-Class Research Center "Digital biodesign and personalized healthcare", Sechenov First Moscow State Medical University, Moscow, Russia.

Study Objective: to develop a prototype of complex gene expression biomarker for the diagnosis of endometriosis based on differences between molecular signatures of endometrium from women with and without endometriosis.

Design: Prospective observational cohort study. II-1. Read More

Radiother Oncol 2021 Apr 8. Epub 2021 Apr 8.

Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong, China. Electronic address:

Background And Purpose: Radiation therapy (RT)-induced neurocognitive disability may be mediated by brain tissue damage. The aim of the present study was to investigate the effects of standard RT on normal brain tissue via in vivo neuroimaging in patients with nasopharyngeal carcinoma (NPC).

Materials And Methods: A total of 146 newly diagnosed NPC patients who were treated with standard RT were longitudinally followed up at multiple time points during the first year post-RT, with 19 comparable healthy controls followed up in parallel serving as normal age-related benchmarks. Read More

Ann Chir Plast Esthet 2021 Apr 7. Epub 2021 Apr 7.

Department of Maxillo-Facial Surgery, Purpan University Hospital, Toulouse, France.

Background: The management of bone exposure in patients with extensive burns could be a challenge due to the lack of healthy tissue. In such cases, it could be interesting to use any still healthy tissue initially destined for amputation and use it to cover up another site. We present the case of a sever burn patient for whom we used the only healthy palmar hand skin to cover an olecranon exposure. Read More

Res Vet Sci 2021 Mar 31;136:472-477. Epub 2021 Mar 31.

Department of Veterinary Clinical Sciences, University of Copenhagen, Dyrlægevej 16, 1870 Frederiksberg C, Denmark. Electronic address:

Primary hyperfibrinolysis is not well characterised in canine cancer. This prospective case-control pilot study aimed to evaluate tissue plasminogen activator-modified thromboelastography (tPA-TEG) for diagnosis of primary hyperfibrinolysis in dogs with cancer and establish the in vitro therapeutic concentration of tranexamic acid (TXA). Nine dogs with sarcomas and normocoagulable thromboelastograms and 11 healthy dogs were included. Read More

Neuroimage 2021 Apr 7:118012. Epub 2021 Apr 7.

Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA.

Non-heme iron is an important element supporting the structure and functioning of biological tissues. Imbalance in non-heme iron can lead to different neurological disorders. Several MRI approaches have been developed for iron quantification relying either on the relaxation properties of MRI signal or measuring tissue magnetic susceptibility. Read More