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Evaluation of prognostic factors in patients with Bell's palsy.

Brain Behav 2021 Sep 27:e2385. Epub 2021 Sep 27.

Department of ENT, Nobel Medical College, Biratnagar, Nepal.

Background: Bell's palsy is a common neurological problem that leads to peripheral palsy of the facial nerve. Most patients have a favorable response with or without treatment while some are left with significant facial deformity. Identification of factors which influence the outcome in patients with Bell's palsy may help clinicians counsel better. Read More

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September 2021

Rapid nanowelding of silver nanowires by focused-light-scanning for high-performance flexible transparent electrodes.

Nanotechnology 2021 Sep 27. Epub 2021 Sep 27.

The University of Tennessee Knoxville, Knoxville, TN, USA, Knoxville, Tennessee, 37996-4519, UNITED STATES.

Silver nanowires (AgNWs) have been considered as one of the most promising flexible transparent electrodes (FTEs) material for next-generation optoelectronic devices. However, the large contact resistance between AgNWs could deteriorate the conductivity of FTEs. In the present work, high-performance AgNWs FTEs were obtained by means of focused-light-scanning (FLS), which could lead to the large-area, rapid and high-quality welding between AgNWs within a short time, forming the reliable and stable AgNWs network. Read More

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September 2021

Aptamer-based electrochemical biosensor for rapid detection of SARS-CoV-2: Nanoscale electrode-aptamer-SARS-CoV-2 imaging by photo-induced force microscopy.

Biosens Bioelectron 2021 Aug 30;195:113595. Epub 2021 Aug 30.

Department of Chemistry and Biochemistry, Université Du Québec à Montréal, Montréal, QC, H3C 3P8, Canada. Electronic address:

Rapid, mass diagnosis of the coronavirus disease 2019 (COVID-19) is critical to stop the ongoing infection spread. The two standard screening methods to confirm the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are polymerase chain reaction (PCR), through the RNA of the virus, and serology by detecting antibodies produced as a response to the viral infection. However, given the detection complexity, cost and relatively long analysis times of these techniques, novel technologies are urgently needed. Read More

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Immunomolecular evaluation of dihydroartemisinin effects on apoptosis in chronic lymphocytic leukemia cell lines.

Leuk Res 2021 Sep 16;110:106702. Epub 2021 Sep 16.

Division of Hematology, Internal Medicine Department, Faculty of Medicine, Gazi University, Ankara, Turkey.

Introduction: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown to induce apoptosis in many types of cancer cells. In this study, we aimed to determine the effects of DHA on apoptosis in human chronic lymphocytic leukemia (CLL) cell lines.

Methods: The cells were treated separately and combined by DHA and Fludurabine (FLU) during 24, 48 and 72 hours. Read More

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September 2021

Ketamine's modulation of cerebro-cerebellar circuitry during response inhibition in major depression.

Neuroimage Clin 2021 Sep 9;32:102792. Epub 2021 Sep 9.

Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.

Patients with major depressive disorder (MDD) exhibit impaired control of cognitive and emotional systems, including deficient response selection and inhibition. Though these deficits are typically attributed to abnormal communication between macro-scale cortical networks, altered communication with the cerebellum also plays an important role. Yet, how the circuitry between the cerebellum and large-scale functional networks impact treatment outcome in MDD is not understood. Read More

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September 2021

Lack of 5-lipoxygenase in intramembranous and endochondral 129Sv mice skeleton and intramembranous healing.

Arch Oral Biol 2021 Sep 20;131:105266. Epub 2021 Sep 20.

Department of Basic Sciences, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.

Objective: To analyze the lack of 5-lipoxygenase (5LO) on dental socket healing and post-natal phenotype of intramembranous and endochondral bones.

Design: Wild type (WT) 129/SvEv (n = 20) and 5LO knockout (5LOKO) (n = 20) male mice underwent tooth extraction of the upper right incisor and were euthanized after 7, 14, and 30 day time points for the evaluation of dental socket healing and histological phenotyping of intramembranous (IM) and endochondral (EC) bones. Microscopic analysis of alveolar sockets included histopathological description, histomorphometry, and immunohistochemistry for 5LO, cyclooxygenase 2 (COX2), and tartrate resistant acid phosphatase (TRAP). Read More

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September 2021

Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination.

EBioMedicine 2021 Sep 24;72:103589. Epub 2021 Sep 24.

Department of Internal Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands. Electronic address:

Background: To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination.

Methods: We tested serum IgG binding to SARS-CoV-2 spike protein and neutralising capacity in 110 healthcare workers, before and after both BNT162b2 messenger RNA (mRNA) vaccinations. Read More

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September 2021

The role of inhibitory processes in the relationship between subsyndromal PTSD symptoms and aggressive behaviour.

J Psychiatr Res 2021 Sep 23;143:357-363. Epub 2021 Sep 23.

Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

The issue of aggressive behaviours among military populations is important for a number of reasons, including the potential associated occupational, social and functional impacts. Controlled aggressive behaviour is an adaptive requirement of some military roles, however, this aggression can become maladaptive when uncontrolled, or contextually inappropriate. Elevated aggression among deployed veterans has been identified in a number of studies, although the reasons for it are not well understood. Read More

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September 2021

Multiple phase transitions and microstructural rearrangements shape milk fat crystal networks.

J Colloid Interface Sci 2021 Sep 20;607(Pt 2):1050-1060. Epub 2021 Sep 20.

Physics and Physical Chemistry of Foods, Wageningen University, Bornse Weilanden 9, Wageningen 6700 AA, the Netherlands. Electronic address:

Hypothesis: The rheology of milk fat, which is strongly related to its functionality, reflects multiscale structural transitions in the colloidal network formed by crystallizing triacylglycerols.

Experiments: To relate rheology to structure, early stages of milk fat crystallization at 15-22 °C were studied combining different techniques; XRD and microscopy to study structural changes, NMR to quantify the different structures, and rheology to evaluate their effect on macroscopic properties.

Findings: Network strength increased with the synchronized formation of micro- and nanostructures. Read More

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September 2021

Perceived impacts of Urban Heat Island phenomenon in a tropical metropolitan city: Perspectives from stakeholder dialogue sessions.

Sci Total Environ 2021 Sep 14;806(Pt 1):150331. Epub 2021 Sep 14.

Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

The stakeholders' perceptions on the impacts of Urban Heat Island (UHI) are critical for reducing exposure and influencing their response to interventions that are aimed at encouraging a behaviour change. A proper understanding of the UHI impacts on the society, economy and environment is deemed an essential motivating factor for the stakeholders to work towards UHI mitigations in the local context. This study adopted an inductive qualitative approach using Stakeholder Dialogue Sessions (SDSs) to assess the perceived impacts of UHI among various stakeholders, comprising policy makers, academicians, developers and Non-Governmental Organizations (NGO), in a tropical metropolitan city. Read More

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September 2021

Bone adaptation to mechanical loading in mice is affected by circadian rhythms.

Bone 2021 Sep 24:116218. Epub 2021 Sep 24.

Research Centre, Shriners Hospital for Children-Canada, Montreal, Canada; Department of Pediatric Surgery, McGill University, Montreal, Canada; Department of Experimental Surgery, McGill University, Montreal, Canada. Electronic address:

Physical forces are critical for successful function of many organs including bone. Interestingly, the timing of exercise during the day alters physiology and gene expression in many organs due to circadian rhythms. Circadian clocks in tissues, such as bone, express circadian clock genes that target tissue-specific genes (clock-controlled genes), resulting in tissue-specific rhythmic gene expression. Read More

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September 2021

Transcriptome analysis of host response to porcine epidemic diarrhea virus nsp15 in IPEC-J2 cells.

Microb Pathog 2021 Sep 24:105195. Epub 2021 Sep 24.

Institute of Pathogenic Microorganism and College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, China. Electronic address:

Background: Porcine epidemic diarrhea virus (PEDV) is an enveloped positive-sense ssRNA virus which is highly lethal to piglets, causing enormous economic losses to swine industry worldwide. Nsp15 protein is an endoribonuclease of PEDV and plays an indispensable role in the viral proliferation. We reported the transcription files of nsp15 transfected IPEC-J2 cells for the first time to broaden our understanding of PEDV pathogenesis. Read More

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September 2021

Identification of novel biomarkers of inflammation in Atlantic salmon (Salmo salar L.) by a plasma proteomic approach.

Dev Comp Immunol 2021 Sep 24:104268. Epub 2021 Sep 24.

Faculty of Veterinary Medicine, University of Life Sciences (NMBU), Ås, Norway. Electronic address:

Monitoring fish welfare has become a central issue for the fast-growing aquaculture industry, and finding proper biomarkers of stress, inflammation and infection is necessary for surveillance and documentation of fish health. In this study, a proteomic approach using mass spectrometry was applied to identify indicators of the acute response in Atlantic salmon blood plasma by comparing Aeromonas salmonicida subsp. salmonicida infected fish and non-infected controls. Read More

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September 2021

Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae.

J Biol Chem 2021 Sep 24:101050. Epub 2021 Sep 24.

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany. Electronic address:

The universally conserved P-loop ATPase Ola1 is implicated in various cellular stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species and the involved mechanisms are only poorly understood. Here, we studied the role of Ola1p in the heat shock response of the yeast Saccharomyces cerevisiae using a combination of quantitative and pulse labeling-based proteomics approaches, in vitro studies and cell-based assays. Read More

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September 2021

Detection of changes of functioning over time after asthma exacerbation in children with the use of PROMIS domains.

J Asthma 2021 Sep 27:1-12. Epub 2021 Sep 27.

National Institutes of Health, Division of Blood Diseases and Resources at the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

Patient reported outcome measures, such as the Patient Reported Outcomes Measurement Information System (PROMIS) may be utilized to understand experiences of patients. The purpose of this study was to determine the ability of PROMIS domains to detect changes in pain, physical functioning, and asthma impact over time for children experiencing asthma exacerbation.Our prospective cohort study included children presenting to the emergency department (ED) for asthma exacerbation. Read More

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September 2021

Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.

Immun Inflamm Dis 2021 Sep 27. Epub 2021 Sep 27.

The Department of Thoracic Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, Hubei Province, China.

Background: T helper 17 (Th17) cells actively participate in the tumor immune response in lung cancer. However, the heterogeneity and plasticity of intratumoral Th17 cells in lung cancer remain elusive. In this study, Th17 subpopulations were characterized in a mouse lung cancer model. Read More

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September 2021

Effects of a BMI1008 mixture on postoperative pain in a rat model of incisional pain.

PLoS One 2021 27;16(9):e0257267. Epub 2021 Sep 27.

Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.

Background: The purpose of this study was to evaluate the analgesic effect of BMI1008 (a new drug containing lidocaine, methylene blue, dexamethasone and vitamin B complex) and to investigate the analgesic effect of lidocaine and BMI-L (other components of BMI1008 except lidocaine) at different concentrations in a rat model of incisional pain.

Methods: Male Sprague-Dawley rats (250-300 g) were used for the incisional pain model simulating postoperative pain. After the operation, normal saline, various concentrations of BMI1008, lidocaine with a fixed concentration of BMI-L, and BMI-L with a fixed concentration of lidocaine were injected at the incision site. Read More

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September 2021

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

PLoS Genet 2021 Sep 27;17(9):e1009822. Epub 2021 Sep 27.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitochondrial dysfunction to PD remains uncertain. Here, we developed a mouse model lacking Mitofusin 2 (MFN2), a key regulator of mitochondrial network homeostasis, in adult midbrain DA neurons. Read More

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September 2021

Pyronaridine-Artesunate (Pyramax®) for the Treatment of Artemisinin- and Piperaquine-Resistant in the Central Highlands of Vietnam.

Antimicrob Agents Chemother 2021 Sep 27:AAC0027621. Epub 2021 Sep 27.

Australian Defence Force Malaria and Infectious Disease Institute (ADFMIDI), Brisbane, Australia.

The rise in resistance to dihydroartemisinin-piperaquine in Vietnam justifies the need to evaluate alternative artemisinin-based combination therapies. Between July 2018 and October 2019, a single-arm trial of pyronaridine-artesunate (Pyramax, PA) was conducted in Dak Nong province, Vietnam. PA (3-day course) was administered to adults and children infected with . Read More

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September 2021

Uropathogenic shows antibiotic tolerance and growth heterogeneity in an in-vitro model of intracellular infection.

Antimicrob Agents Chemother 2021 Sep 27:AAC0146821. Epub 2021 Sep 27.

Institute of Technology, University of Tartu, Tartu, Estonia.

Uropathogenic (UPEC), the major causative agent of urinary tract infections, is able to invade different types of host cells. To compare the pharmacodynamic properties of antibiotics against intra- and extracellular UPEC, an model of intracellular infection was established in J774 mouse macrophages infected by the UPEC strain CFT073. We tested antibiotics commonly-prescribed against urinary tract infections (gentamicin, ampicillin, nitrofurantoin, trimethoprim, sulfamethoxazole, ciprofloxacin) and the investigational fluoroquinolone finafloxacin. Read More

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September 2021

Inhibitory Cognitive Control Allows Automated Advice to Improve Accuracy While Minimizing Misuse.

Psychol Sci 2021 Sep 27:9567976211012676. Epub 2021 Sep 27.

School of Psychological Sciences, University of Tasmania.

Humans increasingly use automated decision aids. However, environmental uncertainty means that automated advice can be incorrect, creating the potential for humans to act on incorrect advice or to disregard correct advice. We present a quantitative model of the cognitive process by which humans use automation when deciding whether aircraft would violate requirements for minimum separation. Read More

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September 2021

Human optional stopping in a heteroscedastic world.

Psychol Rev 2021 Sep 27. Epub 2021 Sep 27.

Department of Experimental Psychology.

When making decisions, animals must trade off the benefits of information harvesting against the opportunity cost of prolonged deliberation. Deciding when to stop accumulating information and commit to a choice is challenging in natural environments, where the reliability of decision-relevant information may itself vary unpredictably over time (variable variance or "heteroscedasticity"). We asked humans to perform a categorization task in which discrete, continuously valued samples (oriented gratings) arrived in series until the observer made a choice. Read More

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September 2021

S100B as a biomarker of blood-brain barrier disruption after thoracoabdominal aortic aneurysm repair: a secondary analysis from a prospective cohort study.

Can J Anaesth 2021 Sep 27. Epub 2021 Sep 27.

Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Purpose: The objective of this study was to determine whether the magnitude of the peripheral inflammatory response to cardiovascular surgery is associated with increases in blood-brain barrier (BBB) permeability as reflected by changes in cerebrospinal fluid (CSF)/plasma S100B concentrations.

Methods: We conducted a secondary analysis from a prospective cohort study of 35 patients undergoing elective thoracoabdominal aortic aneurysm repair with (n = 17) or without (n = 18) cardiopulmonary bypass (CPB). Plasma and CSF S100B, interleukin-6 (IL-6), and albumin concentrations were measured at baseline (C) and serially for up to five days. Read More

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September 2021

Terahertz pump-probe of liquid water at 12.3 THz.

Phys Chem Chem Phys 2021 Sep 27. Epub 2021 Sep 27.

Department of Physical Chemistry II, Ruhr University Bochum, 44780 Bochum, Germany.

The dynamical complexity of the hydrogen-bonded water network can be investigated with intense Terahertz (THz) spectroscopy, which can drive the liquid into the nonlinear response regime and probe anharmonicity effects. Here we report single-color and polarization-dependent pump-probe experiments at 12.3 THz on liquid water, exciting the librational mode. Read More

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September 2021

Utilization of chest pain decision aids in a community hospital emergency department: A mixed-methods implementation study.

Crit Pathw Cardiol 2021 Sep 24. Epub 2021 Sep 24.

Clinical Coordinator Department of Preventive Cardiology Pulse Heart Institute Tacoma General Hospital Tacoma, Washington Cardiologist Pulse Heart Institute Tacoma, Washington Attending Physician Emergency Department Good Samaritan Hospital Puyallup, Washington Chief Hospitalist Sound Physicians Good Samaritan Hospital Puyallup, Washington And now: Chief Hospitalist Swedish Hospital Medicine Seattle, Washington Research Project Manager Institute for Research and Innovation MultiCare Health System Tacoma, Washington.

Introduction: Chest pain is a common reason for emergency department (ED) visits. Evidence-based decision aids assessing risk for an adverse cardiac event are underused in community hospital emergency care. This study explored the acceptability, barriers, facilitators, and potential strategies for implementation of the HEART Score risk stratification tool, accelerated diagnostic pathway, and shared decision-making visual aid with physicians and chest pain patients ages 45 > in a community hospital ED. Read More

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September 2021

Artemisinin derivative-containing therapies and abnormal hemoglobin: Do we need to adapt the treatment?

Parasite 2021 27;28:67. Epub 2021 Sep 27.

Unité de Paludologie, Institut Pasteur Côte d'Ivoire, 01 BP 490, Abidjan 01, Côte d'Ivoire - Département de santé globale, Institut Pasteur Paris, 25 rue du Dr Roux, 75015 Paris, France.

Background: Artemisinin-based treatment in malaria patients with abnormal hemoglobin may be ineffective because of their genetic particularity, which could lead to resistance. The main purpose of this study was to assess the effect of artemisinin derivatives on in vivo parasite clearance according to erythrocyte variants. In vivo response was investigated through retrospective data obtained over a 42-day artemether-lumefantrine/artesunate amodiaquine efficacy protocol conducted from 2012 to 2016. Read More

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September 2021

The First Intra-Action Review of Indonesia's Response to the COVID-19 Pandemic, August 2020.

Health Secur 2021 Sep 27. Epub 2021 Sep 27.

Sudarto Ronoatmodjo, MD, SKM, MSc, is a Lecturer, Department Epidemiology, Faculty of Public Health, University of Indonesia, Depok, West Java, Indonesia.

The COVID-19 pandemic has had an unprecedented impact on health, society, and the economy globally and in Indonesia. The World Health Organization (WHO) recommended the use of intra-action reviews (IARs) to identify best practices, gaps, and lessons learned to make real-time improvements to the COVID-19 response. The Emergency Committee of the International Health Regulations (2005) has recommended that countries share COVID-19 best practices and lessons learned with peer countries through IARs. Read More

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September 2021

A Simplistic Single-Step Method for Preparing Biomimetic Nanoparticles from Endogenous Biomaterials.

ACS Appl Mater Interfaces 2021 Sep 27. Epub 2021 Sep 27.

Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.

Many works utilize products isolated from nature as capping agents to functionalize gold nanoparticles for targeting and therapeutic applications. Some of the most advanced of these strategies utilize complex multicomponent biomaterials, such as whole cell-membranes, for nanoparticle functionalization strategies for evading or initializing immune response as well as for targeting. Strategies like these, wherein whole cell membrane is utilized for functionalization, take advantage of the complexity of the protein-lipid content and organization, which cells normally use for communication and interaction (instilling these capacities to nanoparticle vectors). Read More

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September 2021

Predicting Covid-19 Emergency Medical Service Incidents from Daily Hospitalization Trends.

Int J Clin Pract 2021 Sep 27:e14920. Epub 2021 Sep 27.

Department of Mathematics, University of Texas at Austin, Austin, TX, 78712, USA.

Introduction: The aim of our retrospective study was to quantify the impact of Covid-19 on the temporal distribution of Emergency Medical Services (EMS) demand in Travis County, Austin, Texas, and propose a robust model to forecast Covid-19 EMS incidents.

Methods: We analyzed the temporal distribution of EMS calls in the Austin-Travis County area between January 1st, 2019, and December 31st, 2020. Change point detection was performed to identify critical dates marking changes in EMS call distributions, and time series regression was applied for forecasting Covid-19 EMS incidents. Read More

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September 2021