Neuroimage 2021 Apr 10:118046. Epub 2021 Apr 10.
University of British Columbia MRI Research Centre, 2221 Wesbrook Mall, M10 Purdy Pavilion, Vancouver, BC V6T 2B5, Canada; Radiology, University of British Columbia, 2775 Laurel Street, 11th Floor, Vancouver, BC, V5Z 1M9; ICORD (International Collaboration on Repair Discoveries), 818 W. 10(th) Ave., Vancouver, BC V5Z 1M9, Canada. Electronic address:
Purpose: The promise of inhomogeneous magnetization transfer (ihMT) as a new myelin imaging method was studied in ex vivo human brain tissue and in relation to myelin water fraction (MWF). The temperature dependence of both methods was characterized, as well as their correspondence with a histological measure of myelin content. Unfiltered and filtered ihMT protocols were studied by adjusting the saturation scheme to preserve or attenuate signal from tissue with short dipolar relaxation time T. Read More