5,636 results match your criteria time neuropsychiatric

Mixed dementia and hyperactive delirium: a diagnostic challenge.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Department of Acute Medicine, Royal Berkshire NHS Foundation Trust, Reading, UK.

It is well recognised that acute confusion or delirium complicates up to 10% of acute medical admissions. Disorientation in time and place with an impaired short-term memory and conscious level are the hallmarks of an acute confusion. In delirium, disorders of perception may produce restlessness and agitation. Read More

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BCCT: A GUI Toolkit for Brain Structural Covariance Connectivity Analysis on MATLAB.

Front Hum Neurosci 2021 20;15:641961. Epub 2021 Apr 20.

College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.

Brain structural covariance network (SCN) can delineate the brain synchronized alterations in a long-range time period. It has been used in the research of cognition or neuropsychiatric disorders. Recently, causal analysis of structural covariance network (CaSCN), winner-take-all and cortex-subcortex covariance network (WTA-CSSCN), and modulation analysis of structural covariance network (MOD-SCN) have expended the technology breadth of SCN. Read More

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Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer's Disease and Cognitively Healthy People.

J Alzheimers Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of Neurology and Neurosurgery Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.

Background: Behavioral features may reflect proteinopathies predicting pathophysiology in neurodegenerative diseases.

Objective: We aimed to investigate associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with neuropsychiatric features in dementia with Lewy bodies (DLB) compared with late-onset Alzheimer's disease (AD) and cognitively healthy people.

Methods: Consecutive outpatients with DLB were paired with outpatients with AD according to sex, dementia stage, and cognitive scores, and with cognitively healthy controls according to sex and age to investigate associations of cerebrospinal fluid amyloid-β (Aβ)42, Aβ40, Aβ38, total tau, phospho-tau Thr181, α-synuclein, ubiquitin, and neurofilament light with neuropsychiatric features according to APOEɛ4 carrier status. Read More

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Evaluating the Clinical Impact of National Dementia Behaviour Support Programs on Neuropsychiatric Outcomes in Australia.

Front Psychiatry 2021 13;12:652254. Epub 2021 Apr 13.

The Dementia Centre, HammondCare, St Leonards, NSW, Australia.

People living with dementia (PLWD) in residential aged care homes (RACHs) are frequently prescribed psychotropic medications due to the high prevalence of neuropsychiatric symptoms, also known as behaviours and psychological symptoms of dementia (BPSD). However, the gold standard to support BPSD is using psychosocial/non-pharmacological therapies. This study aims to describe and evaluate services and neuropsychiatric outcomes associated with the provision of psychosocial person-centred care interventions delivered by national multidisciplinary dementia-specific behaviour support programs. Read More

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Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study.

Lupus Sci Med 2021 04;8(1)

Computational Bio-Medicine Laboratory, Institute of Computer Science, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece

Objective: To examine the hypothesis that perfusion and functional connectivity disturbances in brain areas implicated in emotional processing are linked to emotion-related symptoms in neuropsychiatric SLE (NPSLE).

Methods: Resting-state fMRI (rs-fMRI) was performed and anxiety and/or depression symptoms were assessed in 32 patients with NPSLE and 18 healthy controls (HC). Whole-brain time-shift analysis (TSA) maps, voxel-wise global connectivity (assessed through intrinsic connectivity contrast (ICC)) and within-network connectivity were estimated and submitted to one-sample t-tests. Read More

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Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence.

Int J Environ Res Public Health 2021 Apr 28;18(9). Epub 2021 Apr 28.

Department of Psychology and Health Research Centre, University of Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.

Immune activation during early developmental stages has been proposed as a contributing factor in the pathogenesis of neuropsychiatric conditions such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism in both human and animal studies. However, its relationship with the vulnerability to inhibitory control deficit, which is a shared feature among those conditions, remains unclear. The present work studied whether postnatal immune activation during early adolescence, combined with exposure to early-life adverse events, could lead to adult vulnerability to impulsive and/or compulsive behaviors. Read More

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Long Covid-19: Proposed Primary Care Clinical Guidelines for Diagnosis and Disease Management.

Int J Environ Res Public Health 2021 04 20;18(8). Epub 2021 Apr 20.

Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, 08036 Barcelona, Spain.

Long COVID-19 may be defined as patients who, four weeks after the diagnosis of SARS-Cov-2 infection, continue to have signs and symptoms not explainable by other causes. The estimated frequency is around 10% and signs and symptoms may last for months. The main long-term manifestations observed in other coronaviruses (Severe Acute Respiratory Syndrome (SARS), Middle East respiratory syndrome (MERS)) are very similar to and have clear clinical parallels with SARS-CoV-2: mainly respiratory, musculoskeletal, and neuropsychiatric. Read More

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Plasminogen Activator Inhibitor-1 () Gene Polymorphisms Associated with Cardiovascular Risk Factors Involved in Cerebral Venous Sinus Thrombosis.

Metabolites 2021 Apr 23;11(5). Epub 2021 Apr 23.

Department of Neurology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Cerebral venous sinus thrombosis (CVST), accounting for less than 1% of stroke cases, is characterized by various causes, heterogeneous clinical presentation and different outcome. The plasminogen activator inhibitor-1 () gene polymorphisms has been found to be associated with CVST. The aim of this retrospective study was to determine the potential association of polymorphisms and homocysteine levels with cardiovascular risk factors in a group of young patients with CVST. Read More

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Frontal Transcranial Direct Current Stimulation as a Potential Treatment of Parkinson's Disease-Related Fatigue.

Tino Zaehle

Brain Sci 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Neurology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany.

In contrast to motor symptoms, non-motor symptoms in Parkinson's disease (PD) are often poorly recognized and inadequately treated. Fatigue is one of the most common non-motor symptoms in PD and affects a broad range of everyday activities, causes disability, and substantially reduces the quality of life. It occurs at every stage of PD, and once present, it often persists and worsens over time. Read More

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Cariprazine and akathisia, restlessness, and extrapyramidal symptoms in patients with bipolar depression.

J Affect Disord 2021 Mar 31;288:191-198. Epub 2021 Mar 31.

Clinical Development, AbbVie, Madison, NJ, United States.

Background: Akathisia is a neuropsychiatric syndrome that is commonly related to the use of dopamine receptor antagonists/partial agonists. The characteristics of cariprazine-related akathisia, restlessness, and extrapyramidal symptoms (EPS) were investigated in patients with bipolar I depression.

Methods: Akathisia-related data from 3 fixed-dose clinical studies of cariprazine 1. Read More

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Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility.

Front Neurol 2021 12;12:656752. Epub 2021 Apr 12.

Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Read More

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Considerations for Pairing Cognitive Behavioral Therapies and Non-invasive Brain Stimulation: Ignore at Your Own Risk.

Front Psychiatry 2021 12;12:660180. Epub 2021 Apr 12.

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.

Multimodal approaches combining cognitive behavioral therapies (CBT) with non-invasive brain stimulation (NIBS) hold promise for improving the treatment of neuropsychiatric disorders. As this is a relatively new approach, it is a critical time to identify guiding principles and methodological considerations to enhance research rigor. In the current paper, we argue for a principled approach to CBT and NIBS pairings based on synergistic activation of neural circuits and identify key considerations about CBT that may influence pairing with NIBS. Read More

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[Apomorphine: a powerful ally in Parkinson's disease].

Rev Neurol 2021 May;72(9):323-332

Hospital Universitario Ramón y Cajal, 28034 Madrid, España.

Introduction: Apomorphine, a D1-D2 dopamine agonist, is the oldest drug with proven efficacy in the treatment of Parkinson's disease (PD), and the only with similar symptomatic power to levodopa. Its usefulness in the control of motor fluctuations, both as intermittent injections and in continuous subcutaneous infusion, has been demonstrated in open label and placebo controlled trials.

Aim: To analyse the role of apomorphine in the varied clinical symptoms and different clinical stages of PD through a narrative review of scientific literature (1951-2020). Read More

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Global and Parallel Cortical Processing Based on Auditory Gamma Oscillatory Responses in Humans.

Cereb Cortex 2021 Apr 28. Epub 2021 Apr 28.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Gamma oscillations are physiological phenomena that reflect perception and cognition, and involve parvalbumin-positive γ-aminobutyric acid-ergic interneuron function. The auditory steady-state response (ASSR) is the most robust index for gamma oscillations, and it is impaired in patients with neuropsychiatric disorders such as schizophrenia and autism. Although ASSR reduction is known to vary in terms of frequency and time, the neural mechanisms are poorly understood. Read More

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Long-Term Risk of Developing Dementia After Electroconvulsive Therapy for Affective Disorders.

J ECT 2021 Apr 26. Epub 2021 Apr 26.

From the Department for Affective Disorders Department of Clinical Epidemiology, Aarhus University Hospital Psychiatric Centre Amager, Mental Health Services Capital Region of Denmark, Aarhus Centre for Neuropsychiatric Depression Research, Mental Health Centre Glostrup, Glostrup, Denmark.

Objectives: Severe depression is associated with an increased risk of developing dementia, however, whether treatment with electroconvulsive therapy (ECT) modify this risk remains unknown.

Methods: In this matched cohort study, 1089 consecutive in-patients with affective disorders, receiving ECT during the period 1982 to 2000, were matched with 3011 in-patients with affective disorders not treated with ECT (non-ECT), and 108,867 individuals randomly selected from the background population. The comparison cohorts were matched on sex, age, and the non-ECT cohort was further matched according to diagnoses and admission period and hospital. Read More

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Gangliosides of Human Glioblastoma Multiforme: A Comprehensive Mapping and Structural Analysis by Ion Mobility Tandem Mass Spectrometry.

J Am Soc Mass Spectrom 2021 May 26;32(5):1249-1257. Epub 2021 Apr 26.

Department of Condensed Matter, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224, Timisoara, Romania.

Glioblastoma multiforme (GBM), a malignant, highly aggressive, grade IV brain tumor, which rapidly infiltrates into the nearby tissue, has drawn a significant amount of attention because of its poor prognosis and the limited treatment options available. In GBM, nearly all tumor cells exhibit aberrant cell-surface glycosylation patterns due to the alteration of their biosynthesis or postsynthesis modification process. Since gangliosides (GGs) are acknowledged as tumor-associated antigens, we have carried out here a comprehensive profiling of native ganglioside mixtures extracted and purified from GBM specimens. Read More

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NLX-101, a cortical 5-HT receptor biased agonist, reverses scopolamine-induced deficit in the delayed non-matching to position model of cognition.

Brain Res 2021 Apr 20;1765:147493. Epub 2021 Apr 20.

Neurolixis SAS, 2 rue Georges Charpak, 81100 Castres, France.

NLX-101 is a selective, high efficacy, biased agonist at post-synaptic cortical 5-HT receptors. We have previously shown that it opposes deficits produced by blockade of NMDA receptors and has pro-cognitive activity of its own. Based on the strong interaction between 5-HT receptors and the central cholinergic system, we tested NLX-101 on scopolamine-induced impairment of cognition in a delayed non-matching to position (DNMTP) model. Read More

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Exploratory study on neurochemical effects of low-intensity pulsed ultrasound in brains of mice.

Med Biol Eng Comput 2021 Apr 21. Epub 2021 Apr 21.

Department of Electrical and Computer Engineering, Faculty of Engineering, University of Alberta, Edmonton, Canada.

There is now a relatively large body of evidence suggesting a relationship between dysfunction of myelin and oligodendrocytes and the etiology of several neuropsychiatric disorders, including depression and schizophrenia, and also suggesting that ultrasound methods may alleviate some of the symptoms of depression. We have applied low-intensity pulsed ultrasound (LIPUS) to the brains of mice treated with the demyelinating drug cuprizone, a drug that has been used as the basis for a rodent model relevant to a number of psychiatric and neurologic disorders including depression, schizophrenia, and multiple sclerosis. Prior to conducting the studies in mice, preliminary studies were carried out on the effects of LIPUS in vitro in neuron-like SH-SY5Y cells and primary glial cells. Read More

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The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia.

Oncotarget 2021 Mar 30;12(7):698-707. Epub 2021 Mar 30.

N.N. Petrov National Medical Research Center of Oncology, Pesochny, St. Petersburg, 197758, Russia.

Polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time (PSADT) corresponding to unfavorable and favorable disease prognosis respectively. The 'unfavorable prognosis' group (40 cases) was defined by PSADT ≤ 2 months, whereas patients in the 'favorable prognosis' group (67 cases) had PSADT ≥ 30 months. The following gene polymorphisms known to be associated with neuropsychiatric disorders were investigated: a) the STin2 VNTR in the serotonin transporter gene; b) the 30-bp VNTR in the monoamine oxidase A gene; c) the Val158Met polymorphism in the catechol-ortho-methyltransferase gene; d) the promoter region C-521T polymorphism and the 48 VNTR in the third exon of the dopamine receptor gene. Read More

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Objective electrophysiological fatigability markers and their modulation through tDCS.

Clin Neurophysiol 2021 Mar 29. Epub 2021 Mar 29.

Department of Neurology, Otto-von-Guericke-University Magdeburg, Leipziger Street 44, Magdeburg 39120, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg 39106, Germany. Electronic address:

Objective: Cognitive fatigability is a frequent symptom after sustained performance. Fatigability is evident in healthy subjects but is also often comorbid in several neuropsychiatric diseases. However, to date, clinical diagnostic almost solely relies on the self-reported subjective experience of fatigue. Read More

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Dynamics of brain function in chronic pain patients assessed by microstate analysis of resting-state electroencephalography.

Pain 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurology, School of Medicine, Technical University of Munich (TUM), Munich, Germany TUM-Neuroimaging Center, School of Medicine, TUM, Munich, Germany Center for Interdisciplinary Pain Medicine, School of Medicine, TUM, Munich, Germany.

Abstract: Chronic pain is a highly prevalent and severely disabling disease that is associated with substantial changes of brain function. Such changes have mostly been observed when analyzing static measures of resting-state brain activity. However, brain activity varies over time and it is increasingly recognized that the temporal dynamics of brain activity provide behaviorally relevant information in different neuropsychiatric disorders. Read More

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The Role of Parvalbumin Interneuron GIRK Signaling in the Regulation of Affect and Cognition in Male and Female Mice.

Front Behav Neurosci 2021 26;15:621751. Epub 2021 Mar 26.

Department of Biomedical Sciences, Marquette University, Milwaukee, WI, United States.

Pathological impairments in the regulation of affect (i.e., emotion) and flexible decision-making are commonly observed across numerous neuropsychiatric disorders and are thought to reflect dysfunction of cortical and subcortical circuits that arise in part from imbalances in excitation and inhibition within these structures. Read More

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A combined stimuli presentation for assessing facial emotion related N170, N250 and visual mismatch negativity in neuropsychiatric disorders.

Asian J Psychiatr 2021 May 2;59:102639. Epub 2021 Apr 2.

Department of Physiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India; Department of Medical Education, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, India.

Event-related potential (ERP) is a useful approach to assess the neurophysiological correlates of facial emotion processing. Previous studies examined the facial emotion recognition (FER) related ERPs (N170, N250, visual MisMatch Negativity) individually using ERP specific paradigms. This approach can be time-consuming and may not resemble real-life scenarios where an individual must process multiple stimuli simultaneously. Read More

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Searching for a paradigm shift in the research on the epilepsies and associated neuropsychiatric comorbidities. From ancient historical knowledge to the challenge of contemporary systems complexity and emergent functions.

Epilepsy Behav 2021 Apr 6:107930. Epub 2021 Apr 6.

Departamento de Psicologia, Universidade Federal de Sergipe, Brazil. Electronic address:

In this review, we will discuss in four scenarios our challenges to offer possible solutions for the puzzle associated with the epilepsies and neuropsychiatric comorbidities. We need to recognize that (1) since quite old times, human wisdom was linked to the plural (distinct global places/cultures) perception of the Universe we are in, with deep respect for earth and nature. Plural ancestral knowledge was added with the scientific methods; however, their joint efforts are the ideal scenario; (2) human behavior is not different than animal behavior, in essence the product of Darwinian natural selection; knowledge of animal and human behavior are complementary; (3) the expression of human behavior follows the same rules that complex systems with emergent properties, therefore, we can measure events in human, clinical, neurobiological situations with complexity systems' tools; (4) we can use the semiology of epilepsies and comorbidities, their neural substrates, and potential treatments (including experimental/computational modeling, neurosurgical interventions), as a source and collection of integrated big data to predict with them (e. Read More

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All of the accuracy in half of the time: assessing abbreviated versions of the Test of Memory Malingering in the context of verbal and visual memory impairment.

Clin Neuropsychol 2021 Apr 9:1-17. Epub 2021 Apr 9.

Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

Objective: The Test of Memory Malingering (TOMM) Trial 1 (T1) and errors on the first 10 items of T1 (T1-e10) were developed as briefer versions of the TOMM to minimize evaluation time and burden, although the effect of genuine memory impairment on these indices is not well established. This study examined whether increasing material-specific verbal and visual memory impairment affected T1 and T1-e10 performance and accuracy for detecting invalidity. Data from 155 neuropsychiatric patients administered the TOMM, Rey Auditory Verbal Learning Test (RAVLT), and Brief Visuospatial Memory Test-Revised (BVMT-R) during outpatient evaluation were examined. Read More

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Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.

Clin Genet 2021 Apr 9. Epub 2021 Apr 9.

Laboratory of Medical Systems Biology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

RAPGEF1 is a guanine nucleotide exchange factor responsible for transmitting extracellular signals to the Ras family of GTPase located at the inside of membrane. Here, we report for the first time a homozygous mutation of RAPGEF1 in a consanguineous family with two siblings affected by neuropsychiatric disorder. To confirm the correlation of the mutation and the phenotype, we utilized in silico analysis and established a zebrafish model. Read More

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Sport Contact Level Affects Post-Concussion Neurocognitive Performance in Young Athletes.

Arch Clin Neuropsychol 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objective: Contact level affects the incidence of sports-related concussion. However, the effects of contact level on injury severity and recovery are less clear and are the focus of this study.

Method: Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) for athletes aged 12-22 was performed at baseline (n = 10,907 for 7,058 athletes), after suspected concussion determined by physicians or athletic trainers (n = 5,062 for 4,419 athletes), and during follow-up visits (n = 3,264 for 2,098 athletes). Read More

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Critical Dynamics in Spontaneous Resting-State Oscillations Are Associated With the Attention-Related P300 ERP in a Go/Nogo Task.

Front Neurosci 2021 22;15:632922. Epub 2021 Mar 22.

School of Education and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

Sustained attention is the ability to continually concentrate on task-relevant information, even in the presence of distraction. Understanding the neural mechanisms underlying this ability is critical for comprehending attentional processes as well as neuropsychiatric disorders characterized by attentional deficits, such as attention deficit hyperactivity disorder (ADHD). In this study, we aimed to investigate how trait-like critical oscillations during rest relate to the P300 evoked potential-a biomarker commonly used to assess attentional deficits. Read More

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Psychometric evaluation of personal evaluation of transitions in treatment amongst patients with schizophrenia.

S Afr J Psychiatr 2021 5;27:1491. Epub 2021 Mar 5.

Department of Clinical Services, Faculty of Psychiatry, Emergency Psychiatric Unit, Neuropsychiatric Hospital Aro, Abeokuta, Nigeria.

Background: Monitoring the antipsychotic medication adherence of outpatients with schizophrenia has focused majorly on the medication construct of adherence, whilst neglecting its psychosocial construct.

Aim: The aim of this study was to provide the psychometric properties of personal evaluation of transitions in treatment (PETiT).

Setting: This study was conducted at the Neuropsychiatric Hospital, Aro, Abeokuta, Ogun State, Nigeria. Read More

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Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine: Randomized Double-Blind Controlled Study.

Pediatr Neurol 2021 Mar 8;119:15-21. Epub 2021 Mar 8.

Department of Pediatric Neurology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia; Sidra Medicine, Division of Pediatric Neurology, Doha, Qatar.

Background: Levetiracetam is a relatively new-generation antiseizure drug approved for the treatment of focal and generalized seizures. Despite its favorable side effect profile and minimal drug-drug interactions, neuropsychiatric side effects are reported in up to 13% of children. A few case series have suggested that supplementation of pyridoxine may mitigate these side effects, but controlled trials are lacking. Read More

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