4,470,743 results match your criteria time mvp

Same goals, different challenges: a systematic review of perspectives of people with diabetes and healthcare professionals on Type 2 diabetes care.

Diabet Med 2021 Jun 21:e14625. Epub 2021 Jun 21.

Centre for Health Services Research, The University of Queensland, Brisbane, Australia.

Aims: To identify the views of people with diabetes (PWD) and healthcare professionals (HCP) about Type 2 diabetes care.

Methods: A systematic review of qualitative studies reporting both groups' views using thematic synthesis frameworked by the eHealth Enhanced Chronic Care Model was conducted.

Results: We searched six electronic databases between 2010-2020, identified 6,999 studies and included 21. Read More

View Article and Full-Text PDF

Inferior cure rate in pilot study of four-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C.

Liver Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Background & Aims: Shortening the treatment duration for chronic hepatitis C may increase feasibility and reduce cost of cure. The aims of this study were to compare four weeks of glecaprevir/pibrentasvir (GLE/PIB) treatment with and without ribavirin for patients with chronic hepatitis C and favorable baseline characteristics, and to monitor the development of resistance-associated substitutions (RAS) and re-treatment outcomes if treatment failed.

Methods: We performed an open-label single center randomized controlled trial, in which patients with chronic hepatitis C were randomized 1:1 to GLE/PIB +/- ribavirin, stratified by genotype 3. Read More

View Article and Full-Text PDF

Primary Hyperparathyroidism Masquerading as Acute Pancreatitis.

Horm Metab Res 2021 Jun 21;53(6):377-381. Epub 2021 Jun 21.

Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab, India.

Acute pancreatitis as an initial manifestation of primary hyperparathyroidism (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in preventing repeat attack of pancreatitis. The study aimed at evaluating the clinico-radiological profile of patients admitted with acute pancreatitis as the index presentation of PHPT and to determine the factors associated with development of severe pancreatitis. This series included retrospective analysis of medical records of 30 patients admitted with acute pancreatitis as initial manifestation of PHPT. Read More

View Article and Full-Text PDF

Effect of Adrenocorticotropic Hormone Stimulation During Simultaneous Bilateral Adrenal Vein Sampling in Primary Aldosteronism.

Horm Metab Res 2021 Jun 21;53(6):364-370. Epub 2021 Jun 21.

National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China.

The aim of the study was to investigate the significance and influence of adrenocorticotropic hormone (ACTH) stimulation in primary aldosteronism (PA) patients with simultaneous bilateral adrenal vein sampling (AVS). All patients diagnosed with PA underwent simultaneous bilateral AVS with ACTH. In 95 patients, the post-ACTH SI significantly increased (p<0. Read More

View Article and Full-Text PDF

[Background, Necessity and Methodology of the S3 Guideline "Perioperative Management of Gastrointestinal Tumours (POMGAT)"].

Zentralbl Chir 2021 Jun 21;146(3):241-248. Epub 2021 Jun 21.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Malignancies are among the most common diseases, especially in old age, and are responsible for 25% of all deaths in Germany. Especially carcinomas of the gastrointestinal tract can be cured in most cases only through extensive surgery with significant morbidity. About 25 years ago, the multimodal, perioperative Fast Track (FT) concept for reducing postoperative complications was introduced and additional elements were added in the following years. Read More

View Article and Full-Text PDF

Precision medicine in immunoglobulin A nephropathy: still a journey ahead.

Nephrol Dial Transplant 2021 Jun;36(Supplement_2):24-30

Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide and since its first description extensive research has identified a number of key central pathogenetic contributors, including genetic, immunological and environmental factors. Along with its multifaceted pathophysiology, the clinical presentation of IgAN varies, ranging from mild forms with only minor urinary findings and preserved renal function to cases that rapidly progress to end-stage renal disease. Because of this, early identification of patients at risk for a progressive course is urgently needed. Read More

View Article and Full-Text PDF

The Prevalence of HIV-infected Patients with Virological Suppression but a CD4 T-cell Count of ≤ 200 Cells/mm after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis.

AIDS Rev 2021 Jun 21. Epub 2021 Jun 21.

The First Clinical Medical School, Henan University of Traditional Chinese Medicine. Zhengzhou, China.

Highly active antiretroviral therapy (HAART) strongly inhibits HIV replication. However, many patients show suboptimal immune recovery (SIR), as defined by virological suppression (i.e. Read More

View Article and Full-Text PDF

Frequency and Severity of Moral Distress in Nephrology Fellows: A National Survey.

Am J Nephrol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Introduction: Moral distress is a negative affective response to a situation in which one is compelled to act in a way that conflicts with one's values. Little is known about the workplace scenarios that elicit moral distress in nephrology fellows.

Methods: We sent a moral distress survey to 148 nephrology fellowship directors with a request to forward it to their fellows. Read More

View Article and Full-Text PDF

Low-energy subband wave-functions and effective g-factor of one-dimensional hole gas.

Rui Li

J Phys Condens Matter 2021 Jun 21. Epub 2021 Jun 21.

Yanshan University, No. 438 West Hebei Avenue, Qinhuangdao, Hebei, China, Qinhuangdao, 066004, CHINA.

One-dimensional hole gas confined in a cylindrical Ge nanowire has potential applications in quantum information technologies. Here, we analytically study the low-energy properties of this one-dimensional hole gas. The subbands of the hole gas are two-fold degenerate. Read More

View Article and Full-Text PDF

Water calorimetry-basedfactors for Farmer-type ionization chambers in the SOBP of a carbon-ion beam.

Phys Med Biol 2021 Jun 21. Epub 2021 Jun 21.

Dosimetry for Radiotherapy, Physikalisch-Technische Bundesanstalt, Braunschweig, Niedersachsen, GERMANY.

The dosimetry of carbon-ion beams based on calibrated ionization chambers still shows a significantly higher uncertainty compared to high-energy photon beams, a fact influenced mainly by the uncertainty of the correction factor for the beam quality. Due to a lack of experimental data,factors in carbon-ion beams used today are based on theoretical calculations whose standard uncertainty is three times higher than that of photon beams. To reduce their uncertainty, in this work,factors for two ionization chambers were determined experimentally by means of water calorimetry for the spread-out Bragg peak of a carbon-ion beam, these factors are presented here for the first time. Read More

View Article and Full-Text PDF

Brain variability in dynamic resting-state networks identified by fuzzy entropy: a scalp EEG study.

J Neural Eng 2021 Jun 21. Epub 2021 Jun 21.

University of Electronic Science and Technology of China, No.2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, 611731, CHINA.

Objective: Exploring the temporal variability in spatial topology during the resting state attracts growing interest and becomes increasingly useful to tackle the cognitive process of brain networks. In particular, the temporal brain dynamics during the resting state may be delineated and quantified aligning with cognitive performance, but few studies investigated the temporal variability in the electroencephalogram (EEG) network as well as its relationship with cognitive performance.

Approach: In this study, we proposed an EEG-based protocol to measure the nonlinear complexity of the dynamic resting-state network by applying the fuzzy entropy. Read More

View Article and Full-Text PDF

Underperformance of Contemporary Phase III Oncology Trials and Strategies for Improvement.

J Natl Compr Canc Netw 2021 Jun 21:1-7. Epub 2021 Jun 21.

1Richard A. and Susan F. Smith Cancer Center for Outcomes Research in Cardiology, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center.

Background: Statistical testing in phase III clinical trials is subject to chance errors, which can lead to false conclusions with substantial clinical and economic consequences for patients and society.

Methods: We collected summary data for the primary endpoints of overall survival (OS) and progression-related survival (PRS) (eg, time to other type of event) for industry-sponsored, randomized, phase III superiority oncology trials from 2008 through 2017. Using an empirical Bayes methodology, we estimated the number of false-positive and false-negative errors in these trials and the errors under alternative P value thresholds and/or sample sizes. Read More

View Article and Full-Text PDF

Salvia officinalis and Lippia triphylla: Chemical characterization and evaluation of antidepressant-like activity.

J Pharm Biomed Anal 2021 Jun 12;203:114207. Epub 2021 Jun 12.

Laboratory of Health and Environment, Department of Biology, Moulay Ismail University, Meknes, Morocco.

Salvia officinalis (Lamiaceae) and Lippia triphylla (Verbenaceae) are two plants known for their therapeutic effects in conventional medicine for the treatment of a wide extent of diseases, including the ones on the central nervous system. In the present study, the impact of aqueous extract from the leaves of these two herbs for the treatment of depression was examined. The phytochemical profile highlighted the presence of eighteen and ten polyphenolic compounds in Salvia officinalis and Lippia triphylla, respectively. Read More

View Article and Full-Text PDF

Stability study over time of clinical solutions of ziv-aflibercept prepared in infusion bags using a proper combination of physicochemical and functional strategies.

J Pharm Biomed Anal 2021 Jun 16;203:114209. Epub 2021 Jun 16.

Department of Analytical Chemistry, Sciences Faculty, Instituto de Investigación Biosanitaria (ibs.Granada), University of Granada, E-18071, Granada, Spain. Electronic address:

A range of biopharmaceutical products are used to target Vascular Endothelial Growth Factor (VEGF), including Eylea® (aflibercept, AFL) and Zaltrap® (ziv-aflibercept, ziv-AFL). The first is indicated for ophthalmological diseases such as neovascular (wet) age-related macular degeneration, while the second is used in the treatment of metastatic colorectal cancer. The stability of AFL in prefilled syringes has been widely studied; however, no research has yet been done on the stability of ziv-AFL in polyolefin infusion bags. Read More

View Article and Full-Text PDF

Peak shape enhancement using diethylamine in hydrophilic liquid interaction chromatography: Application in simultaneous determination of methionine and paracetamol.

J Pharm Biomed Anal 2021 Jun 16;203:114214. Epub 2021 Jun 16.

Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam. Electronic address:

Methionine (MET) is combined with paracetamol (PAR) in a pain relief soft capsule in order to prevent the haematologic damage of paracetamol. A hydrophillic liquid chromatographic (HILIC) method was developed for simultaneous determination of PAR and MET in the combined formulation. Various analytical conditions were investigated, and the final method was chosen using silica column (150 × 4,6 mm; 5 μm), mobile phase of acetonitrile - aqueous solution of 10 mM formic acid 5 mM diethylamine (60:40, v/v), UV detection at 254 nm for PAR and 210 nm for MET. Read More

View Article and Full-Text PDF

Computer-assisted UHPLC method development and optimization for the determination of albendazole and its related substances.

J Pharm Biomed Anal 2021 Jun 11;203:114203. Epub 2021 Jun 11.

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gh. Marinescu 38, RO-540139, Tîrgu Mureș, Romania; Sz-imfidum Ltd, RO-525401, Lunga No. 504, Romania. Electronic address:

Computer-aided ultrahigh performance liquid chromatographic (UHPLC) method development and optimization was undertaken in order to replace an underperforming European Pharmacopoeia method for the determination of albendazole and its related substances. In the preliminary screening, a temperature-gradient time bidimensional model was chosen to aid selection of the proper stationary phase. Hereinafter temperature-gradient time-ternary composition and temperature-gradient time-pH tridimensional models were applied for the optimization of critical method parameters. Read More

View Article and Full-Text PDF

Validation of the plasmid study to relate DNA damaging effects of radionuclides to those from external beam radiotherapy.

Nucl Med Biol 2021 Jun 15;100-101:36-43. Epub 2021 Jun 15.

School of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London SE1 7EH, United Kingdom. Electronic address:

Introduction: The biological consequences of absorbed radiation doses are ill-defined for radiopharmaceuticals, unlike for external beam radiotherapy (EBRT). A reliable assay that assesses the biological consequences of any radionuclide is much needed. Here, we evaluated the cell-free plasmid DNA assay to determine the relative biological effects of radionuclides such as Auger electron-emitting [Ga]GaCl or [In]InCl compared to EBRT. Read More

View Article and Full-Text PDF

Microwave-assisted synthesis of ZnAl-LDH/g-CN composite for degradation of antibiotic ciprofloxacin under visible-light illumination.

Chemosphere 2021 Jun 16;283:131182. Epub 2021 Jun 16.

Department of Chemistry, National Institute of Technology Warangal, Warangal, 506004, Telangana, India; Center for Advanced Materials, National Institute of Technology Warangal, Warangal, 506004, Telangana, India. Electronic address:

Ciprofloxacin (CIP) is a fluoroquinolone family antibiotic pollutant. CIP existence in water environment has been rising very fast in day-to-day life and subsequently, it gives enormous health issues for humans because of its potent biological activity. To encounter this, current researchers are focusing on the development of highly efficient visible light semiconductor nanocomposites with potential photocatalytic activity. Read More

View Article and Full-Text PDF

Remediation of GenX from water by amidoxime surface-functionalized electrospun polyacrylonitrile nanofibrous adsorbent.

Chemosphere 2021 Jun 16;283:131235. Epub 2021 Jun 16.

Department of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T State University, Greensboro, NC, 27401, USA. Electronic address:

As a short-chain PFAS, GenX has gained increasing attention in recent years as a hazardous and emerging contaminant in water bodies. However, there is only limited research outcome up to date to address GenX remediation from water. In this research, we investigated amidoxime surface-functionalized PAN nanofibrous material from electrospinning as adsorbent to remove GenX from water. Read More

View Article and Full-Text PDF

Iodine-125 radioactive seed brachytherapy as a treatment for spine and bone metastases: A systematic review and meta-analysis.

Surg Oncol 2021 Jun 10;38:101618. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Aim: To evaluate the analgesic efficacy, safety, and local tumor control of iodine-125 (I) seed brachytherapy (BT) for the management of spine and bone metastases.

Methods: A systematic literature search was conducted using PubMed, the Cochrane Library, and Scopus databases. Data regarding patient demographics, tumor characteristics, procedural parameters, and clinical outcomes were extracted and analyzed. Read More

View Article and Full-Text PDF

Septic arthritis of native joints due to Mycobacterium avium complex: A systematic review of case reports.

Semin Arthritis Rheum 2021 Jun 9;51(4):813-818. Epub 2021 Jun 9.

Pali Momi Medical Center, Hawai'i Pacific Health, 98-1079 Moanalua Road, Suite 300, Aiea, Honolulu 96701, HI, USA. Electronic address:

Introduction: While MAC native joint septic arthritis is historically considered a rare entity, the number of reported cases have increased in recent decades. However, no comprehensive review of this topic has been conducted.

Objectives: To conduct a systematic review of cases of MAC native joint septic arthritis reported in the literature and summarize the presentations, baseline characteristics, risk factors, diagnosis, treatment, and treatment outcomes. Read More

View Article and Full-Text PDF

Reduced ambient PM better lung function, and decreased risk of chronic obstructive pulmonary disease.

Environ Int 2021 Jun 18;156:106706. Epub 2021 Jun 18.

Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong; Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, China. Electronic address:

Background: Several studies reported that long-term exposure to fine particulate matter (PM) was associated with an increased risk of chronic obstructive pulmonary disease (COPD). It remains unclear whether reduced PM can decrease the risk of COPD development.

Objective: To investigate the associations of dynamic changes (including deterioration and improvement) in long-term exposure to ambient PM with changes in lung function and the incidence of COPD. Read More

View Article and Full-Text PDF

Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China.

Environ Int 2021 Jun 18;156:106709. Epub 2021 Jun 18.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA. Electronic address:

The health impact of airborne contaminants has been challenging to assess due to current limitations in measurement technologies. The emergence of wearable passive samplers coupled with high resolution mass spectrometry (HR-MS) chemical analysis has enabled comprehensive characterization of personal exposures. We conducted a repeated-measure study among 84 older adults in Jinan, China, as part of the Biomarkers for Air Pollutants Exposure (China BAPE) study. Read More

View Article and Full-Text PDF

Cardiac manifestation is evident in chorea-acanthocytosis but different from McLeod syndrome.

Parkinsonism Relat Disord 2021 May 24;88:90-95. Epub 2021 May 24.

Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center, University of Rostock, Rostock, Germany. Electronic address:

Introduction: We aimed to study the various cardiac manifestations of the two core neuroacanthocytosis (NA) syndromes, namely chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS). So far, cardiac involvement has been described as specific feature only for MLS.

Methods: We studied six patients with ChAc (mean age 44. Read More

View Article and Full-Text PDF

Age-related differences in the retrieval of phonologically similar words during sentence processing: Evidence from ERPs.

Brain Lang 2021 Jun 18;220:104982. Epub 2021 Jun 18.

The Pennsylvania State University, United States.

We investigated how phonologically similar words are encoded and retrieved from memory during sentence processing across younger and older adults. Critical sentences included two phonologically similar or dissimilar noun phrases (henceforth NPs) followed by a pronoun. We examined brain activity time-locked to the onsets of the second NP, and the pronoun to investigate the encoding and retrieval of the NPs, respectively. Read More

View Article and Full-Text PDF

The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes.

EBioMedicine 2021 Jun 18;69:103431. Epub 2021 Jun 18.

Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Jan Waldenströms gata 35, Skåne University Hospital SUS, Malmö SE-205 02, Sweden. Electronic address:

Background: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated.

Methods: We used a population-based case-control study of T1D (962 patients and 636 controls) to decipher genetic associations of HLA-DR4 subtypes and specific residues with susceptibility to T1D. Read More

View Article and Full-Text PDF

Deep learning for diagnosing osteonecrosis of the femoral head based on magnetic resonance imaging.

Comput Methods Programs Biomed 2021 Jun 5;208:106229. Epub 2021 Jun 5.

Longwood Valley Medical Technology Co. Ltd, China.

Background And Objective: Early-stage osteonecrosis of the femoral head (ONFH) can be difficult to detect because of a lack of symptoms. Magnetic resonance imaging (MRI) is sufficiently sensitive to detect ONFH; however, the diagnosis of ONFH requires experience and is time consuming. We developed a fully automatic deep learning model for detecting early-stage ONFH lesions on MRI. Read More

View Article and Full-Text PDF

Valorization of de-oiled microalgal biomass as a carbon-based heterogeneous catalyst for a sustainable biodiesel production.

Bioresour Technol 2021 Jun 16;337:125424. Epub 2021 Jun 16.

School of Energy Science and Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India; Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India. Electronic address:

In this study, a novel carbon-based solid acid catalyst was synthesized by carbonization of de-oiled microalgal biomass followed by sulfonation. The effect of catalyst synthesis conditions such as carbonization temperature, sulfonation time, and HSO concentration on the surface acidity of the catalyst and free fatty acid conversion was determined. The de-oiled microalgal biomass-based solid acid (DMB) catalyst was predominantly composed of carboxylic, phenolic, and sulfonic groups as indicated by the FTIR analysis and supported by the XPS analysis. Read More

View Article and Full-Text PDF

Recycling of nutrients from organic waste by advanced compost technology- A case study.

Bioresour Technol 2021 Jun 15;337:125411. Epub 2021 Jun 15.

College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China; Organic Recycling Institute (Suzhou) of China Agricultural University, Wuzhong District, Suzhou 215128, China. Electronic address:

Composting is widely used as an easily operated and economical method to manage organic wastes. However, the long residence time of composting impedes the recycling nutrients from large amounts of organic wastes produced every day. In this study, the intelligent biodrying + continuous dynamic trough (IB + CDT) was created and used in China's first urban and rural organic waste treatment and utilization demonstration center in Suzhou city. Read More

View Article and Full-Text PDF

Lack of active SARS-CoV-2 virus in a subset of PCR-positive COVID-19 congregate care patients.

J Clin Virol 2021 Jun 4;141:104879. Epub 2021 Jun 4.

Departments of Immunology and Microbial Disease, Albany Medical Center, Albany, NY, United States. Electronic address:

Highly sensitive nucleic acid amplification tests (NAATs) designed to detect SARS-CoV-2 RNA are the standard of care for the diagnosis of COVID-19. However, the accuracy of these methods for the quantitation of active virus rather than non-infectious RNA fragments that can persist for extended periods of time has been unclear. This issue is particularly relevant for congregate care patients who are unable to return to their home residence until fully negative by NAATs. Read More

View Article and Full-Text PDF