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Radiation-Induced Lens Opacity and Cataractogenesis: A Lifetime Study Using Mice of Varying Genetic Backgrounds.

Radiat Res 2021 May 13. Epub 2021 May 13.

Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, United Kingdom.

Recent epidemiological findings and reanalysis of historical data suggest lens opacities resulting from ionizing radiation exposures are likely induced at lower doses than previously thought. These observations have led to ICRP recommendations for a reduction in the occupational dose limits for the eye lens, as well as subsequent implementation in EU member states. The EU CONCERT LDLensRad project was initiated to further understand the effects of ionizing radiation on the lens and identify the mechanism(s) involved in radiation-induced cataract, as well as the impact of dose and dose-rate. Read More

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Time series analysis of the in-hospital diagnostic process in suspected pulmonary embolism evaluated by computed tomography: An explorative study.

Eur J Radiol 2021 May 8;140:109758. Epub 2021 May 8.

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Purpose: This retrospective study aims to analyze the distribution of demand and the duration of the diagnostic workup of suspected pulmonary embolism (PE) using computed tomography pulmonary angiography (CTPA).

Methods: Time data from physical examination to report creation were identified for each CTPA in 2013 and 2018 at a tertiary hospital. Multivariable multinomial logistic and linear regression models were used to evaluate differences between 3 time intervals (I1: 6am-2pm, I2: 2pm-10pm, I3: 10pm-6am). Read More

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Masticatory coefficient and physical functioning in older frail patients admitted for a Comprehensive Gerontological Assessment.

Arch Gerontol Geriatr 2021 Apr 20;95:104421. Epub 2021 Apr 20.

Clinical Gerontology Department, CHU Bordeaux, 33000, Bordeaux, France; CRMSB, UMR 5536, CNRS/Bordeaux University, Bordeaux, France. Electronic address:

Background: Physical functioning may be limited in older, frail patients with missing teeth without prosthetic correction. This cross-sectional study examined the relationship between physical performance and the geriatric masticatory coefficient (GMC) in patients who underwent both a comprehensive gerontological assessment (CGA) to improve poly-pathology management and an intra-oral exam.

Methods: All patients were evaluated based on the following: (corrected) GMC, number of posterior occluding pairs (POPs), short physical performance battery (SPPB) or timed up and go (TUG) test, and mini-nutritional assessment (MNA). Read More

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Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse.

Environ Pollut 2021 Apr 24;286:117219. Epub 2021 Apr 24.

State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are one of the most prevalent classes of environmental pollutants resulting from the incomplete combustion of hydrocarbons. Exposure to PAHs is implicated in the pathogenesis of the cardiovascular disease, pulmonary disease, and even cancer. However, little is known about organ- and tissue-specific distribution patterns of PAHs in animals at macro-tissue and microscopic levels. Read More

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Trainee performed total knee arthroplasty is safe and effective: A systematic review and meta-analysis comparing outcomes between trainees and consultants.

Knee 2021 May 10;30:291-304. Epub 2021 May 10.

Department of Trauma and Orthopaedic Surgery, London North West University Healthcare NHS Trust, United Kingdom.

Background: There are concerns that trainee performed knee arthroplasty (KA) may adversely affect patient outcomes. Demand for KA is projected to increase, and trainees must therefore be competent to perform it.

Methods: A systematic literature search was performed identifying articles comparing outcomes following trainee versus consultant surgeon performed primary KA. Read More

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Inflammatory Biomarkers Correlate with Time Evolution in Cerebral Venous Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105844. Epub 2021 May 10.

Department of Neurology, Centro Hospitalar Universitário de São João, EPE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto.

Objectives: We aimed to analyse the relationship between specific inflammatory biomarkers' levels and the temporal pattern of cerebral venous thrombosis (CVT) symptoms.

Materials And Methods: We performed a retrospective study of adult CVT patients admitted between Jan 01 2006 and Dec 31 2019. We excluded patients with infection at admission, autoimmune, inflammatory or haematological disorders. Read More

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Multi-response optimal hot pressurized liquid recovery of extractable polyphenols from leaves of maqui (Aristotelia chilensis [Mol.] Stuntz).

Food Chem 2021 Mar 29;357:129729. Epub 2021 Mar 29.

Chemical and Bioprocess Engineering Department, School of Engineering, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, P.O. Box 306, Santiago 7820436, Chile. Electronic address:

Multi-response optimization of hot pressurized liquid extraction (HPLE) was applied for the first time to obtain maqui (Aristotelia chilensis [Mol.] Stuntz) leaf extracts. The total polyphenol content (TPC), the antioxidant capacity (AC) as well as the total polyphenol purity of the maqui leaf extracts were accurately predicted (RSD < 8%) at the evaluated extraction scales. Read More

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Outcomes of second stage cesarean section following the use of a fetal head elevation device: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2021 May 1;262:1-6. Epub 2021 May 1.

Center for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University of Chieti, Italy. Electronic address:

Objectives: To explore maternal and perinatal outcomes of women undergoing full dilatation cesarean section (CS) who had compared to those who did not have application of fetal head elevation device (FHED).

Material And Methods: Pubmed, Embase, Cinahl, Clinical Trial.Gov and Google Scholar databases were searched. Read More

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CD4CD25CD127 regulatory T cells associated with the effect of CD19 CAR-T therapy for relapsed/refractory B-cell acute lymphoblastic leukemia.

Int Immunopharmacol 2021 May 10;96:107742. Epub 2021 May 10.

Hematology Department, the Second Hospital of Anhui Medical University (SHAMU), Hefei, Anhui Province, China; Hematologic Diseases Research Center of Anhui Medical University, Hefei, Anhui Province, China. Electronic address:

Background: CD19-specific chimeric antigen receptor T-cell (CAR-T) therapy has shown promising clinical outcomes in relapsed/refractory acute B-cell lymphoblastic leukemia (R/R B-ALL) patients. However, some patients did not respond to this therapy or relapsed after remission. Regulatory T cells (Tregs) have shown great importance in promoting tumor escape, but little is known about their role in R/R B-ALL patients with CAR-T therapy. Read More

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Sorptive and microbial riddance of micro-pollutant ibuprofen from contaminated water: A state of the art review.

Sci Total Environ 2021 May 1;786:147327. Epub 2021 May 1.

Department of Chemical Engineering, National Institute of Technology Durgapur, India. Electronic address:

Continuous discharge of ibuprofen, a pharmaceutical compound in local water systems is becoming a budding concern as seen from data procured from the past few decades. Increased concentrations of the compound in water reservoirs resulted in adverse effects on the environment. In order to prevent the deleterious impacts of increasing ibuprofen concentration in water bodies, application of cost effective and energy efficient elimination of ibuprofen (IBP) is needed. Read More

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Quantitative assessment of lung involvement on chest CT at admission: Impact on hypoxia and outcome in COVID-19 patients.

Clin Imaging 2021 Apr 29;77:194-201. Epub 2021 Apr 29.

Experimental Imaging Center, Radiology Unit, IRCCS San Raffaele Hospital, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Background: The aim of this study was to quantify COVID-19 pneumonia features using CT performed at time of admission to emergency department in order to predict patients' hypoxia during the hospitalization and outcome.

Methods: Consecutive chest CT performed in the emergency department between March 1st and April 7th 2020 for COVID-19 pneumonia were analyzed. The three features of pneumonia (GGO, semi-consolidation and consolidation) and the percentage of well-aerated lung were quantified using a HU threshold based software. Read More

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Optimization and application of high-throughput supported liquid extraction for simultaneous determination of carotenoids and fat-soluble vitamins in serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Mar 24;1173:122672. Epub 2021 Mar 24.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shanxi 710061, PR China. Electronic address:

The demand for analysis of carotenoids (CAR) and fat-soluble vitamins (FSV) is continuously expanding, but currently used sample preparation methods either require complicated extraction procedure or large sample volume, let alone the reliability of the results. This study aimed to develop a fast, high-efficient, and high-throughput method based on supported liquid extraction (SLE) for the simultaneous extraction of FSV and CAR from human serum before using high-performance liquid chromatography-diode array detector (HPLC-DAD) analysis. The optimization of SLE parameters was achieved through response surface methodology (RSM) based on the Box-Behnken design (BBD) and included serum-water-extraction solvent ratio and eluent volume. Read More

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The regulating effect of trace elements Si, Zn and Sr on mineralization of gelatin-hydroxyapatite electrospun fiber.

Colloids Surf B Biointerfaces 2021 May 10;204:111822. Epub 2021 May 10.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, PR China. Electronic address:

Biomineralization approaches have been increasingly adopted to synthesizing advanced materials with superior properties. Nevertheless, the potential influence of inorganic trace elements on the mineralization process of collagen has been rarely reported, despite of the significant progress achieved on exploiting the critical roles of organic polymers in regulating the collagen mineralization. To this aim, the potential roles of Si, Zn and Sr in regulating the mineralization of gelatin-hydroxyapatite (HA) composite fibers have been examined in this study. Read More

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Effects of permanent cardiac pacing on ventricular repolarization when compared to cardioneuroablation.

J Electrocardiol 2021 Apr 21;67:13-18. Epub 2021 Apr 21.

Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS, USA.

Introduction: The impact of cardioneuroablation (CNA) on ventricular repolarization by using corrected QT interval (QTc) measurements has been recently demonstrated. The effects of cardiac pacing (CP) on ventricular repolarization have not been studied in patients with vasovagal syncope (VVS). We sought to compare ventricular repolarization effects of CNA (group 1) with CP (group 2) in patients with VVS. Read More

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Blood pressure control measured as "time in range" during initial 24 h for inpatients with spontaneous nontraumatic intracerebral haemorrhage.

J Neurol Sci 2021 May 5;426:117480. Epub 2021 May 5.

PO Box 4545, Rashid Hospital, Umm Hurair, Dubai, United Arab Emirates.

Background And Purpose: Blood pressure (BP) control is an integral part in the management of spontaneous nontraumatic intracerebral haemorrhage. The aim of this study is to propose a novel concept of blood pressure control measured as 'Time in Range'(TiR) and assess its relationship to neurological deterioration.

Method: Retrospective study of 120 patients with Intracerebral haemorrhage who were admitted within 6 h of the symptom onset. Read More

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Sentinel lymph node sampling as an alternative to lymphadenectomy in patients with endometrial cancer and obesity.

J Obstet Gynaecol Can 2021 May 10. Epub 2021 May 10.

Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.; Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, affiliated with the Hebrew.

Objective: Although its use in endometrial cancer staging is relatively new, sentinel lymph node (SLN) sampling has been shown to be highly accurate and is associated with few complications. However, some studies report lower rates of detection with SLN sampling among patients with obesity. The aim of the current study is to evaluate the feasibility of SLN sampling in endometrial cancer for patients with obesity, and to determine whether omitting lymph node dissection (LND) in surgical staging using SLN sampling impacts oncologic outcomes. Read More

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Is Foot Reflexology Effective in Reducing Colic Symptoms in Infants: A Randomized Placebo-Controlled Trial.

Complement Ther Med 2021 May 10:102732. Epub 2021 May 10.

Research Assistant, Department of Pediatric Nursing, Faculty of Nursing, Akdeniz University, Antalya, Turkey. Electronic address:

Objectives: Infantile colic and its accompanying crying represent a major source of stress and have negative physiological, emotional and psychological effects on infants and parents. The aim of this study was to examine the efficacy of foot reflexology for reducing symptoms of infantile colic.

Design: The study was conducted as a single-blind, randomized, placebo-controlled trial with a sample population of 45 infants diagnosed with infantile colic. Read More

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New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3'UTR 14bp polymorphism and sHLA-G.

Gene 2021 May 10:145712. Epub 2021 May 10.

Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey; Tuncer Karpuzoglu Transplantation Center, Akdeniz University Hospital, Antalya, Turkey. Electronic address:

The aim of this study was to evaluate the relation of Human Leukocyte Antigen-G (HLA-G) 14 bp ins/del (insertion/deletion) polymorphism and soluble HLA-G (sHLA-G) level with rejection in kidney transplant recipients. The study was planned as a case-control study involving two hundred fifty kidney transplant recipients. The case group consisted of 125 (female/male:56/69) kidney transplant recipients diagnosed with acute (n=52) and chronic rejection (n=73). Read More

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Nandrolone decanoate causes uterine injury by changing hormone levels and sex steroid receptors in a dose- and time-dependent manner.

Reprod Toxicol 2021 May 10. Epub 2021 May 10.

Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, IBB/UNESP, 16618-689, SP, Brazil. Electronic address:

Different doses of nandrolone decanoate (ND) were used to investigate the expression of uterine sex steroid receptors (AR, ER-α, and ER-β) and the levels of serum sex hormones after treatment and recovery periods in adult rats. ND doses of 1.87, 3. Read More

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Evaluation of the analytical performance and specificity of a SARS-CoV-2 transcription-mediated amplification assay.

J Virol Methods 2021 May 10:114182. Epub 2021 May 10.

Institute for Medical Virology, University Hospital Tuebingen, Elfriede-Aulhorn-Str. 6, 72076 Tuebingen, Germany. Electronic address:

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic requires fast and accurate high-throughput diagnostic tools. To evaluate the analytical performance of the Hologic Aptima transcription-mediated amplification (TMA) assay for detection of SARS-CoV-2 RNA from respiratory samples we analysed 103 clinical and proficiency panel samples pre-tested by real-time RT-PCR (Altona, RealStar) and found a positive percent agreement (sensitivity) of 95.7% and a negative percent agreement (specificity) of 100%. Read More

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An investment case for the prevention and management of rheumatic heart disease in the African Union 2021-30: a modelling study.

Lancet Glob Health 2021 May 10. Epub 2021 May 10.

Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA; Program in Global Noncommunicable Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Partners In Health, Boston, MA, USA. Electronic address:

Background: Despite declines in deaths from rheumatic heart disease (RHD) in Africa over the past 30 years, it remains a major cause of cardiovascular morbidity and mortality on the continent. We present an investment case for interventions to prevent and manage RHD in the African Union (AU).

Methods: We created a cohort state-transition model to estimate key outcomes in the disease process, including cases of pharyngitis from group A streptococcus, episodes of acute rheumatic fever (ARF), cases of RHD, heart failure, and deaths. Read More

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Articulatory Correlates of Stress Pattern Disturbances in Talkers With Dysarthria.

J Speech Lang Hear Res 2021 May 13:1-14. Epub 2021 May 13.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.

Purpose Reduced stress commonly occurs in talkers with Parkinson's disease (PD), whereas excessive and equal stress is frequently associated with dysarthria of talkers with amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). This study sought to identify articulatory impairment patterns that underlie these two impaired stress patterns. We further aimed to determine if talkers with the same stress pattern disturbance but different diseases (ALS and MS) exhibit disease-specific articulatory deficits. Read More

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Effects of resistance training at different intensities of load on cross-education of muscle strength.

Appl Physiol Nutr Metab 2021 May 13. Epub 2021 May 13.

Federal University of Triangulo Mineiro , Department of Sport Sciences, Uberaba, Brazil;

The objectives of this study were 1) to compare the extent of cross-transfer of high- versus low-load unilateral resistance training performed with external pacing of the movement (URTEP) and 2) to compare the time course of the two approaches. Fifty subjects were randomized to one of the following three groups: G80 [two sets at 80% and two sets at 40% of one maximum repetition (1RM), 1 concentric second and 3 eccentric seconds controlled by a metronome]; G40 (four sets at 40% of 1 RM, 1s and 3s controlled by a metronome); or CG (control group). At week 1, the G80 increased the elbow flexion 1RM (P<0. Read More

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The Impact of Post-Prandial Delay Periods on Consumption of a Laboratory Breakfast Meal.

Appl Physiol Nutr Metab 2021 May 13. Epub 2021 May 13.

Griffith University, School of Allied Health Sciences and Griffith Health Institute, Gold Coast, Queensland, Australia, Gold Coast, Queensland, Australia, 4222.

This study examined the impact of varying the holding time following an ad libitum laboratory breakfast on acute dietary behaviour and subsequent intake. 24 participants (20 females (age: 23.4±6. Read More

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Evaluation of strategic uprighting of the mandibular molars using an orthodontic miniplate and a nickel-titanium reverse curve arch wire: Preliminary cephalometric study.

Korean J Orthod 2021 May;51(3):179-188

Department of Orthodontics, Graduate School, Kyung Hee University, Seoul, Korea.

Objective: To evaluate the overall treatment effects in terms of the amount of uprighting with changes in the sagittal and vertical positions of mandibular molars after applying an orthodontic miniplate with a nickel-titanium (NiTi) reverse curve arch wire (biocreative reverse curve [BRC] system).

Methods: A total of 30 female patients (mean age, 25.99 ± 8. Read More

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Minimally invasive aortic valve replacement: short-term efficacy of sutureless compared with stented bioprostheses.

Interact Cardiovasc Thorac Surg 2021 May 13. Epub 2021 May 13.

Department of Cardiac Surgery, Anthea Hospital, GVM Care &Research, Bari, Italy.

Objectives: Sutureless aortic valve prostheses have been introduced to facilitate the implant process, speed up the operating time and improve haemodynamic performance. The goal of this study was to assess the potential advantages of using sutureless prostheses during minimally invasive aortic valve replacement in a large multicentre population.

Methods: From 2011 to 2019, a total of 3402 patients in 11 hospitals underwent isolated aortic valve replacement with minimal access approaches using a bioprosthesis. Read More

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Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

PLoS One 2021 13;16(5):e0251598. Epub 2021 May 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

Background: Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.

Objective: Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Read More

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Applying time series analyses on continuous accelerometry data-A clinical example in older adults with and without cognitive impairment.

PLoS One 2021 13;16(5):e0251544. Epub 2021 May 13.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Stroke Research Berlin (CSB), Berlin, Germany.

Introduction: Many clinical studies reporting accelerometry data use sum score measures such as percentage of time spent in moderate to vigorous activity which do not provide insight into differences in activity patterns over 24 hours, and thus do not adequately depict circadian activity patterns. Here, we present an improved functional data analysis approach to model activity patterns and circadian rhythms from accelerometer data. As a use case, we demonstrated its application in patients with mild cognitive impairment (MCI) and age-matched healthy older volunteers (HOV). Read More

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The effect of remuneration schedule on data completion and retention in the pregnancy eating attributes study (PEAS).

PLoS One 2021 13;16(5):e0251533. Epub 2021 May 13.

Division of Intramural Population Health Research, Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.

Maximizing data completion and study retention is essential in population research. This study examined the effect of remuneration schedule and data collection modality on data completion and retention in the Pregnancy Eating Attributes Study cohort. Participants (n = 458) completed online surveys and attended six in-person study visits. Read More

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Diagnostic Performance of an Antigen Test with RT-PCR for the Detection of SARS-CoV-2 in a Hospital Setting - Los Angeles County, California, June-August 2020.

MMWR Morb Mortal Wkly Rep 2021 May 14;70(19):702-706. Epub 2021 May 14.

Prompt and accurate detection of SARS-CoV-2, the virus that causes COVID-19, has been important during public health responses for containing the spread of COVID-19, including in hospital settings (1-3). In vitro diagnostic nucleic acid amplification tests (NAAT), such as real-time reverse transcription-polymerase chain reaction (RT-PCR) can be expensive, have relatively long turnaround times, and require experienced laboratory personnel.* Antigen detection tests can be rapidly and more easily performed and are less expensive. Read More

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