85,584 results match your criteria time domain


EEG-based emotion classification using LSTM under new paradigm.

Biomed Phys Eng Express 2021 Sep 17. Epub 2021 Sep 17.

Electrical Engineering, National Institute of Technology Silchar, NIT Silchar, Silchar, Assam, 788010, INDIA.

Deep learning has gained much popularity in solving challenging machine learning problems related to image, speech classification, etc. Research has been conducted to apply deep learning models in emotion classification based on physiological signals such as EEG. Most of the research works have based their model on the spatial aspects of the EEG. Read More

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September 2021

Identification of grape H3K4 genes and their expression profiles during grape fruit ripening and postharvest ROS treatment.

Genomics 2021 Sep 14. Epub 2021 Sep 14.

College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, PR China; Henan Engineering Technology Research Center of Quality Regulation of Horticultural Plants, Luoyang 471023, PR China. Electronic address:

Fruit development is modified by different types of epigenetics. Histone methylation is an important way of epigenetic modification. Eight genes related to H3K4 methyltransferase, named VvH3K4s, were identified and isolated from the grape genome based on conserved domain analysis, which could be divided into 3 categories by the phylogenetic relationship. Read More

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September 2021

Collective-Mode Enhanced Matter-Wave Optics.

Phys Rev Lett 2021 Sep;127(10):100401

Institut für Quantenoptik, Leibniz Universität Hannover, Welfengarten 1, D-30167 Hannover, Germany.

In contrast to light, matter-wave optics of quantum gases deals with interactions even in free space and for ensembles comprising millions of atoms. We exploit these interactions in a quantum degenerate gas as an adjustable lens for coherent atom optics. By combining an interaction-driven quadrupole-mode excitation of a Bose-Einstein condensate (BEC) with a magnetic lens, we form a time-domain matter-wave lens system. Read More

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September 2021

A quantitative study of the Golgi retention of glycosyltransferases.

J Cell Sci 2021 Sep 17. Epub 2021 Sep 17.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

How Golgi glycosyltransferases and glycosidases (hereafter glycosyltransferases) localize to the Golgi is still unclear. Here, we first investigated the post-Golgi trafficking of glycosyltransferases. We found that glycosyltransferases can escape the Golgi to the plasma membrane, where they are subsequently endocytosed to the endolysosome. Read More

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September 2021

[Knockdown of NLRC3 promotes proliferation and invasion of human colon cancer cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Sep;37(9):769-774

Department of Microbiology and Pathogenic Biology, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail:

Objective To investigate the effects of nucleotide binding oligomerization domain-like receptor family caspase recruitment domain containing 3 (NLRC3) on the proliferation, migration and invasion of human colon cancer HCT116 and LoVo cells. Methods NLRC3 was knocked down in HCT116 and LoVo cells by NLRC3-specific siRNA (si-NLRC3). NLRC3 mRNA and protein expression was detected by real-time quantitative PCR and Western blotting. Read More

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September 2021

Methodological and reporting quality of pediatric clinical practice guidelines: a systematic review.

Ann Transl Med 2021 Aug;9(15):1258

National Clinical Research Center for Child Health and Disorders, Evidence-Based Medicine Center, Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Background: Pediatric clinical practice guidelines (CPGs) can provide systematically developed clinical recommendations to guide pediatric clinicians and patients making decisions. This study aims to assess the methodological and reporting quality of pediatric CPGs.

Methods: We performed a systematic literature search of MEDLINE from 1 January 1990 to 2 April 2020 to identify pediatric CPGs published in the ten highest-impact pediatric journals and four highest-impact general medical journals. Read More

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Weighted gene co-expression network analysis reveals that CXCL10, IRF7, MX1, RSAD2, and STAT1 are related to the chronic stage of spinal cord injury.

Ann Transl Med 2021 Aug;9(15):1248

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.

Background: The process of spinal cord injury involves acute, subacute, and chronic stages; however, the specific pathological mechanism remains unclear. In this study, weighted gene co-expression network analysis (WGCNA) was used to clarify specific modules and hub genes that associated with SCI.

Methods: The gene expression profiles GEO Series (GSE)45006 and GEO Series (GSE)2599 were downloaded, and the co-expression network modules were identified by the WGCNA package. Read More

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Shedding Light on the Molecular Recognition of Sub-Kilodalton Macrocyclic Peptides on Thrombin by Supervised Molecular Dynamics.

Front Mol Biosci 2021 31;8:707661. Epub 2021 Aug 31.

Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

Macrocycles are attractive structures for drug development due to their favorable structural features, potential in binding to targets with flat featureless surfaces, and their ability to disrupt protein-protein interactions. Moreover, large novel highly diverse libraries of low-molecular-weight macrocycles with therapeutically favorable characteristics have been recently established. Considering the mentioned facts, having a validated, fast, and accurate computational protocol for studying the molecular recognition and binding mode of this interesting new class of macrocyclic peptides deemed to be helpful as well as insightful in the quest of accelerating drug discovery. Read More

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ECG Signal Classification Based on Fusion of Hybrid CNN and Wavelet Features by D-S Evidence Theory.

J Healthc Eng 2021 7;2021:4222881. Epub 2021 Sep 7.

College of Electronic and Information Engineering, Shandong University of Science and Technology, Qingdao 266590, China.

At present, cardiovascular disease is regarded as one of the dangerous diseases that threaten human life. The morbidity and lethality caused by cardiovascular disease are constantly increasing every year. In this paper, we propose a two-stream style operation to handle the electrocardiogram (ECG) classification: one for time-domain features and another for frequency-domain features. Read More

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September 2021

Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner.

Front Immunol 2021 31;12:707426. Epub 2021 Aug 31.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.

Bid (BH3-interacting domain death agonist), a member of the Bcl-2 family, plays a crucial role in the initiation of apoptosis. Independent of its apoptotic function, Bid is also involved in the regulation of inflammation and innate immunity. However, the role of Bid during bacterial pathogen infection remains unclear. Read More

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Evaluation of hybrid controllers for space vector modulation-inverter driven permanent magnet synchronous motor-pump assembly.

ISA Trans 2021 Sep 3. Epub 2021 Sep 3.

Department of Electrical and Electronics Engineering, Krishnasamy College of Engineering & Technology, Cuddalore, Tamil Nadu 607109, India. Electronic address:

Many controllers are available in the market for controlling the Permanent Magnet Synchronous Motor (PMSM) drive application, though the most preferably used one is Proportional Integral (PI), controller. However, it is found that the PI and other latest controllers have their own merits and demerits while analyzing their outputs via comparison. Thus it is decided to test the deed of hybrid controllers that can serve a lot better than standalone controllers for precise control applications. Read More

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September 2021

TP-DDI: Transformer-based pipeline for the extraction of Drug-Drug Interactions.

Artif Intell Med 2021 Sep 23;119:102153. Epub 2021 Aug 23.

School of Informatics, Aristotle University of Thessaloniki, Greece. Electronic address:

Drug-Drug Interaction (DDI) extraction is the task of identifying drug entities and the potential interactions between drug pairs from biomedical literature. Computer-aided extraction of DDIs is vital for drug discovery, as this process remains extremely expensive and time consuming. Therefore, Machine Learning-based approaches can reduce the laborious task during the drug development cycle. Read More

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September 2021

Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5.

Cancer Cell Int 2021 Sep 16;21(1):495. Epub 2021 Sep 16.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, Henan, 450052, People's Republic of China.

Background: Increasing studies focused on the regulatory roles of circular RNAs (circRNAs) in diverse cancers. This study was to evaluate the function and mechanism of circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) in esophageal cancer (EC).

Methods: The circ-SFMBT2, microRNA-107 (miR-107) and solute-linked carrier family A1 member 5 (SLC1A5) levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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September 2021

[Vincristine inhibits the proliferation of ovarian cancer cells by regulating the demethylation of RASSF2A].

Zhonghua Zhong Liu Za Zhi 2021 Sep;43(9):932-938

Department of Gynecology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550025, China.

To investigate the effect of vincristine on the proliferation of ovarian cancer cells by regulating RASSF2A demethylation. SKOV3 cells were infected with control (LV-NC) and RASSF2A lentivirus (LV-RASSF2A) and treated with or without vincristine. Cell counting kit-8 (CCK-8) was used to detect the activity of ovarian cancer cells (SKOV3) treated with different doses of vincristine. Read More

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September 2021

Fluorescence Resonance Energy Transfer in Calf Thymus DNA from a Long-Lifetime Metal-Ligand Complex to Nile Blue.

J Biochem Mol Biol 2001 Nov;34(6):551-558

Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland at Baltimore, Baltimore, MD 21201, USA.

We extended the measurable time scale of DNA dynamics to submicrosecond using a long-lifetime metal-ligand complex, [Ru(phen)(dppz)] (phen =1,10-phenanthroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) (RuPD), which displays a mean lifetime near 350 ns. We partially characterized the fluorescence resonance energy transfer (FRET) in calf thymus DNA from RuPD to nile blue (NB) using frequency-domain fluorometry with a high-intensity, blue light-emitting diode (LED) as the modulated light source. There was a significant overlap of the emission spectrum of the donor RuPD with the absorption spectrum of the acceptor NB. Read More

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November 2001

Contrast Phase Classification with a Generative Adversarial Network.

Proc SPIE Int Soc Opt Eng 2020 Feb 10;11313. Epub 2020 Mar 10.

Department of Eletrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA 37212.

Dynamic contrast enhanced computed tomography (CT) is an imaging technique that provides critical information on the relationship of vascular structure and dynamics in the context of underlying anatomy. A key challenge for image processing with contrast enhanced CT is that phase discrepancies are latent in different tissues due to contrast protocols, vascular dynamics, and metabolism variance. Previous studies with deep learning frameworks have been proposed for classifying contrast enhancement with networks inspired by computer vision. Read More

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February 2020

HEXACO-60 Personality Trait Inventory: Psychometric characteristics in a sample of medical students from Serbia.

Psych J 2021 Sep 16. Epub 2021 Sep 16.

Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

The 60-item HEXACO (HEXACO-60) Personality Trait Inventory may be strategically more important for researchers compared to the 100-item HEXACO. The aim of this study was to assess the psychometric properties of the 60-item HEXACO questionnaire in the Serbian language. This cross-sectional study, conducted at three of five Faculties of Medicine during the summer semester of the 2016/2017 academic year, included 617 students. Read More

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September 2021

Nano-optical trapping using an all-dielectric optical fiber supporting a TEM-like mode.

Nanotechnology 2021 Sep 16. Epub 2021 Sep 16.

School of Optical and Electronic Information, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei, 430074, CHINA.

Fiber optical tweezers benefit from compact structures and compatibility with fiber optic technology, however, trapping of nano-objects are rarely demonstrated. Here, we present stable optical trapping of a 30-nm polystyrene particle using an all-dielectric coaxial optical fiber supporting an axisymmetric TEM-like mode. We demonstrate, via comprehensive finite-difference time-domain simulations, that the trapping behavior arises from a significant shift of the fiber-end-fire radiation directivity originated from the nanoparticle-induced symmetry breaking, rather than the gradient force which assumes an invariant optical field. Read More

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September 2021

Transverse and longitudinal coupling of LSPPs in isolated triangular Al-SiO-Al hybrid nanoplates for generation of local electromagnetic fields with enhanced intensity and increased decay time.

Nanotechnology 2021 Sep 16. Epub 2021 Sep 16.

National Center for Nanoscience and Nanotechnology, No 11,Beiyitiao 11,Zhongguancun, Beijing, 100190, CHINA.

Achieving a large enhancement of local electromagnetic fields in the ultraviolet waveband is desirable for some applications such as surface-enhanced Raman scattering and surface-enhanced fluorescence. In addition, it is more significant for some applications such as plasmon-enhanced harmonic generation to enhance the intensity of local electromagnetic fields and increase their decay time at the same time. In this paper, using the finite-difference time-domain method, we numerically demonstrate that using the linearly polarized light with a wavelength of 325 nm as the illumination light, an isolated triangular Al-SiO-Al hybrid nanoplate with optimized geometric parameters can produce a local electric field enhanced by a factor of about 108 at one of its top apexes, and produce two local electric fields enhanced by a factor of about 150 at two transverse dielectric/metal interfaces of one of its longitudinal side edges. Read More

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September 2021

Acceleration of reconstruction for compressed sensing based synthetic transmit aperture imaging by using in-phase/quadrature data.

Ultrasonics 2021 Sep 6;118:106576. Epub 2021 Sep 6.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address:

Compressed sensing-based synthetic transmit aperture (CS-STA) was previously proposed to recover the full radio-frequency (RF) channel dataset of synthetic transmit aperture (STA) from that of a smaller number of randomly apodized plane wave (PW) transmissions. In this way, the imaging frame rate (FR) and contrast are improved with maintained spatial resolution, compared with those of STA. Because CS-STA reconstruction is repeated for all receive elements and RF samples (with a high sampling frequency), the recovery of STA dataset in RF domain is time-consuming. Read More

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September 2021

Caregiver rating of early childhood development: Reliability and validity of the ASQ-3 in rural Guatemala.

Early Hum Dev 2021 Aug 24;161:105453. Epub 2021 Aug 24.

Department of Rehabilitation, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, United States.

Background: Although performance-based assessment of early childhood development is preferred, there are a number of limitations to this methodology in low resource settings (LRSs). Hence, clinicians and researchers often rely on caregiver report screening tools. The Ages and Stages Questionnaire 3 (ASQ) is one of the most widely used caregiver report measures globally. Read More

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Two orders of magnitude extra SERS enhancement on silver nanoparticle-based substrate induced by laser irradiation in nitrogen ambient.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 8;265:120372. Epub 2021 Sep 8.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, and Collaborative Innovation Centre of Advanced Microstructures, Nanjing University, Nanjing 210093, China. Electronic address:

Photo-reduction of silver oxide and light-induced Ag nanoparticle (NP) generations have been applied for Surface-enhanced Raman spectroscopy (SERS) substrate fabricated for years. In this paper, we demonstrate a general method to enhance the SERS activity of conventional Ag NPs-based SERS substrates by performing Raman scattering measurement in a nitrogen ambient after a period of laser irradiation (photoactivation). The Raman characteristic peak intensity of carbonaceous impurities adsorbed on the surfaces of Ag NPs display an additional enhancement of 93 times after photoactivation in nitrogen ambient. Read More

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September 2021

HFO Detection in Epilepsy: A Stacked Denoising Autoencoder and Sample Weight Adjusting Factors-Based Method.

IEEE Trans Neural Syst Rehabil Eng 2021 Sep 16;PP. Epub 2021 Sep 16.

High-frequency oscillations (HFOs) recorded by the intracranial electroencephalography (iEEG) are the promising biomarkers of epileptogenic zones. Accurate detection of HFOs is the key to pre-operative assessment for epilepsy. Due to the subjective bias caused by manual features and the class imbalance between HFOs and false HFOs, it is difficult to obtain satisfactory detection performance by the existing methods. Read More

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September 2021

Size Doesn't Matter: Predicting Physico- or Biochemical Properties Based on Dozens of Molecules.

J Phys Chem Lett 2021 Sep 16:9213-9219. Epub 2021 Sep 16.

Science Data Software, LLC, 14909 Forest Landing Circle, Rockville, Maryland 20850, United States.

The use of machine learning in chemistry has become a common practice. At the same time, despite the success of modern machine learning methods, the lack of data limits their use. Using a transfer learning methodology can help solve this problem. Read More

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September 2021

Cognition-Enhanced Machine Learning for Better Predictions with Limited Data.

Top Cogn Sci 2021 Sep 16. Epub 2021 Sep 16.

Air Force Research Laboratory.

The fields of machine learning (ML) and cognitive science have developed complementary approaches to computationally modeling human behavior. ML's primary concern is maximizing prediction accuracy; cognitive science's primary concern is explaining the underlying mechanisms. Cross-talk between these disciplines is limited, likely because the tasks and goals usually differ. Read More

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September 2021

Context and Complexity in Telemedicine Evaluation: Work Domain Analysis in a Surgical Setting.

JMIR Perioper Med 2021 Sep 16;4(2):e26580. Epub 2021 Sep 16.

Division of Health Informatics and Logistics, Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden.

Many promising telemedicine innovations fail to be accepted and used over time, and there are longstanding questions about how to best evaluate telemedicine services and other health information technologies. In response to these challenges, there is a growing interest in how to take the sociotechnical complexity of health care into account during design, implementation, and evaluation. This paper discusses the methodological implications of this complexity and how the sociotechnical context holds the key to understanding the effects and outcomes of telemedicine. Read More

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September 2021

Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study.

Indian J Med Res 2021 Sep 16. Epub 2021 Sep 16.

ICMR-National Institute of Virology, Mumbai Unit, Indian Council of Medical Research, Haffkine Institute Campus, Mumbai, Maharashtra, India.

Background & Objectives: : Upper respiratory mucosa is the entryway for SARS-CoV-2, and cells at this site form the first line of resistance against the pathogens. Innate immune response at this point is crucial for managing the replication and early stage symptoms of virus infection. This study was aimed to evaluate the expression of pattern recognition receptors and cytokines in upper airway cells of SARS-CoV-2 infected patients. Read More

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September 2021

Time domain principal component analysis for rapid, real-time 2D MRI reconstruction from undersampled data.

Med Phys 2021 Sep 15. Epub 2021 Sep 15.

Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

Purpose: A rapid real-time 2D accelerated method was developed for MRI using principal component analysis (PCA) in the temporal domain. This method employs a moving window of previous dynamic frames to reconstruct the current, real-time frame within this window. This technique could be particularly useful in real-time tracking applications such as in MR-guided radiotherapy, where low latency real-time reconstructions are essential. Read More

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September 2021

Detection of Isopeptide Bonds in Monoclonal Antibody Aggregates.

Pharm Res 2021 Sep 15. Epub 2021 Sep 15.

Biomolecular Formulation and Characterization Sciences, UCB, Slough, SL3WE, UK.

Purpose: A major difficulty in monoclonal antibody (mAb) therapeutic development is product aggregation. In this study, intermolecular isopeptide bonds in mAb aggregates were characterized for the first time. We aim to propose a mechanism of covalent aggregation in a model antibody using stressed studies at raised temperatures to aid in the understanding of mAb aggregation pathways. Read More

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September 2021

Effect of Subject-Specific, Spatially Reduced, and Idealized Boundary Conditions on the Predicted Hemodynamic Environment in the Murine Aorta.

Ann Biomed Eng 2021 Sep 15. Epub 2021 Sep 15.

Department of Biomedical Engineering, University of Utah, 36 S. Wasatch Drive, SMBB, Rm. 3100, Salt Lake City, UT, 84112, USA.

Mouse models of atherosclerosis have become effective resources to study atherogenesis, including the relationship between hemodynamics and lesion development. Computational methods aid the prediction of the in vivo hemodynamic environment in the mouse vasculature, but careful selection of inflow and outflow boundary conditions (BCs) is warranted to promote model accuracy. Herein, we investigated the impact of animal-specific versus reduced/idealized flow boundary conditions on predicted blood flow patterns in the mouse thoracic aorta. Read More

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September 2021