Neuroimage 2021 Apr 17:118087. Epub 2021 Apr 17.
Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Research Group ExpORL, Department of Neurosciences, KU Leuven, Belgium; Psychological Sciences Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Electronic address:
Although the neural basis of dyslexia has intensively been investigated, results are still unclear about the existence of a white matter deficit in the arcuate fasciculus (AF) throughout development. To unravel this ambiguity, we examined the difference in fractional anisotropy (FA) of the AF between children developing dyslexia and children developing typical reading skills in a longitudinal sample with three MRI time points throughout reading development: the pre-reading stage (5-6 years old), the early reading stage (7-8 years old) and the advanced reading stage (9-10 years old). Applying along-the-tract analyses of white matter organization, our results confirmed that a white matter deficit existed in the left AF prior to the onset of formal reading instruction in children who developed dyslexia later on. Read More