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Association between body temperature and leukocyte telomere length in middle-aged and older adults.

Epidemiol Health 2021 Sep 8:e2021063. Epub 2021 Sep 8.

Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, 02707 Seoul, Republic of Korea.

Objectives: Data on the association between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Aims: The present study aimed to explore the association between a normal BT range (35.0 to 37. Read More

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September 2021

Social competence, leisure time activities, and smoking trajectories among adolescent boys: Data from The Korean Children & Youth Panel Survey.

Epidemiol Health 2021 Sep 9:e2021066. Epub 2021 Sep 9.

Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Objectives: To identify trajectories and potential predictors of tobacco use patterns among adolescents in Korea and to develop appropriate strategies for the implementation of primary prevention of tobacco use.

Methods: Tobacco trajectory and associated predictors were analyzed for 1,169 children from sixth (age 11) to tenth (age 15) grades in The Korean Children & Youth Panel Survey from 2012 to 2016.

Results: The three trajectory of smoking experience was identified: non-smokers (T1; 82. Read More

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September 2021

Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study.

J Perinat Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, Spedali Civili, Brescia, Italy.

Objectives: To review experience with fetoscopic laser ablation of placental anastomoses to treat monochorionic diamniotic (MCDA) twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) in a single centre over a ten-year period.

Methods: A retrospective study on 142 MCDA twin pregnancies complicates by TTTS treated with equatorial laser ablation of placental anastomoses (2008-2018). Solomon technique was also applied after 2013. Read More

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September 2021

Clinical analysis of uterine intravenous leiomyomatosis: A retrospective study of 260 cases.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Methods: We collected the clinical data of 260 patients admitted to the hospital from April 2003 to September 2019 with pathologically confirmed intravenous leiomyomatosis (IVL) and followed up with these patients regularly. Univariate and multivariate logistic regression analyses were carried out on the relevant recurrence factors.

Results: A total of 166 patients were regularly followed up, the median follow-up time was 36 (range 2-168) months, 14 (5. Read More

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September 2021

[Automatic detection of epileptiform potentials and seizures in the EEG].

Fortschr Neurol Psychiatr 2021 Sep 15;89(9):445-458. Epub 2021 Sep 15.

Automatic computer-based algorithms for the detection of epileptiform potentials and seizure patterns on EEG facilitate a time-saving, objective method of quantitative EEG interpretation which is available 7/24. For the automatic detection of interictal epileptiform potentials sensitivities range from 65 to 99% with false positive detections of 0,09 to 13,4 per minute. Recent studies documented equal or even better performance of automatic spike detection programs compared with experienced human EEG readers. Read More

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September 2021

Anxiety and Depression Impact on Inhospital Complications and Outcomes After Total Knee and Hip Arthroplasty: A Propensity Score-Weighted Retrospective Analysis.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Department of Orthopeadic Surgery and Sports Medicine, Detroit Medical Center, Detorit, MI (Zalikha and El-Othmani), and the Department of Biomedical Sciences, Oakland University William Beaumont School of Medicine, Auburn Hills, MI (Karabon and Hajj Hussein).

Introduction: The purpose of this study was to assess the impact of anxiety and depression on immediate inhospital outcomes and complications after total joint arthroplasty of the hip (total hip arthroplasty [THA]) and knee (total knee arthroplasty [TKA]) using a large national registry.

Methods: Data from the National Inpatient Sample was used to identify all patients undergoing TKA and THA between 2006 and 2015. Patients were divided in four groups based on a concomitant diagnosis of depression, anxiety, depression plus anxiety, and neither depression nor anxiety (control group). Read More

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November 2020

The Orthopaedic Match: Defining the Academic Profile of Successful Candidates.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Division of Plastic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD (Ngaage, Xue, Benzel, Rawes, Rasko), the Medical College of Georgia, Augusta, GA (Xue), the Department of Orthopaedic Surgery, Howard University, Washington, DC (Andrews, Wilson), the Yorkshire and Humber Foundation School, Leeds, UK (Rawes), and the Department of Orthopaedic Surgery, University of Maryland School of Medicine, Baltimore, MD (Ludwig).

Background: Research productivity forms a vital part of the resident selection process and can markedly affect the chance of a successful match. Current reports regarding the publication record among prospective orthopaedic surgery residents are likely inaccurate. Potential applicants have a poor understanding of the strength of their research credentials in comparison to other candidates. Read More

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November 2020

Patient Involvement in the Transfusion Decision-Making Can Change Patient Blood Management Practice for Better or Worse.

Acta Haematol 2021 Sep 15:1-4. Epub 2021 Sep 15.

Galilee Medical Center, Nahariya, Israel.

Background: Red blood cell transfusion (RBCT) is a therapeutic procedure with important and undesirable secondary effects. Inappropriate overuse of RBCT is significant, and a significant percentage of physicians prescribe RBCT unnecessarily. Patient involvement in treatment decision-making is poor worldwide. Read More

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September 2021

High-temperature oxidation and reduction of the inverse ceria/Cu(111) catalyst characterized by LEED, STM, nc-AFM and KPFM.

J Phys Condens Matter 2021 Sep 15. Epub 2021 Sep 15.

CNRS, CINaM UMR7325, Campus de Luminy, Case 913, Marseille Cedex 09, Provence, 13288, FRANCE.

The inverse catalyst 'cerium oxide (ceria) on copper' has attracted much interest in recent time because of its promising catalytic activity in the water-gas-shift reaction and the hydrogenation of CO. For such reactions it is important to study the redox behaviour of this system, in particular with respect to the reduction by H. Here, we investigate the high-temperature Ooxidation and Hreduction of ceria nanoparticles (NP) and a Cu(111) support by low energy electron diffraction (LEED), scanning tunnelling microscopy (STM), noncontact atomic force microscopy (nc-AFM) and Kelvin probe force microscopy (KPFM). Read More

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September 2021

High performance and low power consumption resistive random access memory with Ag/Fe2O3/Pt structure.

Nanotechnology 2021 Sep 15. Epub 2021 Sep 15.

Shanghai Jiao Tong University, Shanghai, CHINA.

Due to magnetic field tunability and the abundance of iron in the earth's crust, iron oxide-based resistive random access memory (RRAM) is considered to be low cost and potential for multi-level storage. However, the relatively high operation voltage (›1V) and small storage window (‹100) limit its application. In this work, the devices with simple Ag/Fe2O3/Pt structure exhibit typical bipolar resistive switching with ultralow set voltage (Vset) of 0. Read More

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September 2021

Rationale for developing tunable laser spectroscopy (TLS) technology for high resolution real-time carbon dioxide monitoring (capnography) in human breath.

J Breath Res 2021 Sep 15. Epub 2021 Sep 15.

NASA Jet Propulsion Laboratory, 4800 Oak Grove Dr, Pasadena, CA 91109, Pasadena, California, 91109-8001, UNITED STATES.

Real-time monitoring of exhaled carbon dioxide (CO2), also known as capnography, is a valuable hospital tool for assessing patient health during anesthesia and in both the emergency department and critical care units. The fundamental measurement is referred to as end-tidal carbon dioxide (ETCO2) concentration that reflects pulmonary gas exchange of CO2 representing systemic metabolism. The shape of the exhaled CO2 concentration for individual inhalation/exhalation breath cycles can offer additional information regarding lung function, airway obstruction, alveolar ventilation, and worsening disease. Read More

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September 2021

Magneto- and opto-stimuli responsive nanofibers as a controlled drug delivery system.

Nanotechnology 2021 Sep 15. Epub 2021 Sep 15.

Department of Bioengineering, University of California Riverside, 900 University Avenue, 331 Materials Science and Engineering Building, Riverside, California, 92521, UNITED STATES.

The drawbacks of conventional drug administration include repeated administration, non-specific biodistribution in the body's systems, the long-term unsustainability of drug molecules, and high global cytotoxicity, posing a challenge for the efficient treatment of chronic diseases that require varying drug dosages over time for optimal therapeutic efficacy. Most controlled release methods encapsulate drug molecules in biodegradable materials that dissolve over time to release the drug, making it difficult to deliver drugs on a schedule. To address these limitations, we developed a magneto-, opto-stimuli responsive drug delivery system based on functionalized electrospun nanofibers loaded with superparamagnetic iron oxide nanoparticles (SPIONs). Read More

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September 2021

Utility of a Postural Stability/Perceptual Inhibition Dual Task for Identifying Concussion in Adolescents.

J Sport Rehabil 2021 Sep 15:1-6. Epub 2021 Sep 15.

Context: Research in the area of dual-task paradigms to assess sport-related concussion (SRC) status is growing, but additional assessment of this paradigm in adolescents is warranted.

Design: This case-control study compared 49 adolescent athletes aged 12-20 years with diagnosed SRC to 49 age- and sex-matched controls on visual-spatial discrimination and perceptual inhibition (PIT) reaction time tasks performed while balancing on floor/foam pad conditions.

Methods: The SRC group completed measures at a single time point between 1 and 10 days postinjury. Read More

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September 2021

Predicting length of stay and mortality among hospitalized patients with type 2 diabetes mellitus and hypertension.

Int J Med Inform 2021 Sep 4;154:104569. Epub 2021 Sep 4.

International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Type 2 diabetes mellitus (T2DM) and hypertension (HTN), both non-communicable diseases, are leading causes of death globally, with more imbalances in lower middle-income countries. Furthermore, poor treatment and management are known to lead to intensified healthcare utilization and increased medical care costs and impose a significant societal burden, in these countries, including Indonesia. Predicting future clinical outcomes can determine the line of treatment and value of healthcare costs, while ensuring effective patient care. Read More

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September 2021

Artificial light pollution inhibits plant phenology advance induced by climate warming.

Environ Pollut 2021 Sep 6;291:118110. Epub 2021 Sep 6.

School of Resource and Environmental Sciences, Wuhan University, Wuhan, 430079, China; Key Laboratory of Geographic Information System, Ministry of Education, Wuhan University, Wuhan, 430079, China. Electronic address:

Natural photic regime has been drastically altered by the artificial night sky luminance. Despite evidence of sufficient light brightness inducing plant physiology and affecting phenology, generalization regarding effects of light pollution on plant phenology across species and locations is less clear. Meanwhile, the relative contributions and joint effects of artificial light pollution and climate change or other anthropic stressors still remain unknown. Read More

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September 2021

Ultrasound and heat treatment effects on Staphylococcus aureus cell viability in orange juice.

Ultrason Sonochem 2021 Sep 7;78:105743. Epub 2021 Sep 7.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. Electronic address:

Ultrasounds are being considered an excellent alternative technology in juice preservation. Yet, when combined with heat treatment, the process seems to be further intensified. This work aimed to evaluate and compare the impact of ultrasounds and heat treatments, when applied alone or in combination, on Staphylococcus aureus survival in orange juice. Read More

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September 2021

Seizure-induced reversible MRI abnormalities in status epilepticus: A systematic review.

Seizure 2021 Sep 7;92:166-173. Epub 2021 Sep 7.

School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Monash Medical Centre, Clayton, Melbourne, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

In the context of status epilepticus (SE), seizure-induced reversible MRI abnormalities (SRMA) can be difficult to differentiate from epileptogenic pathologies. To identify patterns and characteristics of SRMA, we conducted a systematic review in accordance with the Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included publications describing patients (a) presenting with status epilepticus, (b) exhibiting seizure-induced MRI abnormalities, (c) who demonstrated complete resolution of MRI abnormality at follow-up, and (d) who had availability of descriptive MRI results. Read More

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September 2021

Time to care - An ethnographic study of how temporal structuring affects caring relationships in clinical nursing.

Soc Sci Med 2021 Aug 27;287:114349. Epub 2021 Aug 27.

Centre for the Study of Professions, OsloMet - Oslo Metropolitan University, P.O. Box 4, St. Olavs Plass, N-0130, Oslo, Norway; Faculty of Health and Welfare Sciences, Østfold University College, P.O. Box 700, NO-1757, Halden, Norway. Electronic address:

This article explores how temporal structuring of clinical activities affects nurses' establishment of caring relationships with patients, based on an ethnographic study in a Norwegian cancer ward in January-June 2017. By drawing on practice-based perspectives on time and care, the article shows how 'medical time', 'patient time' and 'hospital time' represent three distinct but interconnected clinical rhythms affecting caring relationships. In this way, the article provides insights into how caring relationships are established in nurses' intermediate role as temporal agents, accommodation various temporal structures associated with the biomedical and person-centred care models. Read More

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Exposure to hydroxyapatite nanoparticles enhances Toll-like Receptor 4 signal transduction and overcomes endotoxin tolerance in vitro and in vivo.

Acta Biomater 2021 Sep 12. Epub 2021 Sep 12.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.

Emerging studies indicate hydroxyapatite nanoparticles (HANPs) exhibit modest immunogenicity to elicit innate immune response which might involve Toll-like receptor 4 (TLR4) activation. This study was proposed to elucidate how HANPs direct over TLR4 signal activity in macrophage in response to TLR4 ligand, lipopolysaccharide (LPS). The present study for the first time reveals that HANPs themselves can induce TLR4 endocytosis and activate pathways both of nuclear factor-kappa B (NF-κB) and interferon regulatory factor 3 (IRF3), which potentially trigger the production of inflammatory cytokine by macrophage. Read More

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September 2021

Analysis of the impact of COVID-19 on collisions, fatalities and injuries using time series forecasting: The case of Greece.

Accid Anal Prev 2021 Sep 4;162:106391. Epub 2021 Sep 4.

National Technical University of Athens, Department of Transportation Planning and Engineering, 5 Heroon Polytechniou str., GR-15773 Athens, Greece.

The current study aims to investigate the impact of the COVID-19 pandemic on road traffic collisions, fatalities, and injuries using time series analyses. To that aim, a database containing road collisions, fatalities, and slight injuries data from Greece were derived from the Hellenic Statistical Authority (HSA) and covered a ten-year timeframe (from January 2010 to August 2020. The chosen time period contained normal operations, as well as the period of the first COVID-19-induced lockdown period in Greece. Read More

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September 2021

A deep learning approach for synthetic MRI based on two routine sequences and training with synthetic data.

Comput Methods Programs Biomed 2021 Aug 31;210:106371. Epub 2021 Aug 31.

Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain.

Background And Objective: Synthetic magnetic resonance imaging (MRI) is a low cost procedure that serves as a bridge between qualitative and quantitative MRI. However, the proposed methods require very specific sequences or private protocols which have scarcely found integration in clinical scanners. We propose a learning-based approach to compute T1, T2, and PD parametric maps from only a pair of T1- and T2-weighted images customarily acquired in the clinical routine. Read More

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Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar.

Int J Infect Dis 2021 Sep 12. Epub 2021 Sep 12.

Department of Pathology, Sidra Medicine, Doha, Qatar; Pathology and Laboratory Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.

Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves of COVID-19 in Qatar, PCR genotyping, combined with Sanger sequencing of un-typeable samples, was employed to describe the epidemiology of the Alpha, Beta and Delta variants. A total of 9792 nasopharyngeal PCR-positive samples collected between April-June 2021 were successfully genotyped, revealing the importation and transmission dynamics of these three variants in Qatar. Read More

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September 2021

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Biochim Biophys Acta Gen Subj 2021 Sep 12:130010. Epub 2021 Sep 12.

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130021, China. Electronic address:

Background: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

Methods: A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Read More

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September 2021

Neural oscillations track natural but not artificial fast speech: Novel insights from speech-brain coupling using MEG.

Neuroimage 2021 Sep 12:118577. Epub 2021 Sep 12.

Laboratory Dynamique du Langage, UMR5596 CNRS/University of Lyon, 69007, Lyon, France. Electronic address:

Neural oscillations contribute to speech parsing via cortical tracking of hierarchical linguistic structures, including syllable rate. While the properties of neural entrainment have been largely probed with speech stimuli at either normal or artificially accelerated rates, the important case of natural fast speech has been largely overlooked. Using magnetoencephalography, we found that listening to naturally-produced speech was associated with cortico-acoustic coupling, both at normal (∼6 syllables/s) and fast (∼9 syllables/s) rates, with a corresponding shift in peak entrainment frequency. Read More

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September 2021

In situ label-free and sensitive detection assay for cell apoptosis via polyadenosine-coralyne fluorescence enhancement strategy.

Anal Biochem 2021 Sep 12:114329. Epub 2021 Sep 12.

Department of Biotechnology, College of Life Science and Technology, Jinan University Guangzhou, 510632, China. Electronic address:

Cell apoptosis detection is vital for biological analysis and clinical application; some detection assays are already commercially available. However, it is still far from perfect and needs further improvement for less cost, time-consuming and operation demanding. TUNEL, a high market share cell apoptosis assay, depends on adulteration fluorescent labelling dUTP by terminal deoxynucleotidyl transferase(TdT) which randomly adds deoxyribonucleoside triphosphates (dNTPs) at the 3'-OH terminal of ssDNA with a template-free manner. Read More

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September 2021

Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila.

Cell Rep 2021 Sep;36(11):109700

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Integrative Molecular Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA; McNair Medical Institute at The Robert and Janice McNair Foundation, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

The power of Drosophila melanogaster as a model system relies on tractable germline genetic manipulations. Despite Drosophila's expansive genetics toolbox, such manipulations are still accomplished one change at a time and depend predominantly on phenotypic screening. We describe a drug-based genetic platform consisting of four selection and two counterselection markers, eliminating the need to screen for modified progeny. Read More

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September 2021

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development.

Cell Rep 2021 Sep;36(11):109698

MRC Molecular Haematology Unit, MRC WIMM, University of Oxford, Oxford OX3 9DS, UK; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford OX4 2PG, UK; Centre for Computational Biology, Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM), University of Oxford, Oxford OX3 9DS, UK. Electronic address:

Human hematopoiesis is a dynamic process that starts in utero 18-21 days post-conception. Understanding the site- and stage-specific variation in hematopoiesis is important if we are to understand the origin of hematological disorders, many of which occur at specific points in the human lifespan. To unravel how the hematopoietic stem/progenitor cell (HSPC) compartment changes during human ontogeny and the underlying gene regulatory mechanisms, we compare 57,489 HSPCs from 5 different tissues spanning 4 developmental stages through the human lifetime. Read More

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September 2021

Anticipatory weight shift between arms when reaching from a crouched posture.

J Neurophysiol 2021 Sep 15. Epub 2021 Sep 15.

grid.260914.8New York Institute of Technology, College of Osteopathic Medicine, Department of Biomedical Science, Old Westbury, NY, United States.

Reaching movements performed from a crouched body posture require a shift of body weight from both arms to one arm. This situation has remained unexamined despite the analogous load requirements during step initiation and the many studies of reaching from a seated or standing posture. To determine whether the body weight shift involves anticipatory or exclusively reactive control we obtained force plate records, hand kinematics, and arm muscle activity from 11 healthy right-handed participants. Read More

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September 2021

How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

Authors:
Koni Grob

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2021 Sep 15:1-16. Epub 2021 Sep 15.

Retired from Kantonales Labor Zürich (Official Food Control Authority of the Canton of Zurich), Zurich, Switzerland.

Recycled paperboard contains hundreds of non-evaluated or even unidentified substances that could endanger human health if they turn out to be highly toxic. It seems as unrealistic to evaluate each of them as it is to phase out the use of the problematic ones or sort out the papers and boards introducing them into the recyclate. Therefore, measures should be taken that generally reduce migration into food, such as functional barriers or functional sorbents. Read More

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September 2021

A Comparison of Clinical Outcomes Between Two Different Models of Surgical Robots in Roux-en-Y Gastric Bypass.

J Laparoendosc Adv Surg Tech A 2021 Sep 17;31(9):969-977. Epub 2021 Aug 17.

General Surgery Department, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

For the past 20 years, robotic surgical systems have been used for the Roux-en-Y gastric bypass (RYGB). The da Vinci Surgical System (Intuitive Surgical, Inc.) has been one of the most used robotic platforms. Read More

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September 2021