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Risk prediction of major haemorrhage with surgical treatment of live cesarean scar pregnancies.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 22;264:224-231. Epub 2021 Jul 22.

Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, United Kingdom. Electronic address:

Objective: To evaluate the association between demographic and ultrasound variables and major intra-operative blood loss during surgical transcervical evacuation of live caesarean scar pregnancies.

Study Design: This was a retrospective cohort study conducted in a tertiary referral center between 2008 and 2019. We included all women diagnosed with a live caesarean scar ectopic pregnancy who chose to have surgical management in the study center. Read More

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Extreme temperature exposure and acute myocardial infarction: Elevated risk within hours?

Environ Res 2021 Jul 28:111691. Epub 2021 Jul 28.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China. Electronic address:

Day-to-day change in ambient temperature is associated with acute myocardial infarction (AMI) attacks, but evidence is scarce about the effects of extreme temperatures on the risk of AMI within hours of exposure. This study investigated the hour-level associations between extreme temperatures and AMI occurrence. State-wide data on AMI patients and temperature during winter and summer of 2013-2015 were obtained for Queensland state of Australia. Read More

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Association Between Cost-Saving Prescription Policy Changes and Adherence to Chronic Disease Medications: an Observational Study.

J Gen Intern Med 2021 Jul 30. Epub 2021 Jul 30.

Center for Healthcare Delivery Sciences (C4HDS) and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Pharmacy benefit design is one tool for improving access and adherence to medications for the management of chronic disease.

Objective: We assessed the effects of pharmacy benefit design programs, including a change in pharmacy benefit manager (PBM), institution of a prescription out-of-pocket maximum, and a mandated switch to 90 days' medication supply, on adherence to chronic disease medications over time.

Design: We used a difference-in-differences design to assess changes in adherence to chronic disease medications after the transition to new prescription policies. Read More

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Comparison of Conventional Methods for Bowel Length Measurement in Laparoscopic Surgery to a Novel Computer-Assisted 3D Measurement System.

Obes Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.

Purpose: Accurate laparoscopic bowel length measurement (LBLM), which is used primarily in metabolic surgery, remains a challenge. This study aims to three conventional methods for LBLM, namely using visual judgment (VJ), instrument markings (IM), or premeasured tape (PT) to a novel computer-assisted 3D measurement system (BMS).

Materials And Methods: LBLM methods were compared using a 3D laparoscope on bowel phantoms regarding accuracy (relative error in percent, %), time in seconds (s), and number of bowel grasps. Read More

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Resection of vestibular schwannomas after stereotactic radiosurgery: a systematic review.

J Neurosurg 2020 Nov 27:1-9. Epub 2020 Nov 27.

Department of Neurological Surgery, Rush University Medical Center, Chicago.

Objective: Multiple short series have evaluated the efficacy of salvage microsurgery (MS) after stereotactic radiosurgery (SRS) for treatment of vestibular schwannomas (VSs); however, there is a lack of a large volume of patient data available for interpretation and clinical adaptation. The goal of this study was to provide a comprehensive review of tumor characteristics, management, and surgical outcomes of salvage of MS after SRS for VS.

Methods: The Medline/PubMed, Scopus, CINAHL, Cochrane Library, and Google Scholar databases were queried according to PRISMA guidelines. Read More

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November 2020

Effects of technology-based physical activity interventions for women after bariatric surgery: study protocol for a three-arm randomised controlled trial.

BMJ Open 2021 Jul 30;11(7):e046184. Epub 2021 Jul 30.

Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Côte d'Azur, Nice, France.

Introduction: A recent meta-analysis provided proof of efficacy for mobile technology to increase physical activity or weight loss in the short term. Videoconferencing may also be effective, especially as it reduces the barriers related to face-to-face physical activity interventions. Both technologies seem particularly interesting for bariatric surgery management, but their long-term effects on physical activity maintenance are unknown. Read More

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Clinical effect of application of nursing concept of rehabilitation surgery for improvement of quality of postoperative recovery in orthopedics.

Hong Lv Ning Yang

J Orthop Surg Res 2021 Jul 30;16(1):471. Epub 2021 Jul 30.

Inner Mongolia Sports Hospital, No.2 South Tongdao Road, Huimin District, Hohhot, 010030, Inner Mongolia Autonomous Region, China.

Objective: To analyze the application of concept nursing of accelerated rehabilitation surgery in orthopedic postoperative recovery.

Methods: A total of 120 patients who received orthopedic surgery were divided into the control group undergoing routine orthopedic nursing and the observation group undergoing the concept of accelerated rehabilitation surgery nursing.

Results: Patients in the observation group had shorter in-bed activity time and out-of-bed activity time, average time of hospital stay, and lower total treatment costs. Read More

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An Accessible, 16-Week Neck Strength Training Program Improves Head Kinematics Following Chest Perturbation in Young Soccer Athletes.

J Sport Rehabil 2021 Jul 30:1-8. Epub 2021 Jul 30.

Context: Neck size and strength may be associated with head kinematics and concussion risks. However, there is a paucity of research examining neck strengthening and head kinematics in youths. In addition, neck training is likely lacking in youth sport due to a perceived inadequacy of equipment or time. Read More

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Association of transportation noise with sleep during the first year of life: A longitudinal study.

Environ Res 2021 Jul 27:111776. Epub 2021 Jul 27.

Division of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, University of Zurich, Zurich, Switzerland; University Children's Hospital Basel (UKBB), Basel, Switzerland. Electronic address:

Study Objectives: During infancy, adequate sleep is crucial for physical and neurocognitive development. In adults and children, night-time noise exposure is associated with sleep disturbances. However, whether and to what extent infants' sleep is affected, is unknown. Read More

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Meta-analysis of time to extrusion of tympanostomy tubes by tympanic membrane quadrant.

Clin Otolaryngol 2021 Jul 30. Epub 2021 Jul 30.

Department of Otolaryngology Head, Neck and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: To investigate the published time to extrusion of tympanostomy tubes inserted in the various quadrants of the tympanic membrane.

Methods: Publications were selected by a search with "PubMed", "Embase", and "Web of Science". A meta-analysis of time to extrusion as a function of tympanic membrane quadrant intubation was carried out. Read More

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Separation of chemical constituents in Bidens pilosa Linn. var. radiata Sch. Bip. by elution-extrusion counter-current chromatography using two new three-phase solvent systems.

J Sep Sci 2021 Jul 30. Epub 2021 Jul 30.

Shandong Academy of Traditional Chinese Medicine, Jinan, 250014, PR China.

Two new three-phase solvent systems combined with elution-extrusion counter-current chromatography mode was used to study the chemical constituents in Bidens pilosa Linn. var. radiata Sch. Read More

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Assessment of Red Sea temperatures in CMIP5 models for present and future climate.

PLoS One 2021 30;16(7):e0255505. Epub 2021 Jul 30.

King Abdullah University of Science and Technology (KAUST), Red Sea Research Center (RSRC), Thuwal, Saudi Arabia.

The increase of the temperature in the Red Sea basin due to global warming could have a large negative effect on its marine ecosystem. Consequently, there is a growing interest, from the scientific community and public organizations, in obtaining reliable projections of the Red Sea temperatures throughout the 21st century. However, the main tool used to do climate projections, the global climate models (GCM), may not be well suited for that relatively small region. Read More

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Leveraging Health Information Technology to Collect Family Cancer History: A Systematic Review and Meta-Analysis.

JCO Clin Cancer Inform 2021 Jun;5:775-788

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Weill Cornell Medicine, New York, NY.

Purpose: Collection of family cancer histories (FCHs) can identify individuals at risk for familial cancer syndromes. The aim of this study is to evaluate the literature on existing strategies whereby providers use information technology to assemble FCH.

Methods: A systematic search of online databases (Ovid MEDLINE, Cochrane, and Embase) between 1980 and 2020 was performed. Read More

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The influence of biofilm maturation on fluoride's anticaries efficacy.

Clin Oral Investig 2021 Jul 30. Epub 2021 Jul 30.

Department of Cariology, Operative Dentistry and Dental Public Health, School of Dentistry, Indiana University, 415 Lansing Street, Indianapolis, IN, 46202-2876, USA.

Objectives: (1) To explore the influence of biofilm maturation and timing of exposure on fluoride anticaries efficacy and (2) to explore biofilm recovery post-treatment.

Methods: Bovine enamel specimens were utilized in a pH cycling model (28 subgroups [n = 18]). Each subgroup received different treatments [exposure]: sodium fluoride [NaF]; stannous fluoride [SnF]; amine fluoride [AmF]; and de-ionized water [DIW], at a specific period: early: days 1-4; middle: days 3-6; and late: days 7-10. Read More

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Effect of prenatal screening on trends in perinatal mortality associated with congenital anomalies before and after the introduction of prenatal screening: A population-based study in the Northern Netherlands.

Paediatr Perinat Epidemiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Genetics, EUROCAT Registration Northern Netherlands, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Perinatal mortality in foetuses/children with congenital anomalies remains high. Prenatal diagnosis, essential for risk assessment and organisation of perinatal/postnatal care, offers parents the opportunity to consider the termination of pregnancy. In times of quick changes in prenatal screening programmes, it is relevant to evaluate the effect of prenatal screening on perinatal mortality rates. Read More

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Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer.

Cochrane Database Syst Rev 2021 Jul 30;7:CD005343. Epub 2021 Jul 30.

Department of Gynaecological Oncology, Musgrove Park Hospital, Taunton, UK.

Background: Epithelial ovarian cancer presents at an advanced stage in the majority of women. These women require a combination of surgery and chemotherapy for optimal treatment. Conventional treatment has been to perform surgery first and then give chemotherapy. Read More

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Correlation between ultrasound bladder parameters with severity of symptoms and response to treatment in patients with benign prostatic hyperplasia under medical treatment.

Am J Clin Exp Urol 2021 15;9(3):242-247. Epub 2021 Jun 15.

Assistant Professor, Department of Urology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.

Background: Benign prostatic hyperplasia (BPH) is the most common benign mass in men, there are not standard parameter for diagnosis of BPH based on ultrasound bladder parameter, so the aim of the study was correlation between ultrasound bladder parameters with severity of symptoms and response to treatment in patients with benign prostatic hyperplasia under medical treatment.

Methods: This prospective cross-sectional study was performed on 100 men over 40 years of age with a diagnosis of BPH referred to the urology clinics of Al-Zahra and Khorshid hospitals, Isfahan, Iran in 2018-2020. The International Prostate Symptom Score (IPSS), bladder wall thickness, bladder weight, Intravesical prostatic protrusion (IPP) and response to treatment were examined before and after treatment. Read More

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Cost Comparison of Tibial Distraction Osteogenesis Using External Lengthening and Then Nailing vs Internal Magnetic Lengthening Nails.

Strategies Trauma Limb Reconstr 2021 Jan-Apr;16(1):14-19

Department of Limb Lengthening and Complex Reconstruction, Hospital for Special Surgery, New York, United States.

Aim And Objective: Tibial lengthening can be performed by distraction osteogenesis via lengthening and then nailing (LATN) or by using a magnetic lengthening nail (MLN). MLN avoids the complications of external fixation while providing accurate and easily controlled lengthening. Concerns exist still regarding the high upfront cost of the magnetic nail, which serves to limit its use in resource-poor areas and decrease adoption among cost-conscious surgeons. Read More

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Efficacy of afoxolaner (NexGard®) in preventing the transmission of Leishmania infantum and Dirofilaria immitis to sheltered dogs in a highly endemic area.

Parasit Vectors 2021 Jul 29;14(1):381. Epub 2021 Jul 29.

Department of Veterinary Medicine, University of Bari, Valenzano, Italy.

Background: Leishmania infantum and Dirofilaria immitis are among the most important canine vector-borne pathogens (CVBPs) of zoonotic concern in Europe. In endemic areas for both of these CVBPs, the use of systemic ectoparasiticides, such as afoxolaner (NexGard®; Boehringer Ingelheim Animal Health), may have the potential for controlling these infections. The aim of this study was to assess, for the first time, the insecticidal efficacy of NexGard® in decreasing the transmission of D. Read More

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Tuning CO sensing properties of HPTS along with newly synthesized coordination polymers (CPs).

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 21;263:120224. Epub 2021 Jul 21.

Dokuz Eylül University, Faculty of Sciences, Department of Chemistry, Izmir, Turkey.

Coordination polymers (CPs), new functional hybrid materials, have received important attention due to their structural features and many different applications such as gas storage, catalysis, energy storage, small molecule adsorption, luminescence, and chemical sensors. In this study, two newly synthesized metal-organic frameworks (MOFs); [Mn(µ-dmg)-(µ-dmg)(µ-bipy)] (CP1) and [Mn(µ-dmg)(µ-dmg)(µ-dpeten)] (CP2); were used for sensing of gaseous carbon dioxide with a spectrofluorometric method with a dye, 8-hydroxypyrene-1, 3, 6-trisulfonic acid (HPTS) as matrix additive material for the first time. The ion-pair form of the HPTS was used in the polymethyl methacrylate matrix as a thin film form. Read More

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Predicting pain among female survivors of recent interpersonal violence: A proof-of-concept machine-learning approach.

PLoS One 2021 29;16(7):e0255277. Epub 2021 Jul 29.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.

Interpersonal violence (IPV) is highly prevalent in the United States and is a major public health problem. The emergence and/or worsening of chronic pain are known sequelae of IPV; however, not all those who experience IPV develop chronic pain. To mitigate its development, it is critical to identify the factors that are associated with increased risk of pain after IPV. Read More

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Poly-victimization and opioid use during late adolescence and young adulthood: Health behavior disparities and protective factors.

Psychol Addict Behav 2021 Jul 29. Epub 2021 Jul 29.

RAND Corporation.

Objective: Recent work has attempted to uncover heterogeneity in experiences of victimization. However, few studies have included important trauma-related characteristics such as known perpetrator, fear of life or injury, and negative reactions to disclosure. Little focus on potentially important subgroup differences including sexual/gender identity, race/ethnicity, and socioeconomic status as well as protective factors have been assessed. Read More

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Change in mammography screening attendance after removing the out-of-pocket fee: a population-based study in Sweden (2014-2018).

Cancer Causes Control 2021 Jul 28. Epub 2021 Jul 28.

Department of Translational Medicine, Diagnostic Radiology, Skåne University Hospital, Lund University, Malmö, Sweden.

Purpose: To assess the change in mammography screening attendance in Sweden-overall and in sociodemographic groups at risk of low attendance-after removal of the out-of-pocket fee in 2016.

Methods: Individual-level data on all screening invitations and attendance between 2014 and 2018 were linked to sociodemographic data from Statistics Sweden. Odds ratios and 95% confidence intervals (CIs) for attendance by time period and sociodemographic factor were computed using mixed logistic regression to account for repeated measures within women. Read More

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Eosinophil-to-Neutrophil Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis.

Front Neurol 2021 12;12:665827. Epub 2021 Jul 12.

Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

The eosinophil-to-neutrophil ratio (ENR) was recently reported as a novel inflammatory marker in acute ischemic stroke (AIS). However, few studies reported the predictive value of ENR in AIS patients, especially for those with intravenous thrombolysis. Two hundred sixty-six AIS patients receiving intravenous thrombolysis were retrospectively recruited in this study and followed up for 3 months and 1 year. Read More

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Gonioscopy-assisted transluminal trabeculotomy (GATT) outcomes in eyes with open-angle glaucoma resistant to maximum treatment.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Department of Ophthalmology, School of Medicine, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Purpose: To report the initial 2 years' learning curve on gonioscopy-assisted transluminal trabeculotomy performed using the thermally blunted suture technique and review the factors that could potentially affect the outcome.

Methods: This retrospective study evaluated 100 eyes from 89 participants with glaucoma resistant to maximum clinical treatment, which was defined as having an intraocular pressure >21 mmHg in addition to three or four different hypotensive drugs. Intraocular pressure values at baseline, 1 week, and at 1, 2, 3, 6, 12, and 24 months of follow-up and details regarding the need of antiglaucoma medication and further glaucoma surgery were recorded. Read More

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Reconnection Sites in Redo Ablation after Cryoballoon Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation.

Arq Bras Cardiol 2021 Jul;117(1):100-105

Centro Medico Nacional 20 de Noviembre - Hemodinamia y Electrofisiologua, Ciudad de México - México.

Background: In paroxysmal atrial fibrillation (PAF), pulmonary vein isolation using cryoballoon (CB-PVI) has similar efficacy as radiofrequency ablation (RF-PVI) has. In redo ablation procedures following RF-PVI, PV reconnection is high, whereas in patients with redo following CB-PVI, information is scarce.

Objective: To determine the sites of PV reconnection in patients who underwent redo ablation after initial CB-PVI. Read More

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Serologic Surveillance and Phylogenetic Analysis of SARS-CoV-2 Infection Among Hospital Health Care Workers.

JAMA Netw Open 2021 Jul 1;4(7):e2118554. Epub 2021 Jul 1.

Section Infectious Diseases, Department of Internal Medicine, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Importance: It is unclear when, where, and by whom health care workers (HCWs) working in hospitals are infected with SARS-CoV-2.

Objective: To determine how often and in what manner nosocomial SARS-CoV-2 infection occurs in HCW groups with varying exposure to patients with COVID-19.

Design, Setting, And Participants: This cohort study comprised 4 weekly measurements of SARS-CoV-2-specific antibodies and collection of questionnaires from March 23 to June 25, 2020, combined with phylogenetic and epidemiologic transmission analyses at 2 university hospitals in the Netherlands. Read More

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Long-term outcome of supraciliary gold micro shunt in refractory glaucoma.

Acta Ophthalmol 2021 Jul 27. Epub 2021 Jul 27.

Ophthalmology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

Purpose: To evaluate the 10-year follow-up efficacy and safety of gold micro shunt (GMS) in patients with refractory glaucoma, and the potential risk factors for failure.

Methods: Retrospective data analyses based on medical records from 55 patients who underwent GMS implant for refractory glaucoma between March 2007 and April 2008. The primary outcome measure was the cumulative probability of success defined as intraocular pressure (IOP) below 21 mmHg together with a 33% lowering of the baseline IOP with (qualified) or without (complete) topical medications, no reoperation for glaucoma or loss of light perception. Read More

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Spray cryotherapy prevents need for palliative stenting in patients with esophageal cancer-associated dysphagia.

Dis Esophagus 2021 Jul 27. Epub 2021 Jul 27.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: Dysphagia is the most common symptom in advanced esophageal cancer patients. Esophageal stent placement (SP) is a common palliation method but can be associated with significant morbidity. Limited data exist regarding the ability of spray cryotherapy (SC) prolong time to SP. Read More

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Direct Measurement of Creatinine Clearance over a Short Interval in Intensive Care Settings.

Indian J Crit Care Med 2021 Jul;25(7):800-802

Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong.

Background: The definition of acute kidney injury (AKI), based on serum creatinine and urine output, bears significant limitations in intensive care units (ICUs). Serum creatinine has significant lag-time as it needs to be accumulated and stabilized at a new level whereas urine output is affected by diuresis, antidiuresis, and antinatriuresis. Direct measurement of creatinine clearance (CrCl = urine creatinine × urine flow rate/serum creatinine) over a short interval (3-6 hours) was explored to identify patients with AKI. Read More

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