5,788 results match your criteria tick-borne encephalitis

Autochthonous Cases of Tick-Borne Encephalitis, Belgium, 2020.

Emerg Infect Dis 2021 Jun 10;27(8). Epub 2021 Jun 10.

We report 3 confirmed autochthonous tick-borne encephalitis cases in Belgium diagnosed during summer 2020. Clinicians should include this viral infection in the differential diagnosis for patients with etiologically unexplained neurologic manifestations, even for persons without recent travel history. Read More

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[Genetic Variability of Tick-Borne Encephalitis Virus Genome 5'-UTR from Northern Eurasia].

Mol Biol (Mosk) 2021 May-Jun;55(3):431-440

Vector State Scientific Center for Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 630559 Russia.

This paper reports the analysis of the nucleotide sequences of the 5'-untranslated region (5'-UTR) of tick-borne encephalitis virus (TBEV) genomic RNA isolated from 39 individual taiga ticks collected in several regions of Northern Eurasia. The sequences of 5'-UTRs of the Siberian and Far East TBEV genotypes were 89% and 95% identical to the prototype strains (Zausaev and 205), respectively. The detected nucleotide substitutions were typical for these two TBEV genotypes, which made possible unambiguous identification. Read More

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A Virus-Like Particle-Based Vaccine Candidate against the Tick-Borne Powassan Virus Induces Neutralizing Antibodies in a Mouse Model.

Pathogens 2021 May 31;10(6). Epub 2021 May 31.

American Type Culture Collection (ATCC®), ATCC Federal Solutions, 10801 University Boulevard, Manassas, VA 20110, USA.

Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the Russian Far East that can cause severe neuroinvasive diseases, including encephalitis, meningitis, and meningoencephalitis. The reported neuroinvasive case fatality is about 10%, and approximately 50% of the survivors from the neuroinfection exhibit long-lasting or permanent neurological sequelae. Currently, treatment of POWV infection is supportive, and no FDA-approved vaccines or specific therapeutics are available. Read More

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Experimental Assessment of Possible Factors Associated with Tick-Borne Encephalitis Vaccine Failure.

Microorganisms 2021 May 29;9(6). Epub 2021 May 29.

FSBSI "Chumakov FSC R&D IBP RAS", 108819 Moscow, Russia.

Currently the only effective measure against tick-borne encephalitis (TBE) is vaccination. Despite the high efficacy of approved vaccines against TBE, rare cases of vaccine failures are well documented. Both host- and virus-related factors can account for such failures. Read More

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Dynamics and Extent of Non-Structural Protein 1-Antibody Responses in Tick-Borne Encephalitis Vaccination Breakthroughs and Unvaccinated Patients.

Viruses 2021 May 27;13(6). Epub 2021 May 27.

Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.

Tick-borne encephalitis (TBE) has a substantial impact on human public health in many parts of Europe and Asia. Effective inactivated purified whole-virus vaccines are in widespread use in TBE-endemic countries. Nevertheless, vaccination breakthroughs (VBTs) with manifest clinical disease do occur, and their specific serodiagnosis was shown to be facilitated by the detection of antibodies to a non-structural protein (NS1) that is produced during virus replication. Read More

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Detection of Tick-Borne Pathogens in Red Deer (), United Kingdom.

Pathogens 2021 May 23;10(6). Epub 2021 May 23.

Arbovirus Research Team, Virology Department, Animal and Plant Health Agency (Weybridge), Woodham Lane, Addlestone KT15 3NB, UK.

Deer represent a major vertebrate host for all feeding stages of the hard tick in the United Kingdom (UK), and could play a role in the persistence of tick-borne pathogens. However, there have been few studies reporting the presence of spp. and in deer in the UK, and those that detected were unable to confirm the species. Read More

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Bat Flies of the Family (Diptera: Hippoboscoidea) Host Relatives of Medically and Agriculturally Important "Bat-Associated" Viruses.

Viruses 2021 05 8;13(5). Epub 2021 May 8.

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.

Bat flies (Hippoboscoidea: and ) are obligate hematophagous ectoparasites of bats. We collected streblid bat flies from the New World (México) and the Old World (Uganda), and used metagenomics to identify their viruses. In México, we found méjal virus (; ), Amate virus (: ), and two unclassified viruses of invertebrates. Read More

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Mialostatin, a Novel Midgut Cystatin from Ticks: Crystal Structure and Regulation of Host Blood Digestion.

Int J Mol Sci 2021 May 20;22(10). Epub 2021 May 20.

Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Branišovská 1160/31, 37005 České Budějovice, Czech Republic.

The hard tick is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known about the regulation of the digestive proteolytic machinery of . Read More

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Ticking on Pandora's box: a prospective case-control study into 'other' tick-borne diseases.

BMC Infect Dis 2021 May 29;21(1):501. Epub 2021 May 29.

Amsterdam UMC, Center for Experimental and Molecular Medicine, Amsterdam Institute of Infection and Immunology, University of Amsterdam, P.O. Box 22660 (1100 DD), Amsterdam, The Netherlands.

Background: Tick-borne pathogens other than Borrelia burgdorferi sensu lato - the causative agent of Lyme borreliosis - are common in Ixodes ricinus ticks. How often these pathogens cause human disease is unknown. In addition, diagnostic tools to identify such diseases are lacking or reserved to research laboratories. Read More

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A novel approach for predicting risk of vector-borne disease establishment in marginal temperate environments under climate change: West Nile virus in the UK.

J R Soc Interface 2021 May 26;18(178):20210049. Epub 2021 May 26.

School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.

Vector-borne diseases (VBDs), such as dengue, Zika, West Nile virus (WNV) and tick-borne encephalitis, account for substantial human morbidity worldwide and have expanded their range into temperate regions in recent decades. Climate change has been proposed as a likely driver of past and future expansion, however, the complex ecology of host and vector populations and their interactions with each other, environmental variables and land-use changes makes understanding the likely impacts of climate change on VBDs challenging. We present an environmentally driven, stage-structured, host-vector mathematical modelling framework to address this challenge. Read More

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A Serosurvey of Tick-Borne Encephalitis Virus in Sweden: Different Populations and Geographical Locations.

Vector Borne Zoonotic Dis 2021 May 21. Epub 2021 May 21.

Department of Laboratory Medicine and Lund University, Skåne University Hospital, Lund, Sweden.

New risk areas for tick-borne encephalitis (TBE) are emerging and the spread of disease and vaccine coverage is unclear in Sweden. We wanted to study the prevalence and levels of TBE-virus (TBEV) antibodies in southern Sweden, and to investigate whether there were individuals with undiagnosed TBE. Two cohorts of sera were collected: One group of anonymous individuals in rural areas (AIRA) in Skåne and one group of volunteers who often got tick-bites (tick-bitten individuals [TBI]). Read More

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Trends and Opportunities in Tick-Borne Disease Geography.

J Med Entomol 2021 May 24. Epub 2021 May 24.

Center for Global Health Science and Security, Georgetown University Medical Center, Georgetown University, Washington, DC, USA.

Tick-borne diseases are a growing problem in many parts of the world, and their surveillance and control touch on challenging issues in medical entomology, agricultural health, veterinary medicine, and biosecurity. Spatial approaches can be used to synthesize the data generated by integrative One Health surveillance systems, and help stakeholders, managers, and medical geographers understand the current and future distribution of risk. Here, we performed a systematic review of over 8,000 studies and identified a total of 303 scientific publications that map tick-borne diseases using data on vectors, pathogens, and hosts (including wildlife, livestock, and human cases). Read More

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Alkhumra hemorrhagic fever virus infection.

Arch Virol 2021 May 11. Epub 2021 May 11.

Scientific Chair of Sheikh Mohammad Hussein Alamoudi for Viral Hemorrhagic Fever, King Abdulaziz University, Jeddah, Saudi Arabia.

Objectives: This review article summarizes what has been published on Alkhumra hemorrhagic fever virus (AHFV), a novel flavivirus that was discovered in Saudi Arabia in 1995.

Methods: PubMed was used to search for studies published from January 1995 to June 2019 using the key words Alkhumra virus, Alkhurma virus, novel flavivirus, and tick-borne encephalitis virus. Additionally, records of the Saudi Ministry of Health were reviewed. Read More

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Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease.

Digestion 2021 May 10:1-9. Epub 2021 May 10.

Department of Pediatrics, Pediatric Infectious Disease Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of infection and are frequently not up to date with their immunizations.

Objectives: This study aims to review vaccination status and evaluate whether age, disease type, or treatment regimen could predict the absence of seroprotection against selected vaccine-preventable infection in adults with IBD.

Methods: Cross-sectional study using questionnaire, immunization records review, and assessment of tetanus-specific, varicella-specific, and measles-specific immunoglobulin G concentrations. Read More

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Deadly Neuroinvasive Mosquito-Borne Virus: A Case of Eastern Equine Encephalitis.

Perm J 2021 May;25

Department of Medicine, AtlantiCare Regional Medical Center, Atlantic City, NJ.

None: Eastern equine encephalitis (EEE) is a rare and potentially fatal neuroinvasive disease with a high mortality rate of > 30%. It is an uncommon vector-borne illness, with an average of 8 cases reported in the United States annually. Alarmingly, in 2019 alone, the Centers for Disease Control and Prevention (CDC) confirmed 38 cases of EEE virus in the United States, reported from 10 states. Read More

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Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis.

Microorganisms 2021 Apr 10;9(4). Epub 2021 Apr 10.

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Patients with the monophasic course were significantly ( ≤ 0. Read More

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Enteric Ganglioneuritis, a Common Feature in a Subcutaneous TBEV Murine Infection Model.

Microorganisms 2021 Apr 18;9(4). Epub 2021 Apr 18.

Department of Infectious Diseases, Institute for Parasitology, University of Veterinary Medicine, Buenteweg 17, 30559 Hanover, Germany.

Tick-borne encephalitis (TBE) is a severe neurologic disease in Europe and Asia. Disease expression ranges from asymptomatic to severe neurological clinical pictures, involving meningitis, encephalitis, meningoencephalitis and potentially fatal outcome. Humans mostly become infected with TBE virus (TBEV) by the bite of an infected tick. Read More

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Tick-Borne Encephalitis Vaccination Protects from Alimentary TBE Infection: Results from an Alimentary Outbreak.

Microorganisms 2021 Apr 21;9(5). Epub 2021 Apr 21.

Bundeswehr Institute of Microbiology, 80937 Munich, Germany.

In May 2017, a hospitalized index case of tick-borne encephalitis (TBE) was confirmed by Serology. The case was linked to alimentary infection by raw milk from a goat farm in the region of Tübingen, Baden-Württemberg, Germany, where no previous TBE cases in the area had been reported before. The TBE focus was confirmed by isolation of the TBE virus from ticks and Serological confirmation of past infection in one of the five flock goats. Read More

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Neurotropic Viruses, Astrocytes, and COVID-19.

Front Cell Neurosci 2021 9;15:662578. Epub 2021 Apr 9.

Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

At the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered in China, causing a new coronavirus disease, termed COVID-19 by the WHO on February 11, 2020. At the time of this paper (January 31, 2021), more than 100 million cases have been recorded, which have claimed over 2 million lives worldwide. The most important clinical presentation of COVID-19 is severe pneumonia; however, many patients present various neurological symptoms, ranging from loss of olfaction, nausea, dizziness, and headache to encephalopathy and stroke, with a high prevalence of inflammatory central nervous system (CNS) syndromes. Read More

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Analysis of effectivity of the tickborne encephalitis virus detection methods in ixodid ticks.

Klin Lab Diagn 2021 Apr;66(4):237-241

Scientific-Research Institute of epidemiology and microbiology named after G.P. Somov.

Tick-borne encephalitis (TBE) is transmissible viral disease widely common in temperate zone of Eurasia. ELISA and PCR are used for express identification of the vector's infection, but the results of the two methods often do not agree. Aim of the work is comparative analysis for TBE virus of Ixodid ticks from nature using complex of methods, including ELISA, PCR, and isolation of the virus in laboratory mice. Read More

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The increased intrathecal expression of the monocyte-attracting chemokines CCL7 and CXCL12 in tick-borne encephalitis.

J Neurovirol 2021 Apr 19. Epub 2021 Apr 19.

Department, of the Infectious Diseases and Neuroinfections, Medical University in Białystok, ul. Żurawia 14, 15-540, Bialystok, Poland.

Tick-borne encephalitis (TBE) is a relatively severe and clinically variable central nervous system (CNS) disease with a significant contribution of a secondary immunopathology. Monocytes/macrophages play an important role in the CNS inflammation, but their pathogenetic role and migration mechanisms in flavivirus encephalitis in humans are not well known. We have retrospectively analyzed blood and cerebrospinal fluid (CSF) monocyte counts in 240 patients with TBE presenting as meningitis (n = 110), meningoencephalitis (n = 114), or meningoencephalomyelitis (n = 16), searching for associations with other laboratory parameters, clinical presentation, and severity. Read More

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Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors.

Antiviral Res 2021 Jun 16;190:105074. Epub 2021 Apr 16.

Department of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden. Electronic address:

Tick-borne encephalitis (TBE) is a severe neurological disorder caused by tick-borne encephalitis virus (TBEV), a member of the Flavivirus genus. Currently, two vaccines are available in Europe against TBEV. However, TBE cases have been rising in Sweden for the past twenty years, and thousands of cases are reported in Europe, emphasizing the need for antiviral treatments against this virus. Read More

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[A case of tick-borne encephalitis without any sequelae].

Rinsho Shinkeigaku 2021 May 17;61(5):310-313. Epub 2021 Apr 17.

Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

A 43-year-old woman with a history of tick bite in the mountains in Hokkaido presented with a fever of 39°C, headache, and nausea. Cerebrospinal fluid findings indicated meningitis. On day 3 after admission, she presented with restlessness, disturbance of consciousness, and ataxic breathing, indicative of encephalitis. Read More

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Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus.

PLoS Pathog 2021 Apr 15;17(4):e1009505. Epub 2021 Apr 15.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

The Tick-borne encephalitis virus (TBEV) causes different disease symptoms varying from asymptomatic infection to severe encephalitis and meningitis suggesting a crucial role of the human host immune system in determining the fate of the infection. There is a need to understand the mechanisms underpinning TBEV-host interactions leading to protective immunity. To this aim, we studied the response of human peripheral blood mononuclear cells (PBMC) to the whole formaldehyde inactivated TBEV (I-TBEV), the drug substance of Encepur, one of the five commercially available vaccine. Read More

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Wegen Corona? FSME-Infektionszahlen steigen dramatisch.

MMW Fortschr Med 2021 04;163(7):18

Springer Medizin, München, Deutschland.

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Rubella and tick-borne encephalitis vaccination rates among staff and students at Austrian University of Applied Sciences.

Cent Eur J Public Health 2021 Mar;29(1):18-22

University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria.

Objectives: Rubella and tick-borne encephalitis (TBE) are infectious diseases caused by viruses. Rubella is an air-borne infection. TBE, on the other hand, is transmitted by virus-infected ticks. Read More

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Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses.

J Exp Med 2021 May;218(5)

Department of Medicine, Washington University School of Medicine, St. Louis, MO.

Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet been developed. Here, we developed a panel of neutralizing anti-POWV mAbs recognizing six distinct antigenic sites. The most potent of these mAbs bind sites within domain II or III of the envelope (E) protein and inhibit postattachment viral entry steps. Read More

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Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.

J Exp Med 2021 May;218(5)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.

Tick-borne encephalitis virus (TBEV) is an emerging human pathogen that causes potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are protective against TBEV, but little is known about the human antibody response to infection. Here, we report on the human neutralizing antibody response to TBEV in a cohort of infected and vaccinated individuals. Read More

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