1,040 results match your criteria tibiofemoral cartilage


Articular cartilage thickness changes differ between males and females four years following anterior cruciate ligament reconstruction.

J Orthop Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Rehabilitation and Movement Science, College of Nursing and Health Sciences, Univ of Vermont.

Anterior cruciate ligament injury and reconstruction (ACLR) affects articular cartilage thickness profiles about the tibial, femoral, and patellar surfaces; however, it's unclear whether the magnitudes of change in cartilage thickness, as well as the locations and areas over which these changes occur, differ between males and females. This is important to consider as differences exist between the sexes with regard to knee biomechanics, patellofemoral pain, and anatomic alignment, which influence risk of an index and repeated injury. Subjects underwent ACLR with a bone-patella tendon-bone autograft. Read More

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Are structural abnormalities on knee MRI associated with osteophyte development? Data from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2021 Jul 17. Epub 2021 Jul 17.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden.

Objective: To assess which structural abnormalities on knee MRI are associated with development of osteophytes in middle-aged subjects without radiographic knee osteoarthritis.

Design: We included subjects from the Osteoarthritis Initiative, aged 40-55 years, Kellgren & Lawrence grade 0 in both knees, and knee MRIs from both knees available at baseline, 24, 48 and 72 months. Structural exposures on MRI assessed using MOAKS included cartilage damage, bone marrow lesions, meniscal tear, meniscal extrusion, and Hoffa/effusion synovitis. Read More

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Reduction of knee joint load suppresses cartilage degeneration, osteophyte formation, and synovitis in early-stage osteoarthritis using a post-traumatic rat model.

PLoS One 2021 16;16(7):e0254383. Epub 2021 Jul 16.

Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.

The purpose of this study was to clarify the histological effect of reducing the loading to knee on cartilage degeneration, osteophyte formation, and synovitis in early-stage osteoarthritis (OA) using a post-traumatic rat model. Ten male rats were randomly allocated into two experimental groups: OA induction by surgical destabilization of medial meniscus (DMM, OA group) and hindlimb suspension after OA induction by DMM (OAHS group). The articular cartilage, osteophyte formation, and synovial membrane in the medial tibiofemoral joint were analyzed histologically and histomorphometrically at 2 and 4 weeks after surgery. Read More

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Automated Detection of Patellofemoral Osteoarthritis from Knee Lateral View Radiographs Using Deep Learning: Data from the Multicenter Osteoarthritis Study (MOST).

Osteoarthritis Cartilage 2021 Jul 7. Epub 2021 Jul 7.

Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Objective: To assess the ability of imaging-based deep learning to detect radiographic patellofemoral osteoarthritis (PFOA) from knee lateral view radiographs.

Design: Knee lateral view radiographs were extracted from The Multicenter Osteoarthritis Study (MOST) public use datasets (n = 18,436 knees). Patellar region-of-interest (ROI) was first automatically detected, and subsequently, end-to-end deep convolutional neural networks (CNNs) were trained and validated to detect the status of patellofemoral OA. Read More

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Clinical evaluation after matrix-associated autologous chondrocyte transplantation : a comparison of four different graft types.

Bone Joint Res 2021 Jul;10(7):370-379

Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.

Aims: The aim of this retrospective study was to determine if there are differences in short-term clinical outcomes among four different types of matrix-associated autologous chondrocyte transplantation (MACT).

Methods: A total of 88 patients (mean age 34 years (SD 10.03), mean BMI 25 kg/m (SD 3. Read More

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Importance of patellofemoral and tibiofemoral cartilage lesions on trajectory of self-reported outcomes in patients at high risk of knee OA: 4-6 years follow-up of patients undergoing meniscal surgery.

Osteoarthritis Cartilage 2021 Jun 24. Epub 2021 Jun 24.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Research Unit for General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address:

Objective: We evaluated whether patient-reported outcome trajectories (i.e., changes over time) differed by intraoperative compartmental cartilage lesion pattern over 4-6 years following arthroscopic meniscal surgery. Read More

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Knee Joint Line Obliquity Causes Tibiofemoral Subluxation That Alters Contact Areas and Meniscal Loading.

Am J Sports Med 2021 Jul 14;49(9):2351-2360. Epub 2021 Jun 14.

The Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.

Background: Little scientific evidence is available regarding the effect of knee joint line obliquity (JLO) before and after coronal realignment osteotomy.

Hypotheses: Higher JLO would lead to abnormal relative position of the femur on the tibia, a shift of the joint contact areas, and elevated joint contact pressures.

Study Design: Descriptive laboratory study. Read More

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On-demand treatment with the iron chelator deferasirox is ineffective in preventing blood-induced joint damage in haemophilic mice.

Haemophilia 2021 Jul 27;27(4):648-656. Epub 2021 May 27.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Introduction: Early intervention in the devastating process of haemophilic arthropathy (HA) is highly desirable, but no disease-modifying therapy is currently available. Considering the pivotal role of iron in the development of HA, iron chelation is considered a promising therapeutic approach. A previous study in haemophilic mice demonstrated that treatment with the iron chelator deferasirox (DFX) 8 weeks before joint bleed induction, attenuated cartilage damage upon blood exposure. Read More

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Physiological articular contact kinematics and morphological femoral condyle translations of the tibiofemoral joint.

J Biomech 2021 06 15;123:110536. Epub 2021 May 15.

Orthopaedic Bioengineering Research Center, Newton-Wellesley Hospital, Newton, MA, USA; Department of Orthopedic Surgery, Newton-Wellesley Hospital, Newton, MA, USA. Electronic address:

The changes of tibiofemoral articular cartilage contact locations during knee activities represent a physiological functional characteristic of the knee. However, most studies reported relative motions of the tibia and femur using morphological flexion axes. Few data have been reported on comparisons of morphological femoral condyle motions and physiological tibiofemoral cartilage contact location changes. Read More

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Discoid meniscus: High levels of apoptotic and autophagic genes.

Niger J Clin Pract 2021 May;24(5):647-650

Department of Orthopaedics and Traumatology, Faculty of Medicine, Balikesir, Turkey.

Background: How the meniscus adapts to the morphological changes in the lateral tibiofemoral compartment, in terms of gene expression, was the reason to establish this present study.

Objective: This study aimed to determine the changes in the mRNA levels of the apoptotic and autophagic genes in the discoid meniscus.

Subjects And Methods: We have investigated the apoptotic and autophagic gene levels in discoid and normal lateral menisci of 21 patients (11 discoid and 10 control). Read More

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Tibiofemoral Cartilage Contact Pressures in Athletes During Landing: A Dynamic Finite Element Study.

J Biomech Eng 2021 Oct;143(10)

Engineering Center for Orthopaedics Research Excellence (E-CORE), Departments of Bioengineering and Orthopaedics, The University of Toledo, Toledo, OH 43606.

Cartilage defects are common in the knee joint of active athletes and remain a problem as a strong risk factor for osteoarthritis. We hypothesized that landing during sport activities, implication for subfailure ACL loading, would generate greater contact pressures (CP) at the lateral knee compartment. The purpose of this study is to investigate tibiofemoral cartilage CP of athletes during landing. Read More

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October 2021

Superficial cartilage transverse relaxation time is associated with osteoarthritis disease progression - data from the FNIH biomarker study of the osteoarthritis initiative.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy and Cell Biology, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.

Objective: To study whether layer-specific cartilage transverse relaxation time (T2), and/or longitudinal change is associated with clinically relevant knee osteoarthritis (OA) disease progression.

Methods: The FNIH biomarker consortium was a nested case-control study on 600 knees from 600 Osteoarthritis Initiative participants. Progressor knees had both medial tibiofemoral radiographic joint space width (JSW) loss (≥0. Read More

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Anterior Cruciate Ligament Rupture with Medial Collateral Ligament Tear with Lateral Meniscus Posterior Root Tear with Posterolateral Tibia Osteochondral Fracture: A New Injury Tetrad of the Knee.

J Orthop Case Rep 2020 May-Jun;10(3):36-42

The Orthopaedic Speciality Clinic, Pune, Maharashtra, India.

Introduction: Injuries to the knee ligaments, menisci, and cartilage are possible in high-velocity trauma as in road traffic accidents. Similarly, these structures can be disrupted in proximal tibia fractures. We present a series of three cases which had a previously undescribed injury combination. Read More

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Ultrashort echo time adiabatic T (UTE-Adiab-T) is sensitive to human cadaveric knee joint deformation induced by mechanical loading and unloading.

Magn Reson Imaging 2021 Jul 2;80:98-105. Epub 2021 May 2.

Department of Radiology, University of California, San Diego, CA, USA.

Purpose: The development of ultrashort echo time (UTE) MRI sequences has led to improved imaging of tissues with short T relaxation times, such as the deep layer cartilage and meniscus. UTE combined with adiabatic T preparation (UTE-Adiab-T) is an MRI measure with low sensitivity to the magic angle effect. This study aimed to investigate the sensitivity of UTE-Adiab-T to mechanical load-induced deformations in the tibiofemoral cartilage and meniscus of human cadaveric knee joints. Read More

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Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis.

Eur J Pharm Sci 2021 Aug 18;163:105856. Epub 2021 Apr 18.

Escola de Farmácia, Departamento de Fármacos e Alimentos, Universidade Federal de Alfenas, Brazil.

This work proposes new methotrexate (MTX) loaded drug delivery systems (DDS) to treat rheumatoid arthritis via the intra-articular route: a poloxamer based thermosensitive hydrogel (MTX-HG), oligochitosan and hypromellose phthalate-based polyelectrolyte complexes (MTX-PEC) and their association (MTX-PEC-HG). MTX-PEC showed 470 ± 166 nm particle size, 0.298 ± 0. Read More

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Biomechanical characteristics of tibio-femoral joint after partial medial meniscectomy in different flexion angles: a finite element analysis.

BMC Musculoskelet Disord 2021 Apr 2;22(1):322. Epub 2021 Apr 2.

Guangzhou University of Chinese Medicine, 12 Airport Road, Guangzhou, 510405, Guangdong Province, China.

Background: Recent studies have pointed out that arthroscopy, the commonly-used surgical procedure for meniscal tears, may lead to an elevated risk of knee osteoarthritis (KOA). The biomechanical factors of KOA can be clarified by the biomechanical analysis after arthroscopic partial meniscectomy (APM). This study aimed to elucidate the cartilage stress and meniscus displacement of the tibiofemoral joint under flexion and rotation loads after APM. Read More

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MRI-defined Osteophyte Presence and Concomitant Cartilage Damage in Knees with Incident Tibiofemoral Osteoarthritis: Data From The Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses (POMA) Study.

Arthritis Care Res (Hoboken) 2021 Mar 26. Epub 2021 Mar 26.

Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, FGH Building, 820 Harrison Avenue, Boston, MA, 02118, USA.

Objective: To describe compartmental frequencies of MRI-defined osteophytes and co-localized cartilage damage and evaluate the associations of osteophyte (OP) size with any ipsicompartmental cartilage damage in knees with incident tibiofemoral radiographic knee osteoarthritis (ROA).

Methods: We evaluated knees from the Osteoarthritis Initiative without ROA at baseline that developed ROA during a 4-year interval. Semi-quantitative MRI scoring of osteophytes and cartilage damage was performed at the time point when ROA was diagnosed, defined as Kellgren-Lawrence grade ≥ 2, using the MOAKS instrument. Read More

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Can MRI-defined osteoarthritis features explain anterior knee pain in individuals with, or at risk for, knee osteoarthritis? The MOST Study.

Arthritis Care Res (Hoboken) 2021 Mar 25. Epub 2021 Mar 25.

University of Delaware, (Department of Physical Therapy), Newark, USA.

Objective: The lack of strong association between knee osteoarthritis (OA) structural features and pain continues to perplex researchers and clinicians. Evaluating the patellofemoral joint in addition to the tibiofemoral joint alone has contributed to explaining this structure-pain discordance, hence justifying a more comprehensive evaluation of whole-knee OA and pain. We therefore evaluated the association between patellofemoral and tibiofemoral OA features with localized anterior knee pain (AKP) using two study designs. Read More

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Association of machine learning based predictions of medial knee contact force with cartilage loss over 2.5 years in knee osteoarthritis.

Arthritis Rheumatol 2021 Mar 24. Epub 2021 Mar 24.

School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.

Objective: The relationship between in vivo knee load predictions and longitudinal cartilage changes has not been investigated. This study aimed to develop an equation to predict the medial tibiofemoral contact force (MCF) peak during walking in persons with instrumented knee implants, and to apply this equation to determine the relationship between the predicted MCF peak and cartilage loss in persons with knee osteoarthritis.

Methods: In adults with knee osteoarthritis [39 women, 8 men; age 61. Read More

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The mechanical properties of tibiofemoral and patellofemoral articular cartilage in compression depend on anatomical regions.

Sci Rep 2021 Mar 17;11(1):6128. Epub 2021 Mar 17.

State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, 116024, China.

Articular cartilage in knee joint can be anatomically divided into different regions: medial and lateral condyles of femur; patellar groove of femur; medial and lateral plateaus of tibia covered or uncovered by meniscus. The stress-strain curves of cartilage in uniaxially unconfined compression demonstrate strain rate dependency and exhibit distinct topographical variation among these seven regions. The femoral cartilage is stiffer than the tibial cartilage, and the cartilage in femoral groove is stiffest in the knee joint. Read More

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Development of MRI-defined Structural Tissue Damage after Anterior Cruciate Ligament Injury over 5 Years: The KANON Study.

Radiology 2021 May 9;299(2):383-393. Epub 2021 Mar 9.

From the Department of Radiology, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany (F.W.R.); Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, FGH Building, 4th Floor, 820 Harrison Avenue, Boston, MA 02118 (F.W.R., A.G.); Department of Clinical Sciences Lund, Orthopaedics (F.W.R., L.S.L., R.F.), and Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences Lund (M.E.), Lund University, Lund, Sweden; Department of Radiology, VA Boston Healthcare System, West Roxbury, Mass (A.G.); and Clinical Studies Sweden-Forum South, Skåne University Hospital, Lund, Sweden (A.Å.).

Background MRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches. Purpose To describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue damage for a nonsurgical versus a surgical treatment strategy. Materials and Methods In this secondary analysis of a prospective trial (ISRCTN 84752559), 119 participants with an acute ACL injury were evaluated. Read More

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[Finite element analysis on stress concentration improvement in patellofemoral joint by releasing lateral patellar retinaculum with stiletto needle based on the theory of Jinshugu()].

Zhongguo Gu Shang 2021 Feb;34(2):126-30

Department of Orthopaedics, Wangjing Hospital of China Academy of Chinese Medicine, Beijing 100102, China.

Objective: To study mechanism of improvement of stress concentration on patellofemoral joint by stiletto needle releasing lateral patellar retinaculum guided by the theory of Jinshugu() and based on the finite element model of knee joint. and to elucidate the biomechanical mechanism of stiletto needle releasing changing patellar trajectory and reducing patellofemoral joint pressure.

Methods: CT data of knee joint from a normal male (aged 29, heighted 171 cm, weighted 58 kg) was selected. Read More

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February 2021

Quantitative measures of bone shape, cartilage morphometry and joint alignment are associated with disease in an ACLT and MMx rat model of osteoarthritis.

Bone 2021 05 27;146:115903. Epub 2021 Feb 27.

Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; SCANCO Medical AG, Brüttisellen, Switzerland; Department of Biomedical Engineering, The University of Melbourne, Parkville, Australia. Electronic address:

Multi-scale, subject-specific quantitative methods to characterize and monitor osteoarthritis in animal models and therapeutic treatments could help reveal causal relationships in disease development and distinguish treatment strategies. In this work, we demonstrate a reproducible and sensitive quantitative image analysis to characterize bone, cartilage and joint measures describing a rat model of post-traumatic osteoarthritis. Eleven 3-month-old male Wistar rats underwent medial anterior cruciate ligament (ACL) transection and medial meniscectomy on the right knee to destabilise the right tibiofemoral joint. Read More

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Meta-analysis on the association between knee extensor strength and structural changes of knee osteoarthritis.

Clin Rheumatol 2021 Feb 24. Epub 2021 Feb 24.

Department of Orthopaedic Surgery, Tianjin Third Central Hospital, Jin-tang Road No.83, Tianjin, 300170, China.

This study aimed to perform a meta-analysis to evaluate whether knee extensor (KE) strength weakness was associated with increased structural worsening in knee osteoarthritis (KOA) including joint space narrowing (JSN) and cartilage loss. PubMed, Embase, Scopus, ScienceDirect, Web of Science, and Cochrane library were searched from their inception to May 2020, to identify eligible studies. Odds ratios (ORs) accompanied by 95% confidence intervals (CIs) were calculated for the relationship between KE strength and outcomes. Read More

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February 2021

Frontal plane knee alignment mediates the effect of frontal plane rearfoot motion on knee joint load distribution during walking in people with medial knee osteoarthritis.

Osteoarthritis Cartilage 2021 05 12;29(5):678-686. Epub 2021 Feb 12.

School of Health and Society, University of Salford: Manchester, UK. Electronic address:

Objective: To examine the nature of differences in the relationship between frontal plane rearfoot kinematics and knee adduction moment (KAM) magnitudes.

Design: Cross-sectional study resulting from a combination of overground walking biomechanics data obtained from participants with medial tibiofemoral osteoarthritis at two separate sites. Statistical models were created to examine the relationship between minimum frontal plane rearfoot angle (negative values = eversion) and different measures of the KAM, including examination of confounding, mediation, and effect modification from knee pain, radiographic disease severity, static rearfoot alignment, and frontal plane knee angle. Read More

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The effect of lateral extra-articular tenodesis on in vivo cartilage contact in combined anterior cruciate ligament reconstruction.

Knee Surg Sports Traumatol Arthrosc 2021 Feb 12. Epub 2021 Feb 12.

Department of Orthopaedic Surgery, UPMC Freddie Fu Sports Medicine Center, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Lateral extra-articular tenodesis (LET) may confer improved rotational stability after anterior cruciate ligament reconstruction (ACLR). Little is known about how LET affects in vivo cartilage contact after ACLR. The aim of this study was to investigate the effect of LET in combination with ACLR (ACLR + LET) on in vivo cartilage contact kinematics compared to isolated ACLR (ACLR) during downhill running. Read More

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February 2021

Forces at the Anterior Meniscus Attachments Strongly Increase Under Dynamic Knee Joint Loading.

Am J Sports Med 2021 03 9;49(4):994-1004. Epub 2021 Feb 9.

Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Center, Ulm, Germany.

Background: The anatomic appearance and biomechanical and clinical importance of the anterior meniscus roots are well described. However, little is known about the loads that act on these attachment structures under physiological joint loads and movements.

Hypotheses: As compared with uniaxial loading conditions under static knee flexion angles or at very low flexion-extension speeds, more realistic continuous movement simulations in combination with physiological muscle force simulations lead to significantly higher anterior meniscus attachment forces. Read More

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T2 relaxation times of knee cartilage in 109 patients with knee pain and its association with disease characteristics.

Acta Orthop 2021 06 4;92(3):335-340. Epub 2021 Feb 4.

Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, The Netherlands;

Background and purpose - Quantitative T2 mapping MRI of cartilage has proven value for the assessment of early osteoarthritis changes in research. We evaluated knee cartilage T2 relaxation times in a clinical population with knee complaints and its association with patients and disease characteristics and clinical symptoms.Patients and methods - In this cross-sectional study, T2 mapping knee scans of 109 patients with knee pain who were referred for an MRI by an orthopedic surgeon were collected. Read More

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Serum uric acid and knee osteoarthritis in community residents without gout: a longitudinal study.

Rheumatology (Oxford) 2021 Jan 25. Epub 2021 Jan 25.

Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea.

Objectives: Emerging evidence suggests a potential link between osteoarthritis (OA) and gout; however, the association between serum uric acid (UA) itself and knee OA remains uncertain due to a lack of longitudinal studies. Here, we investigated the association between serum UA and knee OA according to cartilage status in elderly community residents without gout.

Methods: In this longitudinal study, participants without a history of gout were recruited from among the Korean cohort of the Hallym Aging Study (n = 296 for radiography study and n = 223 for MRI study). Read More

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January 2021

Surgical meniscal lesions in stable knee: Topographic description in a prospective series of 1424 cases.

Orthop Traumatol Surg Res 2021 04 22;107(2):102812. Epub 2021 Jan 22.

Service de Chirurgie Orthopédique, CHU Lyon Croix-Rousse, Centre Médical d'Excellence FIFA, Hospices Civils de Lyon, 69004 Lyon, France; LIBM-EA 7424, Laboratoire Interuniversitaire de Biologie de la Motricité, Université Claude-Bernard Lyon 1, France.

Background: The epidemiology of meniscal lesions in stable knee has been a focus of study, but exact topography is not clearly known. Tear patterns are thought to differ between pathologies and the difference between a traumatic and a degenerative pattern is not always easy to draw. In 2010, ISAKOS designed a questionnaire to standardize assessment. Read More

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