18,317 results match your criteria thyroid stimulating

Treatment adherence and tolerability of immediate- and prolonged-release lithium formulations in a sample of bipolar patients: a prospective naturalistic study.

Int Clin Psychopharmacol 2021 Jul 20. Epub 2021 Jul 20.

Psychiatry 2 Unit, Department of Clinical and Experimental Medicine, University of Pisa Psychiatry 2 Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

The aim of this study was to compare treatment adherence and tolerability of different lithium formulations in 70 bipolar patients receiving lithium therapy for the first time. During the 1-year follow-up, information was collected regarding patient's clinical course, therapeutic adherence, side effects of the treatment and serum levels of lithium, creatinine and thyroid-stimulating hormone. At baseline, 30 patients (43%) were on prolonged-release lithium formulations and 40 (57%) on immediate-release formulations. Read More

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Methimazole Desensitization in a 4-Year-Old With Refractory Graves Disease.

AACE Clin Case Rep 2021 Jul-Aug;7(4):273-276. Epub 2021 Feb 20.

Department of Pediatrics, Division of Diabetes and Endocrinology.

Objective: To describe a 4-year-old girl with Graves disease and methimazole allergy who underwent desensitization, allowing continued methimazole use when other treatments were contraindicated.

Methods: We formulated a desensitization plan utilizing cetirizine and prednisone for a patient with previously diagnosed Graves disease who developed urticaria and arthralgias from methimazole. She was admitted for monitoring of rash, urticaria, angioedema, and anaphylaxis. Read More

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February 2021

Late Onset of an Overlooked Follicular Thyroid Carcinoma Presenting as a Chest Wall Tumor 10 Years Following Thyroidectomy.

AACE Clin Case Rep 2021 Jul-Aug;7(4):268-272. Epub 2021 Mar 5.

Department of General Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.

Objective: Metastatic chest wall tumors resulting from thyroid carcinomas are not unusual; however, the late onset of metastasis of a follicular thyroid carcinoma (FTC) is extremely rare. We aim to present a report of a case with chest wall metastasis of an FTC 10 years following thyroidectomy.

Methods: Among the studies performed were chest wall tumor imaging, serum thyroid stimulating hormone determination, and histopathology of the chest wall tumor and thyroid tissue examination. Read More

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Metastatic Malignant Struma Ovarii and Graves' Disease: A Rare Occurrence.

AACE Clin Case Rep 2021 Jul-Aug;7(4):243-246. Epub 2021 Jan 6.

Tan Tock Seng Hospital, Department of Endocrinology, Novena, Singapore.

Objective: Malignant struma ovarii (SO) is a rare condition. Although there have been a few reported cases of malignant SO with coexisting Graves' disease (GD), the exact incidence of metastasis in these cases is not known. We report a rare case of metastatic malignant SO coexisting with GD. Read More

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January 2021

Atypical Thyroid Function Tests and Thyroid Hormone Resistance.

Cureus 2021 Jul 12;13(7):e16328. Epub 2021 Jul 12.

Critical Care Medicine, Mayo Clinic, Rochester, USA.

Clinical interpretation of thyroid labs is usually straightforward. However, there are rare instances when the atypical profile of thyroid labs warrants systematic investigation to determine the underlying cause. We report the case of a 90-year-old Caucasian male with a chronic history of atrial fibrillation with chronic pacemaker dependence who presented with significantly elevated free thyroxine level (>7. Read More

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Effect of comprehensive care on the negative emotions and life quality in parturients with postpartum depression and gestational hypertension.

Am J Transl Res 2021 15;13(6):7228-7234. Epub 2021 Jun 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China.

Objective: To investigate the efficacy of comprehensive care during the nursing process of parturients with gestational hypertension and postpartum depression.

Methods: This prospective study recruited 70 patients with gestational hypertension concurrent with postpartum depression, and the patients were randomly divided into a control group (35 patients received routine care) and an observation group (35 patients, treated by comprehensive care). Indicators including psychological condition, life quality, thyroid function, the incidence of eclampsia, and nursing satisfaction were recorded and compared before intervention (at the diagnosis of postpartum depression) and after intervention (three months after delivery) in the two groups. Read More

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Serum TSH levels are associated with postoperative recurrence and lymph node metastasis of papillary thyroid carcinoma.

Am J Transl Res 2021 15;13(6):6108-6116. Epub 2021 Jun 15.

Department of Breast Surgery, The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, PR China.

Objective: To explore the relationship between thyroid-stimulating hormone (TSH) levels in the serum and postoperative recurrence and lymph node metastasis (LNM) in papillary thyroid cancer (PTC) patients after surgery.

Methods: We selected 272 patients diagnosed with PTC from June 2011 to July 2014. The clinical and pathological data of 272 PTC patients were collected at the First Affiliated Hospital of Wenzhou Medical University and analysed retrospectively. Read More

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Impact of Thyroid Autoimmunity on Fertilization/Intracytoplasmic Sperm Injection Outcomes and Fetal Weight.

Front Endocrinol (Lausanne) 2021 8;12:698579. Epub 2021 Jul 8.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Several studies have reported the association between thyroid autoimmunity (TAI) and fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes. However, the findings remain controversial. We performed a large-scale retrospective cohort study to verify the effect of the presence of thyroid antibodies on IVF/ICSI outcomes and fetal growth and to evaluate the association between the types and titers of thyroid antibodies and adverse IVF/ICSI outcomes. Read More

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The Effects of L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study.

Front Pharmacol 2021 7;12:654459. Epub 2021 Jul 7.

School of Biology, Damghan University, Damghan, Iran.

Menopause is the last menstrual period associated with a decline in ovarian steroid secretion and follicular loss. Hormone profile changes during menopause include a decrease in the production of estrogen, dehydroepiandrosterone (DHEA), and prolactin (PRL), and an increase in thyroid-stimulating hormone (TSH) and cortisol. Herbal medicines are considered as alternatives to hormone therapy. Read More

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Transcatheter arterial chemoembolization combined with Hippo/YAP inhibition significantly improve the survival of rats with transplanted hepatocellular carcinoma.

Lipids Health Dis 2021 Jul 25;20(1):74. Epub 2021 Jul 25.

Department of Oncology Medilcal Center, The First People's Hospital of Zhaoqing, Zhaoqing, Guangdong, 526000, China.

Background: This study aimed to explore the effect of inhibiting the Hippo/Yes-associated protein (YAP) signaling pathway on the outcomes of transcatheter arterial chemoembolization (TACE) in treating transplanted hepatocellular carcinoma (HCC).

Methods: A transplanted HCC rat model was established. Then, rats were randomly divided into four groups: Sham, TACE, verteporfin (inhibitor of Hippo/YAP), and TACE+verteporfin. Read More

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The effect of food groups and nutrients on thyroid hormone levels in healthy individuals.

Nutrition 2021 Jun 20;91-92:111394. Epub 2021 Jun 20.

Department of Nuclear Medicine, University Hospital Split, Split, Croatia; Department of Medical Biology, School of Medicine, University of Split, Split, Croatia. Electronic address:

Objectives: The aim of the study was to analyze the association of dietary groups (groups of food items) with thyroid hormone levels in healthy individuals.

Methods: This cross-sectional study enrolled 4585 healthy individuals from the Dalmatian region of south Croatia with measurements of plasma free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) levels. Dietary intake was assessed according to data of the completed food frequency questionnaire, containing 58 food items. Read More

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Prenatal exposure to polycyclic aromatic hydrocarbons and effects on neonatal anthropometric indices and thyroid-stimulating hormone in a Middle Eastern population.

Chemosphere 2021 Jul 19;286(Pt 1):131605. Epub 2021 Jul 19.

Research Center for Health Sciences, Institute of Health, Department of Environmental Health, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) evokes extensive concerns regarding public health. Monitoring the pregnant women's exposure can be considered a suitable alternative to assess the fetus's exposure. This study aimed to monitor pregnant women's exposure (n = 126) to PAHs using a biomonitoring approach to evaluate effects on anthropometric indices and neonatal thyroid-stimulating hormone (TSH) in Shiraz, Iran. Read More

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Acute suppurative thyroiditis seeded from infective endocarditis and intravenous drug use.

IDCases 2021 7;25:e01221. Epub 2021 Jul 7.

Saint Bernards Healthcare, 300 Carson Street, Jonesboro, AR, 72401, United States.

Acute suppurative thyroiditis (AST) is a rare infection of the thyroid gland, and most patients are euthyroid upon presentation. We present an interesting case of a 42-year-old man with a history of intravenous drug use (IVDU) and poorly controlled type 2 diabetes mellitus who was admitted for sepsis and thyrotoxicosis from infective endocarditis (IE), AST, prostate abscess, and pyelonephritis. He suffered from a cerebral vascular accident (CVA) from septic embolic showering. Read More

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Oral Levothyroxine Treatment in Lithium Intoxication- Induced Myxedema Coma: A Case Report.

Po-Hsuan Kao

J Acute Med 2021 Jun;11(2):68-71

National Taiwan University Hospital Department of Emergency Medicine Taipei Taiwan.

Lithium intoxication-induced myxedema coma, a rare but dangerous condition of severe hypothyroidism, can be easily misdiagnosed in patients without history of hypothyroidism. The objective of this case report is to describe a lithium-treated patient who presented to emergency department with obtundation and moderate hypothermia and was diagnosed with myxedema coma and lithium toxicity. A 64-year-old female presented to the emergency department with obtundation and hypothermia. Read More

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Thyroid-Stimulating Hormone and Free Thyroxine Alterations in Subjects with Occupational Hearing Loss.

Indian J Occup Environ Med 2021 Jan-Mar;25(1):4-10. Epub 2021 Apr 26.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

Context And Aim: Occupational hearing loss (OHL) is caused by exposure to industrial noise. Alterations in the thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are related to hearing loss. The purpose of this study is to investigate the TSH and FT4 level alterations in OHL. Read More

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Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

The Pacific Center for Oculofacial and Aesthetic Plastic Surgery, San Francisco, California, U.S.A. California Pacific Medical Center, San Francisco, California, U.S.A. University of California San Francisco, San Francisco, California, U.S.A.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment. Read More

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How to use thionamide anti-thyroid drug in the young- what's new?

Tim Cheetham

Thyroid Res 2021 Jul 21;14(1):18. Epub 2021 Jul 21.

Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The excess thyroid hormone secretion that characterises Graves' disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.This underlying mechanism cannot easily be abolished and the mainstay of Graves' disease (GD) management in the young remains thionamide anti-thyroid drug (ATD). Unfortunately, GD will usually recur after a 2 or 3 year course of ATD, even when the stimulatory antibody titres have fallen. Read More

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High Iodine Nutrition May Be a Risk Factor for Cervical Lymph Node Metastasis in Papillary Thyroid Cancer Patients.

Ann Nutr Metab 2021 Jul 21:1-10. Epub 2021 Jul 21.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.

Purpose: The aim of this study was to retrospectively identify the effect of iodine on the papillary thyroid cancer (PTC) process and investigate the risk clinicopathologic characteristics of cervical lymph node metastasis (CLNM) for achieving a better preventive strategy of PTC.

Methods: Totally 187 patients with CLNM and 279 without CLNM (NCLNM) were enrolled, and their urinary iodine concentration (UIC) and serum iodine concentration (SIC) were measured. Logistic regressions were used to reveal the effects of iodine nutrition on the CLNM status of PTC. Read More

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C-reactive protein and thyroid-stimulating hormone levels as risk factors for hypothyroidism in patients with subacute thyroiditis.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

N Zhang, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, 310016, China.

Objective: This study was designed to explore the relationships between the clinical characteristics and outcomes of patients with subacute thyroiditis (SAT).

Design: This is a single-center retrospective study.

Patients: Eighty-nine patients with SAT who were hospitalized in the Sir Run Run Shaw Hospital in Zhejiang, China, from October 2014 to September 2020 were included. Read More

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Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.

Clin Exp Pharmacol Physiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology and Andrology, Al-Azhar University (Assuit), Egypt.

Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, forty-seven patients received (0. Read More

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Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study.

Bioengineered 2021 Dec;12(1):4183-4190

Department of Obstetrics, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.

To reassess the efficacy of levothyroxine on subclinical hypothyroidism (SCH, 4.0 mIU/L ≤ TSH (thyroid stimulating hormone) <10 mIU/L with normal free T4) during pregnancy. 165 levothyroxine-treated pregnant women experiencing SCH were screened. Read More

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December 2021

Burnout and metabolic syndrome among healthcare workers: Is subclinical hypothyroidism a mediator?

J Occup Health 2021 Jan;63(1):e12252

Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taiwan.

Objectives: Evidence suggests that subclinical hypothyroidism (SCH) is associated with burnout and metabolic syndrome (MetS). We examined the relationship between burnout and MetS among healthcare workers (HCWs) and investigated the potential mediation of SCH.

Methods: This cross-sectional study included HCWs from a tertiary medical center; demographic data were obtained using a questionnaire. Read More

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January 2021

Interpretative commenting in clinical chemistry with worked examples for thyroid function test reports.

Pract Lab Med 2021 Aug 9;26:e00243. Epub 2021 Jul 9.

Department of Laboratory Medicine, National University Hospital, Singapore.

Correct interpretation of pathology results is a requirement for accurate diagnosis and appropriate patient management. Clinical Pathologists and Scientists are increasingly focusing on providing quality interpretative comments on their reports and these comments are appreciated by clinicians who receive them. Interpretative comments may improve patient outcomes by helping reduce errors in application of the results in patient management. Read More

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Giant plurihormonal pituitary adenoma in a child - case study.

J Pediatr Endocrinol Metab 2021 Jul 21. Epub 2021 Jul 21.

Department of Endocrinology and Diabetology, Children's Memorial Health Institute, Warsaw, Poland.

Objectives: To describe the case of a 12-year-old girl with a rare plurihormonal pituitary macroadenoma secreting prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), and alpha subunit (α-SU).

Case Presentation: The patient experienced recurrent headaches and progressing loss of vision in one eye. During the examination, abnormalities such as tall stature, coarse facial features, enlarged feet and hands, tachycardia, hand tremor, hyperhidrosis, galactorrhea, and goiter were observed. Read More

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Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0069). Epub 2021 Jul 19.

Department of Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, UK.

Summary: Hypothyroidism occurring in the postpartum period can be due to pituitary or hypothalamic disease as in Sheehan's syndrome and postpartum autoimmune hypophysitis or due to a primary thyroid disease as in postpartum thyroiditis. It is important that the correct diagnosis is ascertained because hypothalamic or pituitary disorders are often associated with other pituitary hormone deficiencies, especially life-threatening adrenal insufficiency or adrenal crisis. A combination of various symptoms and biochemical markers, especially serum thyroid-stimulating hormone levels dictate the initial diagnostic pathway. Read More

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Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0070). Epub 2021 Jul 19.

Diabetes and Endocrinology Unit, National Hospital Kandy, Kandy, Sri Lanka.

Summary: Whey protein is a popular dietary supplement that is claimed to provide multiple health benefits. It has been shown to delay gastric emptying and impair ileal nutrient absorption. Additionally, some of the other additives like papain enzyme, soy lecithin in these protein supplements could interfere with L-thyroxine absorption. Read More

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A deeper understanding of the causal relationships between thyroid function and atrial fibrillation.

J Clin Endocrinol Metab 2021 Jul 19. Epub 2021 Jul 19.

Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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Poorly differentiated thyroid carcinoma coexisting with Graves' disease involving T3 thyrotoxicosis due to increased D1 and D2 activities.

Thyroid 2021 Jul 18. Epub 2021 Jul 18.

Kansai Medical University, Department of Internal Medicine II, 2-3-1 Shinmachi, Hirakata, Osaka, Japan, 573-1191;

Background Poorly differentiated thyroid carcinoma is rare and typically euthyroid. We report a novel rarer case of poorly differentiated thyroid carcinoma involving T3 thyrotoxicosis. Patients' Findings A 77-year-old man visited Kuma Hospital due to a neck tumor. Read More

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The Effect of ThyroidߚStimulating Hormone on Stage of Differentiated Thyroid Carcinoma.

Endocrinol Diabetes Metab 2021 Jul 7;4(3):e00266. Epub 2021 Jun 7.

Endocrine and Metabolism Research Center Institute of Basic and Clinical Physiology Sciences Kerman University of Medical Sciences Kerman Iran.

Introduction: Thyroid cancer is the most common endocrine malignancy, and it has the fastest increase rate in incidence in both sexes, with a yearly increase of 3% over the last decade. Thyroid-stimulating hormone (TSH) is the main driver for the thyroid gland to produce thyroid hormone. The main purpose of this study was to assess the relationship between serum TSH level and the stage of malignancy in patients with differentiated thyroid cancer. Read More

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The changes of essential trace elements in residents from an e-waste site and the relationships between elements and hormones of the hypothalamic-pituitary-thyroid (HPT) axis.

Ecotoxicol Environ Saf 2021 Jul 15;222:112513. Epub 2021 Jul 15.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

The heavy metals pollution and related health issues were widely reported in e-waste sites, while the impacts of e-waste exposure on the essential trace elements have been neglected. The aim of this study was focused on the internal Cu, Fe, Mn and Zn levels in the residents from an e-waste site and the potential endocrine disrupting effects of these essential trace elements on the hypothalamic-pituitary-thyroid (HPT) axis. This was a cross-sectional study that 87 subjects were recruited from the e-waste site and 81 from the reference site. Read More

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