4,234 results match your criteria thyroid extent

Risk factors of permanent hypoparathyroidism after total thyroidectomy Retrospective analysis of 285 consecutive patients.

Ann Ital Chir 2021 ;92:339-345

Aim: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy. The aim of the present study was to investigate the risk factors of this complication.

Material And Methods: Patients undergoing thyroidectomy in our Unit between January 2017 and February 2018 were retrospectively analysed. Read More

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January 2021

Training in intraoperative neuromonitoring of recurrent laryngeal nerves reduces the risk of their injury during thyroid surgery.

Arch Med Sci 2021 7;17(5):1294-1302. Epub 2019 Jun 7.

1 Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.

Introduction: Even though incidence of recurrent laryngeal nerve palsy (RLNP) is low, it affects importantly the quality of life of patients and remains one of main medicolegal litigation problems in surgery. Intraoperative neuromonitoring (IONM) has become widely accepted tool helping in recurrent laryngeal nerve identification, however no clear association of IONM with RLNP rate has been demonstrated. The aim of our study was to assess whether training in IONM influences rates of RNLP after thyroid surgery as an independent factor. Read More

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Impact of the Extent of Thyroidectomy on Quality of Life in Differentiated Thyroid Cancer Survivors: A Propensity Score Matched Analysis.

Cancer Manag Res 2021 7;13:6953-6967. Epub 2021 Sep 7.

People's Hospital of Dujiangyan City, Chengdu, 611830, People's Republic of China.

Purpose: As most thyroid cancer patients survive for more than ten years, it has become increasingly important to understand whether the different surgery types have any effect on the quality of life (QoL) of patients.

Patients And Methods: Using observational data from head and neck surgery at the Sichuan Cancer Hospital in China, three scoring methods - sum scoring, domain-based scoring and IRT-based scoring, were employed to measure the QoL in differentiated thyroid cancer (DTC) patients and a propensity score matched analysis performed to explore the impact of surgery type on QoL as measured by the Treatment of Cancer Quality of Life core Questionnaire version 3.0 (EORTC QLQ-C30) and a disease-specific health-related quality of life questionnaire (THYCA-QoL). Read More

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September 2021

Regulation of thyroid hormones and branchial iodothyronine deiodinases during freshwater acclimation in tilapia.

Mol Cell Endocrinol 2021 Sep 7;538:111450. Epub 2021 Sep 7.

Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, 1955 East-West Road, Honolulu, HI, 96822, USA. Electronic address:

Euryhaline fishes are capable of maintaining osmotic homeostasis in a wide range of environmental salinities. Several pleiotropic hormones, including prolactin, growth hormone, and thyroid hormones (THs) are mediators of salinity acclimation. It is unclear, however, the extent to which THs and the pituitary-thyroid axis promote the adaptive responses of key osmoregulatory organs to freshwater (FW) environments. Read More

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September 2021

Multivariate NTCP Model of Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.

Front Oncol 2021 23;11:714536. Epub 2021 Aug 23.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Objective: To evaluate the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT), analyze its correlation with multiple influencing factors such as thyroid exposure dose, thyroid volume, and gender, and construct a multivariate-based normal tissue complication probability (NTCP) model for the occurrence of hypothyroidism after IMRT.

Materials And Methods: The thyroid hormone levels of patients at different points in time before and after radiotherapy were tested, and statistics on the incidence of hypothyroidism after treatment were obtained. The dose-volume data of patients' thyroids were converted into EQD2 equivalent dose values. Read More

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Ultrasound-Guided Thermal Ablation of Bethesda IV Thyroid Nodules: A Pilot Study.

Front Endocrinol (Lausanne) 2021 24;12:674970. Epub 2021 Aug 24.

School of Medicine, Nankai University, Tianjin, China.

Objective: The purpose of our study was to evaluate the effectiveness of thermal ablation (TA) for Bethesda IV thyroid nodules, and to compare TA and surgery in terms of treatment outcomes, complications, and costs.

Method: This study was approved by the local ethics committee. From January 2017 to December 2019, 30 patients elected TA and 31 patients elected surgery for treatment of Bethesda IV thyroid nodules. Read More

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Second Primary Malignancies in Patients With Hepatocellular Carcinoma: A Population-Based Analysis.

Front Oncol 2021 23;11:713637. Epub 2021 Aug 23.

Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Second primary malignancy (SPM) is becoming a threat for the health of cancer survivors. However, data on the features and results of patients with hepatocellular carcinoma (HCC) with SPMs are scarce. This study aimed to explore the characteristics of HCC patients with SPMs and to screen HCC patients who are at a high risk of developing SPMs. Read More

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Indications of Superselective Neck Dissection in Patients With Lateral Node Metastasis of Papillary Thyroid Carcinoma.

Otolaryngol Head Neck Surg 2021 Sep 7:1945998211038318. Epub 2021 Sep 7.

Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, China.

Objective: The extent of neck dissection in papillary thyroid carcinoma (PTC) patients with lateral neck metastasis is controversial. This work aims to screen the patients suitable for superselective neck dissections including only levels III-IV.

Study Design: Prospective observational cohort study. Read More

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September 2021

A Rare Case of Traumatic Thyroid Gland Hypoperfusion/Devascularization After a Gunshot Wound Through the Neck: Computed Tomography Findings.

Am J Case Rep 2021 Aug 30;22:e930505. Epub 2021 Aug 30.

Department of Diagnostic Radiology, University of Puerto Rico, San Juan, Puerto Rico.

BACKGROUND The thyroid gland is rarely injured in cases of penetrating neck trauma. Computed tomography (CT) plays a central role in prompt evaluation of the extent of penetrating neck trauma and can demonstrate thyroid gland injury. The current literature on thyroid gland injury is limited mostly to blunt trauma, with little emphasis on findings seen on CT imaging. Read More

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AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.

Gastroenterology 2021 Aug 25. Epub 2021 Aug 25.

Department of Gastroenterology, Kaiser Permanente Northern California, Santa Clara, California; Division of Research, Kaiser Permanente Northern California, Oakland, California.

Description: The purpose of this Clinical Practice Update Expert Review is to provide clinicians with guidance on the diagnosis and management of atrophic gastritis, a common preneoplastic condition of the stomach, with a primary focus on atrophic gastritis due to chronic Helicobacter pylori infection-the most common etiology-or due to autoimmunity. To date, clinical guidance for best practices related to the diagnosis and management of atrophic gastritis remains very limited in the United States, which leads to poor recognition of this preneoplastic condition and suboptimal risk stratification. In addition, there is heterogeneity in the definitions of atrophic gastritis, autoimmune gastritis, pernicious anemia, and gastric neoplasia in the literature, which has led to confusion in clinical practice and research. Read More

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A Rare Case of Primary Adenocarcinoma of the Eyelid: Case Presentation and Review of Literature.

Cureus 2021 Jul 23;13(7):e16580. Epub 2021 Jul 23.

Internal Medicine, Steward Health Care, Warren, USA.

Primary mucinous adenocarcinoma (PMA) of the eyelid is a very rare malignancy with an incidence of 0.07 per million. Most cases are elderly males with an indolent course of local growth over months. Read More

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[Epidemiological characteristics of the age-related features of malignant neoplasms of the thyroid gland in Saint-Petersburg, index of accurancy, histological structure of the tumor.]

Adv Gerontol 2021 ;34(3):396-403

I.I.Mechnikov North-Western State Medical University, 41 Kirochnaya str., St. Petersburg 191015, Russian Federation.

The problem of thyroid cancer in Russia became especially relevant after the accident at the Chernobyl nuclear power plant in 1986. We can trace the dynamics of morbidity in the population of Leningrad-Saint Petersburg from 1980 to 2018. for the periods before and after the accident, even before the inclusion of this localization of malignant neoplasms in the state reports. Read More

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Voice Changes Without Laryngeal Nerve Alterations After Thyroidectomy: The Need For Prospective Trials - A Review Study.

J Voice 2021 Aug 14. Epub 2021 Aug 14.

Department of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, Sweden.

Background: Thyroidectomy is a commonly performed surgical procedure that is offered for different thyroid pathologies. The most frequent complication after total thyroidectomy is transient or permanent hypoparathyroidism followed by transient or permanent recurrent laryngeal nerve palsy. Patients may experience voice impairment despite intact laryngeal nerve function. Read More

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Role of Thyroidectomy in Recurrent Laryngeal Carcinoma.

Otolaryngol Head Neck Surg 2021 Aug 17:1945998211033523. Epub 2021 Aug 17.

Department of Otorhinolaryngology, Head & Neck Surgery, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

Objective: Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Read More

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Is thyroid hormone supplementation avoidable for patients with low-risk papillary thyroid cancer after thyroid lobectomy? A two-center observational study.

Clin Endocrinol (Oxf) 2021 Aug 16. Epub 2021 Aug 16.

Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Changing insights regarding the extent of surgery for low-risk papillary thyroid cancer (PTC) stir up discussions on the benefits and harms of thyroid lobectomy versus total thyroidectomy. The chance of needing postoperative thyroid hormone supplementation after thyroid lobectomy is still unclear. The purpose of this retrospective two-center study was to identify the incidence and risk factors of postoperative thyroid-stimulating hormone (TSH) elevation (>2. Read More

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Changes in tapered endotracheal tube cuff pressure after changing position to hyperextension of neck: A randomized clinical trial.

Medicine (Baltimore) 2021 Jul;100(29):e26633

Department of Anesthesiology and Pain Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

Background: Endotracheal tube (ETT) with a tapered-shaped cuff had an improved sealing effect when compared to ETTs with a conventional cylindrical-shaped cuff. Positional change and neck movement typically displace an ETT and change the intracuff pressure. The aim of the current study was to compare the ETT cuff pressure in the TaperGuard ETT vs the conventional ETT after a change from the supine, neutral position to the extension of the neck and semi-Fowler position for thyroid surgery. Read More

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Risk Factors and Outcomes of Postoperative Neck Hematomas: An Analysis of 5,900 Thyroidectomies Performed at a Cancer Center.

Int Arch Otorhinolaryngol 2021 Jul 30;25(3):e421-e427. Epub 2020 Sep 30.

AC Camargo Cancer Center, São Paulo, SP, Brazil.

 Postoperative neck hematoma (PNH) is an uncommon but potentially-lethal complication of thyroid surgery.  To identify the risk factors for postthyroidectomy hematoma requiring reoperation, the timing, the source of the bleeding, the related respiratory distress requiring tracheotomy, and the late outcomes.  We retrospectively analyzed the records of 5,900 consecutive patients submitted to surgery for thyroid diseases at a single institution. Read More

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Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data.

Support Care Cancer 2021 Aug 7. Epub 2021 Aug 7.

Northwell Health Department of Occupational Medicine, Epidemiology and Prevention, Great Neck, Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, New York, NY, USA.

Purpose: Patient-reported outcomes are important in the surgical decision-making process for low-risk, differentiated thyroid cancer. Current study aimed to assess patient-reported outcomes in thyroid cancer survivors comparing total thyroidectomy (TT) and lobectomy (LT) using the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry.

Methods: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scales, illness perception questions, Beliefs about Medicines Questionnaire (BMQ) scales and questions about thyroid surgery-related medication use were compared between thyroid cancer patients who underwent TT versus LT using descriptive analyses. Read More

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Association of phthalate exposure with thyroid function during pregnancy.

Environ Int 2021 Aug 4;157:106795. Epub 2021 Aug 4.

Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands. Electronic address:

Background: The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear.

Aim: To investigate the association of maternal urinary phthalates with markers of the thyroid system during early pregnancy.

Methods: Urinary concentrations of phthalate metabolites and serum concentrations of thyroid stimulating hormone (TSH), free and total thyroxine (FT4 and TT4) and free and total triiodothyronine (FT3 and TT3) were measured in pregnant women in early pregnancy in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (2007-ongoing), a population-based prospective cohort. Read More

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Needs, Preferences, and Values during Different Treatment Decisions of Patients with Differentiated Thyroid Cancer.

J Pers Med 2021 Jul 20;11(7). Epub 2021 Jul 20.

Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

Background: The purpose of this study was to identify the needs, preferences, and values of patients with differentiated thyroid cancer (DTC) and the physicians treating patients with DTC regarding two different treatment decisions, namely: the extent of primary surgery (low-risk patients) and the tyrosine kinase inhibitor (TKI) treatment (high-risk patients).

Methods: A qualitative study was conducted. There were two physician focus groups discussing the extent of primary surgery. Read More

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Incidence and predictive factors of postoperative hypocalcaemia according to type of thyroid surgery in older adults.

Endocrine 2021 Aug 4. Epub 2021 Aug 4.

Servicio de Endocrinología y Metabolismo, Unidad Asistencial Dr. César Milstein, Buenos Aires, Argentina.

Purpose: Transient hypocalcaemia after thyroid surgery and its possible predictors have not been extensively described in the elderly. This study aimed to establish the frequency of postsurgical transient hypocalcaemia according to the extent of thyroid surgery in older adults and to assess mineral metabolism biochemical parameters as its predictors.

Methods: All patients ≥60 years undergoing thyroid surgery were prospectively included. Read More

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Comprehensive characterization of pathological stage-related genes of papillary thyroid cancer along with survival prediction.

J Cell Mol Med 2021 Sep 2;25(17):8390-8404. Epub 2021 Aug 2.

College of Chemistry, Sichuan University, Chengdu, China.

It is crucial to understand the differences across papillary thyroid cancer (PTC) stages, so as to provide a basis for individualized treatments. Here, comprehensive function characterization of PTC stage-related genes was performed and a new prognostic signature was developed for advanced patients. Two gene modules were confirmed to be closely associated with PTC stages and further six hub genes were identified that yield excellent diagnostic efficiency between tumour and normal tissues. Read More

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September 2021

Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto's Thyroiditis Patients.

Mediators Inflamm 2021 11;2021:3192409. Epub 2021 Jul 11.

Department of Restorative Dentistry and Independent Laboratory of Experimental Dentistry, Medical University of Bialystok, 24A M. Sklodowskiej-Curie Street, 15-276 Bialystok, Poland.

Hashimoto's thyroiditis (HT) is one of the most common autoimmune diseases. It is suggested that, in addition to thyroid gland dysfunction, HT is responsible for impaired secretion from the salivary glands. The aim of this study was to evaluate the extent of symptoms of salivary gland dysfunction. Read More

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Stepwise Limited Axillary Lymph Node Dissection Based on Lymphatic Drainage from the Breast to Decrease Breast Cancer-Related Lymphedema: A Randomized Controlled Trial.

Ann Surg Oncol 2021 Jul 30. Epub 2021 Jul 30.

Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.

Background: Comprehensive axillary surgery is associated with an elevated rate of morbidity. This trial aimed to demonstrate the feasibility of axillary dissection of lymph nodes from the breast (bALND) for the purpose of limiting the extent of surgery.

Methods: Patients enrolled from two tertiary referral centers from September 2018 to September 2019 were randomly allocated to two groups: bALND and standard axillary lymph node dissection (sALND). Read More

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Risk Factors for Contralateral Occult Carcinoma in Patients With Unilateral Papillary Thyroid Carcinoma: A Retrospective Study and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 12;12:675643. Epub 2021 Jul 12.

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Background: Bilateral lesions are common in papillary thyroid carcinoma (PTC). For patients with unilateral PTC, occult carcinoma that is not detected preoperatively, but pathologically after surgery, might remain in the contralateral lobe. In this situation, inadequate surgical extent could cause relapse and even lead to re-operation. Read More

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Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes.

JAMA Netw Open 2021 Jul 1;4(7):e2118526. Epub 2021 Jul 1.

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Importance: Hashimoto thyroiditis (HT) has been suggested to be associated with papillary thyroid cancer (PTC) development. However, its association with PTC progression remains unclear.

Objective: To examine the association between HT and PTC presentation and outcomes. Read More

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-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo.

Int J Mol Sci 2021 07 17;22(14). Epub 2021 Jul 17.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.

Forkhead box E1 () is a lineage-restricted transcription factor involved in thyroid cancer susceptibility. Cancer-associated polymorphisms map in regulatory regions, thus affecting the extent of gene expression. We have recently shown that genetic reduction of FOXE1 dosage modifies multiple thyroid cancer phenotypes. Read More

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HSA nanoparticles in drug recognition: mechanistic insights with naproxen, diclofenac and methimazole.

J Biomol Struct Dyn 2021 Jul 23:1-13. Epub 2021 Jul 23.

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India.

Protein-based nanoparticles offer a suitable targeted delivery platform to drugs in terms of biocompatibility, biodegradability and abundance in nature. Physicochemical understanding of drug encapsulation by protein nanoparticles and their impact on protein aggregation is essential. In this work, we have examined quantitative aspects of encapsulation of non-steroidal anti-inflammatory drugs naproxen and diclofenac sodium, and anti-thyroid drug methimazole in nanoparticles of human serum albumin (HSA NPs) by using ultrasensitive calorimetry. Read More

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Clinical presentation and survival outcomes of well-differentiated thyroid cancer in Filipinos.

Cancer Med 2021 Sep 21;10(17):5964-5973. Epub 2021 Jul 21.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.

Background: Filipinos have higher recurrence rates compared to other racial/ethnic groups, which might suggest a higher propensity for aggressive disease. The goal of this study was to perform a population-based analysis of disease extent at diagnosis and survival outcomes in Filipino patients with well-differentiated thyroid cancer relative to other racial/ethnic groups.

Methods: The study cohort comprised adult patients with well-differentiated thyroid cancer diagnosed between 2004 and 2015, identified in the California Cancer Registry. Read More

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September 2021

The Effect of ThyroidߚStimulating Hormone on Stage of Differentiated Thyroid Carcinoma.

Endocrinol Diabetes Metab 2021 Jul 7;4(3):e00266. Epub 2021 Jun 7.

Endocrine and Metabolism Research Center Institute of Basic and Clinical Physiology Sciences Kerman University of Medical Sciences Kerman Iran.

Introduction: Thyroid cancer is the most common endocrine malignancy, and it has the fastest increase rate in incidence in both sexes, with a yearly increase of 3% over the last decade. Thyroid-stimulating hormone (TSH) is the main driver for the thyroid gland to produce thyroid hormone. The main purpose of this study was to assess the relationship between serum TSH level and the stage of malignancy in patients with differentiated thyroid cancer. Read More

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