816 results match your criteria thyroid bed


Graves' disease and recurrence in ectopic thyroid tissue after total thyroidectomy.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.

We report a case of a 46-year-old woman who presented with a midline neck mass 2 years after total thyroidectomy for Graves' disease. Despite levothyroxine treatment withdrawal, she remained biochemically with subclinical hyperthyroidism. Her thyroid stimulating hormone receptor antibodies were consistently elevated. Read More

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Population exposure-response model of I in patients with benign thyroid disease.

Eur J Pharm Sci 2021 Jul 14;165:105942. Epub 2021 Jul 14.

Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade - Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Republic of Serbia.

Purpose: The study aimed to explore the relationship of different exposure measures with I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, and discuss dosing implications of the results.

Methods: A population exposure-response analysis was performed using nonlinear mixed-effects modelling. Data from 95 adult patients with benign thyroid disease were analysed. Read More

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Giant cell tumor in the thyroid area: a case report in the novel location and review of literature.

Gland Surg 2021 Jun;10(6):2054-2061

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Giant cell tumor of soft tissue (GCT-ST) is a rare benign tumor of low malignant potential. It is thought to be the soft tissue counterpart of giant cell tumors of the bone due to its pathological resemblances. GCT-ST is most commonly found in superficial soft tissue of thigh, trunk and upper extremities. Read More

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Dosimetry during adjuvant I therapy in patients with differentiated thyroid cancer-clinical implications.

Sci Rep 2021 Jul 6;11(1):13930. Epub 2021 Jul 6.

Department of Nuclear Medicine, Medical University of Bialystok, M. Skłodowskiej-Curie St. 24A, 15-276, Bialystok, Poland.

The activity of radioiodine (I) used in adjuvant therapy for thyroid cancer ranges between 30 mCi (1.1 GBq) and 150 mCi (5.5 GBq). Read More

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Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies.

Acta Clin Croat 2020 Jun;59(Suppl 1):9-17

1Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Medicine, University of Zagreb, Zagreb, Croatia; 3Faculty of Medicine, University of Osijek, Osijek, Croatia; 4Department for Nuclear Medicine and Radiation Protection, Osijek University Hospital Center, Croatia.

The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN) or thyroid bed masses are detected. Knowing that serum anti-Tg antibodies (sTgAb) affect the use of serum Tg (sTg) as a tumor marker, the aim of our study was to assess the usefulness of Tg determination in needle aspirates (FNA-Tg) in presence of sTgAb. Read More

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Introducing day case thyroid lobectomy at a tertiary head and neck centre.

Ann R Coll Surg Engl 2021 Jul;103(7):499-503

Cambridge University Hospitals NHS Foundation Trust, UK.

Background: Thyroid lobectomy is considered to be a safe day case procedure by the British Association of Day Surgery. However, currently only 5.5% of thyroid surgeries in the UK are undertaken as day cases. Read More

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Levatinib treatment for thyroid cancer in COVID era: safety in a patient with lung metastases and SARS-CoV-2 infection.

Anticancer Drugs 2021 Jun 25. Epub 2021 Jun 25.

Unit of Endocrinology, Fondazione Policlinico Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Rome.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, clinicians are required to manage patient care for pre-existing conditions. Currently, there are no clear indications regarding the management of lenvatinib-treated patients for radioiodine-refractory thyroid cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Case Presentation: A 74-year-old male patient was treated with lenvatinib since March 2019, with disease recurrence in the thyroid bed and bilateral multiple lung metastases. Read More

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Comparing surgical thoroughness and recurrence in thyroid cancer patients across race/ethnicity.

Surgery 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, MedStar Georgetown University/Washington Hospital Center, Washington, DC. Electronic address:

Background: For patients with differentiated thyroid cancer who will receive postoperative radioactive iodine, thyroid remnant uptake can be calculated and may point to the thoroughness of the surgical resection. In the United States, outcome disparities exist among ethnic/racial minorities with differentiated thyroid cancer. Data about surgical thoroughness and recurrence rates across races/ethnicities do not exist. Read More

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The Value of Pre-Ablative I-131 Scan for Clinical Management in Patients With Differentiated Thyroid Carcinoma.

Front Endocrinol (Lausanne) 2021 28;12:655676. Epub 2021 May 28.

Department of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Background: A diagnostic I-131 (Dx) scan is used to detect a thyroid remnant or metastases before treatment of differentiated thyroid cancer (DTC) with I-131. The aim of this study is to specify in which patients with DTC a Dx scan could have an additional value, by studying the effect of the Dx scan on clinical management.

Methods: Patients with DTC, treated with I-131 after thyroidectomy were included in this retrospective cohort study. Read More

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3D Printing in Breast Reconstruction: From Bench to Bed.

Front Surg 2021 20;8:641370. Epub 2021 May 20.

Department of Breast and Thyroid Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Surgical management of breast cancer often results in the absence of the breast. However, existing breast reconstruction methods may not meet the need for a replacement tissue. Tissue engineering with the use of emerging materials offers the promise of generating appropriate replacements. Read More

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Conservative Management of Thyroid Eye Disease.

J Coll Physicians Surg Pak 2021 May;30(5):599-601

Department of Radiology, Mayo Hospital, Lahore, Pakistan.

The aim of the study was to determine the result of conservative management of Graves ophthalmopathy in a multi-disciplinary setting by a team of ophthalmologists and endocrinologists. Twenty-seven patients of thyroid eye disease were included in the study who underwent complete ocular examination and complete thyroid biochemical profile. Each patient was advised lubrication with artificial tears, cool compresses, sleeping with elevated head at bed, taping of the eyelids while sleeping and avoidance of smoking. Read More

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Application effects of targeted nursing model in patients undergoing thyroid surgery and its influence on patients' negative emotions.

Am J Transl Res 2021 15;13(4):2822-2830. Epub 2021 Apr 15.

Department of Surgery, Donghu Branch of The Second Affiliated Hospital of Hainan Medical University Haikou 570100, Hainan Province, China.

Objective: To explore the effectiveness of a targeted nursing model for patients undergoing thyroid surgery, and to analyse the influence of intervention on the negative emotions of patients.

Methods: Eighty patients who received thyroid surgery in our hospital were enrolled and divided into a study group (n=40, given targeted nursing) and a control group (n=40, given routine surgical nursing) according to the difference of intervention measures. The postoperative bed-leaving time, hospitalization time, medical expenses, drainage tube indwelling time and incidence of postoperative adverse reactions were compared between the two groups. Read More

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The epidemiology and biology of pulmonary metastases.

J Thorac Dis 2021 Apr;13(4):2585-2589

Division of Cardiothoracic Surgery, Department of Surgery, Washington University, St. Louis, MO, USA.

Our goal in this chapter is to explore the complex processes of metastasis and why there is a predisposition for this to occur in the lung. In addition, we aim to describe the incidence of pulmonary metastases in various contexts and based on the origin of the primary tumor. There are unique characteristics of the pulmonary system that make metastases more likely to occur in the lung than anywhere else in the body. Read More

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Case Report: A New Entity: Multiple Differentiated Variant of Papillary Thyroid Carcinoma With Advanced Clinical Behavior.

Front Endocrinol (Lausanne) 2021 7;12:654638. Epub 2021 Apr 7.

Thyroid and Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.

There are many histological morphological types of papillary thyroid carcinoma (PTC), but the most frequently seen types are conventional. A single PTC commonly has a conventional and/or a variant morphological pattern. PTC with multiple (more than two) well-differentiated morphological patterns are extremely rare. Read More

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NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case.

Virchows Arch 2021 Apr 23. Epub 2021 Apr 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an exceedingly rare low-grade thyroid malignancy of unknown histogenesis. NUT carcinoma is another rare, highly aggressive neoplasm with predilection for the midline, defined by recurrent NUTM1 fusions. The bromodomain family genes (BRD4 or BRD3) and rarely NSD3, ZNF532, or others are known fusion partners. Read More

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RADIATION EXPOSURE TO THE BACK WITH DIFFERENT TYPES OF APRONS.

Radiat Prot Dosimetry 2021 May;193(3-4):185-189

Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Korea.

Physicians and nurses stand with their back towards the C-arm fluoroscope when using the computer, taking things out of closets and preparing drugs for injection or instruments for intervention. This study was conducted to investigate the relationship between the type of lead apron and radiation exposure to the backs of physicians and nurses while using C-arm fluoroscopy. We compared radiation exposure to the back in the three groups: no lead apron (group C), front coverage type (group F) and wrap-around type (group W). Read More

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Can shear wave elastography determine remnant thyroid tissue in the early postoperative period in patients with differentiated thyroid carcinoma?

J Ultrasound 2021 Apr 5. Epub 2021 Apr 5.

Department of Radiology, Faculty of Medicine, Selçuk University, Ardıclı Mahallesi, Celal Bayar Cad. No:313, 42250, Selçuklu, Konya, Turkey.

Purpose: This study aims to investigate the usability of ultrasonography (US) and shear wave elastography (SWE) in detecting remnant thyroid tissue (RTT) within the first three postoperative months in patients who underwent total thyroidectomy (TT) for differentiated thyroid cancer (DTC) and who were scheduled for radioiodine (RAI) ablation therapy.

Methods: Sixty-nine patients who underwent a TT operation due to DTC were included in the study. The participant's thyroid surgical bed was first evaluated by thyroid scintigraphy and then by greyscale US and SWE to investigate RTT. Read More

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Using 2-dimensional color superb microvascular imaging vascularization index technique in the assessment of thyroid surgical bed.

Med Ultrason 2021 Apr 1. Epub 2021 Apr 1.

Department of Nuclear Medicine, Faculty of Medicine, Selçuk University, Selçuklu, Konya, Turkey..

Aim: The purpose of this study was to investigate the effectiveness of the vascularization index (VI) obtained using color superb microvascular imaging (cSMI) technique in the assessment of thyroid surgical bed for remnant thyroid tissue (RTT).

Material And Methods: We evaluated the thyroid surgical bed of 65 patients who had underwent total thyroidectomy (TT) due to papillary carcinoma (PC) using thyroid scintigraphy and cSMI. Color SMI was also performed for the examination of the thyroid parenchyma of 39 healthy asymptomatic participants. Read More

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Human Serum Albumin Decorated Indocyanine Green Improves Fluorescence-Guided Resection of Residual Lesions of Breast Cancer in Mice.

Front Oncol 2021 8;11:614050. Epub 2021 Mar 8.

ChangJiang Scholar's Laboratory, Medical College, Shantou University, Shantou, China.

Objective: Achieving negative resection margin is critical but challenging in breast-conserving surgery. Fluorescence-guided surgery allows the surgeon to visualize the tumor bed in real-time and to facilitate complete resection. We envisioned that intraoperative real-time fluorescence imaging with a human serum albumin decorated indocyanine green probe could enable complete surgical removal of breast cancer in a mouse model. Read More

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Clinical applications of single-photon emission computed tomography/computed tomography in post-ablation iodine scintigraphy in children and young adults with differentiated thyroid carcinoma.

Pediatr Radiol 2021 Mar 24. Epub 2021 Mar 24.

Department of Nuclear Medicine, West China Hospital, Sichuan University, No 37. Guoxue Alley, Chengdu, 610041, China.

Background: The utility of integrated single-photon emission computed tomography/computed tomography (SPECT/CT) in children and young adults with differentiated thyroid carcinoma is incompletely studied.

Objective: To determine the value of adding SPECT/CT to conventional whole-body scintigraphy in post-ablation iodine-131 (I) scintigraphy for children and young adults with differentiated thyroid carcinoma.

Materials And Methods: Planar scintigraphy and SPECT/CT were performed on 42 post-surgical children and young adults (32 female, 10 male; mean age 14. Read More

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Role of Sonographic Characteristics of Thyroid Bed Lesions Identified Following Thyroidectomy in the Diagnosis or Exclusion of Recurrent Cancer.

Radiology 2021 05 2;299(2):374-380. Epub 2021 Mar 2.

From the Department of Radiology (M.C.F., C.B.B.), Department of Medicine, Division of Endocrinology, Diabetes and Hypertension (E.K.A.), and Department of Pathology (J.A.B.), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02067; and University of Vermont Medical School, Burlington, Vt (M.P.P.).

Background US of the thyroid bed in patients with thyroid cancer often depicts small lesions, but it is unclear whether US characteristics of lesions can help predict cancer recurrence. Purpose To determine whether size or US features of lesions in the thyroid bed after thyroidectomy in conjunction with clinical features can help predict thyroid cancer recurrence. Materials and Methods With use of a US reporting database, all patients imaged between July 2006 and June 2016 with an indication of post-thyroidectomy follow-up were retrospectively identified. Read More

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Prediction of Prolonged Length of Hospital Stay After Cancer Surgery Using Machine Learning on Electronic Health Records: Retrospective Cross-sectional Study.

JMIR Med Inform 2021 Feb 22;9(2):e23147. Epub 2021 Feb 22.

Healthcare AI Team, National Cancer Center, Goyang, Republic of Korea.

Background: Postoperative length of stay is a key indicator in the management of medical resources and an indirect predictor of the incidence of surgical complications and the degree of recovery of the patient after cancer surgery. Recently, machine learning has been used to predict complex medical outcomes, such as prolonged length of hospital stay, using extensive medical information.

Objective: The objective of this study was to develop a prediction model for prolonged length of stay after cancer surgery using a machine learning approach. Read More

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February 2021

Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer.

EJNMMI Phys 2021 Feb 15;8(1):14. Epub 2021 Feb 15.

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: In recurrent differentiated thyroid cancer patients, detectability in I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between three generations of PET scanners with different detector technologies. The results are used to suggest an optimized protocol. Read More

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February 2021

Diagnostic Lobectomy for Bethesda III Thyroid Nodules: Pathological Outcomes and Risk Factors for Malignancy.

Ann Otol Rhinol Laryngol 2021 Sep 10;130(9):1064-1068. Epub 2021 Feb 10.

Department of Otolaryngology, San Antonio Military Medical Center, San Antonio, TX, USA.

Objective: An indeterminate thyroid nodule fine-needle aspiration (FNA) presents a unique dilemma. We evaluated our institution's experience with Bethesda III thyroid nodules, including the risk of malignancy (ROM) of these nodules removed for diagnostic lobectomy and radiologic and clinical risk factors for malignancy.

Study Design: Retrospective chart review. Read More

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September 2021

Pituitary metastases of Hürthle cell carcinoma of the thyroid.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Diabetes and Endocrinology, Queen's Medical Centre Nottingham University Hospital NHS Trust, Nottingham, UK.

An 85-year-old man was referred to endocrinology following the discovery of an incidental pituitary mass on cranial imaging which was thought to be a non-functioning adenoma during an admission with headaches, lethargy, confusion and hyponatraemia. He had a history of Hürthle cell carcinoma of the thyroid treated with total thyroidectomy, ablative radioiodine therapy and thyroxine replacement. Subsequently, he developed metastatic spread to the neck, lungs and skeleton. Read More

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January 2021

Medulloblastoma and familial adenomatous polyposis: Good prognosis and good quality of life in the long-term?

Pediatr Blood Cancer 2021 04 18;68(4):e28912. Epub 2021 Jan 18.

Hereditary Digestive Tract Tumors Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Introduction: Mutations of the APC (adenomatous polyposis coli) gene correlate mainly with familial adenomatous polyposis (FAP), but can occasionally be pathogenic for medulloblastoma (MBL) wingless-related integration site (WNT) subtype, the course of which has only recently been described.

Methods: We retrieved all patients with documented germline APC mutations and a diagnosis of MBL to examine their outcome, late effects of treatment, and further oncological events.

Results: Between 2007 and 2016, we treated six patients, all with a pathogenic APC variant mutation and all with MBL, classic histotype. Read More

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Storm and STEMI: a case report of unexpected cardiac complications of thyrotoxicosis.

Eur Heart J Case Rep 2020 Dec 12;4(6):1-5. Epub 2020 Nov 12.

Division of Cardiology, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.

Background : Thyroid storm is a rare condition with well-known cardiovascular manifestations including tachycardia, atrial fibrillation, heart failure, and myocardial infarction (MI). Several uncommon conditions that can mimic MI are associated with thyrotoxicosis and discussed in this case.

Case Summary : A 23-year-old previously healthy male presented after the onset of generalized weakness and inability to rise from bed in the setting of 35 kg of unintentional weight loss, and was found to have profound hypokalaemia, elevated thyroid hormone, and suppressed thyroid-stimulating hormone consistent with thyrotoxicosis secondary to Grave's disease. Read More

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December 2020

Update on the systemic management of radioactive iodine refractory differentiated thyroid cancer (Review).

Mol Clin Oncol 2021 Feb 24;14(2):35. Epub 2020 Dec 24.

Department of Radiation Oncology, Regional Cancer Center, Medical College Campus, Trivandrum, 695011 Kerala, India.

The incidence of differentiated thyroid cancer (DTC) has increased over the last few decades, though it remains to be a rare disease. The prognosis of DTC is excellent; its treatment includes surgery (near-/total thyroidectomy), which is usually followed by remnant thyroid bed ablation using radio-iodine, as well as a risk-stratified follow-ups, including hormone replacement. Treatment of patients who are non-responsive to radioactive iodine (RAI) remains a challenge. Read More

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February 2021

The effects of different degrees of head-of-bed elevation on the respiratory pattern and drainage following thyroidectomy: a randomized controlled trial.

Afr Health Sci 2020 Mar;20(1):488-497

Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of General Surgery, İstanbul, Turkey. Office phone: +902124143000.

Background: The patient's position is important for ensuring patient comfort and preventing complications after thyroidectomy.

Objectives: This study was carried out to determine the effects of different degrees of head-of-bed elevation (HOBE) on the respiratory pattern and drainage following thyroidectomy and to provide suggestions for evidence-based clinical practice.

Methods: The sample of this prospective, parallel arm, randomized controlled trial included 114 patients undergoing thyroidectomy in a university hospital in Turkey. Read More

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Applying postoperative radioiodine therapy before 3 months seems to decrease ablation success in patients with differentiated thyroid carcinoma.

Ann Nucl Med 2021 Feb 3;35(2):223-231. Epub 2021 Jan 3.

Department of Ear Nose Throat and Head and Neck Surgery, Dokuz Eylül University School of Medicine, Inciralti, 35340, Izmir, Turkey.

Objectives: Radioiodine can be applied for remnant ablation in low and low to intermediate-risk patients with differentiated thyroid cancer (DTC). A controversy still exists about the application time interval of radioiodine following total thyroidectomy. In this study, we investigated the effect of radioiodine (RAI) therapy timing on the success rates of the ablation. Read More

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February 2021