18,204 results match your criteria thyroid antibodies


Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade.

J Endocr Soc 2021 Sep 15;5(9):bvab093. Epub 2021 May 15.

Endocrinology Unit, Azienda Ospedaliero-Universitaria Pisana and Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa 56124, Italy.

Context: Thyrotoxicosis is a common immune-related adverse event in patients treated with programmed cell death protein-1 (PD1) or programmed cell death protein ligand-1 (PD-L1) blockade. A detailed endocrinological assessment, including thyroid ultrasound and scintigraphy, is lacking, as are data on response to treatment and follow-up.

Objective: The aim of this study was to better characterize the thyrotoxicosis secondary to immune checkpoint inhibitors, gaining insights into pathogenesis and treatment. Read More

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September 2021

First case recognized as autoimmune polyglandular syndrome type 2 with myasthenia gravis in Palestine: A case report and literature review.

Ann Med Surg (Lond) 2021 Aug 16;68:102575. Epub 2021 Jul 16.

An-Najah National University Hospital, Nablus, Palestine.

Background: Myasthenia gravis is an organ specific autoimmune disorder that is potentially serious but treatable. It is characterized by fatigability of the voluntary muscles and weakness caused by antibodies against the nicotinic acetylcholine receptor (AChR) on the postsynaptic membrane at the neuromuscular junction.Sometimes, and in very rare cases, it can be associated with other autoimmune conditions in a so called autoimmune polyglandular syndrome type 2, which consists mainly of autoimmune adrenal insufficiency (Addison's disease) with autoimmune thyroid disease and/or type 1 diabetes mellitus. Read More

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Does concomitance of Hashimoto's disease and type 1 diabetes affect diabetes control and development of its complications?

Arch Med Sci 2021 16;17(4):900-904. Epub 2019 Nov 16.

Department of Diabetology, Institute of Rural Health, Lublin, Poland.

Introduction: Autoimmune diseases concomitant with diabetes may complicate the treatment and adversely affect the prognosis. The most common is Hashimoto's disease (HD). We compared diabetes control and prevalence of chronic complications in type 1 diabetes patients differing in the coexistence of HD. Read More

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November 2019

Pre-existing thyroiditis ameliorates papillary thyroid cancer: insights from a new mouse model.

Endocrinology 2021 Jul 31. Epub 2021 Jul 31.

Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Ross Research Building-Room 656, 720 Rutland Avenue, Baltimore, MD, 21205, USA.

Papillary Thyroid Cancer (PTC) often co-occurs with Hashimoto's thyroiditis, an association that has long been reported in clinical studies yet remains controversial. Some studies, in fact, have suggested a protective effect of thyroiditis while others have not. We generated a mouse model where PTC and thyroiditis develop in a predictable manner, combining the oncogenic drive of the BRAF v600E mutation (inducible by tamoxifen) to the thyroiditis susceptibility of the NOD. Read More

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Highly sensitive electrochemical immunosensor using a protein-polyvinylidene fluoride nanocomposite for human thyroglobulin.

Bioelectrochemistry 2021 Jul 16;142:107888. Epub 2021 Jul 16.

LABEL, Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas 69067-005, Brazil. Electronic address:

The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods. This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs). The functionalized polymer matrices were characterized by UV-Vis, FTIR, XPS, SEM, dynamic light scattering, and free surface energy. Read More

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Clinical value of functional thyrotropin receptor antibodies in Serbian patients with Graves' orbitopathy.

J Endocrinol Invest 2021 Jul 29. Epub 2021 Jul 29.

Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Purpose: Thyrotropin receptor autoantibodies (TSH-R-Ab) are heterogeneous in their biological function and play a significant role in the pathophysiology of both Graves' disease and Graves' orbitopathy (GO). The clinical significance and utility of determining functional TSH-R-Ab in a Serbian collective were evaluated.

Methods: 91 consecutive patients with GO were included in this study. Read More

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Indication for radioactive iodine in patients with papillary thyroid carcinoma without apparent disease after total thyroidectomy but with elevated antithyroglobulin antibodies.

Clin Endocrinol (Oxf) 2021 Jul 29. Epub 2021 Jul 29.

Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

Objective: To evaluate a criterion for the selective indication of radioactive iodine (RAI) based on the short-term behavior of antithyroglobulin antibodies (TgAb) in patients with papillary thyroid carcinoma (PTC) who have negative thyroglobulin (Tg) and neck ultrasonography (US) without abnormalities after total thyroidectomy but elevated TgAb.

Design: This was a prospective study that evaluated 216 patients with low- or intermediate risk PTC who had nonstimulated Tg ≤ 0.2 ng/ml and no US abnormalities but elevated TgAb 3 months after thyroidectomy. Read More

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Old Bottle, New Wine: Diplopia Sans Proptosis as the Sole Presentation of Thyroid Orbitopathy.

Cureus 2021 Jun 23;13(6):e15850. Epub 2021 Jun 23.

Neurology, Lady Hardinge Medical College, New Delhi, IND.

Thyroid orbitopathy holds a dominant place in the list of causes for external ophthalmoplegia and is commonly accompanied by eye surface signs such as congestion, lacrimation, and proptosis. An elderly male presented to us with painless diplopia in the absence of proptosis, conjunctival congestion, tearing or irritative symptoms. He had bilateral complete external ophthalmoplegia. Read More

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Graves' disease patients with iron deficiency anemia: serologic evidence of co-existent autoimmune gastritis.

Am J Blood Res 2021 15;11(3):238-247. Epub 2021 Jun 15.

Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Harbor-UCLA Medical Center and The David Geffen School of Medicine at UCLA Los Angeles, CA, USA.

Background: Graves' disease (GD) has been associated with iron deficiency anemia (IDA). Atrophic gastritis leads to IDA and has been associated with autoimmune thyroid disease. This study prospectively determined the prevalence of atrophic gastritis markers and the relationship between these markers and markers of IDA in GD subjects. Read More

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Graves' disease and recurrence in ectopic thyroid tissue after total thyroidectomy.

BMJ Case Rep 2021 Jul 27;14(7). Epub 2021 Jul 27.

Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.

We report a case of a 46-year-old woman who presented with a midline neck mass 2 years after total thyroidectomy for Graves' disease. Despite levothyroxine treatment withdrawal, she remained biochemically with subclinical hyperthyroidism. Her thyroid stimulating hormone receptor antibodies were consistently elevated. Read More

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Application of biomarkers in the diagnosis of uncertain samples of core needle biopsy of thyroid nodules.

Virchows Arch 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Peking University First Hospital, 7 Xishiku Street, Xicheng District, Beijing, 100034, China.

Core needle biopsy (CNB) is now more frequently used for the preoperative diagnosis of thyroid nodules. Based on morphology alone, 5-20% of CNB samples cannot be determined as malignant or benign. Compared to fine-needle biopsy (FNB), samples collected by CNB are more accessible for various tests. Read More

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Impact of Thyroid Autoimmunity on Fertilization/Intracytoplasmic Sperm Injection Outcomes and Fetal Weight.

Front Endocrinol (Lausanne) 2021 8;12:698579. Epub 2021 Jul 8.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Several studies have reported the association between thyroid autoimmunity (TAI) and fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes. However, the findings remain controversial. We performed a large-scale retrospective cohort study to verify the effect of the presence of thyroid antibodies on IVF/ICSI outcomes and fetal growth and to evaluate the association between the types and titers of thyroid antibodies and adverse IVF/ICSI outcomes. Read More

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A rare presentation of ectopic thyroid gland at right axilla.

Med J Malaysia 2021 Jul;76(4):600-602

Hospital Sultanah Nora Ismail, Batu Pahat, Johor, Malaysia.

The thyroid gland and its hormones play important roles in organ development and in the homeostatic control of physiological mechanisms in human beings. As a result of embryogenic descent of thyroid gland, it commonly resides along the midline - from tongue to mediastinum (90%). Ectopic thyroid gland is a rare occurrence, with extra-lingual ectopic thyroid gland being even rarer. Read More

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Placental pathologic features in thyroid autoimmunity.

Placenta 2021 Jul 15;112:66-72. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, Piazzale Golgi n.19, 27100 Pavia, Italy; University of Pavia, Corso Strada Nuova n.65, 27100, Pavia, Italy.

Introduction: Data on placental pathologic features associated with thyreoperoxidase antibodies (TPO Ab) and/or hypothyroidism are limited. The objective of the study was to analyze placental pathologic features of women with TPO Ab positivity.

Methods: Prospective case-control observational study of pregnancy outcome among women screened for TPO Ab positivity and/or isolated hypothyroidism (TSH>4mU/L) during the first trimester of pregnancy. Read More

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Correction to: Thyrotropin receptor antibodies and Graves' orbitopathy.

J Endocrinol Invest 2021 Jul 24. Epub 2021 Jul 24.

Molecular Thyroid Research Laboratory, Department of Medicine I (TD, GJK), Johannes Gutenberg University (JGU) Medical Center, 55101, Mainz, Germany.

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TNF-α May Exert Different Antitumor Effects in Response to Radioactive Iodine Therapy in Papillary Thyroid Cancer with/without Autoimmune Thyroiditis.

Cancers (Basel) 2021 Jul 19;13(14). Epub 2021 Jul 19.

Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, 022328 Bucharest, Romania.

Autoimmune thyroiditis (AIT) may impair radioiodine (I) uptake in papillary thyroid cancer (PTC). Finding the mechanisms that govern immune cells during I therapy of PTC with concomitant AIT (PTC + AIT) could provide a rationale. Our study aimed to evaluate the effects of I on anti-thyroglobulin antibodies (TgAb), matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor TIMP-1 and tumor necrosis factor-α (TNF-α) and its receptors TNFR1 and TNFR2, in PTC and PTC + AIT patients. Read More

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THE 2021 EUROPEAN GROUP ON GRAVES' ORBITOPATHY (EUGOGO) CLINICAL PRACTICE GUIDELINES FOR THE MEDICAL MANAGEMENT OF GRAVES' ORBITOPATHY.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

W Wiersinga, Endocrinology and Metabolism, AMC, Amsterdam, 1105 AZ, Netherlands.

Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). Choice of treatment should be based on assessment of clinical activity and severity of GO. Early referral to specialized centers is fundamental for most patients with GO. Read More

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Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus.

Trop Anim Health Prod 2021 Jul 22;53(4):408. Epub 2021 Jul 22.

ICAR-International Centre for Foot-and-Mouth Disease (ICFMD), DFMD, Arugul, Jatni, Odisha, 752050, India.

The study aimed to explore the serum levels of HSP70 and identify its possible association with serum cortisol, thyroid hormones, and acute-phase protein concentrations in cattle naturally infected with foot-and-mouth disease (FMD) virus. After the FMD outbreak in an organized dairy cattle farm in India, blood samples were obtained from clinically infected (n = 40) and apparently healthy (n = 30) animals. Samples were processed and tested by an in-house DIVA assay for confirmation of FMD infection. Read More

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How to use thionamide anti-thyroid drug in the young- what's new?

Authors:
Tim Cheetham

Thyroid Res 2021 Jul 21;14(1):18. Epub 2021 Jul 21.

Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The excess thyroid hormone secretion that characterises Graves' disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.This underlying mechanism cannot easily be abolished and the mainstay of Graves' disease (GD) management in the young remains thionamide anti-thyroid drug (ATD). Unfortunately, GD will usually recur after a 2 or 3 year course of ATD, even when the stimulatory antibody titres have fallen. Read More

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Clinical features and treatment efficacy for IgG4-related thyroiditis.

Orphanet J Rare Dis 2021 07 21;16(1):324. Epub 2021 Jul 21.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Education and National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), No.1 Shuai Fu Yuan, Dong Cheng District, Beijing, 100730, People's Republic of China.

Purpose: This study aimed to clarify the clinical features of and evaluate the treatment efficacy for IgG4-related thyroiditis.

Methods: Fourteen IgG4-related thyroiditis patients and 42 randomly matched IgG4-related disease (IgG4-RD) patients without thyroiditis in a prospective cohort at the Peking Union Medical College Hospital (PUMCH) were enrolled from 2011 to 2019. Patient demographics, clinical characteristics, laboratory parameters and treatment efficacy were analysed. Read More

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THE ASSOCIATION OF SUBCLINICAL INSULIN RESISTANCE WITH THYROID AUTOIMMUNITY IN EUTHYROID INDIVIDUALS.

Acta Clin Croat 2020 Dec;59(4):696-702

1Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4University of Applied Health Sciences, Zagreb, Croatia; 5Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6School of Medicine, University of Zagreb, Zagreb, Croatia; 7Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia.

Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. Read More

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December 2020

Anti-thyroid antibodies as biomarkers in Chronic Spontaneous Urticaria.

Eur Ann Allergy Clin Immunol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pediatrics, Allergy, Clinical Immunology and Rheumatology Discipline, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

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Age Moderates the Impact of TRAbs on Thyroid Hormones and Hepatic Function in Patients with Graves' Disease.

Horm Metab Res 2021 Jul 19;53(7):453-460. Epub 2021 Jul 19.

Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Thyrotropin receptor antibodies (TRAbs) play a significant role in the course of hepatic dysfunction (HDF) in patients with Graves' disease (GD). However, few studies have considered the factors that influence the relationships among TRAbs, thyroid hormone levels, and hepatic function in subjects with newly diagnosed GD. Here we investigated the associations of TRAbs with thyroid hormones and hepatic function and assessed potential factors that can influence these associations among patients with GD. Read More

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Poorly differentiated thyroid carcinoma coexisting with Graves' disease involving T3 thyrotoxicosis due to increased D1 and D2 activities.

Thyroid 2021 Jul 18. Epub 2021 Jul 18.

Kansai Medical University, Department of Internal Medicine II, 2-3-1 Shinmachi, Hirakata, Osaka, Japan, 573-1191;

Background Poorly differentiated thyroid carcinoma is rare and typically euthyroid. We report a novel rarer case of poorly differentiated thyroid carcinoma involving T3 thyrotoxicosis. Patients' Findings A 77-year-old man visited Kuma Hospital due to a neck tumor. Read More

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Metabolic and Hormonal Profile of Adolescent Girls With Polycystic Ovary Syndrome With Concomitant Autoimmune Thyroiditis.

Front Endocrinol (Lausanne) 2021 2;12:708910. Epub 2021 Jul 2.

Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Introduction: Both polycystic ovary syndrome (PCOS) and autoimmune thyroiditis (AT) are considered to be among the most common endocrinopathies in young women, and they are classified as diseases that affect many processes in the human body. Their role in the development of metabolic disorders and diseases of the cardiovascular system in adult women is also emphasized. However, there are no data available to assess such risk in the teenage girl population. Read More

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Identification of two different phenotypes of patients with amiodarone-induced thyrotoxicosis and positive thyrotropin receptor antibody tests.

Thyroid 2021 Jul 16. Epub 2021 Jul 16.

Università degli Studi di Pisa Facolta di Medicina e Chirurgia, 9310, Department of Clinical and Experimental Medicine, Pisa, Italy;

Introduction: Serum TSH receptor antibodies (TRAbs) are occasionally found in patients with AIT, and usually orient toward a diagnosis of type 1 AIT (AIT1) due to Graves' disease (GD). However, TRAb role and function in AIT are unsettled.

Methods: Retrospective cohort study of 309 AIT patients followed at a single Academic center over a 30-year period. Read More

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Thyroid dysfunction following radiofrequency ablation for benign thyroid nodules: more likely to occur within one-week and in high-risk population.

Int J Hyperthermia 2021 ;38(1):1060-1068

Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research Guangzhou, Guangdong, China.

Background: Radiofrequency ablation (RFA) has been recommended as the treatment for benign thyroid nodules (BTNs) by some guidelines. However, detailed follow-up instructions for thyroid function about the timing and affected populations after RFA are lacked due to insufficient researches. This 12-month prospective study aimed to evaluate the incidence and risk factors of thyroid dysfunction at different time points after RFA, especially within 1 week that previous studies didn't concern. Read More

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January 2021

Updates on the understanding and management of thyroid eye disease.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211027760. Epub 2021 Jun 30.

Bascom Palmer Eye Institute, Department of Ophthalmology, McKnight Vision Research Center, University of Miami School of Medicine, Miami, FL, USA.

Thyroid eye disease (TED) is a complex disease associated with myriad clinical presentations, including facial disfigurement, vision loss, and decreased quality of life. Traditionally, steroid therapy and/or radiation therapy were commonly used in the treatment of active TED. While these therapies can help reduce inflammation, they often do not have a sustainable, significant long-term effect on disease outcomes, including proptosis and diplopia. Read More

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Napsin A Expression in Human Tumors and Normal Tissues.

Pathol Oncol Res 2021 20;27:613099. Epub 2021 Apr 20.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Novel aspartic proteinase of the pepsin family A (Napsin A, TAO1/TAO2) is a functional aspartic proteinase which is involved in the maturation of prosurfactant protein B in type II pneumocytes and the lysosomal protein catabolism in renal cells. Napsin A is highly expressed in adenocarcinomas of the lung and is thus commonly used to affirm this diagnosis. However, studies have shown that other tumors can also express Napsin A. Read More

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OTOACOUSTIC EMISSION AND AUDITORY BRAINSTEM RESPONSE IN PATIENTS WITH AUTOIMMUNE THYROIDITIS.

Georgian Med News 2021 May(314):42-48

Bogomolets National Medical University, Department of Оtorhinolaryngology, Kiev, Ukraine.

The function of the outer hair cells (OHC) in patients with euthyroid autoimmune thyroiditis (AIT) was investigated in frequency range of 1000 - 8000 Hz. Our aim was to measured of AIT factors influence on auditory function in patients with no subjective sensations of hearing loss. For this study we selected patients with euthyroid AIT. Read More

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