248,618 results match your criteria thrombus

Sudden death due to cardiac contusion: Forensic implications in a rare pediatric case.

J Forensic Sci 2021 May 7. Epub 2021 May 7.

Dipartimento di Scienze Biomediche per la Salute, Sezione di Medicina Legale e delle Assicurazioni, Università degli Studi di Milano, Milano, Italy.

Blunt chest trauma (BCT) often results in blunt cardiac injuries of little clinical concern, but cases of severe heart damage with high mortality rates have also been described. In particular, BCT should never be underestimated, especially when it is located in the anterior thoracic region. Among traffic accidents, motorcyclists are the most vulnerable and at the greatest risk. Read More

View Article and Full-Text PDF

Acute upper limb ischemia as a complication of tunneled hemodialysis catheter placement via the right internal jugular vein.

Ahmet Can Topcu

J Vasc Access 2021 May 7:11297298211015041. Epub 2021 May 7.

Department of Cardiovascular Surgery, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.

Arterial injury during internal jugular vein cannulation can cause devastating complications such as stroke, hematoma, hemothorax, pseudoaneurysm, AV fistula, or even death. Acute upper limb ischemia caused by inadvertent arterial puncture during internal jugular vein cannulation has been rarely reported. The present report describes the case of a patient who experienced right upper limb ischemia caused by subclavian artery thrombosis developed during attempted placement of a tunneled hemodialysis catheter via the right internal jugular vein. Read More

View Article and Full-Text PDF

How well do we understand pulsatility in the context of modern ventricular assist devices?

Int J Artif Organs 2021 May 7:3913988211012707. Epub 2021 May 7.

St Vincent's Hospital (Sydney), Darlinghurst, NSW, Australia.

Background: Modern ventricular assist devices (VADs) use a continuous flow design. It has been suggested that a lack of pulsatility contributes to a range of adverse outcomes including pump thrombus, gastrointestinal bleeding and stroke. To better assess the role of pulsatility in these adverse events, we first require a clear definition of 'pulsatility' in the setting of a severely impaired ventricle and a modern continuous flow VAD. Read More

View Article and Full-Text PDF

The Impact of Anticoagulation on COVID-19 (SARS CoV-2) Patient Outcomes: A Systematic Review.

J Pharm Pract 2021 May 7:8971900211015055. Epub 2021 May 7.

Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Davie, FL, USA.

Background: Emerging data suggest that coagulopathy, cytokine storm, and acute respiratory distress syndrome are associated with the 2019 coronavirus disease (COVID-19). The prevalence of hypercoagulable state in these patients is unknown, but appears to be higher compared to those with other critically ill patients. Elevated D-dimer, large blood vessels clots, deep vein thrombosis, pulmonary embolism and disseminated intravascular coagulation have been reported in patients diagnosed with COVID-19 either on admission or during hospitalization and may be predictors of poor outcomes. Read More

View Article and Full-Text PDF

Prognostic factors of clot resolution on follow-up computed tomography angiography and recurrence after a first acute pulmonary embolism.

Clin Respir J 2021 May 6. Epub 2021 May 6.

Internal Medicine Department. Hospital, Universitario Infanta Elena. Valdemoro Madrid, Spain.

Background: Recent studies seem to confirm the relationship between residual pulmonary obstruction (RPO) in pulmonary embolism (PE) and risk of recurrent thrombosis and chronic thromboembolic pulmonary hypertension (CTEPH). However, the prognostic factors associated with PE resolution on follow-up computed tomography angiography (CTA) are not clear.

Objectives: To determine the prognostic factors of resolution of PE diagnosed and monitored by CTA and the impact of RPO on late complications. Read More

View Article and Full-Text PDF

Safety and effectiveness of hemorrhoidal artery ligation using the HAL-RAR technique for hemorrhoidal disease.

Langenbecks Arch Surg 2021 May 6. Epub 2021 May 6.

Amalia Fleming Surgical Department, Sismanoglio - Amalia Fleming General Hospital, Athens, Greece.

Purpose: A wide variety of methods has been proposed for treating hemorrhoidal disease. The aim of the study is to assess the safety and effectiveness of hemorrhoidal artery ligation with rectoanal repair (HAL-RAR).

Methods: Retrospective study from January 2010 to November 2019 of patients who underwent HAL-RAR for grade II, resistant to conservative treatment, and grades III and IV hemorrhoidal disease. Read More

View Article and Full-Text PDF

Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia.

Cancer Chemother Pharmacol 2021 May 7. Epub 2021 May 7.

Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Background: Asparaginase (ASNase) is a key component in the treatment protocols of childhood acute lymphoblastic leukemia (ALL). Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) mediate the anti-leukemic effect of ASNase. Only a few reports studied the association between polymorphisms in these genes and treatment-related toxicity and response. Read More

View Article and Full-Text PDF

A case report: adenosine triggered myocardial infarction during myocardial perfusion stress test imaging in a diabetic patient.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab133. Epub 2021 Apr 30.

Department of Cardiology, Amphia Hospital, Breda, Amphia Ziekenhuis, Molengracht 21, 4818 CK, Breda, The Netherlands.

Background: Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) can in general be used safely in daily clinical practice. However, under the right circumstances, it can lead to serious complications.

Case Summary: A 68-year-old female patient with diabetes and a history of inferior ST-elevation myocardial infarction 8 years earlier, visited our outpatient clinic with atypical chest discomfort. Read More

View Article and Full-Text PDF

From Testing to Decision-Making: A Data-Driven Analytics COVID-19 Response.

Acad Pathol 2021 Jan-Dec;8:23742895211010257. Epub 2021 Apr 20.

NorthShore University Health System, Evanston, IL, USA.

In March 2020, NorthShore University Health System laboratories mobilized to develop and validate polymerase chain reaction based testing for detection of SARS-CoV-2. Using laboratory data, NorthShore University Health System created the Data Coronavirus Analytics Research Team to track activities affected by SARS-CoV-2 across the organization. Operational leaders used data insights and predictions from Data Coronavirus Analytics Research Team to redeploy critical care resources across the hospital system, and real-time data were used daily to make adjustments to staffing and supply decisions. Read More

View Article and Full-Text PDF

Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus.

Front Med (Lausanne) 2021 20;8:638750. Epub 2021 Apr 20.

Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual MPV fluctuations and investigate if such variations are associated with disease activity and clinical phenotypes of SLE. Read More

View Article and Full-Text PDF

Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome.

Cureus 2021 Apr 1;13(4):e14239. Epub 2021 Apr 1.

Faculty of Medicine, Memorial University of Newfoundland, St. John's, CAN.

Adrenocortical carcinoma (ACC) is a rare, highly malignant endocrine tumor, often associated with a poor prognosis. Most patients who develop ACC are either children of ages 1-6, or adults in their fourth to fifth decade of life. Individuals with a functional cortisol-secreting ACC frequently present with Cushing syndrome. Read More

View Article and Full-Text PDF

Follow-Up of Coronavirus Infected Patients Using Telemedicine in a Referral Pulmonary Center.

Tanaffos 2020 Dec;19(4):356-363

Telemedicine research center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti university of Medical Sciences, Tehran, Iran.

Background: Telemedicine is considered an innovative approach for management and follow up of communicable diseases, when person to person contact has the risk of disease dissemination, such as the situation being experienced with corona virus infection. The aim of this study was to evaluate the role of telemedicine in patient follow-up and patient compliance in different communication methods.

Materials And Methods: All patients discharged from a referral pulmonary hospital dedicated to coronavirus infected patients were given instructions on follow-up of symptoms. Read More

View Article and Full-Text PDF
December 2020

Portal Vein Thrombosis after the Consumption of Date Seed Powder: A Case Study.

Case Rep Med 2021 17;2021:6668722. Epub 2021 Apr 17.

Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Date seeds can be used as ingredients to enhance the nutritional value of some functional foods for human consumption as well as additives in pharmaceutical and cosmetic industries. However, there are no reports on the complications of date seeds after oral consumption. We currently report a patient with no history of gastrointestinal disease, who has been admitted to the hospital with portal vein thrombosis (PVT) and suffered from complications. Read More

View Article and Full-Text PDF

Interplay between inflammation and thrombosis in cardiovascular pathology.

Nat Rev Cardiol 2021 May 6. Epub 2021 May 6.

Medizinische Klinik und Poliklinik I, University Hospital, LMU Munich, Munich, Germany.

Thrombosis is the most feared complication of cardiovascular diseases and a main cause of death worldwide, making it a major health-care challenge. Platelets and the coagulation cascade are effectively targeted by antithrombotic approaches, which carry an inherent risk of bleeding. Moreover, antithrombotics cannot completely prevent thrombotic events, implicating a therapeutic gap due to a third, not yet adequately addressed mechanism, namely inflammation. Read More

View Article and Full-Text PDF

Antiphospholipid antibodies in COVID-19: a meta-analysis and systematic review.

RMD Open 2021 May;7(2)

Department of Pulmonary/Critical Care, Wayne State University, Detroit, Michigan, USA

Background: Many studies reported high prevalence of antiphospholipid antibodies (aPL) in patients with COVID-19 raising questions about its true prevalence and its clinical impact on the disease course.

Methods: We conducted a meta-analysis and a systematic review to examine the prevalence of aPL and its clinical impact in patients with COVID-19.

Results: 21 studies with a total of 1159 patients were included in our meta-analysis. Read More

View Article and Full-Text PDF

Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.

Burns 2020 Dec 15. Epub 2020 Dec 15.

Fujian Provincial Key Laboratory of Burn and Trauma, Fujian Burn Institute, Fujian Burn Medical Center, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China. Electronic address:

Background: Patients with severe burns often show systemic coagulation changes in the early stage and even develop extensive coagulopathy. Previous studies have confirmed that soluble TREM-like transcript-1 (sTLT-1) mediates a novel mechanism of haemostasis and thrombosis in inflammatory vascular injury. At present, the role of sTLT-1 in patients with severe burns is not well known. Read More

View Article and Full-Text PDF
December 2020

Utility of preoperative vascular embolization of renal tumors with left renal vein tumor thrombus.

Actas Urol Esp 2021 May 3. Epub 2021 May 3.

Unidad de Tumores Renales con Afectación Venosa (TRAV), Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction And Objectives: Preoperative renal artery embolization (PRAE) for large renal masses may be performed prior to nephrectomy in order to simplify the procedure and reduce intraoperative bleeding. The objective of this work is to determine the role of PRAE on intraoperative bleeding and postoperative complications in left renal tumors with tumor thrombus limited to the left renal vein (level 0).

Material And Methods: Retrospective analysis to evaluate 46 patients who underwent left radical nephrectomy and thrombectomy for the treatment of renal cell carcinoma with level 0 tumor thrombus during the period 1990-2020. Read More

View Article and Full-Text PDF

[Refractory pulmonary edema under ECMO: Is there a place for Rashkind atrioseptotomy?]

Ann Cardiol Angeiol (Paris) 2021 May 3. Epub 2021 May 3.

Service de réanimation médicale, institut de cardiologie, groupe hospitalier Pitié-Salpêtrière, 75651 Paris cedex 13, France.

Hydrostatic pulmonary edema is a well-known complication of veinoarterial extracorporeal membrane oxygenation (VA-ECMO) caused by increased left ventricle afterload due to reverse blood flow in the aorta. Several techniques are commonly used for left ventricle venting such as intra-aortic balloon pump, Impella® (Abiomed, Danvers, MA), central surgical cannulation or Rahskind atrial septostomy. We reported two cases of hydrostatic pulmonary edema in patients under VA-ECMO for whom it was decided to perform Rashkind technique. Read More

View Article and Full-Text PDF

Acute Coronary Tree Thrombosis After Vaccination for COVID-19.

JACC Cardiovasc Interv 2021 May;14(9):e103-e104

3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Silesian Centre for Heart Diseases, Medical University of Silesia, Katowice, Poland.

View Article and Full-Text PDF

ACR Appropriateness Criteria® Renal Failure.

J Am Coll Radiol 2021 May;18(5S):S174-S188

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama, Chair, ACR Appropriateness Committee.

Renal failure can be divided into acute kidney injury and chronic kidney disease. Both are common and result in increased patient morbidity and mortality. The etiology is multifactorial and differentiation of acute kidney injury from chronic kidney disease includes clinical evaluation, laboratory tests, and imaging. Read More

View Article and Full-Text PDF

Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset.

Lupus 2021 May 6:9612033211014248. Epub 2021 May 6.

Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands.

Objective: Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-beta 2-glycoprotein I IgA in SLE versus other rheumatic diseases. Read More

View Article and Full-Text PDF

Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE.

Lupus 2021 May 6:9612033211014570. Epub 2021 May 6.

Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Objectives: Antiphosphatidylserine/prothrombin complex antibodies (aPS/PT) are risk factors for thrombosis, yet further validation of their clinical relevance in different ethnic groups is required. We investigated the performance of aPS/PT of IgA/G/M isotypes among Sudanese and Swedish systemic lupus erythematosus (SLE) patients.

Methods: Consecutive SLE patients/matched controls from Sudan (n = 91/102) and Sweden (n = 332/163) were included. Read More

View Article and Full-Text PDF

Effect of hyperparathyroidism on coagulation: A global assessment by modified rotation thromboelastogram (ROTEM).

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Objective: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium?s effects on parathyroid glands, bone, intestine and kidney, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Read More

View Article and Full-Text PDF

Middle Meningeal Artery Embolization of a Pediatric Patient With Progressive Chronic Subdural Hematoma.

Oper Neurosurg (Hagerstown) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background And Importance: Evidence suggests middle meningeal artery (MMA) embolization benefits adult patients with chronic subdural hematoma (CSDH) at high risk for recurrence or hemorrhagic complications. Yet, there has not been any report discussing MMA embolization in the pediatric population. Thus, we present a case of an infant with CSDH successfully managed with MMA embolization without surgical management. Read More

View Article and Full-Text PDF

A comprehensive comparison of various patient-specific CFD models of the left atrium for atrial fibrillation patients.

Comput Biol Med 2021 Apr 24;133:104423. Epub 2021 Apr 24.

Sección de Cardiología Intervencionista, Servicio de Cardiología, Hospital Universitario de Badajoz, Avda. de Elvas S/n, 06006, Badajoz, Spain.

Background: Recently, advances in medical imaging, segmentation techniques, and high-performance computing have supported the use of patient-specific computational fluid dynamics (CFD) simulations. At present, CFD-compatible atrium geometries can be easily reconstructed from atrium images, providing important insight into the atrial fibrillation (AF) phenomenon, and assistance during therapy selection and surgical procedures. However, the hypothesis assumed for such CFD models should be adequately validated. Read More

View Article and Full-Text PDF

Coil assisted glue embolization to improve safety and accuracy in endovascular management of Vein of Galen patients.

Clin Neurol Neurosurg 2021 Apr 21;205:106652. Epub 2021 Apr 21.

Army Hospital (Referral & Research), Delhi Cantt, New Delhi 110010, India. Electronic address:

Background: Vein of Galen malformation (VOGM) patients present in neonatal age with cardiac failure or significant neurologic consequences. The most established method of treatment has been transarterial embolization with high concentration glue (N-Butyl Cyano Acrylate) which may be difficult to control due to very high flow rates and may migrate to the venous side with undesirable consequences. We describe our experience in four patients in whom initial coil placement in prominent feeding arteries helped inflow reduction thereby facilitating controlled glue injection with a good result and no incidence of non-target embolization. Read More

View Article and Full-Text PDF

Coagulation profile in newly diagnosed T-cell acute lymphoblastic leukemia.

Thromb Res 2021 Apr 19;203:69-71. Epub 2021 Apr 19.

Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China; Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, Zhejiang, China. Electronic address:

View Article and Full-Text PDF

Management of anticoagulation associated reproductive tract bleeding in adolescent and young adult females - Results of a multinational survey.

Thromb Res 2021 Apr 23;203:61-68. Epub 2021 Apr 23.

University of Rochester School of Medicine and the Mary M. Gooley Hemophilia Center, USA.

Introduction: Reproductive tract bleeding (RTB) is an important outcome in menstruating females on anticoagulant therapy (AC). The diagnosis and management of AC-RTB in adolescent and young adult (AYA) females is unknown.

Aims: The aim of this study was to survey the contemporary patterns of diagnosis and management of AC-RTB in AYA females. Read More

View Article and Full-Text PDF

Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine - United States, March-April 2021.

MMWR Morb Mortal Wkly Rep 2021 May 7;70(18):680-684. Epub 2021 May 7.

CDC COVID-19 Response Team.

On February 27, 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for Janssen (Ad.26.COV2. Read More

View Article and Full-Text PDF