44,038 results match your criteria thrombus formation

High-power short-duration vs. standard radiofrequency cardiac ablation: comparative study based on an in-silico model.

Int J Hyperthermia 2021 ;38(1):582-592

Electrical and Electronic Engineering, National University of Ireland Galway, Ireland.

Purpose: While the standard setting during radiofrequency catheter ablation (RFCA) consists of applying low power for long times, a new setting based on high power and short duration (HPSD) has recently been suggested as safer and more effective. Our aim was to compare the electrical and thermal performance of standard vs. HPSD settings, especially to assess the effect of the catheter orientation. Read More

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January 2021

Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.

J Biomech 2021 Mar 26;121:110397. Epub 2021 Mar 26.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address:

Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and crevices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influenced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. Read More

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Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors.

Blood Adv 2021 Apr;5(7):1977-1990

Wellcome-Medical Research Council (MRC) Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Department of Haematology, University of Cambridge, Cambridge, United Kingdom.

The production of in vitro-derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects of the complex challenges to bring this technology to the bedside. We first identify clinical-grade hPSC lines that generate MKs efficiently. Read More

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Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ.

Blood Adv 2021 Apr;5(7):2017-2026

Department of Clinical and Laboratory Medicine and.

There is increasing evidence that platelets participate in multiple pathophysiological processes other than thrombosis and hemostasis, such as immunity, inflammation, embryonic development, and cancer progression. A recent study revealed that heme (hemin)-activated platelets induce macrophage extracellular traps (METs) and exacerbate rhabdomyolysis-induced acute kidney injury (RAKI); however, how hemin activates platelets remains unclear. Here, we report that both C-type lectin-like receptor-2 (CLEC-2) and glycoprotein VI (GPVI) are platelet hemin receptors and are involved in the exacerbation of RAKI. Read More

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Metabolomic profile of patients with left ventricular assist devices: a pilot study.

Ann Cardiothorac Surg 2021 Mar;10(2):240-247

Anesthesia and Intensive Care, IRCCS ISMETT, UPMC Italy, Palermo, Italy.

Background: Metabolomic profiling has important diagnostic and prognostic value in heart failure (HF). We investigated whether left ventricular assist device (LVAD) support has an impact on the metabolomic profile of chronic HF patients and if specific metabolic patterns are associated with the development of adverse events.

Methods: We applied untargeted metabolomics to detect and analyze molecules such as amino acids, sugars, fatty acids and other metabolites in plasma samples collected from thirty-three patients implanted with a continuous-flow LVAD. Read More

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Surgical management for unruptured sinus of Valsalva aneurysms: a narrative review of the literature.

J Thorac Dis 2021 Mar;13(3):1833-1850

Division of Cardiovascular Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

Unruptured sinus of Valsalva aneurysms (SVAs) are rare cardiac lesions that arise due to congenital or acquired etiologies. They could be asymptomatic or cause various clinical manifestations as a consequence of their mass effect on the coronary arteries, heart valves, and other adjacent structures. While the factors predicting SVA rupture are not fully understood, ruptured SVAs carry a high complication and mortality rate, highlighting the need for early recognition and management of unruptured SVAs. Read More

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Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca Signaling Pathway.

Front Pharmacol 2021 22;12:606245. Epub 2021 Mar 22.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

XueShuanTong (XST) comprising therapeutically active ginsenosides, a lyophilized extract of roots, is extensively used in traditional Chinese medicine to treat ischemic heart and cerebrovascular diseases. Our recent study shows that treatment with XST inhibits shear-induced thrombosis formation but the underlying mechanism remained unclear. This study aimed to investigate the hypothesis that XST inhibited shear-induced platelet aggregation via targeting the mechanosensitive Ca-permeable Piezo1 channel by performing platelet aggregation assay, Ca imaging and Western blotting analysis. Read More

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Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients.

Platelets 2021 Apr 11:1-6. Epub 2021 Apr 11.

Rothschild Foundation Hospital, Interventional Neuroradiology Department, Paris, France.

- Immediate reocclusion after mechanical thrombectomy (MT) for acute ischemic stroke (AIS) is a rare but devastating condition associated with poor functional outcome. - The aim of this study was to gain insights into the mechanisms underlying immediate reocclusion, and to evaluate the efficacy and safety of the glycoprotein IIb/IIIa antagonist abciximab, for its treatment. - Clinical data were collected from April 2015 to April 2019 in a monocentric prospective registry of AIS patients treated by MT. Read More

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Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation.

Aging (Albany NY) 2021 Apr 4;13. Epub 2021 Apr 4.

Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

Atherosclerosis (AS)-related diseases remain among the leading causes of death worldwide. Modified Xiaoyaosan (also called Tiaogan-Liqi prescription, TGLQ), a traditional Chinese medical formulation, has been widely applied in the treatment of AS-related diseases. The aim of this study was to investigate the underlying pharmacological mechanisms of TGLQ in acting on AS. Read More

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