74,064 results match your criteria thrombosis hospital

Efficacy and safety of endocrine therapy for breast-cancer prevention in high-risk premenopausal or postmenopausal women: a Bayesian network meta-analysis of nine randomized controlled trials.

Menopause 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical Oncology, Affiliated Hospital of Qinghai University, Xining, China Department of Oncology, Affiliated Hospital of Jining Medical University, Zaozhuang Municipal Hospital, Zaozhuang, China Zaozhuang Vocational College Gucheng Campus, Shandong, China Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.

Importance: Findings in this work might provide certain guidance for current clinical work.

Objective: This study aimed to evaluate the efficacy and safety of these drugs based on the Bayesian network meta-analysis.

Evidence Review: Two researchers systematically and comprehensively searched PubMed, Embase, and the central databases of the Cochrane Library from inception to September 15, 2020. Read More

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Trauma Center Outcomes After Transition From Level 2 to Level 1: A National Trauma Data Bank Analysis.

J Surg Res 2021 Apr 12;264:499-509. Epub 2021 Apr 12.

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Previous US-based studies have shown that a trauma center designation of level 1 is associated with improved patient outcomes. However, most studies are cross-sectional, focus on volume-related issues and are direct comparisons between levels. This study investigates the change in patient characteristics when individual trauma centers transition from level 2 to level 1 and whether the patients have similar outcomes during the initial period of the transition. Read More

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Efficacy and safety of apixaban for primary prevention in gastrointestinal cancers: A post-hoc analysis of the AVERT trial.

Thromb Res 2021 Mar 21;202:151-154. Epub 2021 Mar 21.

Department of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada. Electronic address:

Background: Recent trials have demonstrated that thromboprophylaxis using direct oral anticoagulants is effective but associated with a higher rate of major bleeding in intermediate-to-high risk (Khorana score ≥ 2) patients with cancer initiating systemic chemotherapy. Patients with gastrointestinal cancer may be at higher risk of major bleeding complications. We sought to assess the efficacy and safety of using thromboprophylaxis with apixaban in this patient population. Read More

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Cerebral venous sinus thrombosis and thrombocytopenia after COVID-19 vaccination - a report of two UK cases.

Brain Behav Immun 2021 Apr 12. Epub 2021 Apr 12.

Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK. Electronic address:

Recent reports have highlighted rare, and sometimes fatal, cases of cerebral venous sinus thrombosis (CVST) and thrombocytopenia following the Vaxzevria vaccine. An underlying immunological mechanism similar to that of spontaneous heparin-induced thrombocytopenia (HIT) is suspected, with the identification of antibodies to platelet factor-4 (PF4), but without previous heparin exposure. This unusual mechanism has significant implications for the management approach used, which differs from usual treatment of CVST. Read More

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Plasminogen Activator Inhibitor-1 in poorly controlled vs well controlled Type-2 Diabetes Mellitus patients: A case-control study in a district hospital in Ghana.

PLoS One 2021 15;16(4):e0250090. Epub 2021 Apr 15.

Department of Medical Diagnostics, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Hypofibrinolysis resulting from the up-regulation of plasminogen activator inhibitor-1 (PAI-1) usually occurs in patients with type 2 diabetes mellitus (T2DM), rendering them hypercoagulable. This study assessed the plasma antigen and activity levels of the PAI-1 enzyme in T2DM patients in a district hospital in Ghana.

Methods: This was a hospital-based case-control study conducted from December 2018 to May 2019 at Nkenkaasu District Hospital. Read More

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COVID-19 and Cardiovascular Disease: From Bench to Bedside.

Circ Res 2021 Apr 15;128(8):1214-1236. Epub 2021 Apr 15.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.).

A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. Read More

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GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through preferential interaction with the G allele.

Mol Genet Genomics 2021 Apr 15. Epub 2021 Apr 15.

Department of Cardiology, The People's Hospital of China Three Gorges University, Yichang, 443000, Hubei Province, China.

Myocardial infarction (MI) is a frequent outcome of coronary artery disease (CAD) and the key factor contributing to worldwide disability and death. Genetic factors contribute to the pathogenesis of CAD/MI, and SNP rs6903956 in the ADTRP gene was first found associated with CAD/MI in the Chinese Han population, which was successfully replicated in other cohorts. However, whether rs6903956 is a functional SNP and its risk mechanism to CAD/MI remains unknown. Read More

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Clinical evaluation of retrievable inferior vena cava filters for the prevention of pulmonary thromboembolism.

Heart Vessels 2021 Apr 15. Epub 2021 Apr 15.

Department of Cardiovascular Medicine, Faculty of Medicine Graduate School of Medicine, Toho University, Tokyo, Ota-ku, Japan.

Background And Aims: Inferior vena cava filters (IVCFs) have been reported to cause chronic complications. Recently, retrievable IVCFs (r-IVCF) have been increasingly used to prevent acute pulmonary thromboembolism (PTE) and allow retrieval upon reduction of PTE risk. However, the outcomes of their use in Japan remain unknown. Read More

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Effects of electret coating technology on coronary stent thrombogenicity.

Platelets 2021 Apr 15:1-8. Epub 2021 Apr 15.

Department of Medicine, AtheroThrombosis Research Unit (ATRU), Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Stent thrombosis (ST) is a catastrophic event and efforts to reduce its incidence by altering blood-stent interactions are longstanding. A new electret coating technology that produces long-lasting negative charge on stent surface could make them intrinsically resistant to thrombosis. We assessed the thrombogenicity of stents using an annular perfusion model with confocal microscopy, and determined the efficacy of electret coating technology to confer thrombo-resistant properties to standard stents. Read More

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Simultaneous Bilateral Central Retinal Artery Occlusion following COVID-19 Infection.

Ocul Immunol Inflamm 2021 Apr 15:1-4. Epub 2021 Apr 15.

Bapaye Eye Hospital, Nashik, Maharashtra, India.

: Coronavirus-19 disease (COVID-19) has been associated with a high risk of thrombotic complications. Here, we report the case of a patient who developed simultaneous bilateral retinal artery occlusion following COVID-19 infection.: A 42-year-old male with no systemic co-morbidities presented with sudden, painless loss of vision in both eyes. Read More

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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital.

Brain 2021 Apr 15. Epub 2021 Apr 15.

Department of Pathology and Cell Biology, Division of Neuropathology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, and the New York Presbyterian Hospital, New York, NY, 10032, USA.

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, and molecular findings of 41 consecutive patients with SARS-CoV-2 infections who died and underwent autopsy in our medical center. The mean age was 74 years (38-97 years), 27 patients (66%) were male and 34 (83%) were of Hispanic/Latinx ethnicity. Read More

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Receipt of anticoagulation after venous thromboembolism diagnoses during delivery hospitalizations.

J Matern Fetal Neonatal Med 2021 Apr 15:1-3. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.

Introduction: Obstetric venous thromboembolism (VTE) is a leading cause of maternal mortality. While hospital discharge data provide a readily accessible means of studying this relatively rare outcome, diagnosis codes are of limited validity. Prior studies have demonstrated that VTE billing codes may be subject to misclassification and false positives and overestimate obstetric VTE risk. Read More

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Heparin dosage, level, and resistance in SARS-CoV2 infected patients in intensive care unit.

Int J Lab Hematol 2021 Apr 14. Epub 2021 Apr 14.

Transfusion Center and Haematology Laboratory, Legnano Hospital, ASST Ovest Milanese, Legnano, Italy.

Introduction: Patients with COVID-19 frequently exhibit a hypercoagulable state with high thrombotic risk, particularly those admitted to intensive care units (ICU). Thromboprophylaxis is mandatory in these patients; nevertheless, thrombosis still occurs in many cases. Thus, the problem of assessing an adequate level of anticoagulation in ICU patients becomes evident during the COVID-19 pandemic. Read More

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An unusual cause of prosthetic aortic valve thrombosis detected by multimodality imaging.

Eur Heart J Cardiovasc Imaging 2020 Dec 6. Epub 2020 Dec 6.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.

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December 2020

Incidence and Risk Factors for Venous Thromboembolism Following 2462 Major Abdomino-Pelvic Surgeries in Tertiary Hospital.

Vasc Health Risk Manag 2021 8;17:135-143. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.

Purpose: To determine the incidence and risk factor of postoperative venous thromboembolism (VTE) in Thai populations and to evaluate morbidity, mortality, bleeding complications and the benefit of thromboprophylaxis in real-world practice.

Patients And Methods: We performed a retrospective, single-center, cohort study of patients from all age groups who underwent elective open or laparoscopic major abdomino-pelvic surgery between January 2008 and December 2018 at Chulabhorn Hospital, Bangkok, Thailand. We collected general medical information and specific data based on items from the Caprini risk scoring system. Read More

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Peripherally Inserted Central catheter iNnovation to reduce Infections and Clots (the PICNIC trial): a randomised controlled trial protocol.

BMJ Open 2021 Apr 14;11(4):e042475. Epub 2021 Apr 14.

Royal Brisbane and Woman's Hospital, Metro North Health Service District, Herston, Queensland, Australia.

Introduction: Peripherally inserted central catheters (PICCs) are vital for the delivery of medical therapies, but up to 30% of PICCs are associated with complications such as deep vein thrombosis or infection. The integration of antimicrobial and hydrophobic catheter materials, and pressure-activated valves, into polyurethane PICCs are innovations designed to prevent infective and/or thrombotic complications.

Methods And Analysis: A multicentre, parallel group, superiority randomised controlled trial with two experimental arms ((1) hydrophobic PICC (with pressure-activated valve); (2) chlorhexidine gluconate-impregnated PICC (with external clamp)) and one control group ((3) conventional polyurethane PICC (with external clamp)). Read More

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The effectiveness and safety of LMWH for preventing thrombosis in patients with spinal cord injury: a meta-analysis.

J Orthop Surg Res 2021 Apr 14;16(1):262. Epub 2021 Apr 14.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road. 1277#, Wuhan, 430022, Hubei, P. R. China.

Background: Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are commonly used for preventing venous thrombosis of the lower extremity in patients with traumatic spinal cord injury. Although, LMWH is the most commonly used drug, it has yet to be established whether it is more effective and safer than UFH. Further, a comparison of the effectiveness of LMWH in preventing thrombosis at different locations and different degrees of spinal cord injury has also not been clearly defined. Read More

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Comparing the efficacy of endovascular treatment for iliac vein compression syndrome with or without acute deep venous thrombosis: A single-center retrospective study.

Vascular 2021 Apr 14:17085381211003776. Epub 2021 Apr 14.

Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, China.

Background: To compare the efficacy of endovascular treatment for iliac vein compression syndrome (IVCS) with or without acute deep venous thrombosis of lower extremity.

Methods: This study retrospectively analyzed the clinical data of 300 IVCS patients, who received endovascular treatment between January 2013 and December 2017. According to whether IVCS was complicated by deep venous thrombosis or not, these patients were divided into non-thrombotic iliac vein lesion group (NIVL group,  = 127) and post-thrombotic iliac vein lesion group (PIVL group,  = 173). Read More

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Occult Hepatocellular Carcinoma Associated with Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients.

Liver Transpl 2021 Apr 14. Epub 2021 Apr 14.

Hospital of the University of Pennsylvania, Department of Surgery, Philadelphia, PA, USA.

Introduction: Transplant eligibility for hepatocellular carcinoma (HCC) is determined by the imaging identification of tumor burden within Milan criteria. Transjugular intrahepatic portosystemic shunts (TIPS) reduce portal hypertension but may impact HCC visualization. It was hypothesized that the presence of pre-transplant TIPS would correlate with occult HCC and reduced survival. Read More

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Atrial fibrillation and comorbidities: Clinical characteristics and antithrombotic treatment in GLORIA-AF.

PLoS One 2021 14;16(4):e0249524. Epub 2021 Apr 14.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Background: Patients with AF often have multimorbidity (the presence of ≥2 concomitant chronic conditions).

Objective: To describe baseline characteristics, patterns of antithrombotic therapy, and factors associated with oral anticoagulant (OAC) prescription in patients with AF and ≥2 concomitant, chronic, comorbid conditions.

Methods: Phase III of the GLORIA-AF Registry enrolled consecutive patients from January 2014 through December 2016 with recently diagnosed AF and CHA2DS2-VASc score ≥1 to assess the safety and effectiveness of antithrombotic treatment. Read More

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Catastrophic antiphospholipid syndrome presenting with aortic barrage: case report and review of the literature.

Lupus 2021 May;30(6):1005-1009

Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Hospital, Milano, Italy.

Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition characterized by multiple thromboembolic events occurring in a short period of time, frequently accompanied by significant systemic inflammation. Aortic involvement is rare in antiphospholipid syndrome and it had been never described in the context of its catastrophic variant. Here, we report an unusual case of aortic occlusion as a debut manifestation of CAPS and discuss its clinical features with an up-to-date review of the literature to identify risk factors and clues for clinical practice. Read More

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Pterostilbene, a Dimethylether Analogue of Resveratrol, Possesses High Potency in the Prevention of Platelet Activation in Humans and the Reduction of Vascular Thrombosis in Mice.

J Agric Food Chem 2021 Apr 14. Epub 2021 Apr 14.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.

Platelets play a crucial role in cardiovascular disorders (CVDs); thus, development of a therapeutic target that prevents platelet activation reduces CVDs. Pterostilbene (PTE) has several remarkable pharmacological activities, including anticancer and neuroprotection. Herein, we examined the inhibitory mechanisms of PTE in human platelets and its role in the prevention of vascular thrombosis in mice. Read More

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Development of bilateral subdural hematoma after endovascular embolization of a dural sinus malformation.

Childs Nerv Syst 2021 Apr 14. Epub 2021 Apr 14.

School of Medicine& School of Clinical Medicine, Tsinghua University, Beijing, China.

Introduction: Dural sinus malformation is a rare congenital malformation characterized by a remarkable dilated dural sinus pouch. We described the development of bilateral subdural hematoma after endovascular embolization of a dural sinus malformation in an infant.

Case Description: A 32-day male infant was observed to have a fever and enlarged head circumference. Read More

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

JAMA Surg 2021 Apr 14:e210884. Epub 2021 Apr 14.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany.

Importance: Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.

Objective: To examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.

Data Source: Cochrane Central Register of Controlled Trials and MEDLINE were searched for eligible studies investigating intravenous TXA and postinterventional outcome published between 1976 and 2020. Read More

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Management of primary immune thrombocytopenia in a real-world setting in Japan: eltrombopag versus corticosteroids.

Int J Hematol 2021 Apr 13. Epub 2021 Apr 13.

Department of Blood Transfusion, Osaka University Hospital, Suita, Osaka, Japan.

This real-world study in Japan assessed the long-term safety of persistent use of eltrombopag compared to corticosteroids. Overall, 1887 patients with primary immune thrombocytopenia were included in the study cohort, based on hospital claims data. Eltrombopag was frequently used as a second- or third-line therapy (monotherapy: 13. Read More

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Aortic valve endocarditis by and oral pathogens.

IDCases 2021 19;24:e01079. Epub 2021 Mar 19.

Zucker School of Medicine at Hofstra Northwell, Department of Internal Medicine, Lenox Hill Hospital New York, New York, United States.

A 56-year-old female with a history of poor dental hygiene and aortic insufficiency status post aortic valve replacement in 2015 presented with chest pain and fevers. She was found to have portal vein thrombosis, colitis, and infective endocarditis with aortic valve thickening. Blood cultures were positive for and Transesophageal echocardiogram was positive for aortic root thickening. Read More

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-Related Infections and their Significance: A 9-Year Retrospective Study.

J Microsc Ultrastruct 2021 Jan-Mar;9(1):18-25. Epub 2020 Nov 9.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.

Introduction: is a Gram-positive, catalase- and oxidase-negative, microaerophilic, nonmotile bacteria species rarely associated with human infections such as arthritis, bacteremia, endocarditis, and meningitis. The bacteria are also often confused with streptococci species or treated as a contaminant.

Patients And Methodology: We conducted a retrospective, observational cohort study on all patients with isolates in blood samples from July 2010 to June 2019. Read More

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November 2020

Thrombotic Microangiopathy Associated with Pazopanib in a Kidney Transplant Recipient.

J Kidney Cancer VHL 2021 24;8(1):25-31. Epub 2021 Mar 24.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Thrombotic microangiopathy (TMA) is characterised by abnormalities in the walls of arterioles and capillaries, precipitated by hereditary or acquired characteristics, and culminating in microvascular thrombosis because of dysregulated complement activity. A number of drugs can precipitate TMA, including vascular endothelial growth factor (VEGF) inhibitors, because of their effects on endothelial repair. Pazopanib is a VEGF inhibitor used for the treatment of renal cell carcinoma (RCC); it is uncommonly associated with TMA. Read More

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Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population.

Sci Rep 2021 Apr 13;11(1):8050. Epub 2021 Apr 13.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.

Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD). In this study, we investigated the relationship between MIF gene polymorphism and CAD in Chinese Han population. Three single nucleotide polymorphisms (SNP, rs755622, rs1007888 and rs2096525) of MIF gene were genotyped by TaqMan genotyping assay in 1120 control participants and 1176 CAD patients. Read More

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The effect of deep vein thrombosis on major adverse limb events in diabetic patients: a nationwide retrospective cohort study.

Sci Rep 2021 Apr 13;11(1):8082. Epub 2021 Apr 13.

Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 6, Sec. West Chai-Pu Road, Pu-TZ City, 61363, Chiayi, Taiwan.

Little is known about the association between deep vein thrombosis (DVT) and arterial complications in patients with type 2 diabetes (T2DM). The aim of this retrospective cohort study was to assess the influence of prior DVT on major adverse limb events (MALEs) and major adverse cardiovascular events (MACEs) in T2DM. A total of 1,628,675 patients with T2DM with or without a history of DVT from 2001 to 2013 were identified in the National Health Insurance Research Database of Taiwan. Read More

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