33,304 results match your criteria thrombolytic therapy

Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, 875 Monroe Avenue, Wittenborg Bldg, Room-231, Memphis, TN, 38163, USA.

Thrombolytic therapy has remained quite challenging in hyperglycemic patients for its association with poor prognosis and increased hemorrhagic conversions. We recently showed that tissue plasminogen activator (tPA)-induced cerebrovascular damage is associated with thioredoxin-interacting protein (TXNIP) upregulation, which has an established role in the detrimental effects of hyperglycemia. In the present work, we investigated whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption. Read More

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Multiple arterial and venous thromboembolism in a male patient with hereditary protein C deficiency: A case report.

Medicine (Baltimore) 2021 Apr;100(15):e25575

Department of Vascular Surgery, The Second Xiangya Hospital of Central South University.

Rationale: Hereditary protein C deficiency has a high prevalence in Asian populations, being the important risk factor associated with thrombophilia. Traditionally, conservative medication is the first choice for patients with hereditary protein C deficiency. However, there are few reports on whether aggressive surgical treatment can be performed when patients continue to develop life-threatening ischemic symptoms after adequate anticoagulant and thrombolytic therapy. Read More

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Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):65-67. Epub 2021 Apr 8.

Vascular Surgery Department- Hospital da Senhora da Oliveira, Guimarães; Portugal.

Catheter directed thrombolysis is a minimally invasive procedure that results in a significant reduction in venous obstruction after deep vein thrombosis. The technique implies the performance of phlebographies to monitor the thrombolysis progression. The objective of this paper is to describe the use of vascular ultrasound to follow the thrombus lysis and to adjust the catheter position according to the progression of the thrombolysis. Read More

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A case of acute cerebral infarction with a favorable prognosis after rt-PA administration by a general physician with telestroke support.

J Rural Med 2021 Apr 1;16(2):119-122. Epub 2021 Apr 1.

Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Japan.

Herein, we report a patient with acute cerebral infarction with a favorable prognosis after being managed by a general physician with support from the telestroke program. An 85-year-old man was transferred to a regional hospital due to sudden onset of dysarthria and left hemiparesis. As no neurosurgeons or neurologists were available in that hospital or area, the patient was examined by a general physician who diagnosed him with cardioembolic stroke on the left middle cerebral artery territory. Read More

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Exercise Self-efficacy, Perceived Benefits, and Barriers to Exercise Among Patients Following Acute Myocardial Infarction.

J Cardiovasc Nurs 2021 Apr 6. Epub 2021 Apr 6.

Abedalmajeed Shajrawi, PhD, MSN, BSN Assistant Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan. Heba Khalil, PhD, BSN Assistant Professor, Faculty of Health Sciences, Higher Colleges of Technology-Fujairah Women's Campus, Fujairah, United Arab Emirates. Raghad Abdel Qader, PhD, BSN Associate Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan. Manal Al-Sutry, PhD, BSN Assistant Professor, Faculty of Nursing, Jeddah University, Jeddah, Kingdom of Saudi Arabia. Mohannad Abu Al-Ruz, PhD, BSN Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan.

Background: Increasing patient adherence to regular exercise post acute myocardial infarction (AMI) is a major goal after hospitalization. It is therefore essential to identify perceived benefits and barriers to exercise and its association with exercise self-efficacy among patients post AMI.

Aims: The purpose of this study was to identify the perceived benefits and barriers to exercise and the predictors of exercise self-efficacy among patients after AMI. Read More

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Management of Acute Pulmonary Embolism With a Pulmonary Embolism Response Team.

J Am Board Fam Med 2021 Mar-Apr;34(2):402-408

From the Division of Cardiology, Yale University, New Haven, CT (JC); Division of Cardiology, Medical College of Georgia at the Augusta University Medical Center (VA); and the Department of Family Medicine, Medical College of Georgia at the Augusta University Medical Center, Augusta (TW).

Despite recent advances in the assessment, risk stratification, and treatment of acute pulmonary embolism (PE), it remains a leading cause of cardiovascular morbidity and mortality in the United States each year. Patient presentation and prognosis are heterogeneous, and a variety of diagnostic and therapeutic instruments have arisen to assist in providing patients with the appropriate level of care and aggressiveness of approach. Fortunately, a growing number of institutions now have pulmonary embolism response teams (PERT) that urgently assist with risk assessment and management of patients with massive and sub-massive PE. Read More

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Treatment challenges in patients with early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25371

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery is one of the most fatal surgical complications. It is often accompanied by shock and hypotension, with high mortality rate. Due to surgical wounds, patients with early acute massive PTE after lung cancer surgery have a high risk of thrombolytic bleeding, which renders treatment more challenging and there is currently no standard protocol on how to safely and effectively treat these patients in the clinic. Read More

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[Catheter-directed thrombolysis in iliofemoral thrombosis and aplasia of the inferior vena cava].

Angiol Sosud Khir 2021 ;27(1):91-95

Department of Surgery #3, Alexandrovskaya Hospital, Saint Petersburg, Russia.

Demonstrated in the article are the results of catheter-directed thrombolysis in a male patient presenting with bilateral acute iliofemoral venous thrombosis on the background of aplasia of the inferior vena cava. The incidence rate of this pathology is specified, with an emphasis on no recommendations on choosing optimal therapeutic strategy in this cohort of patients. The main causes and complications of the disease are described. Read More

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[Efficacy of apixaban in prevention of haemorrhagic complications in treatment of deep vein thromboses with endovascular techniques].

Angiol Sosud Khir 2021 ;27(1):33-38

Department of X-ray Surgical Methods of Diagnosis and Treatment, Orel Regional Clinical Hospital, Orel, Russia.

Purpose: This study was undertaken to investigate efficacy of apixaban in prevention of haemorrhagic complications during treatment of proximal thromboses of deep veins of the lower extremities using endovascular techniques.

Patients And Methods: We retrospectively studied the results of treating a total of 50 patients presenting with deep vein thromboses at late stages of the pathological process. The patients were subdivided into 2 statistically homogeneous groups. Read More

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Efficacy of intra-arterial thrombolytic therapy for vision loss resulting from hyaluronic acid filler embolization.

J Cosmet Dermatol 2021 Apr 6. Epub 2021 Apr 6.

Department of Burns and Plastic Surgery of The Forth Medical Center of Chinese, PLA General Hospital.

Background: The incidence of hyaluronic acid (HA) embolism has increased markedly in recent years. HA embolism can lead to serious complications such as blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. However, there is a lack of robust clinical evidence regarding the benefits of treatment of HA embolism with intra-arterial thrombolytic therapy (IATT). Read More

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Decade-Long Nationwide Trends and Disparities in Use of Comfort Care Interventions for Patients With Ischemic Stroke.

J Am Heart Assoc 2021 Apr 7:e019785. Epub 2021 Apr 7.

Center for Outcomes Research Houston Methodist Houston TX.

Background Stroke remains one of the leading causes of disability and death in the United States. We characterized 10-year nationwide trends in use of comfort care interventions (CCIs) among patients with ischemic stroke, particularly pertaining to acute thrombolytic therapy with intravenous tissue-type plasminogen activator and endovascular thrombectomy, and describe in-hospital outcomes and costs. Methods and Results We analyzed the National Inpatient Sample from 2006 to 2015 and identified adult patients with ischemic stroke with or without thrombolytic therapy and CCIs using validated ( codes. Read More

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In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d.

Michael D Hill

Ann Intern Med 2021 Apr 6. Epub 2021 Apr 6.

University of Calgary and Hotchkiss Brain Institute & Foothills Medical Centre, Calgary, Alberta, Canada (M.D.H.).

Source Citation: Thomalla G, Boutitie F, Ma H, et al. Lancet. 2020;396:1574-84. Read More

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Opium Addiction and Correlation with Early and Six-month Outcomes of Presenting with ST Elevation Myocardial Infarction Treated Initially with Thrombolytic Therapy.

Am J Cardiovasc Dis 2021 15;11(1):115-123. Epub 2021 Feb 15.

University of Arizona Department of Medicine Tucson, AZ, USA.

Background: Myocardial infarction is one of the most important causes of mortality worldwide. The role of opium addiction in the outcome of myocardial infarction is not known with many unproven beliefs surrounding it. This study was designed to evaluate the effects of opium addiction on in-hospital and six-month outcomes of patients presenting with ST elevation myocardial infarction (STEMI). Read More

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February 2021

Impact of COVID-19 on the rate of stroke cases at a tertiary hospital in Makkah, Saudi Arabia.

Neurosciences (Riyadh) 2021 Apr;26(2):158-162

From the Department of Neurology (Samkari, Alkhotani), King Abdullah Medical City, from the Department of Community Medicine (Siddiqui), and from the Department of Medicine (Alkhotani), Umm AlQura University, Makkah, Kingdom of Saudi Arabia.

Objectives: To assess and quantify the impact COVID-19 has had thus far on ischemic stroke admission rate and severity (National Institutes of Health Stroke Scale (NIHSS) score) at a single tertiary center in Makkah, Saudi Arabia.

Methods: This is a retrospective analysis performed on admitted cases with definitive final diagnoses of transient ischemic attack (TIA) and ischemic stroke at King Abdullah Medical City in Makkah between January 1, 2020 and July 2020.

Results: Sixty-nine patients were included in our study, 41 of whom presented at our facility before the pandemic and 29 during the pandemic. Read More

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Microbubbles Mimicking Prosthetic Mitral Valve Thrombosis.

J Invasive Cardiol 2021 Apr;33(4):E317

Assistant Prof/Consultant Interventional Cardiologist, Sultan Qaboos University Hospital, Muscat, Oman.

A 36-year-old woman with a history of redo mitral valve replacement (bileaflet mechanical mitral valve prosthesis) in 2002 for prosthetic mitral valve endocarditis presented to the emergency department with a history of recurrent palpitations. A transthoracic echocardiogram was performed and falsely indicated a diagnosis of prosthetic mitral valve thrombosis. However, review of the echocardiogram by an experienced echocardiologist revised the diagnosis to microbubbles formation phenomenon with mechanical mitral prosthesis. Read More

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Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation.

Front Neurol 2021 15;12:593582. Epub 2021 Mar 15.

Department of Physiology and Neuroscience, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, United States.

Ischemic stroke is the most widespread cause of disability and a leading cause of death in developed countries. To date, the most potent approved treatment for acute stroke is recanalization therapy with thrombolytic drugs such as tissue plasminogen activator (rt-PA or tPA) or endovascular mechanical thrombectomy. Although tPA and thrombectomy are widely available in the United States, it is currently estimated that only 10-20% of stroke patients get tPA treatment, in part due to restrictive selection criteria. Read More

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Midterm Prognosis of Patients With Pulmonary Embolism Receiving Catheter-Directed Thrombolysis or Systemic Thrombolysis: A Nationwide Population-Based Study.

J Am Heart Assoc 2021 Apr 31;10(7):e019296. Epub 2021 Mar 31.

Division of Cardiology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan.

Background This study compared the efficacy and safety between catheter-directed thrombolysis (CDT) and systemic thrombolysis for patients with acute pulmonary embolism (PE) with midterm follow-up. Methods and Results We conducted a prospective open cohort study by using data from the Taiwan National Health Insurance Research Database for 2001 to 2013. Patients who were first admitted for PE and were treated by either systemic thrombolysis or CDT were included and compared. Read More

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Thrombolysis Combined Therapy Using CuS@SiO-PEG/uPA Nanoparticles.

Front Chem 2021 11;9:643411. Epub 2021 Mar 11.

Department of Vascular Surgery, The Second People's Hospital of Anhui, Province, Hefei, China.

Massive hemorrhage caused by the uncontrolled release of thrombolysis drugs is a key issue of thrombolysis therapy in clinical practice. In this study, we report a near-infrared (NIR) light-triggered drug delivery system, i.e. Read More

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Tube feeding predictors after ischemic hemispheric stroke during hospitalization.

Logoped Phoniatr Vocol 2021 Mar 29:1-6. Epub 2021 Mar 29.

Department of Health Sciences, Speech-Language Pathology Department, Universidade Federal de Santa Catarina, Florianopolis, Brazil.

Purpose: To verify the factors associated with the need of tube feeding (TF) during patients post-ischemic stroke hospitalization.

Method: This is a retrospective study with 70 adult post-ischemic hemispheric stroke adult patients hospitalized in the Neurology department at a tertiary public hospital in Santa Catarina, Brazil. We investigated associations between the need of a feeding tube during hospitalization and the variables age, gender, admission and discharge NIHSS and FOIS, length of hospital stay in days, presence of thrombolytic therapy, extensive stroke, hemisphere affected, prior stroke, pneumonia during hospitalization, presence of signs of laryngeal penetration and laryngotracheal aspiration and dysphagia in the first and last swallowing clinical evaluation. Read More

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Thrombolytic Therapy for 'Wake-Up Stroke' - A Systematic Review and Meta-Analysis.

Eur J Neurol 2021 Mar 26. Epub 2021 Mar 26.

Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Introduction: According to evidence-based clinical practice guidelines, patients presenting with disabling stroke symptoms should be treated with intravenous tissue plasminogen activator (IV tPA) within 4.5 hours of time last known well. However, 25% of strokes are detected upon awakening ('wake-up strokes'; WUS) which renders patients ineligible for IV tPA administered via time-based treatment algorithms because it is impossible to establish a reliable time of symptom onset. Read More

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Low-dose urokinase thrombolytic therapy for patients with acute intermediate-high-risk pulmonary embolism: A retrospective cohort study.

PLoS One 2021 26;16(3):e0248603. Epub 2021 Mar 26.

Department of Otorhinolaryngology, Fujian Provincial Hospital, The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.

Introduction: Patients at intermediate-high risk of developing a pulmonary embolism (PE) are very likely to experience adverse outcomes, such as cardiovascular instability and death. The role of thrombolytic therapy in intermediate-high-risk PE remains controversial.

Objectives: This study aimed to determine the efficacy and safety of low-dose urokinase (UK) thrombolytic therapy for intermediate-high-risk PE. Read More

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Hyperdense middle cerebral artery sign in large cerebral infarction.

Brain Behav 2021 Mar 25:e02116. Epub 2021 Mar 25.

Department of Radiology, General Hospital of Northern Theater Command, Shenyang, China.

Objectives: To evaluate if the hyperdense middle cerebral artery sign (HMCAS) is an imaging biomarker for hemorrhagic transformation (HT) and the functional outcome of patients with large cerebral infarctions without thrombolytic therapy.

Materials And Methods: The clinical and imaging data of 312 patients with large cerebral infarction without thrombolytic therapy were retrospectively analyzed. They were divided into patients who presented with HMCAS (n = 121) and those who did not (non-HMCAS[n = 168] patients), and the clinical data of the 2 groups were compared. Read More

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Does thrombolysis for pulmonary embolism reduce the risk of chronic complications?

Acute Med 2021 ;20(1):15-17

Acute Internal Medicine, East Surrey Hospital, Surrey and Sussex Healthcare National Health Service Trust, Redhill.

We assessed the efficacy of thrombolysis in avoiding long-term complications. Notes of patients thrombolysed for PE in the 2-year period were reviewed. The initial CTPA and echocardiogram results before thrombolysis were compared to the results of follow up imaging repeated after 6 months. Read More

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The use of intrapleural thrombolytic and/or fibrinolytic therapy via indwelling tunneled pleural catheters with or without concurrent anticoagulation usage.

Chest 2021 Mar 18. Epub 2021 Mar 18.

Thoracic Surgery and Interventional Pulmonology, Swedish Cancer Institute, Seattle, WA.

Background: Indwelling tunneled pleural catheters are commonly used for recurrent pleural effusion management. Catheter obstruction is not uncommon, often requiring intrapleural medications instillation (i.e. Read More

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Should We Use Expired Drugs When Necessary?

J Emerg Med 2021 Mar 18. Epub 2021 Mar 18.

Department of Emergency Medicine, The University of Arizona, Tucson, Arizona.

Background: Medication shortages commonly occur in resource-poor settings. The relatively short expiry dates on many medications exacerbate these shortages, often requiring clinicians to choose between providing needed medications to the patient and violating rules governing drug dispensing.

Case Report: A patient presented to an emergency department in a resource-poor setting with an acute anterior myocardial infarction. Read More

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