198,031 results match your criteria thrombolytic

Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, 875 Monroe Avenue, Wittenborg Bldg, Room-231, Memphis, TN, 38163, USA.

Thrombolytic therapy has remained quite challenging in hyperglycemic patients for its association with poor prognosis and increased hemorrhagic conversions. We recently showed that tissue plasminogen activator (tPA)-induced cerebrovascular damage is associated with thioredoxin-interacting protein (TXNIP) upregulation, which has an established role in the detrimental effects of hyperglycemia. In the present work, we investigated whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption. Read More

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Multiple arterial and venous thromboembolism in a male patient with hereditary protein C deficiency: A case report.

Medicine (Baltimore) 2021 Apr;100(15):e25575

Department of Vascular Surgery, The Second Xiangya Hospital of Central South University.

Rationale: Hereditary protein C deficiency has a high prevalence in Asian populations, being the important risk factor associated with thrombophilia. Traditionally, conservative medication is the first choice for patients with hereditary protein C deficiency. However, there are few reports on whether aggressive surgical treatment can be performed when patients continue to develop life-threatening ischemic symptoms after adequate anticoagulant and thrombolytic therapy. Read More

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Improvement in plasma D-dimer level in severe SARS-CoV-2 infection can be an indicator of fibrinolysis suppression: Case reports.

Medicine (Baltimore) 2021 Apr;100(15):e25255

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Rationale: Fibrinolysis shutdown associated with severe thrombotic complications is a recently recognized syndrome that was previously seldom investigated in patients with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It presents a unique therapeutic dilemma, as anticoagulation with heparin alone is insufficient to address the imbalance in fibrinolysis. And while the use of fibrinolytic agents could limit the disease severity, it is often associated with bleeding complications. Read More

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[Inferior vena cava agenesis presenting as deep vein thrombosis. Report of one case].

Rev Med Chil 2020 Dec;148(12):1833-1837

Hospital San Martín de Quillota, Quillota, Chile.

Abnormalities of the inferior vena cava are rare. Its embryological development occurs between the sixth and eighth week of gestation and depends on the persistence or regression of three pairs of veins: the posterior cardinal veins, the subcardinal veins and the supracardinal veins. The type of congenital alteration depends on the moment that embryogenesis is altered. Read More

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December 2020

Targeted delivery of thrombolytic enzymes.

Young M Kwon

Bioimpacts 2021 29;11(2):85-86. Epub 2020 Oct 29.

Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Nova Southeastern University 3200 S. University Dr. Fort Lauderdale, FL 33328.

Although thrombolytic agents have been used for several decades in the treatment of thromboembolic conditions, there is an unmet need for the development of safer thrombolytic agents. The development of new molecules themselves may not be sufficient. This has sparked a growing interest in the design of novel nanoscale drug carrier systems for the delivery of thrombolytic enzymes in an effort to address its fatal side effects. Read More

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October 2020

[Factor Xa inhibitors - equivalent to low molecular weight heparin for the treatment of cancer-associated venous thromboembolism].

Lakartidningen 2021 Apr 8;118. Epub 2021 Apr 8.

ST-läkare,, internmedicin, Gävle sjukhus, Centrum för forskning och utveckling, Uppsala universitet/ Region Gävleborg.

Venous thromboembolism (VTE) is a common cause of morbidity and mortality in cancer patients. Cancer-associated VTE has an increased risk of recurrence and often cancer confers an increased risk of bleeding, which complicates treatment with anticoagulation. Traditionally, patients with cancer-associated VTE was treated with low molecular weight heparin (LMH). Read More

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Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):65-67. Epub 2021 Apr 8.

Vascular Surgery Department- Hospital da Senhora da Oliveira, Guimarães; Portugal.

Catheter directed thrombolysis is a minimally invasive procedure that results in a significant reduction in venous obstruction after deep vein thrombosis. The technique implies the performance of phlebographies to monitor the thrombolysis progression. The objective of this paper is to describe the use of vascular ultrasound to follow the thrombus lysis and to adjust the catheter position according to the progression of the thrombolysis. Read More

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Thrombolytic strategies for ischemic stroke in the thrombectomy era.

J Thromb Haemost 2021 Apr 9. Epub 2021 Apr 9.

Normandie Univ, UNICAEN, INSERM, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000, Caen, France.

Twenty-five years ago, intravenous thrombolysis has revolutionized the care of patients with acute ischemic stroke. Since 2015, randomized clinical trials have demonstrated that mechanical thrombectomy improves functional outcome in stroke patients over intravenous thrombolysis alone. More recently, three randomized clinical trials have suggested that mechanical thrombectomy alone is non-inferior to a combined strategy with both intravenous thrombolysis and mechanical thrombectomy. Read More

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A case of acute cerebral infarction with a favorable prognosis after rt-PA administration by a general physician with telestroke support.

J Rural Med 2021 Apr 1;16(2):119-122. Epub 2021 Apr 1.

Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Japan.

Herein, we report a patient with acute cerebral infarction with a favorable prognosis after being managed by a general physician with support from the telestroke program. An 85-year-old man was transferred to a regional hospital due to sudden onset of dysarthria and left hemiparesis. As no neurosurgeons or neurologists were available in that hospital or area, the patient was examined by a general physician who diagnosed him with cardioembolic stroke on the left middle cerebral artery territory. Read More

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Exercise Self-efficacy, Perceived Benefits, and Barriers to Exercise Among Patients Following Acute Myocardial Infarction.

J Cardiovasc Nurs 2021 Apr 6. Epub 2021 Apr 6.

Abedalmajeed Shajrawi, PhD, MSN, BSN Assistant Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan. Heba Khalil, PhD, BSN Assistant Professor, Faculty of Health Sciences, Higher Colleges of Technology-Fujairah Women's Campus, Fujairah, United Arab Emirates. Raghad Abdel Qader, PhD, BSN Associate Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan. Manal Al-Sutry, PhD, BSN Assistant Professor, Faculty of Nursing, Jeddah University, Jeddah, Kingdom of Saudi Arabia. Mohannad Abu Al-Ruz, PhD, BSN Professor, Faculty of Nursing, Applied Science Private University, Amman, Jordan.

Background: Increasing patient adherence to regular exercise post acute myocardial infarction (AMI) is a major goal after hospitalization. It is therefore essential to identify perceived benefits and barriers to exercise and its association with exercise self-efficacy among patients post AMI.

Aims: The purpose of this study was to identify the perceived benefits and barriers to exercise and the predictors of exercise self-efficacy among patients after AMI. Read More

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Management of Acute Pulmonary Embolism With a Pulmonary Embolism Response Team.

J Am Board Fam Med 2021 Mar-Apr;34(2):402-408

From the Division of Cardiology, Yale University, New Haven, CT (JC); Division of Cardiology, Medical College of Georgia at the Augusta University Medical Center (VA); and the Department of Family Medicine, Medical College of Georgia at the Augusta University Medical Center, Augusta (TW).

Despite recent advances in the assessment, risk stratification, and treatment of acute pulmonary embolism (PE), it remains a leading cause of cardiovascular morbidity and mortality in the United States each year. Patient presentation and prognosis are heterogeneous, and a variety of diagnostic and therapeutic instruments have arisen to assist in providing patients with the appropriate level of care and aggressiveness of approach. Fortunately, a growing number of institutions now have pulmonary embolism response teams (PERT) that urgently assist with risk assessment and management of patients with massive and sub-massive PE. Read More

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Biomarkers for the diagnosis of sepsis-associated acute kidney injury: systematic review and meta-analysis.

Ann Palliat Med 2021 Mar 22. Epub 2021 Mar 22.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: With the development of new techniques, blood and other humoral biomarkers have become increasingly important in the diagnosis of sepsis-associated acute kidney injury (AKI). We aimed to review and summarize the biomarkers associated with the diagnosis of sepsis-associated AKI.

Methods: We performed a systematic review in PubMed, Embase, Web of Science, Cochrane and CNKI literature databases. Read More

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Treatment challenges in patients with early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25371

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Early acute massive pulmonary thrombosis embolism (PTE) after lung cancer surgery is one of the most fatal surgical complications. It is often accompanied by shock and hypotension, with high mortality rate. Due to surgical wounds, patients with early acute massive PTE after lung cancer surgery have a high risk of thrombolytic bleeding, which renders treatment more challenging and there is currently no standard protocol on how to safely and effectively treat these patients in the clinic. Read More

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Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke.

Sci Transl Med 2021 Apr;13(588)

NoNO Inc., Toronto, Ontario M5V 1E7, Canada.

Neuroprotection for acute ischemic stroke is achievable with the eicosapeptide nerinetide, an inhibitor of the protein-protein interactions of the synaptic scaffolding protein PSD-95. However, nerinetide is subject to proteolytic cleavage if administered after alteplase, a standard-of-care thrombolytic agent that nullifies nerinetide's beneficial effects. Here, we showed, on the basis of pharmacokinetic data consistent between rats, primates, and humans, that in a rat model of embolic middle cerebral artery occlusion (eMCAO), nerinetide maintained its effectiveness when administered before alteplase. Read More

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Study on the activity of recombinant mutant tissue-type plasminogen activator fused with the C-terminal fragment of hirudin.

J Thromb Thrombolysis 2021 Apr 7. Epub 2021 Apr 7.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

In the present study, bifunctional fusion proteins were designed by fusing the kringle 2 and protease domains of tissue-type plasminogen activator (tPA) to the C-terminal fragment of hirudin. The thrombolytic and anticoagulant activities of these recombinant proteins from mammalian cells were investigated using in vitro coagulation models and chromogenic assays. The results showed that all assayed tPA mutants retained catalytic activity. Read More

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[Catheter-directed thrombolysis in iliofemoral thrombosis and aplasia of the inferior vena cava].

Angiol Sosud Khir 2021 ;27(1):91-95

Department of Surgery #3, Alexandrovskaya Hospital, Saint Petersburg, Russia.

Demonstrated in the article are the results of catheter-directed thrombolysis in a male patient presenting with bilateral acute iliofemoral venous thrombosis on the background of aplasia of the inferior vena cava. The incidence rate of this pathology is specified, with an emphasis on no recommendations on choosing optimal therapeutic strategy in this cohort of patients. The main causes and complications of the disease are described. Read More

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[Efficacy of apixaban in prevention of haemorrhagic complications in treatment of deep vein thromboses with endovascular techniques].

Angiol Sosud Khir 2021 ;27(1):33-38

Department of X-ray Surgical Methods of Diagnosis and Treatment, Orel Regional Clinical Hospital, Orel, Russia.

Purpose: This study was undertaken to investigate efficacy of apixaban in prevention of haemorrhagic complications during treatment of proximal thromboses of deep veins of the lower extremities using endovascular techniques.

Patients And Methods: We retrospectively studied the results of treating a total of 50 patients presenting with deep vein thromboses at late stages of the pathological process. The patients were subdivided into 2 statistically homogeneous groups. Read More

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[Randomized study of tolerability, safety and efficacy of Pletax in intermittent claudication].

Angiol Sosud Khir 2021 ;27(1):7-16

Therapeutic Department #11, Municipal Clinical Hospital #23, Moscow, Russia.

Aim: This study was aimed at assessing tolerability, safety and therapeutic efficacy of Pletax® (cilostazol) compared with Trental® (pentoxifylline) in patients with moderate-to-severe intermittent claudication.

Patients And Methods: The study included a total of one hundred 40-to-65-year-old patients presenting with confirmed diagnosis of moderate-to-severe intermittent claudication. Depending on the therapeutic regimen, the patients were divided into two groups. Read More

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Efficacy of intra-arterial thrombolytic therapy for vision loss resulting from hyaluronic acid filler embolization.

J Cosmet Dermatol 2021 Apr 6. Epub 2021 Apr 6.

Department of Burns and Plastic Surgery of The Forth Medical Center of Chinese, PLA General Hospital.

Background: The incidence of hyaluronic acid (HA) embolism has increased markedly in recent years. HA embolism can lead to serious complications such as blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. However, there is a lack of robust clinical evidence regarding the benefits of treatment of HA embolism with intra-arterial thrombolytic therapy (IATT). Read More

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Decade-Long Nationwide Trends and Disparities in Use of Comfort Care Interventions for Patients With Ischemic Stroke.

J Am Heart Assoc 2021 Apr 7:e019785. Epub 2021 Apr 7.

Center for Outcomes Research Houston Methodist Houston TX.

Background Stroke remains one of the leading causes of disability and death in the United States. We characterized 10-year nationwide trends in use of comfort care interventions (CCIs) among patients with ischemic stroke, particularly pertaining to acute thrombolytic therapy with intravenous tissue-type plasminogen activator and endovascular thrombectomy, and describe in-hospital outcomes and costs. Methods and Results We analyzed the National Inpatient Sample from 2006 to 2015 and identified adult patients with ischemic stroke with or without thrombolytic therapy and CCIs using validated ( codes. Read More

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Fibrinolytic and Thrombolytic Effects of an Enzyme Purified from the Fruiting Bodies of Boletus pseudocalopus (Agaricomycetes) from Korea.

Int J Med Mushrooms 2021 ;23(4):47-57

Department of Food Science and Biotechnology, Gwangju University, Gwangju 61743, Republic of Korea.

A fibrinolytic enzyme with thrombolytic, anticoagulant activities was purified from fruiting bodies of wild-growing mushroom Boletus pseudocalopus Hongo and homogenized with a two-step procedure with a 6.11-fold increase in specific activity and 3.2% recovery. Read More

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January 2021

In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d.

Michael D Hill

Ann Intern Med 2021 Apr 6. Epub 2021 Apr 6.

University of Calgary and Hotchkiss Brain Institute & Foothills Medical Centre, Calgary, Alberta, Canada (M.D.H.).

Source Citation: Thomalla G, Boutitie F, Ma H, et al. Lancet. 2020;396:1574-84. Read More

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Opium Addiction and Correlation with Early and Six-month Outcomes of Presenting with ST Elevation Myocardial Infarction Treated Initially with Thrombolytic Therapy.

Am J Cardiovasc Dis 2021 15;11(1):115-123. Epub 2021 Feb 15.

University of Arizona Department of Medicine Tucson, AZ, USA.

Background: Myocardial infarction is one of the most important causes of mortality worldwide. The role of opium addiction in the outcome of myocardial infarction is not known with many unproven beliefs surrounding it. This study was designed to evaluate the effects of opium addiction on in-hospital and six-month outcomes of patients presenting with ST elevation myocardial infarction (STEMI). Read More

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February 2021